3owt - Revision history

OCA at 09:45, 6 September 2023

OCA — Wed, 06 Sep 2023 09:45:14 GMT

←Older revision		Revision as of 09:45, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3owt' size='340' side='right'caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3owt' size='340' side='right'caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWT FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GRF1~~, ~~N1310, RAP1, TUF1, YNL216W (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824~~]~~), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [https://pdbe.org/3owt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [https://www.ebi.ac.uk/pdbsum/3owt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [https://pdbe.org/3owt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [https://www.ebi.ac.uk/pdbsum/3owt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.	+	[https://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, Y~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Lei, M]]~~	+	[[Category: Chen Y]]
-	~~[[Category: Yang,~~ Y]]	+	[[Category: Lei M]]
-	[[Category: ~~Protein binding~~]]	+	[[Category: Yang Y]]
-	[[Category: ~~Rct domain~~]]	+

OCA at 11:00, 18 May 2022

OCA — Wed, 18 May 2022 11:00:49 GMT

←Older revision		Revision as of 11:00, 18 May 2022
Line 1:		Line 1:

	==Crystal structure of S. cerevisiae RAP1-Sir3 complex==		==Crystal structure of S. cerevisiae RAP1-Sir3 complex==
-	<StructureSection load='3owt' size='340' side='right' caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3owt' size='340' side='right'caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWT FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRF1, N1310, RAP1, TUF1, YNL216W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRF1, N1310, RAP1, TUF1, YNL216W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [~~http~~://pdbe.org/3owt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3owt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3owt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [https://pdbe.org/3owt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [https://www.ebi.ac.uk/pdbsum/3owt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[~~http~~://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.	+	[[https://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Lei, M]]		[[Category: Lei, M]]

OCA at 16:24, 5 August 2016

OCA — Fri, 05 Aug 2016 16:24:10 GMT

←Older revision		Revision as of 16:24, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of S. cerevisiae RAP1-Sir3 complex==		==Crystal structure of S. cerevisiae RAP1-Sir3 complex==
	<StructureSection load='3owt' size='340' side='right' caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3owt' size='340' side='right' caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWT FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRF1, N1310, RAP1, TUF1, YNL216W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRF1, N1310, RAP1, TUF1, YNL216W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [http://www.ebi.ac.uk/pdbsum/3owt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [http://pdbe.org/3owt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [http://www.ebi.ac.uk/pdbsum/3owt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3owt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3owt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Lei, M]]		[[Category: Lei, M]]

OCA at 03:57, 25 December 2014

OCA — Thu, 25 Dec 2014 03:57:43 GMT

←Older revision		Revision as of 03:57, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [http://www.ebi.ac.uk/pdbsum/3owt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [http://www.ebi.ac.uk/pdbsum/3owt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:04, 19 December 2014

OCA — Fri, 19 Dec 2014 07:04:24 GMT

←Older revision		Revision as of 07:04, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3owt\| PDB~~=3owt \| ~~SCENE~~= }}	+	==Crystal structure of S. cerevisiae RAP1-Sir3 complex==
-	===~~Crystal~~ structure ~~of S~~. cerevisiae RAP1-~~Sir3 complex~~===	+	<StructureSection load='3owt' size='340' side='right' caption='[[3owt]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21217703}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWT FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRF1, N1310, RAP1, TUF1, YNL216W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CMT1, L9753.10, MAR2, SIR3, STE8, YLR442C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owt RCSB], [http://www.ebi.ac.uk/pdbsum/3owt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Repressor activator protein 1 (RAP1) is the most highly conserved telomere protein. It is involved in protecting chromosome ends in fission yeast and promoting gene silencing in Saccharomyces cerevisiae, whereas it represses homology-directed recombination at telomeres in mammals. To understand how RAP1 has such diverse functions at telomeres, we solved the crystal or solution structures of the RAP1 C-terminal (RCT) domains of RAP1 from multiple organisms in complex with their respective protein-binding partners. Our analysis establishes RAP1(RCT) as an evolutionarily conserved protein-protein interaction module. In mammalian and fission yeast cells, this module interacts with TRF2 and Taz1, respectively, targeting RAP1 to chromosome ends for telomere protection. In contrast, S. cerevisiae RAP1 uses its RCT domain to recruit Sir3 to telomeres to mediate gene silencing. Together, our results show that, depending on the organism, the evolutionarily conserved RAP1 RCT motif has diverse functional roles at telomeres.

-	~~==Function==~~	+	A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.,Chen Y, Rai R, Zhou ZR, Kanoh J, Ribeyre C, Yang Y, Zheng H, Damay P, Wang F, Tsujii H, Hiraoka Y, Shore D, Hu HY, Chang S, Lei M Nat Struct Mol Biol. 2011 Jan 9. PMID:21217703<ref>PMID:21217703</ref>
-	~~[[http://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein~~ in ~~yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers,~~ and ~~telomeres~~. ~~RAP1 is also involved in the regulation of telomere structure~~, ~~where its binding sites are found within the terminal poly[~~C~~(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but~~, ~~instead~~, ~~result from interactions with different factors at promoters and silencers~~. ~~RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres~~. ~~May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[http~~://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3owt]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021217703</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Lei, M.]]	+	[[Category: Lei, M]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Rct domain]]		[[Category: Rct domain]]

OCA at 08:15, 2 May 2013

OCA — Thu, 02 May 2013 08:15:21 GMT

←Older revision		Revision as of 08:15, 2 May 2013
Line 1:		Line 1:
-	[[Image:3owt.png\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3owt\| PDB=3owt \| SCENE= }}		{{STRUCTURE_3owt\| PDB=3owt \| SCENE= }}
-
	===Crystal structure of S. cerevisiae RAP1-Sir3 complex===		===Crystal structure of S. cerevisiae RAP1-Sir3 complex===
		+	{{ABSTRACT_PUBMED_21217703}}

-		+	==Function==
-	<!--	+	[[http://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. [[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
-	The ~~line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21217703}}~~, ~~adds the Publication Abstract~~ to the ~~page~~	+
-	~~(as it appears on PubMed~~ at http://www.~~pubmed~~.~~gov)~~, ~~where 21217703 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21217703}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21217703~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021217703</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]
	[[Category: Lei, M.]]		[[Category: Lei, M.]]
	[[Category: Yang, Y.]]		[[Category: Yang, Y.]]
		+	[[Category: Protein binding]]
		+	[[Category: Rct domain]]

OCA at 04:52, 16 February 2011

OCA — Wed, 16 Feb 2011 04:52:37 GMT

←Older revision		Revision as of 04:52, 16 February 2011
Line 1:		Line 1:
-	[[Image:3owt.~~jpg~~\|left\|200px]]	+	[[Image:3owt.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of S. cerevisiae RAP1-Sir3 complex===		===Crystal structure of S. cerevisiae RAP1-Sir3 complex===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21217703}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21217703 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21217703}}

	==About this Structure==		==About this Structure==
	[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA].		[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21217703</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]
	[[Category: Lei, M.]]		[[Category: Lei, M.]]
	[[Category: Yang, Y.]]		[[Category: Yang, Y.]]

OCA: Protected "3owt" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:17:25 GMT

Protected "3owt" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 12 January 2011

OCA at 05:17, 12 January 2011

OCA — Wed, 12 Jan 2011 05:17:23 GMT

←Older revision		Revision as of 05:17, 12 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3owt.jpg\|left\|200px]]

-	The ~~entry 3owt~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3owt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3owt\| PDB=3owt \| SCENE= }}

-	~~Authors: Chen, Y., Yang, Y., Lei, M~~.	+	===Crystal structure of S. cerevisiae RAP1-Sir3 complex===

-	Description: Crystal structure of S. cerevisiae RAP1-Sir3 complex

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Oct 6 05~~:49:~~34 2010''~~	+	==About this Structure==
		+	[[3owt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWT OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Lei, M.]]
		+	[[Category: Yang, Y.]]

OCA at 02:40, 6 October 2010

OCA — Wed, 06 Oct 2010 02:40:03 GMT

←Older revision		Revision as of 02:40, 6 October 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3owt is ON HOLD	+	The entry 3owt is ON HOLD until Paper Publication

	Authors: Chen, Y., Yang, Y., Lei, M.		Authors: Chen, Y., Yang, Y., Lei, M.
Line 7:		Line 7:
	Description: Crystal structure of S. cerevisiae RAP1-Sir3 complex		Description: Crystal structure of S. cerevisiae RAP1-Sir3 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 29 07~~:57:57 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:49:34 2010''