3odw - Revision history

OCA at 09:36, 6 September 2023

OCA — Wed, 06 Sep 2023 09:36:16 GMT

←Older revision		Revision as of 09:36, 6 September 2023
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	<StructureSection load='3odw' size='340' side='right'caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3odw' size='340' side='right'caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ARHGEF1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [https://pdbe.org/3odw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [https://www.ebi.ac.uk/pdbsum/3odw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [https://pdbe.org/3odw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [https://www.ebi.ac.uk/pdbsum/3odw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>	+	[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>

	==See Also==		==See Also==
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Guo, L]]	+	[[Category: Guo L]]
-	[[Category: Sprang~~, S R~~]]	+	[[Category: Sprang SR]]
-	[[Category: Sternweis~~, P C]]~~	+	[[Category: Sternweis PC]]
-	~~[[Category: Dh]]~~	+
-	~~[[Category: Ph]]~~	+
-	~~[[Category: Regulation of rhoa gtpase]]~~	+
-	~~[[Category: Rho]]~~	+
-	~~[[Category: Rhogef]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:40, 18 May 2022

OCA — Wed, 18 May 2022 10:40:54 GMT

←Older revision		Revision as of 10:40, 18 May 2022
Line 1:		Line 1:

	==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==		==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==
-	<StructureSection load='3odw' size='340' side='right' caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='3odw' size='340' side='right'caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ODW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [~~http~~://pdbe.org/3odw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3odw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3odw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [https://pdbe.org/3odw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [https://www.ebi.ac.uk/pdbsum/3odw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>	+	[[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>

	==See Also==		==See Also==
-	*[[Rho guanine nucleotide exchange factor\|Rho guanine nucleotide exchange factor]]	+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Guo, L]]		[[Category: Guo, L]]

OCA at 23:08, 4 August 2016

OCA — Thu, 04 Aug 2016 23:08:00 GMT

←Older revision		Revision as of 23:08, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==		==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==
	<StructureSection load='3odw' size='340' side='right' caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3odw' size='340' side='right' caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://pdbe.org/3odw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3odw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>		[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
		+
		+	==See Also==
		+	*[[Rho guanine nucleotide exchange factor\|Rho guanine nucleotide exchange factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:31, 24 December 2014

OCA — Wed, 24 Dec 2014 20:31:50 GMT

←Older revision		Revision as of 20:31, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:13, 21 December 2014

OCA — Sun, 21 Dec 2014 18:13:13 GMT

←Older revision		Revision as of 18:13, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3odw\| PDB=3odw \| SCENE= }}~~	+	==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==
-	===Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF===	+	<StructureSection load='3odw' size='340' side='right' caption='[[3odw]], [[Resolution\|resolution]] 3.20Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ODW FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~ARHG1_HUMAN ARHG1_HUMAN~~]] ~~Seems to play~~ a ~~role in~~ the ~~regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits~~. ~~Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase~~. ~~Activated G alpha 13~~/~~GNA13 stimulates the RhoGEF activity through interaction with the RGS~~-~~like domain~~. ~~This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation~~.<~~ref~~>~~PMID:8810315~~</~~ref~~> <~~ref~~>~~PMID:9641915~~<~~/ref~~> <~~ref~~>~~PMID~~:~~9641916~~</~~ref~~> <~~ref~~>~~PMID:20098430~~</~~ref~~>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3odo\|3odo]], [[1txd\|1txd]], [[1xcg\|1xcg]], [[3kz1\|3kz1]], [[1x86\|1x86]], [[3odx\|3odx]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	==~~About this Structure==~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum]</span></td></tr>
-	[[~~3odw~~]] ~~is a 2 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Human Human~~]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~3ODW~~ OCA].	+	</table>
-		+	__TOC__
-	~~==Reference=~~=	+	</StructureSection>
-	<~~references group="xtra"~~/><~~references~~/>	+
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Guo, L.]]	+	[[Category: Guo, L]]
-	[[Category: Sprang, S R.]]	+	[[Category: Sprang, S R]]
-	[[Category: Sternweis, P C.]]	+	[[Category: Sternweis, P C]]
	[[Category: Dh]]		[[Category: Dh]]
	[[Category: Ph]]		[[Category: Ph]]

OCA at 15:07, 19 February 2014

OCA — Wed, 19 Feb 2014 15:07:45 GMT

←Older revision		Revision as of 15:07, 19 February 2014
Line 6:		Line 6:

	==About this Structure==		==About this Structure==
-	[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].	+	[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
	[[Category: Guo, L.]]		[[Category: Guo, L.]]

OCA at 08:32, 2 May 2013

OCA — Thu, 02 May 2013 08:32:54 GMT

←Older revision		Revision as of 08:32, 2 May 2013
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-	[[Image:3odw.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3odw\| PDB=3odw \| SCENE= }}		{{STRUCTURE_3odw\| PDB=3odw \| SCENE= }}
-
	===Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF===		===Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>

	==About this Structure==		==About this Structure==
	[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].		[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
Line 19:		Line 15:
	[[Category: Sprang, S R.]]		[[Category: Sprang, S R.]]
	[[Category: Sternweis, P C.]]		[[Category: Sternweis, P C.]]
		+	[[Category: Dh]]
		+	[[Category: Ph]]
		+	[[Category: Regulation of rhoa gtpase]]
		+	[[Category: Rho]]
		+	[[Category: Rhogef]]
		+	[[Category: Signaling protein]]

OCA: Protected "3odw" [edit=sysop:move=sysop]

OCA — Wed, 05 Jan 2011 16:28:25 GMT

Protected "3odw" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:28, 5 January 2011

OCA at 16:28, 5 January 2011

OCA — Wed, 05 Jan 2011 16:28:24 GMT

←Older revision		Revision as of 16:28, 5 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3odw.jpg\|left\|200px]]

-	The ~~entry 3odw~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3odw", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3odw\| PDB=3odw \| SCENE= }}

-	~~Authors: Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.~~	+	===Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF===

-	Description: Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Oct 6 05~~:47:~~55 2010''~~	+	==About this Structure==
		+	[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, Z.]]
		+	[[Category: Guo, L.]]
		+	[[Category: Sprang, S R.]]
		+	[[Category: Sternweis, P C.]]

OCA at 02:38, 6 October 2010

OCA — Wed, 06 Oct 2010 02:38:23 GMT

←Older revision		Revision as of 02:38, 6 October 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3odw is ON HOLD	+	The entry 3odw is ON HOLD until Paper Publication

	Authors: Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.		Authors: Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Line 7:		Line 7:
	Description: Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF		Description: Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 25 08~~:38:30 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:47:55 2010''