3omu - Revision history

OCA at 09:41, 6 September 2023

OCA — Wed, 06 Sep 2023 09:41:58 GMT

←Older revision		Revision as of 09:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3omu' size='340' side='right'caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3omu' size='340' side='right'caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IBD:2~~-~~AMINO-4-{2~~,~~4-DICHLORO-5-~~[~~2-(DIETHYLAMINO)ETHOXY~~]~~PHENYL}-N-ETHYLTHIENO[~~2~~,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[[~~3o6o\|3o6o~~]~~]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">Tb10.26.1080 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [https://pdbe.org/3omu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [https://www.ebi.ac.uk/pdbsum/3omu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [https://pdbe.org/3omu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [https://www.ebi.ac.uk/pdbsum/3omu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q389P1_TRYB2 Q389P1_TRYB2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: Bochkarev, A]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bochkarev A]]
-	[[Category: Cossar, D]]	+	[[Category: Bountra C]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Cossar D]]
-	[[Category: Fairlamb~~, A H~~]]	+	[[Category: Edwards AM]]
-	[[Category: Ferguson~~, M A.J~~]]	+	[[Category: Fairlamb AH]]
-	[[Category: Hills, T]]	+	[[Category: Ferguson MAJ]]
-	[[Category: Hui, R]]	+	[[Category: Hills T]]
-	[[Category: Hutchinson, A]]	+	[[Category: Hui R]]
-	[[Category: Kozieradzki, I]]	+	[[Category: Hutchinson A]]
-	[[Category: Li, Y]]	+	[[Category: Kozieradzki I]]
-	[[Category: MacKenzie, C]]	+	[[Category: Li Y]]
-	[[Category: Pizarro~~, J C]]~~	+	[[Category: MacKenzie C]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Pizarro JC]]
-	[[Category: Sullivan, H]]	+	[[Category: Sullivan H]]
-	[[Category: Weadge, J]]	+	[[Category: Weadge J]]
-	[[Category: Weigelt, J]]	+	[[Category: Weigelt J]]
-	[[Category: Wernimont~~, A K~~]]	+	[[Category: Wernimont AK]]
-	[[Category: Wyatt~~, P G]]~~	+	[[Category: Wyatt PG]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Hsp90]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Trypanosoma bruceii~~]]	+

OCA at 10:49, 18 May 2022

OCA — Wed, 18 May 2022 10:49:14 GMT

←Older revision		Revision as of 10:49, 18 May 2022
Line 1:		Line 1:

	==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative==		==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative==
-	<StructureSection load='3omu' size='340' side='right' caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='3omu' size='340' side='right'caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o6o\|3o6o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3o6o\|3o6o]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [~~http~~://pdbe.org/3omu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3omu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [https://pdbe.org/3omu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [https://www.ebi.ac.uk/pdbsum/3omu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3omu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3omu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev, A]]

OCA at 07:16, 29 November 2017

OCA — Wed, 29 Nov 2017 07:16:34 GMT

←Older revision		Revision as of 07:16, 29 November 2017
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://pdbe.org/3omu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://pdbe.org/3omu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The current drugs available to eliminate the causative agent Trypanosoma brucei have multiple liabilities, including toxicity, increasing problems due to treatment failure and limited efficacy. There are two approaches to discover novel antimicrobial drugs--whole-cell screening and target-based discovery. In the latter case, there is a need to identify and validate novel drug targets in Trypanosoma parasites. The heat shock proteins (Hsp), while best known as cancer targets with a number of drug candidates in clinical development, are a family of emerging targets for infectious diseases. In this paper, we report the exploration of T. brucei Hsp83--a homolog of human Hsp90--as a drug target using multiple biophysical and biochemical techniques. Our approach included the characterization of the chemical sensitivity of the parasitic chaperone against a library of known Hsp90 inhibitors by means of differential scanning fluorimetry (DSF). Several compounds identified by this screening procedure were further studied using isothermal titration calorimetry (ITC) and X-ray crystallography, as well as tested in parasite growth inhibitions assays. These experiments led us to the identification of a benzamide derivative compound capable of interacting with TbHsp83 more strongly than with its human homologs and structural rationalization of this selectivity. The results highlight the opportunities created by subtle structural differences to develop new series of compounds to selectively target the Trypanosoma brucei chaperone and effectively kill the sleeping sickness parasite.
		+
		+	Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.,Pizarro JC, Hills T, Senisterra G, Wernimont AK, Mackenzie C, Norcross NR, Ferguson MA, Wyatt PG, Gilbert IH, Hui R PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2492. doi: 10.1371/journal.pntd.0002492., eCollection 2013. PMID:24147171<ref>PMID:24147171</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3omu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:48, 8 November 2017

OCA — Wed, 08 Nov 2017 08:48:00 GMT

←Older revision		Revision as of 08:48, 8 November 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://pdbe.org/3omu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://pdbe.org/3omu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>
	</table>		</table>
-
-	==See Also==
-	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:07, 10 December 2016

OCA — Sat, 10 Dec 2016 04:07:57 GMT

←Older revision		Revision as of 04:07, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative==		==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative==
	<StructureSection load='3omu' size='340' side='right' caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3omu' size='340' side='right' caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OMU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o6o\|3o6o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o6o\|3o6o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://pdbe.org/3omu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3omu ProSAT]</span></td></tr>
	</table>		</table>

Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Trypanosoma brucei]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev, A]]

OCA at 12:16, 9 December 2014

OCA — Tue, 09 Dec 2014 12:16:35 GMT

←Older revision		Revision as of 12:16, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3omu.png\|left\|200px]]~~	+	==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative==
-		+	<StructureSection load='3omu' size='340' side='right' caption='[[3omu]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~{{STRUCTURE_3omu\| PDB=3omu \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3omu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OMU FirstGlance]. <br>
-	===Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBD:2-AMINO-4-{2,4-DICHLORO-5-[2-(DIETHYLAMINO)ETHOXY]PHENYL}-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>IBD</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o6o\|3o6o]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3omu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3omu RCSB], [http://www.ebi.ac.uk/pdbsum/3omu PDBsum]</span></td></tr>
-	[[3omu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA].	+	</table>

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Cossar, D.]]	+	[[Category: Cossar, D]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Fairlamb, A H.]]	+	[[Category: Fairlamb, A H]]
-	[[Category: Ferguson, M A.J.]]	+	[[Category: Ferguson, M A.J]]
-	[[Category: Hills, T.]]	+	[[Category: Hills, T]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Hutchinson, A.]]	+	[[Category: Hutchinson, A]]
-	[[Category: Kozieradzki, I.]]	+	[[Category: Kozieradzki, I]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: MacKenzie, C.]]	+	[[Category: MacKenzie, C]]
-	[[Category: Pizarro, J C.]]	+	[[Category: Pizarro, J C]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sullivan, H.]]	+	[[Category: Sullivan, H]]
-	[[Category: Weadge, J.]]	+	[[Category: Weadge, J]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Wernimont, A K.]]	+	[[Category: Wernimont, A K]]
-	[[Category: Wyatt, P G.]]	+	[[Category: Wyatt, P G]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Drug discovery]]		[[Category: Drug discovery]]
	[[Category: Hsp90]]		[[Category: Hsp90]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Trypanosoma bruceii]]		[[Category: Trypanosoma bruceii]]

OCA at 06:02, 20 October 2012

OCA — Sat, 20 Oct 2012 06:02:50 GMT

←Older revision		Revision as of 06:02, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3omu]] is a 2 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA].	+	[[3omu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA].

	==See Also==		==See Also==

OCA at 11:56, 25 July 2012

OCA — Wed, 25 Jul 2012 11:56:42 GMT

←Older revision		Revision as of 11:56, 25 July 2012
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	[[Image:3omu.png\|left\|200px]]		[[Image:3omu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3omu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3omu\| PDB=3omu \| SCENE= }}		{{STRUCTURE_3omu\| PDB=3omu \| SCENE= }}

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	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "3omu" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 22:12:15 GMT

Protected "3omu" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:12, 26 December 2010

OCA at 22:12, 26 December 2010

OCA — Sun, 26 Dec 2010 22:12:14 GMT

←Older revision		Revision as of 22:12, 26 December 2010
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-	~~{{Seed}}~~	+	[[Image:3omu.png\|left\|200px]]
-	[[Image:3omu.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~3OMU~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA].	+	[[3omu]] is a 2 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMU OCA].
		+
		+	==See Also==
		+	*[[Heat Shock Proteins]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
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	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Trypanosoma bruceii]]		[[Category: Trypanosoma bruceii]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:15:40 2010''