3ofs - Revision history

OCA at 16:55, 1 November 2023

OCA — Wed, 01 Nov 2023 16:55:14 GMT

←Older revision		Revision as of 16:55, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3ofs' size='340' side='right'caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ofs' size='340' side='right'caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i9m\|3i9m]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [https://pdbe.org/3ofs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [https://www.ebi.ac.uk/pdbsum/3ofs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ofs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [https://pdbe.org/3ofs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [https://www.ebi.ac.uk/pdbsum/3ofs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ofs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	+	[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Lee~~, H C~~]]	+	[[Category: Lee HC]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Adpr]]~~	+
-	~~[[Category: Ara-2'f-adpr]]~~	+
-	~~[[Category: Ara-2'f-nad]]~~	+
-	~~[[Category: Cadpr]]~~	+
-	~~[[Category: Cd38]]~~	+
-	~~[[Category: Cyclization]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolysis~~]]	+

OCA at 10:42, 18 May 2022

OCA — Wed, 18 May 2022 10:42:17 GMT

←Older revision		Revision as of 10:42, 18 May 2022
Line 1:		Line 1:

	==Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography==		==Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography==
-	<StructureSection load='3ofs' size='340' side='right' caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3ofs' size='340' side='right'caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9m\|3i9m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i9m\|3i9m]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [~~http~~://pdbe.org/3ofs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ofs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ofs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [https://pdbe.org/3ofs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [https://www.ebi.ac.uk/pdbsum/3ofs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ofs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	+	[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3ofs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ofs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cluster of Differentiation CD38\|Cluster of Differentiation CD38]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]
	[[Category: Lee, H C]]		[[Category: Lee, H C]]

OCA at 08:44, 8 November 2017

OCA — Wed, 08 Nov 2017 08:44:31 GMT

←Older revision		Revision as of 08:44, 8 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3ofs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ofs" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cluster of Differentiation CD38\|Cluster of Differentiation CD38]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:34, 5 August 2016

OCA — Fri, 05 Aug 2016 11:34:31 GMT

←Older revision		Revision as of 11:34, 5 August 2016
Line 1:		Line 1:
		+
	==Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography==		==Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography==
	<StructureSection load='3ofs' size='340' side='right' caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ofs' size='340' side='right' caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OFS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9m\|3i9m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9m\|3i9m]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [http://www.ebi.ac.uk/pdbsum/3ofs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [http://pdbe.org/3ofs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [http://www.ebi.ac.uk/pdbsum/3ofs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ofs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ofs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]
	[[Category: Lee, H C]]		[[Category: Lee, H C]]

OCA at 18:29, 25 December 2014

OCA — Thu, 25 Dec 2014 18:29:12 GMT

←Older revision		Revision as of 18:29, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [http://www.ebi.ac.uk/pdbsum/3ofs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [http://www.ebi.ac.uk/pdbsum/3ofs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:08, 9 December 2014

OCA — Tue, 09 Dec 2014 12:08:35 GMT

←Older revision		Revision as of 12:08, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ofs.~~png~~\|~~left~~\|~~200px~~]]	+	==Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography==
		+	<StructureSection load='3ofs' size='340' side='right' caption='[[3ofs]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ofs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OFS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVU:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AVU</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9m\|3i9m]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ofs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ofs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ofs RCSB], [http://www.ebi.ac.uk/pdbsum/3ofs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The extracellular domain of human CD38 is a multifunctional enzyme involved in the metabolism of two Ca(2+) messengers: cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate. When NAD is used as substrate, CD38 predominantly hydrolyzes it to ADP-ribose, with a trace amount of cyclic ADP-ribose produced through cyclization of the substrate. However, mutation of a key residue at the active site, E146, inhibits the hydrolysis activity of CD38 but greatly increases its cyclization activity. To understand the role of the residue E146 in the catalytic process, we determined the crystal structure of the E146A mutant protein with a substrate analogue, arabinosyl-2'-fluoro-deoxy-nicotinamide adenine dinucleotide. The structure captured the enzymatic reaction intermediates in six different conformations in a crystallographic asymmetric unit. The structural results indicate a folding-back process for the adenine ring of the substrate and provide the first multiple snapshots of the process. Our approach of utilizing multiple molecules in the crystallographic asymmetric unit should be generally applicable for capturing the dynamic nature of enzymatic catalysis.

-	~~{{STRUCTURE_3ofs\| PDB=3ofs \| SCENE= }}~~	+	Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal.,Zhang H, Graeff R, Chen Z, Zhang L, Zhang L, Lee H, Hao Q J Mol Biol. 2011 Jan 28;405(4):1070-8. Epub 2010 Dec 8. PMID:21134381<ref>PMID:21134381</ref>

-	~~===Dynamic conformations~~ of the ~~CD38-mediated NAD cyclization captured using multi-copy crystallography===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21134381}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ofs]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA].~~	+

	==See Also==		==See Also==
-	*[[Cluster of Differentiation 38\|Cluster of Differentiation 38]]	+	*[[Cluster of Differentiation CD38\|Cluster of Differentiation CD38]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021134381<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hao, Q.]]	+	[[Category: Hao, Q]]
-	[[Category: Lee, H C.]]	+	[[Category: Lee, H C]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Adpr]]		[[Category: Adpr]]
	[[Category: Ara-2'f-adpr]]		[[Category: Ara-2'f-adpr]]

OCA at 20:00, 20 October 2012

OCA — Sat, 20 Oct 2012 20:00:17 GMT

←Older revision		Revision as of 20:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ofs]] is a 6 chain structure ~~of [[Cluster of Differentiation 38]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA].	+	[[3ofs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA].

	==See Also==		==See Also==

OCA at 09:07, 27 July 2012

OCA — Fri, 27 Jul 2012 09:07:45 GMT

←Older revision		Revision as of 09:07, 27 July 2012
Line 1:		Line 1:
	[[Image:3ofs.png\|left\|200px]]		[[Image:3ofs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ofs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ofs\| PDB=3ofs \| SCENE= }}		{{STRUCTURE_3ofs\| PDB=3ofs \| SCENE= }}

	===Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography===		===Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21134381}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21134381 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21134381}}		{{ABSTRACT_PUBMED_21134381}}

OCA at 15:30, 5 June 2012

OCA — Tue, 05 Jun 2012 15:30:16 GMT

←Older revision		Revision as of 15:30, 5 June 2012
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3ofs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA].	+	[[3ofs]] is a 6 chain structure of [[Cluster of Differentiation 38]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFS OCA].
		+
		+	==See Also==
		+	*[[Cluster of Differentiation 38\|Cluster of Differentiation 38]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21134381~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021134381</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q.]]
	[[Category: Lee, H C.]]		[[Category: Lee, H C.]]
	[[Category: Zhang, H.]]		[[Category: Zhang, H.]]
		+	[[Category: Adpr]]
		+	[[Category: Ara-2'f-adpr]]
		+	[[Category: Ara-2'f-nad]]
		+	[[Category: Cadpr]]
		+	[[Category: Cd38]]
		+	[[Category: Cyclization]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolysis]]

OCA: Protected "3ofs" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2011 05:38:21 GMT

Protected "3ofs" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 19 January 2011