3p0g - Revision history

OCA at 09:47, 6 September 2023

OCA — Wed, 06 Sep 2023 09:47:05 GMT

←Older revision		Revision as of 09:47, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3p0g' size='340' side='right'caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='3p0g' size='340' side='right'caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=P0G:8~~-[~~(1R)-2-{~~[~~1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL~~]~~AMINO}-1-HYDROXYETHYL~~]-5~~-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ADRB2, ADRB2R, B2AR, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~2.1~~.17 3.~~2.1~~.17~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [https://pdbe.org/3p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [https://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [https://pdbe.org/3p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [https://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.	+	[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus glama~~]]	+	[[Category: Escherichia virus T4]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lysozyme]]
	[[Category: Nanobodies]]		[[Category: Nanobodies]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Casarosa, P]]	+	[[Category: Casarosa P]]
-	[[Category: Chae~~, P S~~]]	+	[[Category: Chae PS]]
-	[[Category: Choi, H J]]	+	[[Category: Choi H-J]]
-	[[Category: DeVree~~, B T~~]]	+	[[Category: DeVree BT]]
-	[[Category: Fung~~, J J~~]]	+	[[Category: Fung JJ]]
-	[[Category: Gellman~~, S H~~]]	+	[[Category: Gellman SH]]
-	[[Category: Kobilka~~, B K~~]]	+	[[Category: Kobilka BK]]
-	[[Category: Kobilka~~, T S~~]]	+	[[Category: Kobilka TS]]
-	[[Category: Konetzki, I]]	+	[[Category: Konetzki I]]
-	[[Category: Pardon, E]]	+	[[Category: Pardon E]]
-	[[Category: Pautsch, A]]	+	[[Category: Pautsch A]]
-	[[Category: Rasmussen~~, S G.F~~]]	+	[[Category: Rasmussen SGF]]
-	[[Category: Rosenbaum~~, D M~~]]	+	[[Category: Rosenbaum DM]]
-	[[Category: Schnapp, A]]	+	[[Category: Schnapp A]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: Sunahara~~, R K~~]]	+	[[Category: Sunahara RK]]
-	[[Category: Thian~~, F S~~]]	+	[[Category: Thian FS]]
-	[[Category: Weis~~, W I]]~~	+	[[Category: Weis WI]]
-	~~[[Category: Agonist]]~~	+
-	~~[[Category: Beta-2 adrenoceptor]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Nanobody]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:06, 18 May 2022

OCA — Wed, 18 May 2022 11:06:06 GMT

←Older revision		Revision as of 11:06, 18 May 2022
Line 1:		Line 1:

	==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor==		==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor==
-	<StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='3p0g' size='340' side='right'caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [~~http~~://en.wikipedia.org/wiki/Human Human]. The April 2011 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [https://en.wikipedia.org/wiki/Human Human]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [~~http~~://pdbe.org/3p0g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [https://pdbe.org/3p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [https://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.	+	[[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
		+	*[[Adrenergic receptor 3D structures\|Adrenergic receptor 3D structures]]
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[3D structures of antibody\|3D structures of antibody]]	+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 32:
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Nanobodies]]		[[Category: Nanobodies]]

OCA at 08:53, 8 November 2017

OCA — Wed, 08 Nov 2017 08:53:02 GMT

←Older revision		Revision as of 08:53, 8 November 2017
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Adrenergic receptor\|Adrenergic receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	*[[3D structures of antibody\|3D structures of antibody]]		*[[3D structures of antibody\|3D structures of antibody]]

OCA at 14:33, 4 August 2016

OCA — Thu, 04 Aug 2016 14:33:02 GMT

←Older revision		Revision as of 14:33, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor==		==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor==
	<StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_t4 Enterobacteria phage t4~~] and [http://en.wikipedia.org/wiki/~~Lama_glama Lama glama~~]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10665 Enterobacteria phage T4~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://pdbe.org/3p0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p0g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Adrenergic receptor\|Adrenergic receptor]]		*[[Adrenergic receptor\|Adrenergic receptor]]
-	*[[Antibody\|Antibody]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage t4~~]]	+	[[Category: Camelus glama]]
-	[[Category: ~~Lama glama~~]]	+	[[Category: Human]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Nanobodies]]		[[Category: Nanobodies]]

OCA at 10:09, 25 December 2014

OCA — Thu, 25 Dec 2014 10:09:38 GMT

←Older revision		Revision as of 10:09, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:38, 9 December 2014

OCA — Tue, 09 Dec 2014 10:38:49 GMT

←Older revision		Revision as of 10:38, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3p0g.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of a nanobody-stabilized active state of the beta2 adrenoceptor==
		+	<StructureSection load='3p0g' size='340' side='right' caption='[[3p0g]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [http://www.ebi.ac.uk/pdbsum/3p0g PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human beta(2) adrenergic receptor (beta(2)AR) that exhibits G protein-like behaviour, and obtained an agonist-bound, active-state crystal structure of the receptor-nanobody complex. Comparison with the inactive beta(2)AR structure reveals subtle changes in the binding pocket; however, these small changes are associated with an 11 A outward movement of the cytoplasmic end of transmembrane segment 6, and rearrangements of transmembrane segments 5 and 7 that are remarkably similar to those observed in opsin, an active form of rhodopsin. This structure provides insights into the process of agonist binding and activation.

-	~~{{STRUCTURE_3p0g\| PDB=3p0g \| SCENE= }}~~	+	Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor.,Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK Nature. 2011 Jan 13;469(7329):175-80. PMID:21228869<ref>PMID:21228869</ref>

-	~~===Structure of~~ a ~~nanobody-stabilized active state~~ of the ~~beta2 adrenoceptor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21228869}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3p0g]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of ~~the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx~~.~~doi.org~~/~~10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].~~	+

	==See Also==		==See Also==
	*[[Adrenergic receptor\|Adrenergic receptor]]		*[[Adrenergic receptor\|Adrenergic receptor]]
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Antibody\|Antibody]]
-		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:021228869<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
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	[[Category: Nanobodies]]		[[Category: Nanobodies]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Casarosa, P.]]	+	[[Category: Casarosa, P]]
-	[[Category: Chae, P S.]]	+	[[Category: Chae, P S]]
-	[[Category: Choi, H J.]]	+	[[Category: Choi, H J]]
-	[[Category: DeVree, B T.]]	+	[[Category: DeVree, B T]]
-	[[Category: Fung, J J.]]	+	[[Category: Fung, J J]]
-	[[Category: Gellman, S H.]]	+	[[Category: Gellman, S H]]
-	[[Category: Kobilka, B K.]]	+	[[Category: Kobilka, B K]]
-	[[Category: Kobilka, T S.]]	+	[[Category: Kobilka, T S]]
-	[[Category: Konetzki, I.]]	+	[[Category: Konetzki, I]]
-	[[Category: Pardon, E.]]	+	[[Category: Pardon, E]]
-	[[Category: Pautsch, A.]]	+	[[Category: Pautsch, A]]
-	[[Category: Rasmussen, S G.F.]]	+	[[Category: Rasmussen, S G.F]]
-	[[Category: Rosenbaum, D M.]]	+	[[Category: Rosenbaum, D M]]
-	[[Category: Schnapp, A.]]	+	[[Category: Schnapp, A]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
-	[[Category: Sunahara, R K.]]	+	[[Category: Sunahara, R K]]
-	[[Category: Thian, F S.]]	+	[[Category: Thian, F S]]
-	[[Category: Weis, W I~~.]]~~	+	[[Category: Weis, W I]]
-	~~[[Category: 7tm~~]]	+
	[[Category: Agonist]]		[[Category: Agonist]]
	[[Category: Beta-2 adrenoceptor]]		[[Category: Beta-2 adrenoceptor]]

OCA at 15:28, 20 October 2012

OCA — Sat, 20 Oct 2012 15:28:40 GMT

←Older revision		Revision as of 15:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3p0g]] is a 2 chain structure ~~of [[Adrenergic receptor]] and [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria~~ phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].	+	[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	==Reference==		==Reference==
	<ref group="xtra">PMID:021228869</ref><references group="xtra"/>		<ref group="xtra">PMID:021228869</ref><references group="xtra"/>
-	[[Category: ~~Homo sapiens, enterobacteria~~ phage t4]]	+	[[Category: Enterobacteria phage t4]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 18:30, 26 July 2012

OCA — Thu, 26 Jul 2012 18:30:23 GMT

←Older revision		Revision as of 18:30, 26 July 2012
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	[[Image:3p0g.png\|left\|200px]]		[[Image:3p0g.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3p0g\| PDB=3p0g \| SCENE= }}		{{STRUCTURE_3p0g\| PDB=3p0g \| SCENE= }}

	===Structure of a nanobody-stabilized active state of the beta2 adrenoceptor===		===Structure of a nanobody-stabilized active state of the beta2 adrenoceptor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21228869}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21228869 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21228869}}		{{ABSTRACT_PUBMED_21228869}}

	==About this Structure==		==About this Structure==
-	[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].	+	[[3p0g]] is a 2 chain structure of [[Adrenergic receptor]] and [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].
		+
		+	==See Also==
		+	*[[Adrenergic receptor\|Adrenergic receptor]]
		+	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]

	==Reference==		==Reference==
Line 46:		Line 39:
	[[Category: Thian, F S.]]		[[Category: Thian, F S.]]
	[[Category: Weis, W I.]]		[[Category: Weis, W I.]]
		+	[[Category: 7tm]]
		+	[[Category: Agonist]]
		+	[[Category: Beta-2 adrenoceptor]]
		+	[[Category: Gpcr]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Nanobody]]
		+	[[Category: Signaling protein]]

OCA at 06:09, 4 May 2011

OCA — Wed, 04 May 2011 06:09:06 GMT

←Older revision		Revision as of 06:09, 4 May 2011
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21228869~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021228869</ref><references group="xtra"/>
	[[Category: Homo sapiens, enterobacteria phage t4]]		[[Category: Homo sapiens, enterobacteria phage t4]]
	[[Category: Lama glama]]		[[Category: Lama glama]]

OCA at 05:33, 24 April 2011

OCA — Sun, 24 Apr 2011 05:33:21 GMT

←Older revision		Revision as of 05:33, 24 April 2011
Line 1:		Line 1:
-	[[Image:3p0g.~~jpg~~\|left\|200px]]	+	[[Image:3p0g.png\|left\|200px]]

	<!--		<!--
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	===Structure of a nanobody-stabilized active state of the beta2 adrenoceptor===		===Structure of a nanobody-stabilized active state of the beta2 adrenoceptor===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21228869}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21228869 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21228869}}

	==About this Structure==		==About this Structure==
-	[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].	+	[[3p0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21228869</ref><references group="xtra"/>
	[[Category: Homo sapiens, enterobacteria phage t4]]		[[Category: Homo sapiens, enterobacteria phage t4]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
		+	[[Category: Nanobodies]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Casarosa, P.]]		[[Category: Casarosa, P.]]
	[[Category: Chae, P S.]]		[[Category: Chae, P S.]]