3p4i - Revision history

OCA at 09:48, 6 September 2023

OCA — Wed, 06 Sep 2023 09:48:24 GMT

←Older revision		Revision as of 09:48, 6 September 2023
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	<StructureSection load='3p4i' size='340' side='right'caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3p4i' size='340' side='right'caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis_gallinarum"_sternberg_1892 "bacillus tuberculosis gallinarum" sternberg 1892~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4I FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ackA, MAV_4758 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1764~~ "~~Bacillus tuberculosis gallinarum~~" ~~Sternberg 1892])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [https://pdbe.org/3p4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [https://www.ebi.ac.uk/pdbsum/3p4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [https://pdbe.org/3p4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [https://www.ebi.ac.uk/pdbsum/3p4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACKA_MYCA1 ACKA_MYCA1]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[https://www.uniprot.org/uniprot/ACKA_MYCA1 ACKA_MYCA1] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus tuberculosis gallinarum sternberg 1892]]
-	[[Category: Acetate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Mycobacterium avium]]
-	~~[[Category: Acetyl-coa biosynthesis]]~~	+
-	~~[[Category: Kinase]]~~	+
-	[[Category: Mycobacterium]]	+
-	~~[[Category: Non-pathogenic species]]~~	+
-	~~[[Category: Ortholog]]~~	+
-	~~[[Category: Propanoate]]~~	+
-	~~[[Category: Pyruvate]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tuberculosis~~]]	+

OCA at 11:18, 18 May 2022

OCA — Wed, 18 May 2022 11:18:36 GMT

OCA at 17:18, 18 January 2017

OCA — Wed, 18 Jan 2017 17:18:22 GMT

←Older revision		Revision as of 17:18, 18 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of acetate kinase from Mycobacterium avium==		==Crystal structure of acetate kinase from Mycobacterium avium==
	<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 "Bacillus tuberculosis gallinarum" Sternberg 1892])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 "Bacillus tuberculosis gallinarum" Sternberg 1892])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://pdbe.org/3p4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p4i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:43, 11 March 2015

OCA — Wed, 11 Mar 2015 05:43:46 GMT

←Older revision		Revision as of 05:43, 11 March 2015
Line 2:		Line 2:
	<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_avium Mycobacterium avium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis_gallinarum"_sternberg_1892 "bacillus tuberculosis gallinarum" sternberg 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P4I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 ~~Mycobacterium avium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 "Bacillus tuberculosis gallinarum" Sternberg 1892])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~A0QLU8_MYCA1 A0QLU8_MYCA1~~]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[[http://www.uniprot.org/uniprot/ACKA_MYCA1 ACKA_MYCA1]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus tuberculosis gallinarum sternberg 1892]]
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
-	[[Category: Mycobacterium avium]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]

OCA at 12:57, 25 December 2014

OCA — Thu, 25 Dec 2014 12:57:56 GMT

←Older revision		Revision as of 12:57, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0QLU8_MYCA1 A0QLU8_MYCA1]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:03, 19 December 2014

OCA — Fri, 19 Dec 2014 07:03:18 GMT

←Older revision		Revision as of 07:03, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3p4i\| PDB=3p4i \| SCENE= }}~~	+	==Crystal structure of acetate kinase from Mycobacterium avium==
-	===Crystal structure of acetate kinase from Mycobacterium avium===	+	<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P4I FirstGlance]. <br>
-	[[3p4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 Mycobacterium avium])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [http://www.ebi.ac.uk/pdbsum/3p4i PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]
	[[Category: Kinase]]		[[Category: Kinase]]
Line 14:		Line 20:
	[[Category: Propanoate]]		[[Category: Propanoate]]
	[[Category: Pyruvate]]		[[Category: Pyruvate]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]

OCA: Protected "3p4i" [edit=sysop:move=sysop]

OCA — Thu, 02 May 2013 08:14:02 GMT

Protected "3p4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 2 May 2013

OCA at 08:13, 2 May 2013

OCA — Thu, 02 May 2013 08:13:58 GMT

←Older revision		Revision as of 08:13, 2 May 2013
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-	{{Seed}}
-	[[Image:3p4i.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3p4i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3p4i\| PDB=3p4i \| SCENE= }}		{{STRUCTURE_3p4i\| PDB=3p4i \| SCENE= }}
-
	===Crystal structure of acetate kinase from Mycobacterium avium===		===Crystal structure of acetate kinase from Mycobacterium avium===
-

	==About this Structure==		==About this Structure==
-	~~3P4I~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA].	+	[[3p4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA].
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
Line 30:		Line 19:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:52:20 2010''

OCA at 03:41, 10 November 2010

OCA — Wed, 10 Nov 2010 03:41:26 GMT

←Older revision		Revision as of 03:41, 10 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3p4i.jpg\|left\|200px]]

-	The ~~entry 3p4i~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3p4i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3p4i\| PDB=3p4i \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of acetate kinase from Mycobacterium avium===

-	Description: Crystal structure of acetate kinase from Mycobacterium avium

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 13~~ 10:33:49 2010''	+	==About this Structure==
		+	3P4I is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA].
		+	[[Category: Acetate kinase]]
		+	[[Category: Mycobacterium avium]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Acetyl-coa biosynthesis]]
		+	[[Category: Kinase]]
		+	[[Category: Mycobacterium]]
		+	[[Category: Non-pathogenic species]]
		+	[[Category: Ortholog]]
		+	[[Category: Propanoate]]
		+	[[Category: Pyruvate]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]
		+	[[Category: Tuberculosis]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:52:20 2010''

OCA: New page: '''Unreleased structure''' The entry 3p4i is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of acetate kinase from M...

OCA — Wed, 13 Oct 2010 07:24:01 GMT

New page: '''Unreleased structure''' The entry 3p4i is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of acetate kinase from M...

New page

'''Unreleased structure'''

The entry 3p4i is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of acetate kinase from Mycobacterium avium

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:33:49 2010''

←Older revision		Revision as of 11:18, 18 May 2022
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	==Crystal structure of acetate kinase from Mycobacterium avium==		==Crystal structure of acetate kinase from Mycobacterium avium==
-	<StructureSection load='3p4i' size='340' side='right' caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3p4i' size='340' side='right'caption='[[3p4i]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis_gallinarum"_sternberg_1892 "bacillus tuberculosis gallinarum" sternberg 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis_gallinarum"_sternberg_1892 "bacillus tuberculosis gallinarum" sternberg 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 "Bacillus tuberculosis gallinarum" Sternberg 1892])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MAV_4758 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 "Bacillus tuberculosis gallinarum" Sternberg 1892])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [~~http~~://pdbe.org/3p4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4i OCA], [https://pdbe.org/3p4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4i RCSB], [https://www.ebi.ac.uk/pdbsum/3p4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACKA_MYCA1 ACKA_MYCA1]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[[https://www.uniprot.org/uniprot/ACKA_MYCA1 ACKA_MYCA1]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Bacillus tuberculosis gallinarum sternberg 1892]]		[[Category: Bacillus tuberculosis gallinarum sternberg 1892]]
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]