3o4z - Revision history

OCA at 10:32, 21 February 2024

OCA — Wed, 21 Feb 2024 10:32:40 GMT

←Older revision		Revision as of 10:32, 21 February 2024
Line 1:		Line 1:

	==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==		==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==
-	<StructureSection load='3o4z' size='340' side='right' caption='[[3o4z]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3o4z' size='340' side='right'caption='[[3o4z]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TEL2~~, ~~YGR099W (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [~~http~~://pdbe.org/3o4z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3o4z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [https://pdbe.org/3o4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [https://www.ebi.ac.uk/pdbsum/3o4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.	+	[https://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4z ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK complexes. Quantitative immunoblotting showed that the abundance of Tel2 is low compared with the PIKKs, and Tel2 preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs. Tel2 complexes contained, in addition to Tti1-Tti2, the Hsp90 chaperone, and inhibition of Hsp90 interfered with the interaction of Tel2 with the PIKKs. Analysis of in vivo labeled nascent protein complexes showed that Tel2 and Hsp90 mediate the formation of the mTOR TORC1 and TORC2 complexes and the association of ATR with ATRIP. The structure of yeast Tel2, reported here, shows that Tel2 consists of HEAT-like helical repeats that assemble into two separate alpha-solenoids. Through mutagenesis, we identify a surface patch of conserved residues involved in binding to the Tti1-Tti2 complex in vitro. In vivo, mutation of this conserved patch affects cell growth, levels of PIKKs, and ATM/ATR-mediated checkpoint signaling, highlighting the importance of Tti1-Tti2 binding to the function of Tel2. Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.
-
-	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.,Takai H, Xie Y, de Lange T, Pavletich NP Genes Dev. 2010 Aug 27. PMID:20801936<ref>PMID:20801936</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3o4z" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pavletich, N P~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Xie, Y~~]]	+	[[Category: Pavletich NP]]
-	[[Category: ~~Heat like helical repeat]]~~	+	[[Category: Xie Y]]
-	~~[[Category: Protein binding~~]]	+

OCA at 17:54, 5 August 2016

OCA — Fri, 05 Aug 2016 17:54:33 GMT

←Older revision		Revision as of 17:54, 5 August 2016
Line 1:		Line 1:
		+
	==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==		==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==
	<StructureSection load='3o4z' size='340' side='right' caption='[[3o4z]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3o4z' size='340' side='right' caption='[[3o4z]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEL2, YGR099W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEL2, YGR099W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [http://www.ebi.ac.uk/pdbsum/3o4z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [http://pdbe.org/3o4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [http://www.ebi.ac.uk/pdbsum/3o4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3o4z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Pavletich, N P]]		[[Category: Pavletich, N P]]
	[[Category: Xie, Y]]		[[Category: Xie, Y]]
	[[Category: Heat like helical repeat]]		[[Category: Heat like helical repeat]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 04:36, 25 December 2014

OCA — Thu, 25 Dec 2014 04:36:58 GMT

←Older revision		Revision as of 04:36, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [http://www.ebi.ac.uk/pdbsum/3o4z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [http://www.ebi.ac.uk/pdbsum/3o4z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:15, 19 December 2014

OCA — Fri, 19 Dec 2014 07:15:19 GMT

←Older revision		Revision as of 07:15, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3o4z\| PDB=3o4z \| SCENE= }}~~	+	==Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes==
-	===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes===	+	<StructureSection load='3o4z' size='340' side='right' caption='[[3o4z]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20801936}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O4Z FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEL2, YGR099W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o4z RCSB], [http://www.ebi.ac.uk/pdbsum/3o4z PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK complexes. Quantitative immunoblotting showed that the abundance of Tel2 is low compared with the PIKKs, and Tel2 preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs. Tel2 complexes contained, in addition to Tti1-Tti2, the Hsp90 chaperone, and inhibition of Hsp90 interfered with the interaction of Tel2 with the PIKKs. Analysis of in vivo labeled nascent protein complexes showed that Tel2 and Hsp90 mediate the formation of the mTOR TORC1 and TORC2 complexes and the association of ATR with ATRIP. The structure of yeast Tel2, reported here, shows that Tel2 consists of HEAT-like helical repeats that assemble into two separate alpha-solenoids. Through mutagenesis, we identify a surface patch of conserved residues involved in binding to the Tti1-Tti2 complex in vitro. In vivo, mutation of this conserved patch affects cell growth, levels of PIKKs, and ATM/ATR-mediated checkpoint signaling, highlighting the importance of Tti1-Tti2 binding to the function of Tel2. Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

-	~~==Function==~~	+	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.,Takai H, Xie Y, de Lange T, Pavletich NP Genes Dev. 2010 Aug 27. PMID:20801936<ref>PMID:20801936</ref>
-	~~[[http://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of~~ the ~~TTT complex that is required to stabilize protein levels~~ of ~~the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation~~ and ~~telomere position effect~~. ~~Regulates telomere length and participates in gene silencing at subtelomeric regions~~. ~~Binds to telomeric DNA repeats~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3o4z]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020801936</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Pavletich, N P.]]	+	[[Category: Pavletich, N P]]
-	[[Category: Xie, Y.]]	+	[[Category: Xie, Y]]
	[[Category: Heat like helical repeat]]		[[Category: Heat like helical repeat]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA: Protected "3o4z" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 11:57:31 GMT

Protected "3o4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:57, 24 April 2013

OCA at 11:57, 24 April 2013

OCA — Wed, 24 Apr 2013 11:57:29 GMT

←Older revision		Revision as of 11:57, 24 April 2013
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-	{{Seed}}
-	[[Image:3o4z.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3o4z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3o4z\| PDB=3o4z \| SCENE= }}		{{STRUCTURE_3o4z\| PDB=3o4z \| SCENE= }}
-
	===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes===		===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes===
		+	{{ABSTRACT_PUBMED_20801936}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20801936}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20801936~~ is the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20801936}}~~	+

	==About this Structure==		==About this Structure==
-	~~3O4Z~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA].	+	[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20801936~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020801936</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Pavletich, N P.]]		[[Category: Pavletich, N P.]]
Line 29:		Line 16:
	[[Category: Heat like helical repeat]]		[[Category: Heat like helical repeat]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:18:52 2010''

OCA at 11:09, 22 September 2010

OCA — Wed, 22 Sep 2010 11:09:53 GMT

←Older revision		Revision as of 11:09, 22 September 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3o4z.~~jpg~~\|left\|200px]]	+	[[Image:3o4z.png\|left\|200px]]

	<!--		<!--
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	[[Category: Protein binding]]		[[Category: Protein binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~15 10~~:54:15 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:18:52 2010''

OCA at 07:45, 15 September 2010

OCA — Wed, 15 Sep 2010 07:45:40 GMT

←Older revision		Revision as of 07:45, 15 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3o4z.jpg\|left\|200px]]

-	The ~~entry 3o4z~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3o4z", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3o4z\| PDB=3o4z \| SCENE= }}

-	~~Authors: Xie, Y., Pavletich, N.P.~~	+	===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes===

-	Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 25 08~~:37:20 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20801936}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20801936 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20801936}}
		+
		+	==About this Structure==
		+	3O4Z is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20801936</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Pavletich, N P.]]
		+	[[Category: Xie, Y.]]
		+	[[Category: Heat like helical repeat]]
		+	[[Category: Protein binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:54:15 2010''

OCA at 04:29, 25 August 2010

OCA — Wed, 25 Aug 2010 04:29:29 GMT

←Older revision		Revision as of 04:29, 25 August 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3o4z is ON HOLD	+	The entry 3o4z is ON HOLD until Paper Publication

	Authors: Xie, Y., Pavletich, N.P.		Authors: Xie, Y., Pavletich, N.P.
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	Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes		Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:53:38 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:37:20 2010''

OCA: New page: '''Unreleased structure''' The entry 3o4z is ON HOLD Authors: Xie, Y., Pavletich, N.P. Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR comple...

OCA — Wed, 04 Aug 2010 04:46:39 GMT

New page: '''Unreleased structure''' The entry 3o4z is ON HOLD Authors: Xie, Y., Pavletich, N.P. Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR comple...

New page

'''Unreleased structure'''

The entry 3o4z is ON HOLD

Authors: Xie, Y., Pavletich, N.P.

Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:53:38 2010''