3p5e - Revision history

OCA at 11:20, 21 February 2024

OCA — Wed, 21 Feb 2024 11:20:51 GMT

←Older revision		Revision as of 11:20, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3p5e' size='340' side='right'caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3p5e' size='340' side='right'caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5E FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7012Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CD207, CLEC4K ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [https://pdbe.org/3p5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [https://www.ebi.ac.uk/pdbsum/3p5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [https://pdbe.org/3p5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [https://www.ebi.ac.uk/pdbsum/3p5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Langerin mediates the carbohydrate-dependent uptake of pathogens by Langerhans cells in the first step of antigen presentation to the adaptive immune system. Langerin binds to an unusually diverse number of endogenous and pathogenic cell surface carbohydrates, including mannose-containing Ospecific polysaccharides derived from bacterial lipopolysaccharides identified here by probing a microarray of bacterial polysaccharides. Crystal structures of the carbohydrate-recognition domain from human langerin bound to a series of oligomannose compounds, the blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose residues by Ca(2+) coordination of vicinal hydroxyl groups with similar stereochemistry. Oligomannose compounds bind through a single-mannose residue, with no other mannose residues contacting the protein directly. There is no evidence for a second Ca(2+)-independent binding site. Likewise, a beta-glucan fragment, Glcbeta1-3Glcbeta1-3Glc, binds to langerin through the interaction of a single-glucose residue with the Ca(2+) site. The fucose moiety of the blood group B trisaccharide Galalpha1-3(Fucalpha1-2)Gal also binds to the Ca(2+) site, and selective binding to this glycan compared to other fucose-containing oligosaccharides results from additional favorable interactions of the nonreducing terminal galactose, as well as of the fucose residue. Surprisingly, the equatorial 3-OH group and the axial 4-OH group of the galactose residue in 6SO(4)-Galbeta1-4GlcNAc also coordinate Ca(2+), a heretofore unobserved mode of galactose binding in a C-type carbohydrate-recognition domain bearing the Glu-Pro-Asn signature motif characteristic of mannose binding sites. Salt bridges between the sulfate group and two lysine residues appear to compensate for the nonoptimal binding of galactose at this site.	+
-		+
-	Structural Basis for Langerin Recognition of Diverse Pathogen and Mammalian Glycans through a Single Binding Site.,Feinberg H, Taylor ME, Razi N, McBride R, Knirel YA, Graham SA, Drickamer K, Weis WI J Mol Biol. 2010 Nov 26. PMID:21112338<ref>PMID:21112338</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3p5e" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Drickamer, K]]	+	[[Category: Drickamer K]]
-	[[Category: Feinberg, H]]	+	[[Category: Feinberg H]]
-	[[Category: Graham~~, S A~~]]	+	[[Category: Graham SA]]
-	[[Category: Knirel~~, Y A~~]]	+	[[Category: Knirel YA]]
-	[[Category: McBride, R]]	+	[[Category: McBride R]]
-	[[Category: Razi, N]]	+	[[Category: Razi N]]
-	[[Category: Taylor~~, M E~~]]	+	[[Category: Taylor ME]]
-	[[Category: Weis~~, W I]]~~	+	[[Category: Weis WI]]
-	~~[[Category: C-type lectin]]~~	+
-	~~[[Category: Carbohydrate-binding]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 11:20, 18 May 2022

OCA — Wed, 18 May 2022 11:20:20 GMT

←Older revision		Revision as of 11:20, 18 May 2022
Line 1:		Line 1:

	==Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)==		==Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)==
-	<StructureSection load='3p5e' size='340' side='right' caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3p5e' size='340' side='right'caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [~~http~~://pdbe.org/3p5e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p5e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [https://pdbe.org/3p5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [https://www.ebi.ac.uk/pdbsum/3p5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[~~http~~://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>	+	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>	+	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Drickamer, K]]		[[Category: Drickamer, K]]
	[[Category: Feinberg, H]]		[[Category: Feinberg, H]]

OCA at 07:05, 5 August 2016

OCA — Fri, 05 Aug 2016 07:05:23 GMT

←Older revision		Revision as of 07:05, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)==		==Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)==
	<StructureSection load='3p5e' size='340' side='right' caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3p5e' size='340' side='right' caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [http://www.ebi.ac.uk/pdbsum/3p5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [http://pdbe.org/3p5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [http://www.ebi.ac.uk/pdbsum/3p5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p5e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Drickamer, K]]		[[Category: Drickamer, K]]
	[[Category: Feinberg, H]]		[[Category: Feinberg, H]]

OCA at 06:49, 19 December 2014

OCA — Fri, 19 Dec 2014 06:49:11 GMT

←Older revision		Revision as of 06:49, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3p5e\| PDB=3p5e \| SCENE= }}~~	+	==Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)==
-	===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===	+	<StructureSection load='3p5e' size='340' side='right' caption='[[3p5e]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21112338}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3p5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p5d\|3p5d]], [[3p5f\|3p5f]], [[3p5g\|3p5g]], [[3p5h\|3p5h]], [[3p5i\|3p5i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p5e RCSB], [http://www.ebi.ac.uk/pdbsum/3p5e PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Langerin mediates the carbohydrate-dependent uptake of pathogens by Langerhans cells in the first step of antigen presentation to the adaptive immune system. Langerin binds to an unusually diverse number of endogenous and pathogenic cell surface carbohydrates, including mannose-containing Ospecific polysaccharides derived from bacterial lipopolysaccharides identified here by probing a microarray of bacterial polysaccharides. Crystal structures of the carbohydrate-recognition domain from human langerin bound to a series of oligomannose compounds, the blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose residues by Ca(2+) coordination of vicinal hydroxyl groups with similar stereochemistry. Oligomannose compounds bind through a single-mannose residue, with no other mannose residues contacting the protein directly. There is no evidence for a second Ca(2+)-independent binding site. Likewise, a beta-glucan fragment, Glcbeta1-3Glcbeta1-3Glc, binds to langerin through the interaction of a single-glucose residue with the Ca(2+) site. The fucose moiety of the blood group B trisaccharide Galalpha1-3(Fucalpha1-2)Gal also binds to the Ca(2+) site, and selective binding to this glycan compared to other fucose-containing oligosaccharides results from additional favorable interactions of the nonreducing terminal galactose, as well as of the fucose residue. Surprisingly, the equatorial 3-OH group and the axial 4-OH group of the galactose residue in 6SO(4)-Galbeta1-4GlcNAc also coordinate Ca(2+), a heretofore unobserved mode of galactose binding in a C-type carbohydrate-recognition domain bearing the Glu-Pro-Asn signature motif characteristic of mannose binding sites. Salt bridges between the sulfate group and two lysine residues appear to compensate for the nonoptimal binding of galactose at this site.

-	~~==Disease==~~	+	Structural Basis for Langerin Recognition of Diverse Pathogen and Mammalian Glycans through a Single Binding Site.,Feinberg H, Taylor ME, Razi N, McBride R, Knirel YA, Graham SA, Drickamer K, Weis WI J Mol Biol. 2010 Nov 26. PMID:21112338<ref>PMID:21112338</ref>
-	~~[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause~~ of ~~Birbeck granule deficiency (BIRGD) [MIM:[http://omim~~.~~org/entry/613393 613393]]~~. ~~It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells~~. ~~Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>~~PMID:~~15816828</ref>~~<ref>PMID:~~16567809~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs)~~; is a ~~potent regulator~~ of ~~membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in~~ the ~~routing and/or processing of antigen for presentation to T cells~~. ~~Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur~~. ~~Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting~~ of ~~the virus to the Birbeck granules leading to its rapid degradation~~.<~~ref~~>~~PMID:10661407~~</~~ref~~>~~<ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3p5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:021112338</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Drickamer, K.]]	+	[[Category: Drickamer, K]]
-	[[Category: Feinberg, H.]]	+	[[Category: Feinberg, H]]
-	[[Category: Graham, S A.]]	+	[[Category: Graham, S A]]
-	[[Category: Knirel, Y A.]]	+	[[Category: Knirel, Y A]]
-	[[Category: McBride, R.]]	+	[[Category: McBride, R]]
-	[[Category: Razi, N.]]	+	[[Category: Razi, N]]
-	[[Category: Taylor, M E.]]	+	[[Category: Taylor, M E]]
-	[[Category: Weis, W I.]]	+	[[Category: Weis, W I]]
	[[Category: C-type lectin]]		[[Category: C-type lectin]]
	[[Category: Carbohydrate-binding]]		[[Category: Carbohydrate-binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 17:21, 24 March 2013

OCA — Sun, 24 Mar 2013 17:21:54 GMT

←Older revision		Revision as of 17:21, 24 March 2013
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-	[[Image:3p5e.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3p5e", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3p5e\| PDB=3p5e \| SCENE= }}		{{STRUCTURE_3p5e\| PDB=3p5e \| SCENE= }}
-
	===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===		===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===
		+	{{ABSTRACT_PUBMED_21112338}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21112338}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21112338~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21112338}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21112338~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021112338</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Drickamer, K.]]		[[Category: Drickamer, K.]]
Line 32:		Line 23:
	[[Category: Taylor, M E.]]		[[Category: Taylor, M E.]]
	[[Category: Weis, W I.]]		[[Category: Weis, W I.]]
		+	[[Category: C-type lectin]]
		+	[[Category: Carbohydrate-binding]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "3p5e" [edit=sysop:move=sysop]

OCA — Wed, 26 Jan 2011 12:31:26 GMT

Protected "3p5e" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:31, 26 January 2011

OCA at 12:31, 26 January 2011

OCA — Wed, 26 Jan 2011 12:31:25 GMT

←Older revision		Revision as of 12:31, 26 January 2011
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-	{{Seed}}
	[[Image:3p5e.png\|left\|200px]]		[[Image:3p5e.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3P5E~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].	+	[[3p5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].

	==Reference==		==Reference==
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	[[Category: Taylor, M E.]]		[[Category: Taylor, M E.]]
	[[Category: Weis, W I.]]		[[Category: Weis, W I.]]
-	[[Category: C-type lectin]]
-	[[Category: Carbohydrate-binding]]
-	[[Category: Sugar binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:13:00 2010''

OCA at 05:00, 15 December 2010

OCA — Wed, 15 Dec 2010 05:00:40 GMT

←Older revision		Revision as of 05:00, 15 December 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3p5e.~~jpg~~\|left\|200px]]	+	[[Image:3p5e.png\|left\|200px]]

	<!--		<!--
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	===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===		===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21112338}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21112338 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21112338}}

	==About this Structure==		==About this Structure==
	3P5E is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].		3P5E is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21112338</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Drickamer, K.]]		[[Category: Drickamer, K.]]
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	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~8 11:53~~:13 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:13:00 2010''

OCA at 08:41, 8 December 2010

OCA — Wed, 08 Dec 2010 08:41:10 GMT

←Older revision		Revision as of 08:41, 8 December 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3p5e.jpg\|left\|200px]]

-	The ~~entry 3p5e~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3p5e", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3p5e\| PDB=3p5e \| SCENE= }}

-	~~Authors: Feinberg, H., Taylor, M.E., Razi, N., McBride, R., Knirel, Y.A., Graham, S.A., Drickamer, K., Weis, W.I.~~	+	===Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)===

-	Description: Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 24 13~~:56:55 2010''	+	==About this Structure==
		+	3P5E is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5E OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Drickamer, K.]]
		+	[[Category: Feinberg, H.]]
		+	[[Category: Graham, S A.]]
		+	[[Category: Knirel, Y A.]]
		+	[[Category: McBride, R.]]
		+	[[Category: Razi, N.]]
		+	[[Category: Taylor, M E.]]
		+	[[Category: Weis, W I.]]
		+	[[Category: C-type lectin]]
		+	[[Category: Carbohydrate-binding]]
		+	[[Category: Sugar binding protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:53:13 2010''

OCA at 10:45, 24 November 2010

OCA — Wed, 24 Nov 2010 10:45:24 GMT

←Older revision		Revision as of 10:45, 24 November 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3p5e is ON HOLD	+	The entry 3p5e is ON HOLD until Paper Publication

	Authors: Feinberg, H., Taylor, M.E., Razi, N., McBride, R., Knirel, Y.A., Graham, S.A., Drickamer, K., Weis, W.I.		Authors: Feinberg, H., Taylor, M.E., Razi, N., McBride, R., Knirel, Y.A., Graham, S.A., Drickamer, K., Weis, W.I.
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	Description: Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)		Description: Structure of the carbohydrate-recognition domain of human Langerin with man4 (Man alpha1-3(Man alpha1-6)Man alpha1-6Man)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 20 06~~:22:25 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:56:55 2010''