3ny9 - Revision history

OCA at 09:24, 6 September 2023

OCA — Wed, 06 Sep 2023 09:24:10 GMT

←Older revision		Revision as of 09:24, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist==		==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist==
-	<StructureSection load='3ny9' size='340' side='right' caption='[[3ny9]], [[Resolution\|resolution]] 2.84Å' scene=''>	+	<StructureSection load='3ny9' size='340' side='right'caption='[[3ny9]], [[Resolution\|resolution]] 2.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.84Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d4s\|3d4s]], [[2rh1\|2rh1]], [[3ny8\|3ny8]], [[3nya\|3nya]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [https://pdbe.org/3ny9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [~~http~~://pdbe.org/3ny9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ny9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.	+	[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 31:

	==See Also==		==See Also==
		+	*[[Adrenergic receptor 3D structures\|Adrenergic receptor 3D structures]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia virus T4]]
-	[[Category: ~~ATCG3D, Accelerated Technologies Center for Gene to 3D Structure~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Abagyan, R]]	+	[[Category: Large Structures]]
-	[[Category: Brown~~, M A~~]]	+	[[Category: Abagyan R]]
-	[[Category: Cherezov, V]]	+	[[Category: Brown MA]]
-	[[Category: Fenalti, G]]	+	[[Category: Cherezov V]]
-	~~[[Category: GPCR, GPCR Network~~]]	+	[[Category: Fenalti G]]
-	[[Category: Katritch, V]]	+	[[Category: Katritch V]]
-	[[Category: Stevens~~, R C~~]]	+	[[Category: Stevens RC]]
-	[[Category: Wacker, D]]	+	[[Category: Wacker D]]
-	~~[[Category: Accelerated technologies center for gene to 3d structure]]~~	+
-	~~[[Category: Adrenalin]]~~	+
-	~~[[Category: Adrenergic]]~~	+
-	~~[[Category: Arrestin]]~~	+
-	~~[[Category: Atcg3d]]~~	+
-	~~[[Category: Compound 2]]~~	+
-	~~[[Category: Fusion]]~~	+
-	~~[[Category: G protein-coupled receptor]]~~	+
-	~~[[Category: G-protein]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Gpcr network]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lysozyme]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Palmitoylation]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Transducer~~]]	+

OCA at 02:29, 16 November 2017

OCA — Thu, 16 Nov 2017 02:29:46 GMT

←Older revision		Revision as of 02:29, 16 November 2017
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Adrenergic receptor\|Adrenergic receptor]]
-	*[[Beta-2 adrenergic receptor\|Beta-2 adrenergic receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
Line 59:		Line 57:
	[[Category: G-protein]]		[[Category: G-protein]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
		+	[[Category: Gpcr]]
		+	[[Category: Gpcr network]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 07:24, 4 August 2016

OCA — Thu, 04 Aug 2016 07:24:36 GMT

←Older revision		Revision as of 07:24, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist==		==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist==
	<StructureSection load='3ny9' size='340' side='right' caption='[[3ny9]], [[Resolution\|resolution]] 2.84Å' scene=''>		<StructureSection load='3ny9' size='340' side='right' caption='[[3ny9]], [[Resolution\|resolution]] 2.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d4s\|3d4s]], [[2rh1\|2rh1]], [[3ny8\|3ny8]], [[3nya\|3nya]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d4s\|3d4s]], [[2rh1\|2rh1]], [[3ny8\|3ny8]], [[3nya\|3nya]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [http://pdbe.org/3ny9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ny9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ny9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Adrenergic receptor\|Adrenergic receptor]]		*[[Adrenergic receptor\|Adrenergic receptor]]
		+	*[[Beta-2 adrenergic receptor\|Beta-2 adrenergic receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
Line 36:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
	[[Category: Abagyan, R]]		[[Category: Abagyan, R]]

OCA at 06:53, 25 December 2014

OCA — Thu, 25 Dec 2014 06:53:40 GMT

←Older revision		Revision as of 06:53, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:50, 9 December 2014

OCA — Tue, 09 Dec 2014 10:50:38 GMT

←Older revision		Revision as of 10:50, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ny9.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist==
		+	<StructureSection load='3ny9' size='340' side='right' caption='[[3ny9]], [[Resolution\|resolution]] 2.84Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d4s\|3d4s]], [[2rh1\|2rh1]], [[3ny8\|3ny8]], [[3nya\|3nya]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny9 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein-coupled receptors (GPCRs) represent a large fraction of current pharmaceutical targets, and of the GPCRs, the beta(2) adrenergic receptor (beta(2)AR) is one of the most extensively studied. Previously, the X-ray crystal structure of beta(2)AR has been determined in complex with two partial inverse agonists, but the global impact of additional ligands on the structure or local impacts on the binding site are not well-understood. To assess the extent of such ligand-induced conformational differences, we determined the crystal structures of a previously described engineered beta(2)AR construct in complex with two inverse agonists: ICI 118,551 (2.8 A), a recently described compound (2.8 A) (Kolb et al, 2009), and the antagonist alprenolol (3.1 A). The structures show the same overall fold observed for the previous beta(2)AR structures and demonstrate that the ligand binding site can accommodate compounds of different chemical and pharmacological properties with only minor local structural rearrangements. All three compounds contain a hydroxy-amine motif that establishes a conserved hydrogen bond network with the receptor and chemically diverse aromatic moieties that form distinct interactions with beta(2)AR. Furthermore, receptor ligand cross-docking experiments revealed that a single beta(2)AR complex can be suitable for docking of a range of antagonists and inverse agonists but also indicate that additional ligand-receptor structures may be useful to further improve performance for in-silico docking or lead-optimization in drug design.

-	~~{{STRUCTURE_3ny9\| PDB=3ny9 \| SCENE= }}~~	+	Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.,Wacker D, Fenalti G, Brown MA, Katritch V, Abagyan R, Cherezov V, Stevens RC J Am Chem Soc. 2010 Aug 25;132(33):11443-5. PMID:20669948<ref>PMID:20669948</ref>

-	~~===Crystal structure~~ of the ~~human beta2 adrenergic receptor in complex with a novel inverse agonist===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20669948}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ny9]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA].~~	+

	==See Also==		==See Also==
	*[[Adrenergic receptor\|Adrenergic receptor]]		*[[Adrenergic receptor\|Adrenergic receptor]]
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020669948<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]	+	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
-	[[Category: Abagyan, R.]]	+	[[Category: Abagyan, R]]
-	[[Category: Brown, M A.]]	+	[[Category: Brown, M A]]
-	[[Category: Cherezov, V.]]	+	[[Category: Cherezov, V]]
-	[[Category: Fenalti, G.]]	+	[[Category: Fenalti, G]]
-	[[Category: GPCR, GPCR Network.]]	+	[[Category: GPCR, GPCR Network]]
-	[[Category: Katritch, V.]]	+	[[Category: Katritch, V]]
-	[[Category: Stevens, R C.]]	+	[[Category: Stevens, R C]]
-	[[Category: Wacker, D.]]	+	[[Category: Wacker, D]]
	[[Category: Accelerated technologies center for gene to 3d structure]]		[[Category: Accelerated technologies center for gene to 3d structure]]
	[[Category: Adrenalin]]		[[Category: Adrenalin]]
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	[[Category: Palmitoylation]]		[[Category: Palmitoylation]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transducer]]		[[Category: Transducer]]

OCA at 13:52, 20 October 2012

OCA — Sat, 20 Oct 2012 13:52:54 GMT

←Older revision		Revision as of 13:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ny9]] is a 1 chain structure ~~of [[Adrenergic receptor]] and [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens~~,_enterobacteria_phage_t4~~ Homo sapiens~~, enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA].	+	[[3ny9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	==Reference==		==Reference==
	<ref group="xtra">PMID:020669948</ref><references group="xtra"/>		<ref group="xtra">PMID:020669948</ref><references group="xtra"/>
-	[[Category: Homo sapiens~~, enterobacteria phage t4~~]]	+	[[Category: Homo sapiens]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
	[[Category: Abagyan, R.]]		[[Category: Abagyan, R.]]

OCA at 04:25, 8 August 2012

OCA — Wed, 08 Aug 2012 04:25:47 GMT

←Older revision		Revision as of 04:25, 8 August 2012
Line 22:		Line 22:
	[[Category: Cherezov, V.]]		[[Category: Cherezov, V.]]
	[[Category: Fenalti, G.]]		[[Category: Fenalti, G.]]
		+	[[Category: GPCR, GPCR Network.]]
	[[Category: Katritch, V.]]		[[Category: Katritch, V.]]
	[[Category: Stevens, R C.]]		[[Category: Stevens, R C.]]

OCA at 13:24, 26 July 2012

OCA — Thu, 26 Jul 2012 13:24:07 GMT

←Older revision		Revision as of 13:24, 26 July 2012
Line 1:		Line 1:
	[[Image:3ny9.png\|left\|200px]]		[[Image:3ny9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ny9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ny9\| PDB=3ny9 \| SCENE= }}		{{STRUCTURE_3ny9\| PDB=3ny9 \| SCENE= }}

	===Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist===		===Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20669948}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20669948 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20669948}}		{{ABSTRACT_PUBMED_20669948}}

OCA: Protected "3ny9" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2012 05:09:52 GMT

Protected "3ny9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 23 May 2012

OCA at 05:09, 23 May 2012

OCA — Wed, 23 May 2012 05:09:51 GMT

←Older revision		Revision as of 05:09, 23 May 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ny9.png\|left\|200px]]		[[Image:3ny9.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3NY9~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA].	+	[[3ny9]] is a 1 chain structure of [[Adrenergic receptor]] and [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA].
		+
		+	==See Also==
		+	*[[Adrenergic receptor\|Adrenergic receptor]]
		+	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20669948~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020669948</ref><references group="xtra"/>
	[[Category: Homo sapiens, enterobacteria phage t4]]		[[Category: Homo sapiens, enterobacteria phage t4]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
Line 52:		Line 55:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transducer]]		[[Category: Transducer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:20:59 2010''