3o2f - Revision history

OCA at 10:02, 14 February 2024

OCA — Wed, 14 Feb 2024 10:02:53 GMT

←Older revision		Revision as of 10:02, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3o2f' size='340' side='right'caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3o2f' size='340' side='right'caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canlf Canlf~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O2F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fwy\|2fwy]], [[3o0i\|3o0i]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [https://pdbe.org/3o2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [https://www.ebi.ac.uk/pdbsum/3o2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [https://pdbe.org/3o2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [https://www.ebi.ac.uk/pdbsum/3o2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ENPL_CANFA ENPL_CANFA]~~] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).	+	[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90alpha, Hsp90beta, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancer phenotype is poorly understood. This is in large part because reagents to study paralog-specific functions in cancer cells have been unavailable. Here we combine compound library screening with structural and computational analyses to identify purine-based chemical tools that are specific for Hsp90 paralogs. We show that Grp94 selectivity is due to the insertion of these compounds into a new allosteric pocket. We use these tools to demonstrate that cancer cells use individual Hsp90 paralogs to regulate a client protein in a tumor-specific manner and in response to proteome alterations. Finally, we provide new mechanistic evidence explaining why selective Grp94 inhibition is particularly efficacious in certain breast cancers.	+
-		+
-	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.,Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. PMID:23995768<ref>PMID:23995768</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3o2f" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]		*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canlf~~]]	+	[[Category: Canis lupus familiaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gewirth~~, D T~~]]	+	[[Category: Gewirth DT]]
-	[[Category: Seidler~~, P M]]~~	+	[[Category: Seidler PM]]
-	~~[[Category: Chaperone-inhibitor complex]]~~	+
-	~~[[Category: Hsp90 heat-shock protein~~]]	+

OCA at 07:14, 12 May 2022

OCA — Thu, 12 May 2022 07:14:10 GMT

←Older revision		Revision as of 07:14, 12 May 2022
Line 1:		Line 1:

	==Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54==		==Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54==
-	<StructureSection load='3o2f' size='340' side='right' caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3o2f' size='340' side='right'caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3O2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O2F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwy\|2fwy]], [[3o0i\|3o0i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fwy\|2fwy]], [[3o0i\|3o0i]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [~~http~~://pdbe.org/3o2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3o2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [https://pdbe.org/3o2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [https://www.ebi.ac.uk/pdbsum/3o2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).	+	[[https://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3o2f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3o2f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Canlf]]		[[Category: Canlf]]
		+	[[Category: Large Structures]]
	[[Category: Gewirth, D T]]		[[Category: Gewirth, D T]]
	[[Category: Seidler, P M]]		[[Category: Seidler, P M]]
	[[Category: Chaperone-inhibitor complex]]		[[Category: Chaperone-inhibitor complex]]
	[[Category: Hsp90 heat-shock protein]]		[[Category: Hsp90 heat-shock protein]]

OCA at 21:53, 15 November 2017

OCA — Wed, 15 Nov 2017 21:53:51 GMT

←Older revision		Revision as of 21:53, 15 November 2017
Line 1:		Line 1:
		+
	==Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54==		==Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54==
	<StructureSection load='3o2f' size='340' side='right' caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3o2f' size='340' side='right' caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canfa Canfa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O2F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O2F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwy\|2fwy]], [[3o0i\|3o0i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwy\|2fwy]], [[3o0i\|3o0i]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 ~~CANFA~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [http://www.ebi.ac.uk/pdbsum/3o2f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [http://pdbe.org/3o2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [http://www.ebi.ac.uk/pdbsum/3o2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3o2f" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Endoplasmin\|Endoplasmin]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canfa~~]]	+	[[Category: Canlf]]
	[[Category: Gewirth, D T]]		[[Category: Gewirth, D T]]
	[[Category: Seidler, P M]]		[[Category: Seidler, P M]]
	[[Category: Chaperone-inhibitor complex]]		[[Category: Chaperone-inhibitor complex]]
	[[Category: Hsp90 heat-shock protein]]		[[Category: Hsp90 heat-shock protein]]

OCA at 14:21, 25 December 2014

OCA — Thu, 25 Dec 2014 14:21:13 GMT

←Older revision		Revision as of 14:21, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}~~	+	==Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54==
-	===Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54===	+	<StructureSection load='3o2f' size='340' side='right' caption='[[3o2f]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23995768}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O2F FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P54:8-[(2,4-DIMETHYLPHENYL)SULFANYL]-3-PENT-4-YN-1-YL-3H-PURIN-6-AMINE'>P54</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwy\|2fwy]], [[3o0i\|3o0i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRP94, HSP90B1, TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o2f RCSB], [http://www.ebi.ac.uk/pdbsum/3o2f PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).		[[http://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90alpha, Hsp90beta, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancer phenotype is poorly understood. This is in large part because reagents to study paralog-specific functions in cancer cells have been unavailable. Here we combine compound library screening with structural and computational analyses to identify purine-based chemical tools that are specific for Hsp90 paralogs. We show that Grp94 selectivity is due to the insertion of these compounds into a new allosteric pocket. We use these tools to demonstrate that cancer cells use individual Hsp90 paralogs to regulate a client protein in a tumor-specific manner and in response to proteome alterations. Finally, we provide new mechanistic evidence explaining why selective Grp94 inhibition is particularly efficacious in certain breast cancers.

-	~~==About this Structure==~~	+	Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.,Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. PMID:23995768<ref>PMID:23995768</ref>
-	~~[[3o2f]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Canfa Canfa]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3O2F OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Endoplasmin\|Endoplasmin]]		*[[Endoplasmin\|Endoplasmin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023995768</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canfa]]		[[Category: Canfa]]
-	[[Category: Gewirth, D T.]]	+	[[Category: Gewirth, D T]]
-	[[Category: Seidler, P M.]]	+	[[Category: Seidler, P M]]
	[[Category: Chaperone-inhibitor complex]]		[[Category: Chaperone-inhibitor complex]]
	[[Category: Hsp90 heat-shock protein]]		[[Category: Hsp90 heat-shock protein]]

OCA at 12:22, 20 November 2013

OCA — Wed, 20 Nov 2013 12:22:03 GMT

←Older revision		Revision as of 12:22, 20 November 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canis_lupus_familiaris Canis lupus familiaris~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].	+	[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].

	==See Also==		==See Also==
Line 14:		Line 14:
	==Reference==		==Reference==
	<ref group="xtra">PMID:023995768</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023995768</ref><references group="xtra"/><references/>
-	[[Category: ~~Canis lupus familiaris~~]]	+	[[Category: Canfa]]
	[[Category: Gewirth, D T.]]		[[Category: Gewirth, D T.]]
	[[Category: Seidler, P M.]]		[[Category: Seidler, P M.]]
	[[Category: Chaperone-inhibitor complex]]		[[Category: Chaperone-inhibitor complex]]
	[[Category: Hsp90 heat-shock protein]]		[[Category: Hsp90 heat-shock protein]]

OCA at 04:15, 12 September 2013

OCA — Thu, 12 Sep 2013 04:15:42 GMT

←Older revision		Revision as of 04:15, 12 September 2013
Line 1:		Line 1:
-	[[Image:3o2f.png\|left\|200px]]
-
	{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}		{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}
-
	===Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54===		===Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54===
		+	{{ABSTRACT_PUBMED_23995768}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).

	==About this Structure==		==About this Structure==
Line 11:		Line 11:
	==See Also==		==See Also==
	*[[Endoplasmin\|Endoplasmin]]		*[[Endoplasmin\|Endoplasmin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023995768</ref><references group="xtra"/><references/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Gewirth, D T.]]		[[Category: Gewirth, D T.]]

OCA at 17:45, 20 October 2012

OCA — Sat, 20 Oct 2012 17:45:27 GMT

←Older revision		Revision as of 17:45, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3o2f]] is a 2 chain structure ~~of [[Endoplasmin]]~~ with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].	+	[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].

	==See Also==		==See Also==

OCA at 01:53, 27 July 2012

OCA — Fri, 27 Jul 2012 01:53:31 GMT

←Older revision		Revision as of 01:53, 27 July 2012
Line 1:		Line 1:
-	[[Image:3o2f.~~jpg~~\|left\|200px]]	+	[[Image:3o2f.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3o2f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}		{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].	+	[[3o2f]] is a 2 chain structure of [[Endoplasmin]] with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].
		+
		+	==See Also==
		+	*[[Endoplasmin\|Endoplasmin]]
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Gewirth, D T.]]		[[Category: Gewirth, D T.]]

OCA at 06:43, 5 October 2011

OCA — Wed, 05 Oct 2011 06:43:16 GMT

←Older revision		Revision as of 06:43, 5 October 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3o2f.jpg\|left\|200px]]

-	The ~~entry 3o2f~~ is ~~ON HOLD~~ ~~until 00 0001~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3o2f", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3o2f\| PDB=3o2f \| SCENE= }}

-	~~Authors: Seidler, P.M., Gewirth, D.T.~~	+	===Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54===

-	~~Description:~~ Structure ~~of the N~~-~~domain of GRP94 bound to the HSP90~~ inhibitor PU-~~H54~~	+
		+	==About this Structure==
		+	[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA].
		+	[[Category: Canis lupus familiaris]]
		+	[[Category: Gewirth, D T.]]
		+	[[Category: Seidler, P M.]]
		+	[[Category: Chaperone-inhibitor complex]]
		+	[[Category: Hsp90 heat-shock protein]]

OCA at 05:06, 28 September 2011

OCA — Wed, 28 Sep 2011 05:06:51 GMT

←Older revision		Revision as of 05:06, 28 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3o2f is ON HOLD until ~~Paper Publication~~	+	The entry 3o2f is ON HOLD until 00 0001

	Authors: Seidler, P.M., Gewirth, D.T.		Authors: Seidler, P.M., Gewirth, D.T.

	Description: Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54		Description: Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54