3oht - Revision history

OCA at 09:39, 6 September 2023

OCA — Wed, 06 Sep 2023 09:39:33 GMT

←Older revision		Revision as of 09:39, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3oht' size='340' side='right'caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3oht' size='340' side='right'caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atlantic_salmon Atlantic salmon~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Atlantic salmon])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [https://pdbe.org/3oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [https://www.ebi.ac.uk/pdbsum/3oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [https://pdbe.org/3oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [https://www.ebi.ac.uk/pdbsum/3oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A9UJZ9_SALSA A9UJZ9_SALSA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atlantic salmon]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Engh, R A~~]]	+	[[Category: Salmo salar]]
-	[[Category: ~~Johnson, K~~]]	+	[[Category: Engh RA]]
-	[[Category: ~~Rothweiler, U~~]]	+	[[Category: Johnson K]]
-	[[Category: ~~Kinase serine/threonine-protein kinase transferase]]~~	+	[[Category: Rothweiler U]]
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 10:44, 18 May 2022

OCA — Wed, 18 May 2022 10:44:20 GMT

←Older revision		Revision as of 10:44, 18 May 2022
Line 1:		Line 1:

	==Crystal Structure of Salmo Salar p38alpha==		==Crystal Structure of Salmo Salar p38alpha==
-	<StructureSection load='3oht' size='340' side='right' caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3oht' size='340' side='right'caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atlantic_salmon Atlantic salmon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atlantic_salmon Atlantic salmon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Atlantic salmon])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Atlantic salmon])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [~~http~~://pdbe.org/3oht PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3oht PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [https://pdbe.org/3oht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [https://www.ebi.ac.uk/pdbsum/3oht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3oht" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3oht" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mitogen-activated protein kinase 3D structures\|Mitogen-activated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Atlantic salmon]]		[[Category: Atlantic salmon]]
		+	[[Category: Large Structures]]
	[[Category: Engh, R A]]		[[Category: Engh, R A]]
	[[Category: Johnson, K]]		[[Category: Johnson, K]]

OCA at 05:09, 5 August 2016

OCA — Fri, 05 Aug 2016 05:09:04 GMT

←Older revision		Revision as of 05:09, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Salmo Salar p38alpha==		==Crystal Structure of Salmo Salar p38alpha==
	<StructureSection load='3oht' size='340' side='right' caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3oht' size='340' side='right' caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmo_salar Salmo salar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_salmon Atlantic salmon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 ~~Salmo salar~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Atlantic salmon])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://pdbe.org/3oht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oht ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3oht" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salmo salar~~]]	+	[[Category: Atlantic salmon]]
	[[Category: Engh, R A]]		[[Category: Engh, R A]]
	[[Category: Johnson, K]]		[[Category: Johnson, K]]

OCA at 23:22, 3 January 2015

OCA — Sat, 03 Jan 2015 23:22:33 GMT

←Older revision		Revision as of 23:22, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Salmo salar])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Salmo salar])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.,Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA J Mol Biol. 2011 Aug 12;411(2):474-85. Epub 2011 Jun 15. PMID:21699901<ref>PMID:21699901</ref>		p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.,Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA J Mol Biol. 2011 Aug 12;411(2):474-85. Epub 2011 Jun 15. PMID:21699901<ref>PMID:21699901</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
-	[[Category: Engh, R A.]]	+	[[Category: Engh, R A]]
-	[[Category: Johnson, K.]]	+	[[Category: Johnson, K]]
-	[[Category: Rothweiler, U.]]	+	[[Category: Rothweiler, U]]
	[[Category: Kinase serine/threonine-protein kinase transferase]]		[[Category: Kinase serine/threonine-protein kinase transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:41, 28 May 2014

OCA — Wed, 28 May 2014 10:41:59 GMT

←Older revision		Revision as of 10:41, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3oht.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Salmo Salar p38alpha==
		+	<StructureSection load='3oht' size='340' side='right' caption='[[3oht]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OHT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N1:N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE'>1N1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p38a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8030 Salmo salar])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oht RCSB], [http://www.ebi.ac.uk/pdbsum/3oht PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many protein kinase functions, including autophosphorylation in trans, require dimerization, possibly by activation segment exchange. Such dimers have been reported for a few autophosphorylating protein kinases, but not for mitogen-activated protein kinases (MAPKs). Activation of MAPKs proceeds not only via the well-characterized action of dual T/Y specificity MAPK kinases, phosphorylating both residues of the MAPK TxY activation loop motif, but also via a noncanonical activation pathway triggered by phosphorylation at Tyr323 and homodimerization. Here, we report the 2. 7-A-resolution structure of p38alpha MAPK from Salmo salar in a novel domain-swapped homodimeric form. The tyrosines of the conserved sequence YxAPE anchor the swapped activation segments in a configuration suitable for autophosphorylation in trans and provide a model for the noncanonical pathway. In the dimer, a structural unit containing Tyr323 is formed at a dimerization contact region that stabilizes the HRD catalytic loop in a unique inactive geometry. This feature is consistent with the requirement of Tyr323 phosphorylation for the initiation of the noncanonical pathway. Despite the interacting surface of more than 2600 A(2), the dimer is not obligate, as gel filtration shows the dimerization to occur only at relatively high concentrations. The transition from monomer to dimer involves a relatively simple hinged displacement of helix EF and adjacent residues. Thus, dimer formation is likely to be transient, compatible with functional requirements for autophosphorylation, allowing further modulation, for example, by scaffolding mechanisms.

-	~~{{STRUCTURE_3oht\| PDB=3oht \| SCENE= }}~~	+	p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.,Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA J Mol Biol. 2011 Aug 12;411(2):474-85. Epub 2011 Jun 15. PMID:21699901<ref>PMID:21699901</ref>

-	~~===Crystal Structure~~ of ~~Salmo Salar p38alpha===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21699901}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3oht]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmo_salar Salmo salar]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021699901<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
	[[Category: Engh, R A.]]		[[Category: Engh, R A.]]

OCA at 04:54, 27 June 2012

OCA — Wed, 27 Jun 2012 04:54:05 GMT

←Older revision		Revision as of 04:54, 27 June 2012
Line 1:		Line 1:
-	[[Image:3oht.~~jpg~~\|left\|200px]]	+	[[Image:3oht.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3oht", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3oht\| PDB=3oht \| SCENE= }}		{{STRUCTURE_3oht\| PDB=3oht \| SCENE= }}

	===Crystal Structure of Salmo Salar p38alpha===		===Crystal Structure of Salmo Salar p38alpha===

		+	{{ABSTRACT_PUBMED_21699901}}

	==About this Structure==		==About this Structure==
	[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA].		[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021699901</ref><references group="xtra"/>
	[[Category: Salmo salar]]		[[Category: Salmo salar]]
	[[Category: Engh, R A.]]		[[Category: Engh, R A.]]
Line 19:		Line 17:
	[[Category: Rothweiler, U.]]		[[Category: Rothweiler, U.]]
	[[Category: Kinase serine/threonine-protein kinase transferase]]		[[Category: Kinase serine/threonine-protein kinase transferase]]
-	[[Category: Transferase]]	+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "3oht" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2011 06:19:33 GMT

Protected "3oht" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 29 June 2011

OCA at 06:19, 29 June 2011

OCA — Wed, 29 Jun 2011 06:19:29 GMT

←Older revision		Revision as of 06:19, 29 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3oht.jpg\|left\|200px]]

-	The ~~entry 3oht~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3oht", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3oht\| PDB=3oht \| SCENE= }}

-	~~Authors: Rothweiler, U., Johnson, K., Engh, R.A.~~	+	===Crystal Structure of Salmo Salar p38alpha===

-	Description: Crystal Structure of Salmo Salar p38alpha

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 15 08~~:21:~~44 2010''~~	+	==About this Structure==
		+	[[3oht]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHT OCA].
		+	[[Category: Salmo salar]]
		+	[[Category: Engh, R A.]]
		+	[[Category: Johnson, K.]]
		+	[[Category: Rothweiler, U.]]
		+	[[Category: Kinase serine/threonine-protein kinase transferase]]
		+	[[Category: Transferase]]

OCA at 05:09, 15 December 2010

OCA — Wed, 15 Dec 2010 05:09:24 GMT

←Older revision		Revision as of 05:09, 15 December 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3oht is ON HOLD	+	The entry 3oht is ON HOLD until Paper Publication

	Authors: Rothweiler, U., Johnson, K., Engh, R.A.		Authors: Rothweiler, U., Johnson, K., Engh, R.A.
Line 7:		Line 7:
	Description: Crystal Structure of Salmo Salar p38alpha		Description: Crystal Structure of Salmo Salar p38alpha

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 25~~ 08:40:18 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:21:44 2010''

OCA: New page: '''Unreleased structure''' The entry 3oht is ON HOLD Authors: Rothweiler, U., Johnson, K., Engh, R.A. Description: Crystal Structure of Salmo Salar p38alpha ''Page seeded by [http://o...

OCA — Wed, 25 Aug 2010 04:32:27 GMT

New page: '''Unreleased structure''' The entry 3oht is ON HOLD Authors: Rothweiler, U., Johnson, K., Engh, R.A. Description: Crystal Structure of Salmo Salar p38alpha ''Page seeded by [http://o...

New page

'''Unreleased structure'''

The entry 3oht is ON HOLD

Authors: Rothweiler, U., Johnson, K., Engh, R.A.

Description: Crystal Structure of Salmo Salar p38alpha

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:40:18 2010''