3owh - Revision history

OCA at 10:37, 21 February 2024

OCA — Wed, 21 Feb 2024 10:37:01 GMT

←Older revision		Revision as of 10:37, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3owh' size='340' side='right'caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3owh' size='340' side='right'caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ovm\|3ovm]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [https://pdbe.org/3owh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [https://www.ebi.ac.uk/pdbsum/3owh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [https://pdbe.org/3owh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [https://www.ebi.ac.uk/pdbsum/3owh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions of quinone substrates. In contrast to quinone reductase 1 (QR1) which uses NAD(P)H as its co-substrate, QR2 utilizes a rare group of hydride donors, N-methyl or N-ribosyl nicotinamide. Several studies have linked QR2 to the generation of quinone free radicals, several neuronal degenerative diseases, and cancer. QR2 has been also identified as the third melatonin receptor (MT3) through in cellulo and in vitro inhibition of QR2 by traditional MT3 ligands, and through recent X-ray structures of human QR2 (hQR2) in complex with melatonin and 2-iodomelatonin. Several MT3 specific ligands have been developed that exhibit both potent in cellulo inhibition of hQR2 nanomolar, affinity for MT3. The potency of these ligands suggest their use as molecular probes for hQR2. However, no definitive correlation between traditionally obtained MT3 ligand affinity and hQR2 inhibition exists limiting our understanding of how these ligands are accommodated in the hQR2 active site. To obtain a clearer relationship between the structures of developed MT3 ligands and their inhibitory properties, in cellulo and in vitro IC(50) values were determined for a representative set of MT3 ligands (MCA-NAT, 2-I-MCANAT, prazosin, S26695, S32797, and S29434). Furthermore, X-ray structures for each of these ligands in complex with hQR2 were determined allowing for a structural evaluation of the binding modes of these ligands in relation to the potency of MT3 ligands.	+
-		+
-	X-ray structural studies of quinone reductase 2 nanomolar range inhibitors.,Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD Protein Sci. 2011 May 2. doi: 10.1002/pro.647. PMID:21538647<ref>PMID:21538647</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
-	*[[Quinone reductase\|Quinone reductase]]	+	*[[Quinone reductase 3D structures\|Quinone reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mesecar~~, A D~~]]	+	[[Category: Mesecar AD]]
-	[[Category: Pegan~~, S D~~]]	+	[[Category: Pegan SD]]
-	[[Category: Sturdy, M]]	+	[[Category: Sturdy M]]
-	~~[[Category: 2-i-mca-nat]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Metal-2 binding]]~~	+
-	~~[[Category: Nq02]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Qr2~~]]	+

OCA at 11:00, 18 May 2022

OCA — Wed, 18 May 2022 11:00:10 GMT

←Older revision		Revision as of 11:00, 18 May 2022
Line 1:		Line 1:

	==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==		==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
-	<StructureSection load='3owh' size='340' side='right' caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='3owh' size='340' side='right'caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ovm\|3ovm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ovm\|3ovm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [~~http~~://pdbe.org/3owh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3owh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3owh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [https://pdbe.org/3owh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [https://www.ebi.ac.uk/pdbsum/3owh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Quinone reductase\|Quinone reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mesecar, A D]]		[[Category: Mesecar, A D]]
	[[Category: Pegan, S D]]		[[Category: Pegan, S D]]

OCA at 08:51, 8 November 2017

OCA — Wed, 08 Nov 2017 08:51:20 GMT

←Older revision		Revision as of 08:51, 8 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Quinone reductase\|Quinone reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:16, 4 August 2016

OCA — Thu, 04 Aug 2016 18:16:14 GMT

←Older revision		Revision as of 18:16, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==		==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
	<StructureSection load='3owh' size='340' side='right' caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3owh' size='340' side='right' caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ovm\|3ovm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ovm\|3ovm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [http://www.ebi.ac.uk/pdbsum/3owh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [http://pdbe.org/3owh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [http://www.ebi.ac.uk/pdbsum/3owh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3owh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3owh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mesecar, A D]]		[[Category: Mesecar, A D]]
	[[Category: Pegan, S D]]		[[Category: Pegan, S D]]

OCA at 11:49, 25 December 2014

OCA — Thu, 25 Dec 2014 11:49:17 GMT

←Older revision		Revision as of 11:49, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [http://www.ebi.ac.uk/pdbsum/3owh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [http://www.ebi.ac.uk/pdbsum/3owh PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:52, 9 December 2014

OCA — Tue, 09 Dec 2014 12:52:59 GMT

←Older revision		Revision as of 12:52, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3owh.~~png~~\|~~left~~\|~~200px~~]]	+	==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
		+	<StructureSection load='3owh' size='340' side='right' caption='[[3owh]], [[Resolution\|resolution]] 2.28Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3owh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52X:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-2-IODO-1H-INDOL-5-YL}CARBAMATE'>52X</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ovm\|3ovm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owh RCSB], [http://www.ebi.ac.uk/pdbsum/3owh PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions of quinone substrates. In contrast to quinone reductase 1 (QR1) which uses NAD(P)H as its co-substrate, QR2 utilizes a rare group of hydride donors, N-methyl or N-ribosyl nicotinamide. Several studies have linked QR2 to the generation of quinone free radicals, several neuronal degenerative diseases, and cancer. QR2 has been also identified as the third melatonin receptor (MT3) through in cellulo and in vitro inhibition of QR2 by traditional MT3 ligands, and through recent X-ray structures of human QR2 (hQR2) in complex with melatonin and 2-iodomelatonin. Several MT3 specific ligands have been developed that exhibit both potent in cellulo inhibition of hQR2 nanomolar, affinity for MT3. The potency of these ligands suggest their use as molecular probes for hQR2. However, no definitive correlation between traditionally obtained MT3 ligand affinity and hQR2 inhibition exists limiting our understanding of how these ligands are accommodated in the hQR2 active site. To obtain a clearer relationship between the structures of developed MT3 ligands and their inhibitory properties, in cellulo and in vitro IC(50) values were determined for a representative set of MT3 ligands (MCA-NAT, 2-I-MCANAT, prazosin, S26695, S32797, and S29434). Furthermore, X-ray structures for each of these ligands in complex with hQR2 were determined allowing for a structural evaluation of the binding modes of these ligands in relation to the potency of MT3 ligands.

-	~~{{STRUCTURE_3owh\| PDB=3owh \| SCENE= }}~~	+	X-ray structural studies of quinone reductase 2 nanomolar range inhibitors.,Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD Protein Sci. 2011 May 2. doi: 10.1002/pro.647. PMID:21538647<ref>PMID:21538647</ref>

-	~~===X-ray Structural study~~ of ~~quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21538647}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3owh]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA].~~	+

	==See Also==		==See Also==
	*[[Quinone reductase\|Quinone reductase]]		*[[Quinone reductase\|Quinone reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021538647<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Mesecar, A D.]]	+	[[Category: Mesecar, A D]]
-	[[Category: Pegan, S D.]]	+	[[Category: Pegan, S D]]
-	[[Category: Sturdy, M.]]	+	[[Category: Sturdy, M]]
	[[Category: 2-i-mca-nat]]		[[Category: 2-i-mca-nat]]
	[[Category: Fad]]		[[Category: Fad]]

OCA at 16:20, 20 October 2012

OCA — Sat, 20 Oct 2012 16:20:57 GMT

←Older revision		Revision as of 16:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3owh]] is a 2 chain structure ~~of [[Quinone reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA].	+	[[3owh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA].

	==See Also==		==See Also==

OCA at 21:22, 26 July 2012

OCA — Thu, 26 Jul 2012 21:22:58 GMT

←Older revision		Revision as of 21:22, 26 July 2012
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	[[Image:3owh.png\|left\|200px]]		[[Image:3owh.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3owh\| PDB=3owh \| SCENE= }}		{{STRUCTURE_3owh\| PDB=3owh \| SCENE= }}

	===X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values===		===X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21538647}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_21538647}}		{{ABSTRACT_PUBMED_21538647}}

	==About this Structure==		==About this Structure==
-	[[3owh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA].	+	[[3owh]] is a 2 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWH OCA].
		+
		+	==See Also==
		+	*[[Quinone reductase\|Quinone reductase]]

	==Reference==		==Reference==

OCA at 17:58, 6 July 2011

OCA — Wed, 06 Jul 2011 17:58:19 GMT

←Older revision		Revision as of 17:58, 6 July 2011
Line 1:		Line 1:
-	[[Image:3owh.~~jpg~~\|left\|200px]]	+	[[Image:3owh.png\|left\|200px]]

	<!--		<!--
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	[[Category: Pegan, S D.]]		[[Category: Pegan, S D.]]
	[[Category: Sturdy, M.]]		[[Category: Sturdy, M.]]
		+	[[Category: 2-i-mca-nat]]
		+	[[Category: Fad]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Metal-2 binding]]
		+	[[Category: Nq02]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Qr2]]

OCA: Protected "3owh" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2011 05:31:42 GMT

Protected "3owh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 25 May 2011