3pc7 - Revision history

OCA at 09:51, 6 September 2023

OCA — Wed, 06 Sep 2023 09:51:20 GMT

←Older revision		Revision as of 09:51, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3pc7' size='340' side='right'caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3pc7' size='340' side='right'caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3pc6\|3pc6]]~~, [[~~3pc8~~\|~~3pc8~~]]~~, [[3qvg\|3qvg]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>LIG3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [https://pdbe.org/3pc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [https://pdbe.org/3pc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.	+	[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cuneo~~, M J~~]]	+	[[Category: Cuneo MJ]]
-	[[Category: Krahn~~, J M~~]]	+	[[Category: Krahn JM]]
-	[[Category: London~~, R E]]~~	+	[[Category: London RE]]
-	~~[[Category: Brct domain]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Protein:protein interaction]]~~	+
-	~~[[Category: Xrcc1 brct2 domain~~]]	+

OCA at 08:33, 25 May 2022

OCA — Wed, 25 May 2022 08:33:37 GMT

←Older revision		Revision as of 08:33, 25 May 2022
Line 1:		Line 1:

	==X-ray crystal structure of the DNA ligase III-alpha BRCT domain.==		==X-ray crystal structure of the DNA ligase III-alpha BRCT domain.==
-	<StructureSection load='3pc7' size='340' side='right' caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3pc7' size='340' side='right'caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc6\|3pc6]], [[3pc8\|3pc8]], [[3qvg\|3qvg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pc6\|3pc6]], [[3pc8\|3pc8]], [[3qvg\|3qvg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [~~http~~://pdbe.org/3pc7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pc7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [https://pdbe.org/3pc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.	+	[[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3pc7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pc7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA ligase 3D structures\|DNA ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]
	[[Category: Krahn, J M]]		[[Category: Krahn, J M]]

OCA at 08:57, 8 November 2017

OCA — Wed, 08 Nov 2017 08:57:45 GMT

←Older revision		Revision as of 08:57, 8 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3pc7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pc7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA ligase\|DNA ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:15, 4 August 2016

OCA — Thu, 04 Aug 2016 18:15:14 GMT

←Older revision		Revision as of 18:15, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray crystal structure of the DNA ligase III-alpha BRCT domain.==		==X-ray crystal structure of the DNA ligase III-alpha BRCT domain.==
	<StructureSection load='3pc7' size='340' side='right' caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3pc7' size='340' side='right' caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc6\|3pc6]], [[3pc8\|3pc8]], [[3qvg\|3qvg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc6\|3pc6]], [[3pc8\|3pc8]], [[3qvg\|3qvg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [http://pdbe.org/3pc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pc7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]
	[[Category: Krahn, J M]]		[[Category: Krahn, J M]]

OCA at 11:48, 25 December 2014

OCA — Thu, 25 Dec 2014 11:48:41 GMT

←Older revision		Revision as of 11:48, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pc7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pc7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:50, 9 December 2014

OCA — Tue, 09 Dec 2014 12:50:14 GMT

←Older revision		Revision as of 12:50, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3pc7.~~png~~\|~~left~~\|~~200px~~]]	+	==X-ray crystal structure of the DNA ligase III-alpha BRCT domain.==
		+	<StructureSection load='3pc7' size='340' side='right' caption='[[3pc7]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PC7 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc6\|3pc6]], [[3pc8\|3pc8]], [[3qvg\|3qvg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3pc7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ultimate step common to almost all DNA repair pathways is the ligation of the nicked intermediate to form contiguous double-stranded DNA. In the mammalian nucleotide and base excision repair pathways, the ligation step is carried out by ligase III-alpha. For efficient ligation, ligase III-alpha is constitutively bound to the scaffolding protein XRCC1 through interactions between the C-terminal BRCT domains of each protein. Although structural data for the individual domains has been available, no structure of the complex has been determined and several alternative proposals for this interaction have been advanced. Interpretation of the models is complicated by the formation of homodimers that, depending on the model, may either contribute to, or compete with heterodimer formation. We report here the structures of both homodimer complexes as well as the heterodimer complex. Structural characterization of the heterodimer formed from a longer XRCC1 BRCT domain construct, including residues comprising the interdomain linker region, revealed an expanded heterodimer interface with the ligase III-alpha BRCT domain. This enhanced linker-mediated binding interface plays a significant role in the determination of heterodimer/homodimer selectivity. These data provide fundamental insights into the structural basis of BRCT-mediated dimerization, and resolve questions related to the organization of this important repair complex.

-	~~{{STRUCTURE_3pc7\| PDB=3pc7 \| SCENE= }}~~	+	The structural basis for partitioning of the XRCC1/DNA ligase III-alpha BRCT-mediated dimer complexes.,Cuneo MJ, Gabel SA, Krahn JM, Ricker MA, London RE Nucleic Acids Res. 2011 Sep 1;39(17):7816-27. Epub 2011 Jun 7. PMID:21652643<ref>PMID:21652643</ref>

-	~~===X-ray crystal structure~~ of the ~~DNA ligase III-alpha BRCT domain~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21652643}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pc7]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].~~	+

	==See Also==		==See Also==
	*[[DNA ligase\|DNA ligase]]		*[[DNA ligase\|DNA ligase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021652643<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cuneo, M J.]]	+	[[Category: Cuneo, M J]]
-	[[Category: Krahn, J M.]]	+	[[Category: Krahn, J M]]
-	[[Category: London, R E.]]	+	[[Category: London, R E]]
	[[Category: Brct domain]]		[[Category: Brct domain]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 16:20, 20 October 2012

OCA — Sat, 20 Oct 2012 16:20:31 GMT

←Older revision		Revision as of 16:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pc7]] is a 2 chain structure ~~of [[DNA ligase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].	+	[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].

	==See Also==		==See Also==

OCA at 21:21, 26 July 2012

OCA — Thu, 26 Jul 2012 21:21:43 GMT

←Older revision		Revision as of 21:21, 26 July 2012
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	[[Image:3pc7.png\|left\|200px]]		[[Image:3pc7.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3pc7\| PDB=3pc7 \| SCENE= }}		{{STRUCTURE_3pc7\| PDB=3pc7 \| SCENE= }}

	===X-ray crystal structure of the DNA ligase III-alpha BRCT domain.===		===X-ray crystal structure of the DNA ligase III-alpha BRCT domain.===

-
-	<!--
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	{{ABSTRACT_PUBMED_21652643}}		{{ABSTRACT_PUBMED_21652643}}

	==About this Structure==		==About this Structure==
-	[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].	+	[[3pc7]] is a 2 chain structure of [[DNA ligase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].
		+
		+	==See Also==
		+	*[[DNA ligase\|DNA ligase]]

	==Reference==		==Reference==

OCA at 07:29, 2 November 2011

OCA — Wed, 02 Nov 2011 07:29:39 GMT

←Older revision		Revision as of 07:29, 2 November 2011
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-	[[Image:3pc7.~~jpg~~\|left\|200px]]	+	[[Image:3pc7.png\|left\|200px]]

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	===X-ray crystal structure of the DNA ligase III-alpha BRCT domain.===		===X-ray crystal structure of the DNA ligase III-alpha BRCT domain.===

		+
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		+	The line below this paragraph, {{ABSTRACT_PUBMED_21652643}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21652643 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21652643}}

	==About this Structure==		==About this Structure==
	[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].		[[3pc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PC7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021652643</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cuneo, M J.]]		[[Category: Cuneo, M J.]]

OCA: Protected "3pc7" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2011 06:30:09 GMT

Protected "3pc7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 15 June 2011