3oyw - Revision history

OCA at 11:19, 21 February 2024

OCA — Wed, 21 Feb 2024 11:19:37 GMT

←Older revision		Revision as of 11:19, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAL:BETA~~-~~D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900027:thiodigalactoside'>PRD_900027</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3oy8\|3oy8]]</div></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [https://pdbe.org/3oyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [https://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [https://pdbe.org/3oyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [https://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>	+	[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	High level galectin-1 expression results in cancer cell evasion of the immune response, increased tumour survival and aggressive metastases. Using a galectin-1 polyclonal antibody, high levels of galectin-1 protein were shown to be expressed by breast cancer cells established from FVB/N MMTV-c-neu mice as well as by the B16F10 melanoma cell line. In mixed lymphocyte cultures using tumour cells as antigenic stimulators, addition of recombinant galectin-1 dose-dependently inhibited lymphocyte production. Disaccharides were identified that inhibited galectin-1 function and increased growth and activation of CD8(+) CTL's killing cancer cells. X-ray crystallographic structures of human galectin-1 in complex with inhibitory disaccharides revealed their mode of binding. Combining galectin-blocking carbohydrates as adjuvants with vaccine immunotherapy in vivo to promote immune responses significantly decreased tumour progression and improved the outcomes for tumour challenged mice. This is the first report showing that suitably selected galectin-1 blocking disaccharides will act as adjuvants promoting vaccine stimulated immune responses against tumours in vivo.	+
-		+
-	Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.,Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ Cancer Lett. 2010 Dec 28;299(2):95-110. Epub 2010 Sep 9. PMID:20826047<ref>PMID:20826047</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blanchard, H]]	+	[[Category: Blanchard H]]
-	[[Category: Collins~~, P M]]~~	+	[[Category: Collins PM]]
-	~~[[Category: Carbohydrate binding protein]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Lactobionic acid~~]]	+

OCA at 11:04, 18 May 2022

OCA — Wed, 18 May 2022 11:04:07 GMT

OCA at 09:51, 12 August 2020

OCA — Wed, 12 Aug 2020 09:51:55 GMT

←Older revision		Revision as of 09:51, 12 August 2020
Line 1:		Line 1:

	==Crystal structure of human galectin-1 in complex with thiodigalactoside==		==Crystal structure of human galectin-1 in complex with thiodigalactoside==
-	<StructureSection load='3oyw' size='340' side='right' caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~TDG~~:~~THIODIGALACTOSIDE~~'>~~TDG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://pdbe.org/3oyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://pdbe.org/3oyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blanchard, H]]		[[Category: Blanchard, H]]
	[[Category: Collins, P M]]		[[Category: Collins, P M]]

OCA at 08:52, 8 November 2017

OCA — Wed, 08 Nov 2017 08:52:11 GMT

←Older revision		Revision as of 08:52, 8 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Galectin\|Galectin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:03, 4 August 2016

OCA — Thu, 04 Aug 2016 13:03:55 GMT

←Older revision		Revision as of 13:03, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human galectin-1 in complex with thiodigalactoside==		==Crystal structure of human galectin-1 in complex with thiodigalactoside==
	<StructureSection load='3oyw' size='340' side='right' caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3oyw' size='340' side='right' caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TDG:THIODIGALACTOSIDE'>TDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TDG:THIODIGALACTOSIDE'>TDG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://pdbe.org/3oyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3oyw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blanchard, H]]		[[Category: Blanchard, H]]
	[[Category: Collins, P M]]		[[Category: Collins, P M]]

OCA at 09:33, 25 December 2014

OCA — Thu, 25 Dec 2014 09:33:31 GMT

←Older revision		Revision as of 09:33, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:02, 9 December 2014

OCA — Tue, 09 Dec 2014 12:02:22 GMT

←Older revision		Revision as of 12:02, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3oyw.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of human galectin-1 in complex with thiodigalactoside==
		+	<StructureSection load='3oyw' size='340' side='right' caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TDG:THIODIGALACTOSIDE'>TDG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [http://www.ebi.ac.uk/pdbsum/3oyw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High level galectin-1 expression results in cancer cell evasion of the immune response, increased tumour survival and aggressive metastases. Using a galectin-1 polyclonal antibody, high levels of galectin-1 protein were shown to be expressed by breast cancer cells established from FVB/N MMTV-c-neu mice as well as by the B16F10 melanoma cell line. In mixed lymphocyte cultures using tumour cells as antigenic stimulators, addition of recombinant galectin-1 dose-dependently inhibited lymphocyte production. Disaccharides were identified that inhibited galectin-1 function and increased growth and activation of CD8(+) CTL's killing cancer cells. X-ray crystallographic structures of human galectin-1 in complex with inhibitory disaccharides revealed their mode of binding. Combining galectin-blocking carbohydrates as adjuvants with vaccine immunotherapy in vivo to promote immune responses significantly decreased tumour progression and improved the outcomes for tumour challenged mice. This is the first report showing that suitably selected galectin-1 blocking disaccharides will act as adjuvants promoting vaccine stimulated immune responses against tumours in vivo.

-	~~{{STRUCTURE_3oyw\| PDB=3oyw \| SCENE= }}~~	+	Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.,Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ Cancer Lett. 2010 Dec 28;299(2):95-110. Epub 2010 Sep 9. PMID:20826047<ref>PMID:20826047</ref>

-	~~===Crystal structure~~ of ~~human galectin-1 in complex with thiodigalactoside===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20826047}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3oyw]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020826047<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blanchard, H.]]	+	[[Category: Blanchard, H]]
-	[[Category: Collins, P M.]]	+	[[Category: Collins, P M]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Lactobionic acid]]		[[Category: Lactobionic acid]]

OCA: Protected "3oyw" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 15:09:20 GMT

Protected "3oyw" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:09, 20 October 2012

OCA at 15:09, 20 October 2012

OCA — Sat, 20 Oct 2012 15:09:16 GMT

←Older revision		Revision as of 15:09, 20 October 2012
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-	~~{{Seed}}~~	+	[[Image:3oyw.png\|left\|200px]]
-	[[Image:3oyw.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3oyw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3oyw\| PDB=3oyw \| SCENE= }}		{{STRUCTURE_3oyw\| PDB=3oyw \| SCENE= }}

	===Crystal structure of human galectin-1 in complex with thiodigalactoside===		===Crystal structure of human galectin-1 in complex with thiodigalactoside===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20826047}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20826047 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20826047}}		{{ABSTRACT_PUBMED_20826047}}

	==About this Structure==		==About this Structure==
-	~~3OYW~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA].	+	[[3oyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20826047~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020826047</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blanchard, H.]]		[[Category: Blanchard, H.]]
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	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Lactobionic acid]]		[[Category: Lactobionic acid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:14:27 2010''

OCA at 08:03, 3 November 2010

OCA — Wed, 03 Nov 2010 08:03:48 GMT

←Older revision		Revision as of 08:03, 3 November 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3oyw.jpg\|left\|200px]]

-	The ~~entry 3oyw~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3oyw", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3oyw\| PDB=3oyw \| SCENE= }}

-	~~Authors: Blanchard, H., Collins, P.M.~~	+	===Crystal structure of human galectin-1 in complex with thiodigalactoside===

-	Description: Crystal structure of human galectin-1 in complex with thiodigalactoside

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 13 10~~:32:33 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20826047}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20826047 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20826047}}
		+
		+	==About this Structure==
		+	3OYW is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20826047</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Blanchard, H.]]
		+	[[Category: Collins, P M.]]
		+	[[Category: Carbohydrate binding protein]]
		+	[[Category: Galectin]]
		+	[[Category: Lactobionic acid]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:14:27 2010''

←Older revision		Revision as of 11:04, 18 May 2022
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	<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3oyw' size='340' side='right'caption='[[3oyw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3oyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OYW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oy8\|3oy8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3oy8\|3oy8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [~~http~~://pdbe.org/3oyw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyw OCA], [https://pdbe.org/3oyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oyw RCSB], [https://www.ebi.ac.uk/pdbsum/3oyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oyw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>	+	[[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==