3oro - Revision history

OCA at 09:43, 6 September 2023

OCA — Wed, 06 Sep 2023 09:43:55 GMT

←Older revision		Revision as of 09:43, 6 September 2023
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	<StructureSection load='3oro' size='340' side='right'caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3oro' size='340' side='right'caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycta Mycta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID~~-~~ADENYLATE+ESTER'>AGS</scene>~~, ~~<scene name='pdbligand=NHE:2-~~[~~N-CYCLOHEXYLAMINO~~]~~ETHANE+SULFONIC+ACID'>NHE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>~~[~~[Gene\|Gene:~~]~~]</b~~></td>~~<td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [https://pdbe.org/3oro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [https://www.ebi.ac.uk/pdbsum/3oro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [https://pdbe.org/3oro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [https://www.ebi.ac.uk/pdbsum/3oro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycta~~]]	+	[[Category: Mycobacterium tuberculosis H37Ra]]
-	[[Category: Alber, T]]	+	[[Category: Alber T]]
-	[[Category: Echols, N]]	+	[[Category: Echols N]]
-	[[Category: Good~~, M C~~]]	+	[[Category: Good MC]]
-	[[Category: Lombana~~, T N]]~~	+	[[Category: Lombana TN]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Kinase domain]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Tbsgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:54, 18 May 2022

OCA — Wed, 18 May 2022 10:54:26 GMT

←Older revision		Revision as of 10:54, 18 May 2022
Line 1:		Line 1:

	==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==		==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==
-	<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3oro' size='340' side='right'caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ORO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [~~http~~://pdbe.org/3oro PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3oro PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [https://pdbe.org/3oro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [https://www.ebi.ac.uk/pdbsum/3oro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycta]]		[[Category: Mycta]]
	[[Category: Alber, T]]		[[Category: Alber, T]]

OCA at 10:04, 13 February 2019

OCA — Wed, 13 Feb 2019 10:04:19 GMT

←Older revision		Revision as of 10:04, 13 February 2019
Line 3:		Line 3:
	<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mycta]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Echols, N]]		[[Category: Echols, N]]

OCA at 07:16, 18 January 2017

OCA — Wed, 18 Jan 2017 07:16:03 GMT

←Older revision		Revision as of 07:16, 18 January 2017
Line 3:		Line 3:
	<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The essential Mycobacterium tuberculosis Ser/Thr protein kinase (STPK), PknB, plays a key role in regulating growth and division, but the structural basis of activation has not been defined. Here, we provide biochemical and structural evidence that dimerization through the kinase-domain (KD) N-lobe activates PknB by an allosteric mechanism. Promoting KD pairing using a small-molecule dimerizer stimulates the unphosphorylated kinase, and substitutions that disrupt N-lobe pairing decrease phosphorylation activity in vitro and in vivo. Multiple crystal structures of two monomeric PknB KD mutants in complex with nucleotide reveal diverse inactive conformations that contain large active-site distortions that propagate > 30 A from the mutation site. These results define flexible, inactive structures of a monomeric bacterial receptor KD and show how "back-to-back" N-lobe dimerization stabilizes the active KD conformation. This general mechanism of bacterial receptor STPK activation affords insights into the regulation of homologous eukaryotic kinases that form structurally similar dimers.
		+
		+	Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.,Lombana TN, Echols N, Good MC, Thomsen ND, Ng HL, Greenstein AE, Falick AM, King DS, Alber T Structure. 2010 Dec 8;18(12):1667-77. doi: 10.1016/j.str.2010.09.019. PMID:21134645<ref>PMID:21134645</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3oro" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycta]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Echols, N]]		[[Category: Echols, N]]

OCA at 03:49, 10 December 2016

OCA — Sat, 10 Dec 2016 03:49:55 GMT

←Older revision		Revision as of 03:49, 10 December 2016
Line 1:		Line 1:
		+
	==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==		==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==
	<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://pdbe.org/3oro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oro ProSAT]</span></td></tr>
	</table>		</table>

Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Mycta]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Echols, N]]		[[Category: Echols, N]]

OCA at 10:34, 9 December 2014

OCA — Tue, 09 Dec 2014 10:34:27 GMT

←Older revision		Revision as of 10:34, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3oro.png\|left\|200px]]~~	+	==Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)==
-		+	<StructureSection load='3oro' size='340' side='right' caption='[[3oro]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{STRUCTURE_3oro\| PDB=3oro \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORO FirstGlance]. <br>
-	===Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3orp\|3orp]], [[3ort\|3ort]], [[1mru\|1mru]], [[1o6y\|1o6y]], [[3ori\|3ori]], [[3ork\|3ork]], [[3orl\|3orl]], [[3orm\|3orm]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRA_0016, pknB, PknB (Rv0014c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oro RCSB], [http://www.ebi.ac.uk/pdbsum/3oro PDBsum]</span></td></tr>
-	[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].	+	</table>

	==See Also==		==See Also==
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Alber, T.]]	+	[[Category: Alber, T]]
-	[[Category: Echols, N.]]	+	[[Category: Echols, N]]
-	[[Category: Good, M C.]]	+	[[Category: Good, M C]]
-	[[Category: Lombana, T N.]]	+	[[Category: Lombana, T N]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Kinase domain]]		[[Category: Kinase domain]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:39, 20 October 2012

OCA — Sat, 20 Oct 2012 17:39:03 GMT

←Older revision		Revision as of 17:39, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3oro]] is a 1 chain structure ~~of [[Serine/threonine protein kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].	+	[[3oro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].

	==See Also==		==See Also==

OCA: Protected "3oro" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 01:35:42 GMT

Protected "3oro" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:35, 27 July 2012

OCA at 01:35, 27 July 2012

OCA — Fri, 27 Jul 2012 01:35:40 GMT

←Older revision		Revision as of 01:35, 27 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3oro.png\|left\|200px]]
-	[[Image:3oro.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3oro", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3oro\| PDB=3oro \| SCENE= }}		{{STRUCTURE_3oro\| PDB=3oro \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3ORO~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].	+	[[3oro]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alber, T.]]		[[Category: Alber, T.]]
Line 27:		Line 23:
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:43:42 2010''

OCA at 05:31, 15 December 2010

OCA — Wed, 15 Dec 2010 05:31:22 GMT

←Older revision		Revision as of 05:31, 15 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3oro.jpg\|left\|200px]]

-	The ~~entry 3oro~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3oro", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3oro\| PDB=3oro \| SCENE= }}

-	~~Authors: Good, M.C., Echols, N., Lombana, T.N., Alber, T., TB Structural Genomics Consortium~~ (~~TBSGC~~)	+	===Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)===

-	Description: Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 29 07~~:57:03 2010''	+	==About this Structure==
		+	3ORO is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORO OCA].
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Alber, T.]]
		+	[[Category: Echols, N.]]
		+	[[Category: Good, M C.]]
		+	[[Category: Lombana, T N.]]
		+	[[Category: TBSGC, TB Structural Genomics Consortium.]]
		+	[[Category: Kinase domain]]
		+	[[Category: Signal transduction]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tb structural genomics consortium]]
		+	[[Category: Tbsgc]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:43:42 2010''