3p6g - Revision history

OCA at 10:38, 21 February 2024

OCA — Wed, 21 Feb 2024 10:38:55 GMT

←Older revision		Revision as of 10:38, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3p6g' size='340' side='right'caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3p6g' size='340' side='right'caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IZP:(2R)-2~~-[~~4-(~~2~~-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[3p6c\|3p6c~~]~~], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">FABP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [https://pdbe.org/3p6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [https://www.ebi.ac.uk/pdbsum/3p6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [https://pdbe.org/3p6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [https://www.ebi.ac.uk/pdbsum/3p6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).	+	[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Inhibition of human adipocyte fatty-acid binding protein (FABP4) has been proposed as a treatment for type 2 diabetes, fatty liver disease and atherosclerosis. However, FABP4 displays a naturally low selectivity towards hydrophobic ligands, leading to the possibility of side effects arising from cross-inhibition of other FABP isoforms. In a search for structural determinants of ligand-binding selectivity, the binding of FABP4 towards a group of small molecules structurally related to the nonsteroidal anti-inflammatory drug ibuprofen was analyzed through X-ray crystallography. Several specific hydrophobic interactions are shown to enhance the binding affinities of these compounds, whereas an aromatic edge-to-face interaction is proposed to determine the conformation of bound ligands, highlighting the importance of aromatic interactions in hydrophobic environments.	+
-		+
-	Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).,Gonzalez JM, Fisher SZ Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):163-70. doi:, 10.1107/S2053230X14027897. Epub 2015 Jan 28. PMID:25664790<ref>PMID:25664790</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3p6g" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gonzalez~~, J M~~]]	+	[[Category: Gonzalez JM]]
-	[[Category: Pozharski, E]]	+	[[Category: Pozharski E]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Fatty acid binding protein]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Lipocalin~~]]	+

OCA at 11:21, 18 May 2022

OCA — Wed, 18 May 2022 11:21:59 GMT

←Older revision		Revision as of 11:21, 18 May 2022
Line 1:		Line 1:

	==Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen==		==Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen==
-	<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3p6g' size='340' side='right'caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [~~http~~://pdbe.org/3p6g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p6g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [https://pdbe.org/3p6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [https://www.ebi.ac.uk/pdbsum/3p6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).	+	[[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]	+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gonzalez, J M]]		[[Category: Gonzalez, J M]]
	[[Category: Pozharski, E]]		[[Category: Pozharski, E]]

OCA at 03:54, 10 December 2016

OCA — Sat, 10 Dec 2016 03:54:57 GMT

←Older revision		Revision as of 03:54, 10 December 2016
Line 1:		Line 1:
		+
	==Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen==		==Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen==
	<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://pdbe.org/3p6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p6g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:57, 25 February 2015

OCA — Wed, 25 Feb 2015 07:57:33 GMT

←Older revision		Revision as of 07:57, 25 February 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).		[[http://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of human adipocyte fatty-acid binding protein (FABP4) has been proposed as a treatment for type 2 diabetes, fatty liver disease and atherosclerosis. However, FABP4 displays a naturally low selectivity towards hydrophobic ligands, leading to the possibility of side effects arising from cross-inhibition of other FABP isoforms. In a search for structural determinants of ligand-binding selectivity, the binding of FABP4 towards a group of small molecules structurally related to the nonsteroidal anti-inflammatory drug ibuprofen was analyzed through X-ray crystallography. Several specific hydrophobic interactions are shown to enhance the binding affinities of these compounds, whereas an aromatic edge-to-face interaction is proposed to determine the conformation of bound ligands, highlighting the importance of aromatic interactions in hydrophobic environments.
		+
		+	Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).,Gonzalez JM, Fisher SZ Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):163-70. doi:, 10.1107/S2053230X14027897. Epub 2015 Jan 28. PMID:25664790<ref>PMID:25664790</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]		*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:04, 12 February 2015

OCA — Thu, 12 Feb 2015 06:04:30 GMT

←Older revision		Revision as of 06:04, 12 February 2015
Line 2:		Line 2:
	<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P6G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gonzalez, J M]]		[[Category: Gonzalez, J M]]
	[[Category: Pozharski, E]]		[[Category: Pozharski, E]]

OCA at 16:14, 24 December 2014

OCA — Wed, 24 Dec 2014 16:14:56 GMT

←Older revision		Revision as of 16:14, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

	==See Also==		==See Also==

OCA at 11:47, 9 December 2014

OCA — Tue, 09 Dec 2014 11:47:32 GMT

←Older revision		Revision as of 11:47, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3p6g.png\|left\|200px]]~~	+	==Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen==
-		+	<StructureSection load='3p6g' size='340' side='right' caption='[[3p6g]], [[Resolution\|resolution]] 1.20Å' scene=''>
-	~~{{STRUCTURE_3p6g\| PDB=3p6g \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P6G FirstGlance]. <br>
-	===Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZP:(2R)-2-[4-(2-METHYLPROPYL)PHENYL]PROPANOIC+ACID'>IZP</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3p6c\|3p6c]], [[3p6d\|3p6d]], [[3p6e\|3p6e]], [[3p6f\|3p6f]], [[3p6h\|3p6h]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6g RCSB], [http://www.ebi.ac.uk/pdbsum/3p6g PDBsum]</span></td></tr>
-	[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].	+	</table>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]		*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gonzalez, J M.]]	+	[[Category: Gonzalez, J M]]
-	[[Category: Pozharski, E.]]	+	[[Category: Pozharski, E]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Fatty acid binding protein]]		[[Category: Fatty acid binding protein]]
	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]
	[[Category: Lipocalin]]		[[Category: Lipocalin]]

OCA at 07:02, 20 October 2012

OCA — Sat, 20 Oct 2012 07:02:59 GMT

←Older revision		Revision as of 07:02, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3p6g]] is a 1 chain structure ~~of [[Fatty acid-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].	+	[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].

	==See Also==		==See Also==

OCA at 15:07, 25 July 2012

OCA — Wed, 25 Jul 2012 15:07:56 GMT

←Older revision		Revision as of 15:07, 25 July 2012
Line 1:		Line 1:
-	[[Image:3p6g.~~jpg~~\|left\|200px]]	+	[[Image:3p6g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3p6g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3p6g\| PDB=3p6g \| SCENE= }}		{{STRUCTURE_3p6g\| PDB=3p6g \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].	+	[[3p6g]] is a 1 chain structure of [[Fatty acid-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gonzalez, J M.]]		[[Category: Gonzalez, J M.]]
	[[Category: Pozharski, E.]]		[[Category: Pozharski, E.]]
		+	[[Category: Beta barrel]]
		+	[[Category: Fatty acid binding protein]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Lipocalin]]

OCA at 05:25, 13 April 2011

OCA — Wed, 13 Apr 2011 05:25:16 GMT

←Older revision		Revision as of 05:25, 13 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3p6g.jpg\|left\|200px]]

-	The ~~entry 3p6g~~ is ~~ON HOLD~~ ~~until Apr 11 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3p6g", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3p6g\| PDB=3p6g \| SCENE= }}

-	~~Authors: Gonzalez, J.M., Pozharski, E.~~	+	===Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen===

-	~~Description~~: ~~Human adipocyte lipid~~-~~binding protein FABP4 in complex with (R)-ibuprofen~~	+
		+	==About this Structure==
		+	[[3p6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6G OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Gonzalez, J M.]]
		+	[[Category: Pozharski, E.]]