3owv - Revision history

OCA at 10:37, 21 February 2024

OCA — Wed, 21 Feb 2024 10:37:06 GMT

←Older revision		Revision as of 10:37, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3owv' size='340' side='right'caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3owv' size='340' side='right'caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">endA, SP_1964 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [https://pdbe.org/3owv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [https://www.ebi.ac.uk/pdbsum/3owv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [https://pdbe.org/3owv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [https://www.ebi.ac.uk/pdbsum/3owv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.	+	[https://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	EndA is a sequence non-specific endonuclease that serves as a virulence factor during Streptococcus pneumoniae infection. Expression of EndA provides a strategy for evasion of the host's neutrophil extracellular traps, digesting the DNA scaffold structure and allowing further invasion by S. pneumoniae. To define mechanisms of catalysis and substrate binding, we solved the structure of EndA at 1.75 A resolution. The EndA structure reveals a DRGH (Asp-Arg-Gly-His) motif-containing betabetaalpha-metal finger catalytic core augmented by an interesting 'finger-loop' interruption of the active site alpha-helix. Subsequently, we delineated DNA binding versus catalytic functionality using structure-based alanine substitution mutagenesis. Three mutants, H154A, Q186A and Q192A, exhibited decreased nuclease activity that appears to be independent of substrate binding. Glu205 was found to be crucial for catalysis, while residues Arg127/Lys128 and Arg209/Lys210 contribute to substrate binding. The results presented here provide the molecular foundation for development of specific antibiotic inhibitors for EndA.	+
-		+
-	Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae.,Moon AF, Midon M, Meiss G, Pingoud A, London RE, Pedersen LC Nucleic Acids Res. 2010 Nov 26. PMID:21113026<ref>PMID:21113026</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3owv" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: London~~, R E~~]]	+	[[Category: Streptococcus pneumoniae]]
-	[[Category: Meiss, G]]	+	[[Category: London RE]]
-	[[Category: Midon, M]]	+	[[Category: Meiss G]]
-	[[Category: Moon~~, A F~~]]	+	[[Category: Midon M]]
-	[[Category: Pedersen~~, L C~~]]	+	[[Category: Moon AF]]
-	[[Category: Pingoud~~, A M]]~~	+	[[Category: Pedersen LC]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Pingoud AM]]
-	~~[[Category: Sequence nonspecific endonuclease~~]]	+

OCA at 11:00, 18 May 2022

OCA — Wed, 18 May 2022 11:00:46 GMT

←Older revision		Revision as of 11:00, 18 May 2022
Line 1:		Line 1:

	==Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae==		==Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae==
-	<StructureSection load='3owv' size='340' side='right' caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3owv' size='340' side='right'caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">endA, SP_1964 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">endA, SP_1964 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [~~http~~://pdbe.org/3owv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3owv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3owv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [https://pdbe.org/3owv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [https://www.ebi.ac.uk/pdbsum/3owv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.	+	[[https://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: London, R E]]		[[Category: London, R E]]
	[[Category: Meiss, G]]		[[Category: Meiss, G]]

OCA at 21:34, 4 August 2016

OCA — Thu, 04 Aug 2016 21:34:54 GMT

←Older revision		Revision as of 21:34, 4 August 2016
Line 1:		Line 1:
		+
	==Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae==		==Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae==
	<StructureSection load='3owv' size='340' side='right' caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3owv' size='340' side='right' caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">endA, SP_1964 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 ~~Streptococcus~~ pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">endA, SP_1964 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [http://www.ebi.ac.uk/pdbsum/3owv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [http://pdbe.org/3owv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [http://www.ebi.ac.uk/pdbsum/3owv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3owv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3owv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus pneumoniae]]
	[[Category: London, R E]]		[[Category: London, R E]]
	[[Category: Meiss, G]]		[[Category: Meiss, G]]

OCA at 19:52, 24 December 2014

OCA — Wed, 24 Dec 2014 19:52:53 GMT

←Older revision		Revision as of 19:52, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [http://www.ebi.ac.uk/pdbsum/3owv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [http://www.ebi.ac.uk/pdbsum/3owv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:46, 19 December 2014

OCA — Fri, 19 Dec 2014 06:46:51 GMT

←Older revision		Revision as of 06:46, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3owv\| PDB=3owv \| SCENE= }}~~	+	==Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae==
-	===Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae===	+	<StructureSection load='3owv' size='340' side='right' caption='[[3owv]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21113026}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3owv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OWV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8t\|1g8t]], [[1zm8\|1zm8]], [[3ism\|3ism]], [[1oup\|1oup]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">endA, SP_1964 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3owv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3owv RCSB], [http://www.ebi.ac.uk/pdbsum/3owv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EndA is a sequence non-specific endonuclease that serves as a virulence factor during Streptococcus pneumoniae infection. Expression of EndA provides a strategy for evasion of the host's neutrophil extracellular traps, digesting the DNA scaffold structure and allowing further invasion by S. pneumoniae. To define mechanisms of catalysis and substrate binding, we solved the structure of EndA at 1.75 A resolution. The EndA structure reveals a DRGH (Asp-Arg-Gly-His) motif-containing betabetaalpha-metal finger catalytic core augmented by an interesting 'finger-loop' interruption of the active site alpha-helix. Subsequently, we delineated DNA binding versus catalytic functionality using structure-based alanine substitution mutagenesis. Three mutants, H154A, Q186A and Q192A, exhibited decreased nuclease activity that appears to be independent of substrate binding. Glu205 was found to be crucial for catalysis, while residues Arg127/Lys128 and Arg209/Lys210 contribute to substrate binding. The results presented here provide the molecular foundation for development of specific antibiotic inhibitors for EndA.

-	~~==Function==~~	+	Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae.,Moon AF, Midon M, Meiss G, Pingoud A, London RE, Pedersen LC Nucleic Acids Res. 2010 Nov 26. PMID:21113026<ref>PMID:21113026</ref>
-	~~[[http://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters~~ the ~~cell~~, ~~plays a role in the competence of cells to be transformed~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3owv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021113026</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: London, R E.]]	+	[[Category: London, R E]]
-	[[Category: Meiss, G.]]	+	[[Category: Meiss, G]]
-	[[Category: Midon, M.]]	+	[[Category: Midon, M]]
-	[[Category: Moon, A F.]]	+	[[Category: Moon, A F]]
-	[[Category: Pedersen, L C.]]	+	[[Category: Pedersen, L C]]
-	[[Category: Pingoud, A M.]]	+	[[Category: Pingoud, A M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Sequence nonspecific endonuclease]]		[[Category: Sequence nonspecific endonuclease]]

OCA at 08:27, 2 May 2013

OCA — Thu, 02 May 2013 08:27:55 GMT

←Older revision		Revision as of 08:27, 2 May 2013
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-	[[Image:3owv.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3owv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3owv\| PDB=3owv \| SCENE= }}		{{STRUCTURE_3owv\| PDB=3owv \| SCENE= }}
-
	===Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae===		===Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae===
		+	{{ABSTRACT_PUBMED_21113026}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/NUCE_STRPN NUCE_STRPN]] By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21113026}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21113026 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21113026}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21113026~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021113026</ref><references group="xtra"/><references/>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: London, R E.]]		[[Category: London, R E.]]
Line 30:		Line 18:
	[[Category: Pedersen, L C.]]		[[Category: Pedersen, L C.]]
	[[Category: Pingoud, A M.]]		[[Category: Pingoud, A M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Sequence nonspecific endonuclease]]

OCA: Protected "3owv" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2011 06:24:03 GMT

Protected "3owv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:24, 27 April 2011

OCA at 06:24, 27 April 2011

OCA — Wed, 27 Apr 2011 06:24:01 GMT

←Older revision		Revision as of 06:24, 27 April 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3owv.png\|left\|200px]]
-	[[Image:3owv.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3OWV~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA].	+	[[3owv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA].

	==Reference==		==Reference==
Line 31:		Line 30:
	[[Category: Pedersen, L C.]]		[[Category: Pedersen, L C.]]
	[[Category: Pingoud, A M.]]		[[Category: Pingoud, A M.]]
-	[[Category: Hydrolase]]
-	[[Category: Sequence nonspecific endonuclease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:58:02 2010''

OCA at 06:45, 22 December 2010

OCA — Wed, 22 Dec 2010 06:45:26 GMT

←Older revision		Revision as of 06:45, 22 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3owv.jpg\|left\|200px]]

-	The ~~entry 3owv~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3owv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3owv\| PDB=3owv \| SCENE= }}

-	~~Authors: Moon, A.F., Midon, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.~~	+	===Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae===

-	Description: Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 6 05~~:49:35 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21113026}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21113026 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21113026}}
		+
		+	==About this Structure==
		+	3OWV is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21113026</ref><references group="xtra"/>
		+	[[Category: Streptococcus pneumoniae]]
		+	[[Category: London, R E.]]
		+	[[Category: Meiss, G.]]
		+	[[Category: Midon, M.]]
		+	[[Category: Moon, A F.]]
		+	[[Category: Pedersen, L C.]]
		+	[[Category: Pingoud, A M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Sequence nonspecific endonuclease]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:58:02 2010''

OCA at 02:40, 6 October 2010

OCA — Wed, 06 Oct 2010 02:40:04 GMT

←Older revision		Revision as of 02:40, 6 October 2010
Line 5:		Line 5:
	Authors: Moon, A.F., Midon, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.		Authors: Moon, A.F., Midon, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.

-	Description: nuclease	+	Description: Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 29 07~~:57:58 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:49:35 2010''