3pd8 - Revision history

OCA at 09:51, 6 September 2023

OCA — Wed, 06 Sep 2023 09:51:46 GMT

←Older revision		Revision as of 09:51, 6 September 2023
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	<StructureSection load='3pd8' size='340' side='right'caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>		<StructureSection load='3pd8' size='340' side='right'caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.476Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m5e\|1m5e]], [[3pd9\|3pd9]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [https://pdbe.org/3pd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [https://pdbe.org/3pd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Frydenvang, K~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Kastrup, J S~~]]	+	[[Category: Frydenvang K]]
-	[[Category: ~~Agonist complex]]~~	+	[[Category: Kastrup JS]]
-	~~[[Category: Ionotropic glutamate receptor glua2]]~~	+
-	~~[[Category: Ligand-binding core]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 08:34, 25 May 2022

OCA — Wed, 25 May 2022 08:34:31 GMT

←Older revision		Revision as of 08:34, 25 May 2022
Line 1:		Line 1:

	==X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution==		==X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution==
-	<StructureSection load='3pd8' size='340' side='right' caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>	+	<StructureSection load='3pd8' size='340' side='right'caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5e\|1m5e]], [[3pd9\|3pd9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m5e\|1m5e]], [[3pd9\|3pd9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [~~http~~://pdbe.org/3pd8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pd8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [https://pdbe.org/3pd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~Ionotropic~~ Glutamate ~~Receptors~~\|~~Ionotropic~~ Glutamate ~~Receptors~~]]	+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Frydenvang, K]]		[[Category: Frydenvang, K]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]

OCA at 08:18, 10 October 2018

OCA — Wed, 10 Oct 2018 08:18:45 GMT

←Older revision		Revision as of 08:18, 10 October 2018
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	</div>		</div>
	<div class="pdbe-citations 3pd8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pd8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:57, 15 November 2017

OCA — Wed, 15 Nov 2017 21:57:08 GMT

←Older revision		Revision as of 21:57, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3pd8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pd8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:01, 4 August 2016

OCA — Thu, 04 Aug 2016 08:01:59 GMT

←Older revision		Revision as of 08:01, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution==		==X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution==
	<StructureSection load='3pd8' size='340' side='right' caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>		<StructureSection load='3pd8' size='340' side='right' caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5e\|1m5e]], [[3pd9\|3pd9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5e\|1m5e]], [[3pd9\|3pd9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pd8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [http://pdbe.org/3pd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pd8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Frydenvang, K]]		[[Category: Frydenvang, K]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]

OCA at 07:21, 24 December 2014

OCA — Wed, 24 Dec 2014 07:21:28 GMT

←Older revision		Revision as of 07:21, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pd8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pd8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:49, 9 December 2014

OCA — Tue, 09 Dec 2014 11:49:25 GMT

←Older revision		Revision as of 11:49, 9 December 2014
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-	[[~~Image:~~3pd8.~~png~~\|~~left~~\|~~200px~~]]	+	==X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution==
		+	<StructureSection load='3pd8' size='340' side='right' caption='[[3pd8]], [[Resolution\|resolution]] 2.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pd8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PD8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HA7:(7S)-3-HYDROXY-4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDINE-7-CARBOXYLIC+ACID'>HA7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5e\|1m5e]], [[3pd9\|3pd9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur2, Gria2, RAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pd8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe an improved synthesis and detailed pharmacological characterization of the conformationally restricted analogue of the naturally occurring nonselective glutamate receptor agonist ibotenic acid (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid (7-HPCA, 5) at AMPA receptor subtypes. Compound 5 was shown to be a subtype-discriminating agonist at AMPA receptors with higher binding affinity and functional potency at GluA1/2 compared to GluA3/4, unlike the isomeric analogue (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid (5-HPCA, 4) that binds to all AMPA receptor subtypes with comparable potency. Biostructural X-ray crystallographic studies of 4 and 5 reveal different binding modes of (R)-4 and (S)-5 in the GluA2 agonist binding domain. WaterMap analysis of the GluA2 and GluA4 binding pockets with (R)-4 and (S)-5 suggests that the energy of hydration sites is ligand dependent, which may explain the observed selectivity.

-	~~{{STRUCTURE_3pd8\| PDB=3pd8 \| SCENE= }}~~	+	Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxazolol Glutamate Receptor Agonist Ibotenic Acid.,Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP J Med Chem. 2010 Nov 10. PMID:21067182<ref>PMID:21067182</ref>

-	~~===X-ray structure~~ of the ~~ligand-binding core of GluA2 in complex with (~~S~~)-7-HPCA at 2~~.~~5 A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21067182}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pd8]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA].~~	+

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021067182<~~/~~ref~~><~~ref group="xtra">PMID:012215417</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Frydenvang, K.]]	+	[[Category: Frydenvang, K]]
-	[[Category: Kastrup, J S.]]	+	[[Category: Kastrup, J S]]
	[[Category: Agonist complex]]		[[Category: Agonist complex]]
	[[Category: Ionotropic glutamate receptor glua2]]		[[Category: Ionotropic glutamate receptor glua2]]
	[[Category: Ligand-binding core]]		[[Category: Ligand-binding core]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 05:25, 20 October 2012

OCA — Sat, 20 Oct 2012 05:25:25 GMT

←Older revision		Revision as of 05:25, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3pd8]] is a 3 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA].	+	[[3pd8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021067182</ref><ref group="xtra">PMID:012215417~~</ref><ref group="xtra">PMID:011086992~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021067182</ref><ref group="xtra">PMID:012215417</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Frydenvang, K.]]		[[Category: Frydenvang, K.]]

OCA at 09:58, 25 July 2012

OCA — Wed, 25 Jul 2012 09:58:59 GMT

←Older revision		Revision as of 09:58, 25 July 2012
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	[[Image:3pd8.png\|left\|200px]]		[[Image:3pd8.png\|left\|200px]]

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	{{STRUCTURE_3pd8\| PDB=3pd8 \| SCENE= }}		{{STRUCTURE_3pd8\| PDB=3pd8 \| SCENE= }}

	===X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution===		===X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21067182}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21067182 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21067182}}		{{ABSTRACT_PUBMED_21067182}}

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	==See Also==		==See Also==
-	*[[Ionotropic Glutamate Receptors]]	+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==

OCA at 10:57, 9 November 2011

OCA — Wed, 09 Nov 2011 10:57:12 GMT

←Older revision		Revision as of 10:57, 9 November 2011
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3pd8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA].	+	[[3pd8]] is a 3 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD8 OCA].
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21067182~~</ref><ref group="xtra">PMID:~~12215417~~</ref><ref group="xtra">PMID:~~11086992~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021067182</ref><ref group="xtra">PMID:012215417</ref><ref group="xtra">PMID:011086992</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Frydenvang, K.]]		[[Category: Frydenvang, K.]]