3o6n - Revision history

OCA at 09:56, 30 January 2019

OCA — Wed, 30 Jan 2019 09:56:29 GMT

←Older revision		Revision as of 09:56, 30 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:03, 4 August 2016

OCA — Thu, 04 Aug 2016 10:03:58 GMT

←Older revision		Revision as of 10:03, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of APL1 leucine-rich repeat domain==		==Crystal Structure of APL1 leucine-rich repeat domain==
	<StructureSection load='3o6n' size='340' side='right' caption='[[3o6n]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3o6n' size='340' side='right' caption='[[3o6n]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anopheles_gambiae Anopheles gambiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o53\|3o53]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o53\|3o53]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ~~Anopheles gambiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o6n RCSB], [http://www.ebi.ac.uk/pdbsum/3o6n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6n OCA], [http://pdbe.org/3o6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o6n RCSB], [http://www.ebi.ac.uk/pdbsum/3o6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6n ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o6n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3o6n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anopheles gambiae~~]]	+	[[Category: Anoga]]
	[[Category: Baxter, R H.G]]		[[Category: Baxter, R H.G]]
	[[Category: Chelliah, Y]]		[[Category: Chelliah, Y]]

OCA at 06:48, 19 December 2014

OCA — Fri, 19 Dec 2014 06:48:11 GMT

←Older revision		Revision as of 06:48, 19 December 2014
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-	~~{{STRUCTURE_3o6n\| PDB=3o6n \| SCENE= }}~~	+	==Crystal Structure of APL1 leucine-rich repeat domain==
-	===Crystal Structure of APL1 leucine-rich repeat domain===	+	<StructureSection load='3o6n' size='340' side='right' caption='[[3o6n]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20826443}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3o6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o53\|3o53]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o6n RCSB], [http://www.ebi.ac.uk/pdbsum/3o6n PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The leucine-rich repeat (LRR) proteins LRIM1 and APL1C control the function of the complement-like protein TEP1 in Anopheles mosquitoes. The molecular structure of LRIM1 and APL1C and the basis of their interaction with TEP1 represent a new type of innate immune complex. The LRIM1/APL1C complex specifically binds and solubilizes a cleaved form of TEP1 without an intact thioester bond. The LRIM1 and APL1C LRR domains have a large radius of curvature, glycosylated concave face, and a novel C-terminal capping motif. The LRIM1/APL1C complex is a heterodimer with a single intermolecular disulfide bond. The structure of the LRIM1/APL1C heterodimer reveals an interface between the two LRR domains and an extensive C-terminal coiled-coil domain. We propose that a cleaved form of TEP1 may act as a convertase for activation of other TEP1 molecules and that the LRIM1/APL1C heterodimer regulates formation of this TEP1 convertase.

-	~~==About this Structure==~~	+	A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.,Baxter RH, Steinert S, Chelliah Y, Volohonsky G, Levashina EA, Deisenhofer J Proc Natl Acad Sci U S A. 2010 Sep 8. PMID:20826443<ref>PMID:20826443</ref>
-	~~[[3o6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae~~ Anopheles gambiae]. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3O6N OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020826443</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Baxter, R H.G.]]	+	[[Category: Baxter, R H.G]]
-	[[Category: Chelliah, Y.]]	+	[[Category: Chelliah, Y]]
-	[[Category: Deisenhofer, J.]]	+	[[Category: Deisenhofer, J]]
-	[[Category: Levashina, E A.]]	+	[[Category: Levashina, E A]]
-	[[Category: Steinert, S.]]	+	[[Category: Steinert, S]]
-	[[Category: Volohonsky, G.]]	+	[[Category: Volohonsky, G]]
	[[Category: Leucine-rich repeat]]		[[Category: Leucine-rich repeat]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 11:59, 24 April 2013

OCA — Wed, 24 Apr 2013 11:59:55 GMT

←Older revision		Revision as of 11:59, 24 April 2013
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-	[[Image:3o6n.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3o6n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3o6n\| PDB=3o6n \| SCENE= }}		{{STRUCTURE_3o6n\| PDB=3o6n \| SCENE= }}
-
	===Crystal Structure of APL1 leucine-rich repeat domain===		===Crystal Structure of APL1 leucine-rich repeat domain===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20826443}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20826443 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20826443}}		{{ABSTRACT_PUBMED_20826443}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20826443~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020826443</ref><references group="xtra"/><references/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Baxter, R H.G.]]		[[Category: Baxter, R H.G.]]
Line 30:		Line 15:
	[[Category: Steinert, S.]]		[[Category: Steinert, S.]]
	[[Category: Volohonsky, G.]]		[[Category: Volohonsky, G.]]
		+	[[Category: Leucine-rich repeat]]
		+	[[Category: Protein binding]]

OCA: Protected "3o6n" [edit=sysop:move=sysop]

OCA — Wed, 05 Jan 2011 15:36:14 GMT

Protected "3o6n" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 5 January 2011

OCA at 15:36, 5 January 2011

OCA — Wed, 05 Jan 2011 15:36:13 GMT

←Older revision		Revision as of 15:36, 5 January 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3o6n.png\|left\|200px]]
-	[[Image:3o6n.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3O6N~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA].	+	[[3o6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA].

	==Reference==		==Reference==
Line 31:		Line 30:
	[[Category: Steinert, S.]]		[[Category: Steinert, S.]]
	[[Category: Volohonsky, G.]]		[[Category: Volohonsky, G.]]
-	[[Category: Leucine-rich repeat]]
-	[[Category: Protein binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:48:52 2010''

OCA at 11:39, 22 September 2010

OCA — Wed, 22 Sep 2010 11:39:53 GMT

←Older revision		Revision as of 11:39, 22 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3o6n.jpg\|left\|200px]]

-	The ~~entry 3o6n~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3o6n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3o6n\| PDB=3o6n \| SCENE= }}

-	~~Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J.~~	+	===Crystal Structure of APL1 leucine-rich repeat domain===

-	Description: Crystal Structure of APL1 leucine-rich repeat domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~15 10~~:35:24 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20826443}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20826443 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20826443}}
		+
		+	==About this Structure==
		+	3O6N is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20826443</ref><references group="xtra"/>
		+	[[Category: Anopheles gambiae]]
		+	[[Category: Baxter, R H.G.]]
		+	[[Category: Chelliah, Y.]]
		+	[[Category: Deisenhofer, J.]]
		+	[[Category: Levashina, E A.]]
		+	[[Category: Steinert, S.]]
		+	[[Category: Volohonsky, G.]]
		+	[[Category: Leucine-rich repeat]]
		+	[[Category: Protein binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:48:52 2010''

OCA at 07:26, 15 September 2010

OCA — Wed, 15 Sep 2010 07:26:42 GMT

←Older revision		Revision as of 07:26, 15 September 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3o6n is ON HOLD	+	The entry 3o6n is ON HOLD until Paper Publication

	Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J.		Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J.
Line 7:		Line 7:
	Description: Crystal Structure of APL1 leucine-rich repeat domain		Description: Crystal Structure of APL1 leucine-rich repeat domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 4 08~~:54:53 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:35:24 2010''

OCA: New page: '''Unreleased structure''' The entry 3o6n is ON HOLD Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J. Description: Crystal Structur...

OCA — Wed, 04 Aug 2010 04:47:54 GMT

New page: '''Unreleased structure''' The entry 3o6n is ON HOLD Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J. Description: Crystal Structur...

New page

'''Unreleased structure'''

The entry 3o6n is ON HOLD

Authors: Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J.

Description: Crystal Structure of APL1 leucine-rich repeat domain

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:54:53 2010''