3p0k - Revision history

OCA at 11:19, 21 February 2024

OCA — Wed, 21 Feb 2024 11:19:56 GMT

←Older revision		Revision as of 11:19, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3p0k' size='340' side='right'caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='3p0k' size='340' side='right'caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Acmnpv Acmnpv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3gwl\|3gwl]], [[3gwn\|3gwn]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~Ac92~~, ~~P33 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 AcMNPV])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [https://pdbe.org/3p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [https://www.ebi.ac.uk/pdbsum/3p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [https://pdbe.org/3p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [https://www.ebi.ac.uk/pdbsum/3p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0k ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style="background-color:#fffaf0;">~~	+	== Function ==
-	== ~~Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/FLSO_NPVAC FLSO_NPVAC] Functional FAD-linked sulfhydryl oxidase that is required for infectious budded virion (BV) production and for the formation of enveloped occluded virion (ODV).<ref>PMID:19409596</ref>
-	Genomes of nucleocytoplasmic large DNA viruses (NCLDVs) encode enzymes that catalyze the formation of disulfide bonds between cysteine amino acid residues in proteins, a function essential for the proper assembly and propagation of NCLDV virions. ~~Recently, a catalyst of disulfide formation was identified in baculoviruses, a group of large double-stranded DNA viruses considered phylogenetically distinct from NCLDVs~~. ~~The NCLDV and baculovirus disulfide catalysts are flavin adenine dinucleotide (~~FAD)-~~binding~~ sulfhydryl ~~oxidases related to the cellular Erv enzyme family, but the baculovirus enzyme, the product of the Ac92 gene in Autographa californica multiple nucleopolyhedrovirus~~ (~~AcMNPV~~)~~, is highly divergent at the amino acid sequence level. The crystal structure of the Ac92 protein presented here shows a configuration of the active-site cysteine residues~~ and bound cofactor similar to that observed in other Erv sulfhydryl oxidases. However, Ac92 has a complex quaternary structural arrangement not previously seen in cellular or viral enzymes of this family. This novel assembly comprises a dimer of pseudodimers with a striking 40-degree kink in the ~~interface helix between subunits. The diversification~~ of ~~the Erv sulfhydryl oxidase enzymes in large double-stranded DNA viruses exemplifies the extreme degree to which these viruses can push the boundaries of protein family folds.~~	+
-		+
-	~~Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family.,Hakim M, Mandelbaum A, Fass D J Virol. 2011 Sep;85~~(18)~~:9406-13~~. ~~Epub 2011 Jul 13. PMID:21752922~~<ref>PMID:~~21752922~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3p0k" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acmnpv~~]]	+	[[Category: Autographa californica nucleopolyhedrovirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thiol oxidase]]~~	+	[[Category: Fass D]]
-	[[Category: Fass, D]]	+	[[Category: Hakim M]]
-	[[Category: Hakim, M]]	+
-	~~[[Category: 4-helix bundle]]~~	+
-	~~[[Category: 5-helix bundle]]~~	+
-	~~[[Category: Flavin adenine dinucleotide]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Sulfhydryl oxidase]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 11:06, 18 May 2022

OCA — Wed, 18 May 2022 11:06:22 GMT

←Older revision		Revision as of 11:06, 18 May 2022
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	==Structure of Baculovirus Sulfhydryl Oxidase Ac92==		==Structure of Baculovirus Sulfhydryl Oxidase Ac92==
-	<StructureSection load='3p0k' size='340' side='right' caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>	+	<StructureSection load='3p0k' size='340' side='right'caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Acmnpv Acmnpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acmnpv Acmnpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwl\|3gwl]], [[3gwn\|3gwn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gwl\|3gwl]], [[3gwn\|3gwn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ac92, P33 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 AcMNPV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ac92, P33 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 AcMNPV])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [~~http~~://pdbe.org/3p0k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p0k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [https://pdbe.org/3p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [https://www.ebi.ac.uk/pdbsum/3p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	==See Also==		==See Also==
	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]		*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
		+	*[[Sulfhydryl oxidase 3D structures\|Sulfhydryl oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Acmnpv]]		[[Category: Acmnpv]]
		+	[[Category: Large Structures]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
	[[Category: Fass, D]]		[[Category: Fass, D]]

OCA at 03:50, 10 December 2016

OCA — Sat, 10 Dec 2016 03:50:18 GMT

←Older revision		Revision as of 03:50, 10 December 2016
Line 1:		Line 1:
		+
	==Structure of Baculovirus Sulfhydryl Oxidase Ac92==		==Structure of Baculovirus Sulfhydryl Oxidase Ac92==
	<StructureSection load='3p0k' size='340' side='right' caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='3p0k' size='340' side='right' caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acmnpv Acmnpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwl\|3gwl]], [[3gwn\|3gwn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwl\|3gwl]], [[3gwn\|3gwn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ac92, P33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 ~~Autographa californica nucleopolyhedrovirus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ac92, P33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 AcMNPV])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [http://www.ebi.ac.uk/pdbsum/3p0k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [http://pdbe.org/3p0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [http://www.ebi.ac.uk/pdbsum/3p0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p0k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Autographa californica nucleopolyhedrovirus~~]]	+	[[Category: Acmnpv]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
	[[Category: Fass, D]]		[[Category: Fass, D]]

OCA at 13:11, 9 December 2014

OCA — Tue, 09 Dec 2014 13:11:48 GMT

←Older revision		Revision as of 13:11, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3p0k.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Baculovirus Sulfhydryl Oxidase Ac92==
		+	<StructureSection load='3p0k' size='340' side='right' caption='[[3p0k]], [[Resolution\|resolution]] 1.47Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P0K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwl\|3gwl]], [[3gwn\|3gwn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ac92, P33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46015 Autographa californica nucleopolyhedrovirus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p0k RCSB], [http://www.ebi.ac.uk/pdbsum/3p0k PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genomes of nucleocytoplasmic large DNA viruses (NCLDVs) encode enzymes that catalyze the formation of disulfide bonds between cysteine amino acid residues in proteins, a function essential for the proper assembly and propagation of NCLDV virions. Recently, a catalyst of disulfide formation was identified in baculoviruses, a group of large double-stranded DNA viruses considered phylogenetically distinct from NCLDVs. The NCLDV and baculovirus disulfide catalysts are flavin adenine dinucleotide (FAD)-binding sulfhydryl oxidases related to the cellular Erv enzyme family, but the baculovirus enzyme, the product of the Ac92 gene in Autographa californica multiple nucleopolyhedrovirus (AcMNPV), is highly divergent at the amino acid sequence level. The crystal structure of the Ac92 protein presented here shows a configuration of the active-site cysteine residues and bound cofactor similar to that observed in other Erv sulfhydryl oxidases. However, Ac92 has a complex quaternary structural arrangement not previously seen in cellular or viral enzymes of this family. This novel assembly comprises a dimer of pseudodimers with a striking 40-degree kink in the interface helix between subunits. The diversification of the Erv sulfhydryl oxidase enzymes in large double-stranded DNA viruses exemplifies the extreme degree to which these viruses can push the boundaries of protein family folds.

-	~~{{STRUCTURE_3p0k\| PDB=3p0k \| SCENE= }}~~	+	Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family.,Hakim M, Mandelbaum A, Fass D J Virol. 2011 Sep;85(18):9406-13. Epub 2011 Jul 13. PMID:21752922<ref>PMID:21752922</ref>

-	~~===Structure~~ of ~~Baculovirus Sulfhydryl Oxidase Ac92===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21752922}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3p0k]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].~~	+

	==See Also==		==See Also==
	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]		*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021752922<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Autographa californica nucleopolyhedrovirus]]		[[Category: Autographa californica nucleopolyhedrovirus]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
-	[[Category: Fass, D.]]	+	[[Category: Fass, D]]
-	[[Category: Hakim, M.]]	+	[[Category: Hakim, M]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: 5-helix bundle]]		[[Category: 5-helix bundle]]

OCA at 17:30, 20 October 2012

OCA — Sat, 20 Oct 2012 17:30:41 GMT

←Older revision		Revision as of 17:30, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3p0k]] is a 1 chain structure ~~of [[Sulfhydryl oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].	+	[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].

	==See Also==		==See Also==

OCA at 01:07, 27 July 2012

OCA — Fri, 27 Jul 2012 01:07:45 GMT

←Older revision		Revision as of 01:07, 27 July 2012
Line 1:		Line 1:
-	[[Image:3p0k.~~jpg~~\|left\|200px]]	+	[[Image:3p0k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3p0k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3p0k\| PDB=3p0k \| SCENE= }}		{{STRUCTURE_3p0k\| PDB=3p0k \| SCENE= }}

	===Structure of Baculovirus Sulfhydryl Oxidase Ac92===		===Structure of Baculovirus Sulfhydryl Oxidase Ac92===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21752922}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21752922 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21752922}}		{{ABSTRACT_PUBMED_21752922}}

	==About this Structure==		==About this Structure==
-	[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].	+	[[3p0k]] is a 1 chain structure of [[Sulfhydryl oxidase]] with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].
		+
		+	==See Also==
		+	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]

	==Reference==		==Reference==

OCA at 07:57, 7 December 2011

OCA — Wed, 07 Dec 2011 07:57:05 GMT

←Older revision		Revision as of 07:57, 7 December 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3p0k.jpg\|left\|200px]]

-	The ~~entry 3p0k~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3p0k", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3p0k\| PDB=3p0k \| SCENE= }}

-	~~Authors: Hakim, M., Fass, D.~~	+	===Structure of Baculovirus Sulfhydryl Oxidase Ac92===

-	~~Description~~: Structure ~~of Baculovirus~~ Sulfhydryl ~~Oxidase Ac92~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21752922}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21752922 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21752922}}
		+
		+	==About this Structure==
		+	[[3p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0K OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021752922</ref><references group="xtra"/>
		+	[[Category: Autographa californica nucleopolyhedrovirus]]
		+	[[Category: Thiol oxidase]]
		+	[[Category: Fass, D.]]
		+	[[Category: Hakim, M.]]
		+	[[Category: 4-helix bundle]]
		+	[[Category: 5-helix bundle]]
		+	[[Category: Flavin adenine dinucleotide]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Sulfhydryl oxidase]]
		+	[[Category: Viral protein]]

OCA at 05:43, 30 November 2011

OCA — Wed, 30 Nov 2011 05:43:24 GMT

←Older revision		Revision as of 05:43, 30 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3p0k is ON HOLD until ~~sometime in the future~~	+	The entry 3p0k is ON HOLD until Paper Publication

	Authors: Hakim, M., Fass, D.		Authors: Hakim, M., Fass, D.

	Description: Structure of Baculovirus Sulfhydryl Oxidase Ac92		Description: Structure of Baculovirus Sulfhydryl Oxidase Ac92

OCA: Protected "3p0k" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2011 05:47:12 GMT

Protected "3p0k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 19 January 2011

OCA at 05:47, 19 January 2011

OCA — Wed, 19 Jan 2011 05:47:12 GMT

←Older revision		Revision as of 05:47, 19 January 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3p0k is ON HOLD	+	The entry 3p0k is ON HOLD until sometime in the future

	Authors: Hakim, M., Fass, D.		Authors: Hakim, M., Fass, D.

	Description: Structure of Baculovirus Sulfhydryl Oxidase Ac92		Description: Structure of Baculovirus Sulfhydryl Oxidase Ac92
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:50:36 2010''