3olc - Revision history

OCA at 11:17, 21 February 2024

OCA — Wed, 21 Feb 2024 11:17:21 GMT

←Older revision		Revision as of 11:17, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3olc' size='340' side='right'caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3olc' size='340' side='right'caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLC FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TOPBP1, KIAA0259 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [https://pdbe.org/3olc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [https://www.ebi.ac.uk/pdbsum/3olc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3olc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [https://pdbe.org/3olc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [https://www.ebi.ac.uk/pdbsum/3olc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3olc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>	+	[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Human DNA Topoisomerase IIbeta binding protein 1 (TopBP1) is a modulating protein that plays an essential role in the response to DNA damage. The N-terminal region of TopBP1, which contains predicted BRCA1-carboxy terminal (BRCT) domains 1 and 2, binds to Rad9, a component of the cell cycle checkpoint clamp Rad9-Hus1-Rad1 complex. Here, we report the crystal structure of the TopBP1N-terminal region (residues 1-290) at 2.4A resolution. Interestingly, in addition to the predicted tandem BRCT1-2 repeats (residues 103-284), residues 7-98 form a previously unreported BRCT domain (here, BRCT0). In contrast to both BRCT1 and BRCT2, which possess the conventional phosphopeptide binding residues within a surface pocket, the corresponding pocket in BRCT0 is largely hydrophobic. Structural comparisons together with peptide binding studies indicate that the tandem BRCT1-2 domains are the binding region for phosphorylated Ser387 in Rad9.	+
-		+
-	Crystal structure of the N-terminal region of human Topoisomerase IIbeta binding protein 1.,Huo YG, Bai L, Xu M, Jiang T Biochem Biophys Res Commun. 2010 Oct 22;401(3):401-5. Epub 2010 Sep 19. PMID:20858457<ref>PMID:20858457</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3olc" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bai, L]]	+	[[Category: Bai L]]
-	[[Category: Huo~~, Y G~~]]	+	[[Category: Huo YG]]
-	[[Category: Jiang, T]]	+	[[Category: Jiang T]]
-	[[Category: Xu, M]]	+	[[Category: Xu M]]
-	~~[[Category: Brct domain]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Rad9~~]]	+

OCA at 10:47, 18 May 2022

OCA — Wed, 18 May 2022 10:47:41 GMT

←Older revision		Revision as of 10:47, 18 May 2022
Line 1:		Line 1:

	==Crystal structure of the N-terminal region of TopBP1==		==Crystal structure of the N-terminal region of TopBP1==
-	<StructureSection load='3olc' size='340' side='right' caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3olc' size='340' side='right'caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [~~http~~://pdbe.org/3olc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3olc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3olc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [https://pdbe.org/3olc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [https://www.ebi.ac.uk/pdbsum/3olc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3olc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>	+	[[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bai, L]]		[[Category: Bai, L]]
	[[Category: Huo, Y G]]		[[Category: Huo, Y G]]

OCA at 21:57, 5 August 2016

OCA — Fri, 05 Aug 2016 21:57:51 GMT

←Older revision		Revision as of 21:57, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the N-terminal region of TopBP1==		==Crystal structure of the N-terminal region of TopBP1==
	<StructureSection load='3olc' size='340' side='right' caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3olc' size='340' side='right' caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OLC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [http://www.ebi.ac.uk/pdbsum/3olc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [http://pdbe.org/3olc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [http://www.ebi.ac.uk/pdbsum/3olc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3olc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3olc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bai, L]]		[[Category: Bai, L]]
	[[Category: Huo, Y G]]		[[Category: Huo, Y G]]

OCA at 06:10, 25 December 2014

OCA — Thu, 25 Dec 2014 06:10:46 GMT

←Older revision		Revision as of 06:10, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [http://www.ebi.ac.uk/pdbsum/3olc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [http://www.ebi.ac.uk/pdbsum/3olc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:15, 19 December 2014

OCA — Fri, 19 Dec 2014 07:15:17 GMT

←Older revision		Revision as of 07:15, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3olc\| PDB=3olc \| SCENE= }}~~	+	==Crystal structure of the N-terminal region of TopBP1==
-	===Crystal structure of the N-terminal region of TopBP1===	+	<StructureSection load='3olc' size='340' side='right' caption='[[3olc]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20858457}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3olc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OLC FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3olc RCSB], [http://www.ebi.ac.uk/pdbsum/3olc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human DNA Topoisomerase IIbeta binding protein 1 (TopBP1) is a modulating protein that plays an essential role in the response to DNA damage. The N-terminal region of TopBP1, which contains predicted BRCA1-carboxy terminal (BRCT) domains 1 and 2, binds to Rad9, a component of the cell cycle checkpoint clamp Rad9-Hus1-Rad1 complex. Here, we report the crystal structure of the TopBP1N-terminal region (residues 1-290) at 2.4A resolution. Interestingly, in addition to the predicted tandem BRCT1-2 repeats (residues 103-284), residues 7-98 form a previously unreported BRCT domain (here, BRCT0). In contrast to both BRCT1 and BRCT2, which possess the conventional phosphopeptide binding residues within a surface pocket, the corresponding pocket in BRCT0 is largely hydrophobic. Structural comparisons together with peptide binding studies indicate that the tandem BRCT1-2 domains are the binding region for phosphorylated Ser387 in Rad9.

-	~~==Function==~~	+	Crystal structure of the N-terminal region of human Topoisomerase IIbeta binding protein 1.,Huo YG, Bai L, Xu M, Jiang T Biochem Biophys Res Commun. 2010 Oct 22;401(3):401-5. Epub 2010 Sep 19. PMID:20858457<ref>PMID:20858457</ref>
-	~~[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in~~ the ~~rescue~~ of ~~stalled replication forks and checkpoint control~~. ~~Binds double-stranded DNA breaks and nicks as well as single-stranded DNA~~. ~~Recruits the SWI/SNF chromatin remodeling complex to E2F1~~-~~responsive promoters~~. ~~Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage~~. ~~Induces a large increase in the kinase activity of ATR.<ref>~~PMID:~~10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref>~~ <ref>PMID:~~16530042~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3olc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020858457</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Topoisomerase binding protein\|Topoisomerase binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bai, L.]]	+	[[Category: Bai, L]]
-	[[Category: Huo, Y G.]]	+	[[Category: Huo, Y G]]
-	[[Category: Jiang, T.]]	+	[[Category: Jiang, T]]
-	[[Category: Xu, M.]]	+	[[Category: Xu, M]]
	[[Category: Brct domain]]		[[Category: Brct domain]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Rad9]]		[[Category: Rad9]]

OCA at 08:27, 2 May 2013

OCA — Thu, 02 May 2013 08:27:19 GMT

←Older revision		Revision as of 08:27, 2 May 2013
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-	[[Image:3olc.jpg\|left\|200px]]
-
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	{{STRUCTURE_3olc\| PDB=3olc \| SCENE= }}		{{STRUCTURE_3olc\| PDB=3olc \| SCENE= }}
-
	===Crystal structure of the N-terminal region of TopBP1===		===Crystal structure of the N-terminal region of TopBP1===
		+	{{ABSTRACT_PUBMED_20858457}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20858457}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20858457 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20858457}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20858457~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020858457</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bai, L.]]		[[Category: Bai, L.]]
Line 28:		Line 16:
	[[Category: Jiang, T.]]		[[Category: Jiang, T.]]
	[[Category: Xu, M.]]		[[Category: Xu, M.]]
		+	[[Category: Brct domain]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna repair]]
		+	[[Category: Rad9]]

OCA: Protected "3olc" [edit=sysop:move=sysop]

OCA — Wed, 30 Mar 2011 08:04:21 GMT

Protected "3olc" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:04, 30 March 2011

OCA at 08:04, 30 March 2011

OCA — Wed, 30 Mar 2011 08:04:17 GMT

←Older revision		Revision as of 08:04, 30 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3olc.jpg\|left\|200px]]

-	The ~~entry 3olc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3olc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3olc\| PDB=3olc \| SCENE= }}

-	~~Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T.~~	+	===Crystal structure of the N-terminal region of TopBP1===

-	Description: Crystal structure of the N-terminal region of TopBP1

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Sep 29 07~~:56:~~28 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20858457}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20858457 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20858457}}
		+
		+	==About this Structure==
		+	[[3olc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20858457</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bai, L.]]
		+	[[Category: Huo, Y G.]]
		+	[[Category: Jiang, T.]]
		+	[[Category: Xu, M.]]

OCA at 04:47, 29 September 2010

OCA — Wed, 29 Sep 2010 04:47:12 GMT

←Older revision		Revision as of 04:47, 29 September 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3olc is ON HOLD	+	The entry 3olc is ON HOLD until Paper Publication

	Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T.		Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T.
Line 7:		Line 7:
	Description: Crystal structure of the N-terminal region of TopBP1		Description: Crystal structure of the N-terminal region of TopBP1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~1 09~~:37:53 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:56:28 2010''

OCA: New page: '''Unreleased structure''' The entry 3olc is ON HOLD Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T. Description: Crystal structure of the N-terminal region of TopBP1 ''Page seeded by ...

OCA — Wed, 01 Sep 2010 05:29:45 GMT

New page: '''Unreleased structure''' The entry 3olc is ON HOLD Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T. Description: Crystal structure of the N-terminal region of TopBP1 ''Page seeded by ...

New page

'''Unreleased structure'''

The entry 3olc is ON HOLD

Authors: Huo, Y.G., Bai, L., Xu, M., Jiang, T.

Description: Crystal structure of the N-terminal region of TopBP1

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:37:53 2010''