3opl - Revision history

OCA at 09:43, 6 September 2023

OCA — Wed, 06 Sep 2023 09:43:02 GMT

←Older revision		Revision as of 09:43, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3opl' size='340' side='right'caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3opl' size='340' side='right'caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EPE:4~~-~~(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>~~, ~~<scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>bla, shv1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~573~~ "~~Bacillus pneumoniae~~" ~~(Schroeter 1886) Flugge 1886])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Beta~~-~~lactamase Beta~~-~~lactamase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [https://pdbe.org/3opl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [https://www.ebi.ac.uk/pdbsum/3opl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3opl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [https://pdbe.org/3opl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [https://www.ebi.ac.uk/pdbsum/3opl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3opl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BLA1_KLEPN BLA1_KLEPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Akker, F van den]]~~	+	[[Category: Sampson JM]]
-	[[Category: Sampson~~, J M~~]]	+	[[Category: Van den Akker F]]
-	[[Category: ~~Class a beta-lactamase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:52, 18 May 2022

OCA — Wed, 18 May 2022 10:52:14 GMT

←Older revision		Revision as of 10:52, 18 May 2022
Line 1:		Line 1:

	==ESBL R164H mutant SHV-1 beta-lactamase==		==ESBL R164H mutant SHV-1 beta-lactamase==
-	<StructureSection load='3opl' size='340' side='right' caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3opl' size='340' side='right'caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [~~http~~://pdbe.org/3opl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3opl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3opl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [https://pdbe.org/3opl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [https://www.ebi.ac.uk/pdbsum/3opl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3opl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Akker, F van den]]		[[Category: Akker, F van den]]
	[[Category: Sampson, J M]]		[[Category: Sampson, J M]]
	[[Category: Class a beta-lactamase]]		[[Category: Class a beta-lactamase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 03:57, 10 December 2016

OCA — Sat, 10 Dec 2016 03:57:09 GMT

←Older revision		Revision as of 03:57, 10 December 2016
Line 1:		Line 1:
		+
	==ESBL R164H mutant SHV-1 beta-lactamase==		==ESBL R164H mutant SHV-1 beta-lactamase==
	<StructureSection load='3opl' size='340' side='right' caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3opl' size='340' side='right' caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae Klebsiella~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 ~~Klebsiella~~ pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [http://www.ebi.ac.uk/pdbsum/3opl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [http://pdbe.org/3opl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [http://www.ebi.ac.uk/pdbsum/3opl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3opl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3opl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Klebsiella pneumoniae]]
	[[Category: Akker, F van den]]		[[Category: Akker, F van den]]
	[[Category: Sampson, J M]]		[[Category: Sampson, J M]]
	[[Category: Class a beta-lactamase]]		[[Category: Class a beta-lactamase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 11:01, 9 December 2014

OCA — Tue, 09 Dec 2014 11:01:24 GMT

←Older revision		Revision as of 11:01, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3opl.~~png~~\|~~left~~\|~~200px~~]]	+	==ESBL R164H mutant SHV-1 beta-lactamase==
		+	<StructureSection load='3opl' size='340' side='right' caption='[[3opl]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1shv\|1shv]], [[2h5s\|2h5s]], [[3oph\|3oph]], [[3opp\|3opp]], [[3opr\|3opr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3opl RCSB], [http://www.ebi.ac.uk/pdbsum/3opl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Among Gram-negative bacteria, resistance to beta-lactams is mediated primarily by beta-lactamases (EC 3.2.6.5), periplasmic enzymes that inactivate beta-lactam antibiotics. Substitutions at critical amino acid positions in the class A beta-lactamase families result in enzymes that can hydrolyze extended-spectrum cephalosporins, thus demonstrating an "extended-spectrum" beta-lactamase (ESBL) phenotype. Using SHV ESBLs with substitutions in the Omega loop (R164H and R164S) as target enzymes to understand this enhanced biochemical capability and to serve as a basis for novel beta-lactamase inhibitor development, we determined the spectra of activity and crystal structures of these variants. We also studied the inactivation of the R164H and R164S mutants with tazobactam and SA2-13, a unique beta-lactamase inhibitor that undergoes a distinctive reaction chemistry in the active site. We noted that the reduced Ki values for the R164H and R164S mutants with SA2-13 are comparable to those with tazobactam (submicromolar). The apo enzyme crystal structures of the R164H and R164S SHV variants revealed an ordered Omega loop architecture that became disordered when SA2-13 was bound. Important structural alterations that result from the binding of SA2-13 explain the enhanced susceptibility of these ESBL enzymes to this inhibitor and highlight ligand-dependent Omega loop flexibility as a mechanism for accommodating and hydrolyzing beta-lactam substrates.

-	~~{{STRUCTURE_3opl\| PDB=3opl \| SCENE= }}~~	+	Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.,Sampson JM, Ke W, Bethel CR, Pagadala SR, Nottingham MD, Bonomo RA, Buynak JD, van den Akker F Antimicrob Agents Chemother. 2011 May;55(5):2303-9. Epub 2011 Feb 28. PMID:21357298<ref>PMID:21357298</ref>

-	~~===ESBL R164H mutant SHV-1 beta-lactamase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21357298}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3opl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021357298<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
-	[[Category: Akker, F van den.]]	+	[[Category: Akker, F van den]]
-	[[Category: Sampson, J M.]]	+	[[Category: Sampson, J M]]
	[[Category: Class a beta-lactamase]]		[[Category: Class a beta-lactamase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 16:34, 20 October 2012

OCA — Sat, 20 Oct 2012 16:34:39 GMT

←Older revision		Revision as of 16:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3opl]] is a 1 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].	+	[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].

	==See Also==		==See Also==

OCA at 22:07, 26 July 2012

OCA — Thu, 26 Jul 2012 22:07:22 GMT

←Older revision		Revision as of 22:07, 26 July 2012
Line 1:		Line 1:
-	[[Image:3opl.~~jpg~~\|left\|200px]]	+	[[Image:3opl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3opl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3opl\| PDB=3opl \| SCENE= }}		{{STRUCTURE_3opl\| PDB=3opl \| SCENE= }}

	===ESBL R164H mutant SHV-1 beta-lactamase===		===ESBL R164H mutant SHV-1 beta-lactamase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21357298}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21357298 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21357298}}		{{ABSTRACT_PUBMED_21357298}}

	==About this Structure==		==About this Structure==
-	[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].	+	[[3opl]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==

OCA: Protected "3opl" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2011 07:38:32 GMT

Protected "3opl" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:38, 13 July 2011

OCA at 07:38, 13 July 2011

OCA — Wed, 13 Jul 2011 07:38:29 GMT

←Older revision		Revision as of 07:38, 13 July 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3opl.jpg\|left\|200px]]

-	The ~~entry 3opl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3opl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3opl\| PDB=3opl \| SCENE= }}

-	~~Authors: Sampson, J.M., van den Akker, F.~~	+	===ESBL R164H mutant SHV-1 beta-lactamase===

-	Description: ESBL R164H mutant SHV-1 beta-lactamase

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Nov 10 06~~:30:~~35 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21357298}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21357298 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21357298}}
		+
		+	==About this Structure==
		+	[[3opl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021357298</ref><references group="xtra"/>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: Akker, F van den.]]
		+	[[Category: Sampson, J M.]]
		+	[[Category: Class a beta-lactamase]]
		+	[[Category: Hydrolase]]

OCA at 03:19, 10 November 2010

OCA — Wed, 10 Nov 2010 03:19:39 GMT

←Older revision		Revision as of 03:19, 10 November 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3opl is ON HOLD	+	The entry 3opl is ON HOLD until Paper Publication

	Authors: Sampson, J.M., van den Akker, F.		Authors: Sampson, J.M., van den Akker, F.
Line 7:		Line 7:
	Description: ESBL R164H mutant SHV-1 beta-lactamase		Description: ESBL R164H mutant SHV-1 beta-lactamase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 15~~ 10:38:24 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:30:35 2010''

OCA: New page: '''Unreleased structure''' The entry 3opl is ON HOLD Authors: Sampson, J.M., van den Akker, F. Description: ESBL R164H mutant SHV-1 beta-lactamase ''Page seeded by [http://oca.weizman...

OCA — Wed, 15 Sep 2010 07:29:42 GMT

New page: '''Unreleased structure''' The entry 3opl is ON HOLD Authors: Sampson, J.M., van den Akker, F. Description: ESBL R164H mutant SHV-1 beta-lactamase ''Page seeded by [http://oca.weizman...

New page

'''Unreleased structure'''

The entry 3opl is ON HOLD

Authors: Sampson, J.M., van den Akker, F.

Description: ESBL R164H mutant SHV-1 beta-lactamase

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:38:24 2010''