3o9m - Revision history

OCA at 10:04, 14 February 2024

OCA — Wed, 14 Feb 2024 10:04:20 GMT

←Older revision		Revision as of 10:04, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3o9m' size='340' side='right'caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='3o9m' size='340' side='right'caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.98Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2pm8\|2pm8]]~~, [[~~2p0p~~\|~~2p0p~~]]~~, [[2wsl\|2wsl]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BCHE, CHE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [https://pdbe.org/3o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [https://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [https://pdbe.org/3o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [https://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a 340 kDa tetrameric glycoprotein that is present in human serum at about 5 mg l(-1) and has well documented therapeutic effects on cocaine toxicity. BChE holds promise as a therapeutic that reduces and finally eliminates the rewarding effects of cocaine, thus weaning an addict from the drug. There have been extensive computational studies of cocaine hydrolysis by BChE. Since there are no reported structures of BChE with cocaine or any of the hydrolysis products, full-length monomeric recombinant wild-type BChE was cocrystallized with cocaine. The refined 3 A resolution structure appears to retain the hydrolysis product benzoic acid in sufficient proximity to form a hydrogen bond to the active-site Ser198.	+
-		+
-	Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine.,Asojo OA, Asojo OA, Ngamelue MN, Homma K, Lockridge O Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):434-7. Epub 2011 Mar 24. PMID:21505234<ref>PMID:21505234</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3o9m" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 30:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cholinesterase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asojo~~, O A~~]]	+	[[Category: Asojo OA]]
-	[[Category: Homma, K]]	+	[[Category: Homma K]]
-	[[Category: Lockridge, O]]	+	[[Category: Lockridge O]]
-	[[Category: Ngamelue~~, M N]]~~	+	[[Category: Ngamelue MN]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:19, 12 May 2022

OCA — Thu, 12 May 2022 07:19:10 GMT

←Older revision		Revision as of 07:19, 12 May 2022
Line 1:		Line 1:

	==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==		==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==
-	<StructureSection load='3o9m' size='340' side='right' caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>	+	<StructureSection load='3o9m' size='340' side='right'caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3O9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pm8\|2pm8]], [[2p0p\|2p0p]], [[2wsl\|2wsl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pm8\|2pm8]], [[2p0p\|2p0p]], [[2wsl\|2wsl]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [~~http~~://pdbe.org/3o9m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [https://pdbe.org/3o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [https://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[~~http~~://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.	+	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>	+	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:

	==See Also==		==See Also==
-	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]	+	*[[Butyrylcholinesterase 3D structures\|Butyrylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 32:
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Asojo, O A]]		[[Category: Asojo, O A]]
	[[Category: Homma, K]]		[[Category: Homma, K]]

OCA at 18:31, 4 August 2016

OCA — Thu, 04 Aug 2016 18:31:34 GMT

←Older revision		Revision as of 18:31, 4 August 2016
Line 1:		Line 1:
		+
	==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==		==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==
	<StructureSection load='3o9m' size='340' side='right' caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>		<StructureSection load='3o9m' size='340' side='right' caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O9M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pm8\|2pm8]], [[2p0p\|2p0p]], [[2wsl\|2wsl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pm8\|2pm8]], [[2p0p\|2p0p]], [[2wsl\|2wsl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [http://www.ebi.ac.uk/pdbsum/3o9m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [http://pdbe.org/3o9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [http://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3o9m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Asojo, O A]]		[[Category: Asojo, O A]]
	[[Category: Homma, K]]		[[Category: Homma, K]]

OCA at 07:02, 19 December 2014

OCA — Fri, 19 Dec 2014 07:02:18 GMT

←Older revision		Revision as of 07:02, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}~~	+	==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==
-	===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===	+	<StructureSection load='3o9m' size='340' side='right' caption='[[3o9m]], [[Resolution\|resolution]] 2.98Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21505234}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O9M FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pm8\|2pm8]], [[2p0p\|2p0p]], [[2wsl\|2wsl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [http://www.ebi.ac.uk/pdbsum/3o9m PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.		[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a 340 kDa tetrameric glycoprotein that is present in human serum at about 5 mg l(-1) and has well documented therapeutic effects on cocaine toxicity. BChE holds promise as a therapeutic that reduces and finally eliminates the rewarding effects of cocaine, thus weaning an addict from the drug. There have been extensive computational studies of cocaine hydrolysis by BChE. Since there are no reported structures of BChE with cocaine or any of the hydrolysis products, full-length monomeric recombinant wild-type BChE was cocrystallized with cocaine. The refined 3 A resolution structure appears to retain the hydrolysis product benzoic acid in sufficient proximity to form a hydrogen bond to the active-site Ser198.

-	~~==Function==~~	+	Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine.,Asojo OA, Asojo OA, Ngamelue MN, Homma K, Lockridge O Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):434-7. Epub 2011 Mar 24. PMID:21505234<ref>PMID:21505234</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity~~. ~~Contributes to the inactivation of the neurotransmitter acetylcholine~~. ~~Can degrade neurotoxic organophosphate esters.<ref>~~PMID:~~19542320</ref>~~<ref>PMID:~~19452557~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3o9m]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]		*[[Butyrylcholinesterase\|Butyrylcholinesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021505234</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Asojo, O A.]]	+	[[Category: Asojo, O A]]
-	[[Category: Homma, K.]]	+	[[Category: Homma, K]]
-	[[Category: Lockridge, O.]]	+	[[Category: Lockridge, O]]
-	[[Category: Ngamelue, M N~~.]]~~	+	[[Category: Ngamelue, M N]]
-	~~[[Category: Cholinesterase~~]]	+
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 00:24, 25 March 2013

OCA — Mon, 25 Mar 2013 00:24:39 GMT

←Older revision		Revision as of 00:24, 25 March 2013
Line 1:		Line 1:
-	[[Image:3o9m.png\|left\|200px]]
-
	{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}		{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}
-
	===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===		===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===
		+	{{ABSTRACT_PUBMED_21505234}}

-	~~{{ABSTRACT_PUBMED_21505234}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021505234</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021505234</ref><references group="xtra"/><references/>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:51, 20 October 2012

OCA — Sat, 20 Oct 2012 07:51:30 GMT

←Older revision		Revision as of 07:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3o9m]] is a 2 chain structure ~~of [[Butyrylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].	+	[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].

	==See Also==		==See Also==

OCA at 17:41, 25 July 2012

OCA — Wed, 25 Jul 2012 17:41:07 GMT

←Older revision		Revision as of 17:41, 25 July 2012
Line 1:		Line 1:
	[[Image:3o9m.png\|left\|200px]]		[[Image:3o9m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3o9m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}		{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}

	===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===		===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21505234}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21505234 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21505234}}		{{ABSTRACT_PUBMED_21505234}}

	==About this Structure==		==About this Structure==
-	[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].	+	[[3o9m]] is a 2 chain structure of [[Butyrylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].
		+
		+	==See Also==
		+	*[[Butyrylcholinesterase\|Butyrylcholinesterase]]

	==Reference==		==Reference==
Line 29:		Line 21:
	[[Category: Lockridge, O.]]		[[Category: Lockridge, O.]]
	[[Category: Ngamelue, M N.]]		[[Category: Ngamelue, M N.]]
		+	[[Category: Cholinesterase]]
		+	[[Category: Hydrolase]]

OCA at 04:00, 12 May 2011

OCA — Thu, 12 May 2011 04:00:51 GMT

←Older revision		Revision as of 04:00, 12 May 2011
Line 1:		Line 1:
-	[[Image:3o9m.~~jpg~~\|left\|200px]]	+	[[Image:3o9m.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===		===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21505234}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21505234 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21505234}}

	==About this Structure==		==About this Structure==
	[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].		[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021505234</ref><references group="xtra"/>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:24, 13 April 2011

OCA — Wed, 13 Apr 2011 05:24:31 GMT

←Older revision		Revision as of 05:24, 13 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3o9m.jpg\|left\|200px]]

-	The ~~entry 3o9m~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3o9m", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3o9m\| PDB=3o9m \| SCENE= }}

-	~~Authors: Asojo, O.A., Ngamelue, M.N., Homma, K., Lockridge, O.~~	+	===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===

-	~~Description~~: Co-~~crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification~~	+
		+	==About this Structure==
		+	[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].
		+	[[Category: Cholinesterase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Asojo, O A.]]
		+	[[Category: Homma, K.]]
		+	[[Category: Lockridge, O.]]
		+	[[Category: Ngamelue, M N.]]

OCA at 06:39, 23 March 2011

OCA — Wed, 23 Mar 2011 06:39:33 GMT

←Older revision		Revision as of 06:39, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3o9m is ON HOLD until ~~sometime in the future~~	+	The entry 3o9m is ON HOLD until Paper Publication

	Authors: Asojo, O.A., Ngamelue, M.N., Homma, K., Lockridge, O.		Authors: Asojo, O.A., Ngamelue, M.N., Homma, K., Lockridge, O.

	Description: Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification		Description: Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification