3o4j - Revision history

OCA at 07:58, 12 July 2023

OCA — Wed, 12 Jul 2023 07:58:22 GMT

←Older revision		Revision as of 07:58, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='3o4j' size='340' side='right'caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3o4j' size='340' side='right'caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aerpx Aerpx~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~APE_1547.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=56636 AERPX])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [https://pdbe.org/3o4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [https://www.ebi.ac.uk/pdbsum/3o4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [https://pdbe.org/3o4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [https://www.ebi.ac.uk/pdbsum/3o4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE]] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.	+	[https://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acylaminoacyl-peptidase]]~~	+	[[Category: Aeropyrum pernix]]
-	~~[[Category: Aerpx~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beke-Somfai, T]]	+	[[Category: Beke-Somfai T]]
-	[[Category: Domokos, K]]	+	[[Category: Domokos K]]
-	[[Category: Harmat, V]]	+	[[Category: Harmat V]]
-	[[Category: Menyhard~~, D K~~]]	+	[[Category: Menyhard DK]]
-	[[Category: Naray-Szabo, G]]	+	[[Category: Naray-Szabo G]]
-	[[Category: Pallo, A]]	+	[[Category: Pallo A]]
-	[[Category: Polgar, L]]	+	[[Category: Polgar L]]
-	[[Category: Szamosi, I]]	+	[[Category: Szamosi I]]
-	[[Category: Szeltner, Z]]	+	[[Category: Szeltner Z]]
-	~~[[Category: Alpha/beta hydrolase fold]]~~	+
-	~~[[Category: Beta propeller]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Oligopeptidase]]~~	+
-	~~[[Category: Size selectivity~~]]	+

OCA at 05:44, 6 October 2021

OCA — Wed, 06 Oct 2021 05:44:13 GMT

←Older revision		Revision as of 05:44, 6 October 2021
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	==Structure and Catalysis of Acylaminoacyl Peptidase==		==Structure and Catalysis of Acylaminoacyl Peptidase==
-	<StructureSection load='3o4j' size='340' side='right' caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3o4j' size='340' side='right'caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3O4J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE_1547.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 AERPX])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE_1547.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 AERPX])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [~~http~~://pdbe.org/3o4j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3o4j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [https://pdbe.org/3o4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [https://www.ebi.ac.uk/pdbsum/3o4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE]] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.	+	[[https://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE]] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3o4j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3o4j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acylaminoacyl peptidase 3D structures\|Acylaminoacyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	[[Category: Acylaminoacyl-peptidase]]		[[Category: Acylaminoacyl-peptidase]]
	[[Category: Aerpx]]		[[Category: Aerpx]]
		+	[[Category: Large Structures]]
	[[Category: Beke-Somfai, T]]		[[Category: Beke-Somfai, T]]
	[[Category: Domokos, K]]		[[Category: Domokos, K]]

OCA at 11:51, 6 November 2017

OCA — Mon, 06 Nov 2017 11:51:46 GMT

←Older revision		Revision as of 11:51, 6 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3o4j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3o4j" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acylaminoacyl peptidase\|Acylaminoacyl peptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:22, 4 August 2016

OCA — Thu, 04 Aug 2016 20:22:57 GMT

←Older revision		Revision as of 20:22, 4 August 2016
Line 1:		Line 1:
		+
	==Structure and Catalysis of Acylaminoacyl Peptidase==		==Structure and Catalysis of Acylaminoacyl Peptidase==
	<StructureSection load='3o4j' size='340' side='right' caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3o4j' size='340' side='right' caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aeropyrum_pernix Aeropyrum pernix~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE_1547.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 ~~Aeropyrum pernix~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE_1547.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 AERPX])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [http://www.ebi.ac.uk/pdbsum/3o4j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [http://pdbe.org/3o4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [http://www.ebi.ac.uk/pdbsum/3o4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3o4j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Acylaminoacyl-peptidase]]		[[Category: Acylaminoacyl-peptidase]]
-	[[Category: ~~Aeropyrum pernix~~]]	+	[[Category: Aerpx]]
	[[Category: Beke-Somfai, T]]		[[Category: Beke-Somfai, T]]
	[[Category: Domokos, K]]		[[Category: Domokos, K]]

OCA at 19:17, 24 December 2014

OCA — Wed, 24 Dec 2014 19:17:20 GMT

←Older revision		Revision as of 19:17, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [http://www.ebi.ac.uk/pdbsum/3o4j PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [http://www.ebi.ac.uk/pdbsum/3o4j PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE]] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:54, 9 December 2014

OCA — Tue, 09 Dec 2014 12:54:23 GMT

←Older revision		Revision as of 12:54, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3o4j.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure and Catalysis of Acylaminoacyl Peptidase==
		+	<StructureSection load='3o4j' size='340' side='right' caption='[[3o4j]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3o4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o4g\|3o4g]], [[3o4h\|3o4h]], [[3o4i\|3o4i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE_1547.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 Aeropyrum pernix])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4j RCSB], [http://www.ebi.ac.uk/pdbsum/3o4j PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acylaminoacyl peptidase from Aeropyrum pernix is a homodimer that belongs to the prolyl oligopeptidase family. The monomer subunit is composed of one hydrolase and one propeller domain. Previous crystal structure determinations revealed that the propeller domain obstructed the access of substrate to the active site of both subunits. Here we investigated the structure and the kinetics of two mutant enzymes in which the aspartic acid of the catalytic triad was changed to alanine or asparagine. Using different substrates, we have determined the pH dependence of specificity rate constants, the rate-limiting step of catalysis, the binding of substrates and inhibitors. The catalysis considerably depended both on the kind of mutation and on the nature of the substrate. The results were interpreted in terms of alterations in the position of the catalytic histidine side chain as demonstrated with crystal structure determination of the native and the two mutant structures (D524N, D524A). Unexpectedly, in the homodimeric structures, only one subunit displayed the closed form of the enzyme. The other subunit exhibited an open gate to the catalytic site, thus revealing the structural basis that controls the oligopeptidase activity. The open form of the native enzyme displayed the catalytic triad in distorted, inactive state. The mutations affected the closed, active form of the enzyme, disrupting its catalytic triad. It is concluded that the two forms are at equilibrium, and the substrates bind by the conformational selection mechanism.

-	~~{{STRUCTURE_3o4j\| PDB=3o4j \| SCENE= }}~~	+	Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase.,Harmat V, Domokos K, Menyhard DK, Pallo A, Szeltner Z, Szamosi I, Beke-Somfai T, Naray-Szabo G, Polgar L J Biol Chem. 2010 Nov 16. PMID:21084296<ref>PMID:21084296</ref>

-	~~===Structure and Catalysis~~ of ~~Acylaminoacyl Peptidase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21084296}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3o4j]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aeropyrum_pernix Aeropyrum pernix]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].~~	+

	==See Also==		==See Also==
	*[[Acylaminoacyl peptidase\|Acylaminoacyl peptidase]]		*[[Acylaminoacyl peptidase\|Acylaminoacyl peptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021084296<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acylaminoacyl-peptidase]]		[[Category: Acylaminoacyl-peptidase]]
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
-	[[Category: Beke-Somfai, T.]]	+	[[Category: Beke-Somfai, T]]
-	[[Category: Domokos, K.]]	+	[[Category: Domokos, K]]
-	[[Category: Harmat, V.]]	+	[[Category: Harmat, V]]
-	[[Category: Menyhard, D K.]]	+	[[Category: Menyhard, D K]]
-	[[Category: Naray-Szabo, G.]]	+	[[Category: Naray-Szabo, G]]
-	[[Category: Pallo, A.]]	+	[[Category: Pallo, A]]
-	[[Category: Polgar, L.]]	+	[[Category: Polgar, L]]
-	[[Category: Szamosi, I.]]	+	[[Category: Szamosi, I]]
-	[[Category: Szeltner, Z.]]	+	[[Category: Szeltner, Z]]
	[[Category: Alpha/beta hydrolase fold]]		[[Category: Alpha/beta hydrolase fold]]
	[[Category: Beta propeller]]		[[Category: Beta propeller]]

OCA at 08:19, 20 October 2012

OCA — Sat, 20 Oct 2012 08:19:13 GMT

←Older revision		Revision as of 08:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3o4j]] is a 4 chain structure ~~of [[Acylaminoacyl peptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].	+	[[3o4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].

	==See Also==		==See Also==

OCA at 19:09, 25 July 2012

OCA — Wed, 25 Jul 2012 19:09:22 GMT

←Older revision		Revision as of 19:09, 25 July 2012
Line 1:		Line 1:
	[[Image:3o4j.png\|left\|200px]]		[[Image:3o4j.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3o4j\| PDB=3o4j \| SCENE= }}		{{STRUCTURE_3o4j\| PDB=3o4j \| SCENE= }}

	===Structure and Catalysis of Acylaminoacyl Peptidase===		===Structure and Catalysis of Acylaminoacyl Peptidase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21084296}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21084296 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21084296}}		{{ABSTRACT_PUBMED_21084296}}

	==About this Structure==		==About this Structure==
-	[[3o4j]] is a 4 chain structure of [[Acylaminoacyl peptidase~~]] and [[Enoyl-Acyl-Carrier Protein Reductase~~]] with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].	+	[[3o4j]] is a 4 chain structure of [[Acylaminoacyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].

	==See Also==		==See Also==
-	*[[Acylaminoacyl peptidase]]	+	*[[Acylaminoacyl peptidase\|Acylaminoacyl peptidase]]
-	*[[Enoyl-Acyl-Carrier Protein Reductase]]	+

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21084296~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021084296</ref><references group="xtra"/>
	[[Category: Acylaminoacyl-peptidase]]		[[Category: Acylaminoacyl-peptidase]]
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
Line 38:		Line 26:
	[[Category: Szamosi, I.]]		[[Category: Szamosi, I.]]
	[[Category: Szeltner, Z.]]		[[Category: Szeltner, Z.]]
		+	[[Category: Alpha/beta hydrolase fold]]
		+	[[Category: Beta propeller]]
		+	[[Category: Hydrolase]]
		+	[[Category: Oligopeptidase]]
		+	[[Category: Size selectivity]]

OCA at 05:34, 9 February 2011

OCA — Wed, 09 Feb 2011 05:34:31 GMT

←Older revision		Revision as of 05:34, 9 February 2011
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3o4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].	+	[[3o4j]] is a 4 chain structure of [[Acylaminoacyl peptidase]] and [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4J OCA].
		+
		+	==See Also==
		+	*[[Acylaminoacyl peptidase]]
		+	*[[Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==

OCA: Protected "3o4j" [edit=sysop:move=sysop]

OCA — Wed, 05 Jan 2011 15:37:24 GMT

Protected "3o4j" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:37, 5 January 2011