3phl - Revision history

OCA at 17:06, 1 November 2023

OCA — Wed, 01 Nov 2023 17:06:24 GMT

←Older revision		Revision as of 17:06, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3phl' size='340' side='right'caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3phl' size='340' side='right'caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae_ntuh~~-~~k2044~~ Klebsiella pneumoniae ~~ntuh~~-~~k2044~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_NTUH-K2044 Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">KP1_3701, ugd ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=484021 Klebsiella pneumoniae NTUH-K2044])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [https://pdbe.org/3phl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [https://www.ebi.ac.uk/pdbsum/3phl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [https://pdbe.org/3phl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [https://www.ebi.ac.uk/pdbsum/3phl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0J9WZA6_KLEPN A0A0J9WZA6_KLEPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Klebsiella pneumoniae ~~ntuh~~-~~k2044~~]]	+	[[Category: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: UDP-glucose 6-dehydrogenase]]~~	+	[[Category: Chen WH]]
-	[[Category: Chen~~, W H~~]]	+	[[Category: Chen YY]]
-	[[Category: Chen~~, Y Y~~]]	+	[[Category: Ko TP]]
-	[[Category: Ko~~, T P~~]]	+	[[Category: Lin CH]]
-	[[Category: Lin~~, C H~~]]	+	[[Category: Wang AHJ]]
-	[[Category: Wang~~, A H.J]]~~	+
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 08:39, 25 May 2022

OCA — Wed, 25 May 2022 08:39:44 GMT

←Older revision		Revision as of 08:39, 25 May 2022
Line 3:		Line 3:
	<StructureSection load='3phl' size='340' side='right'caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3phl' size='340' side='right'caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Klebsiella_pneumoniae_ntuh-k2044 Klebsiella pneumoniae ntuh-k2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_ntuh-k2044 Klebsiella pneumoniae ntuh-k2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484021 Klebsiella pneumoniae NTUH-K2044])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484021 Klebsiella pneumoniae NTUH-K2044])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [~~http~~://pdbe.org/3phl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3phl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3phl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [https://pdbe.org/3phl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [https://www.ebi.ac.uk/pdbsum/3phl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:20, 13 November 2019

OCA — Wed, 13 Nov 2019 11:20:45 GMT

←Older revision		Revision as of 11:20, 13 November 2019
Line 1:		Line 1:

	==The apo-form UDP-glucose 6-dehydrogenase==		==The apo-form UDP-glucose 6-dehydrogenase==
-	<StructureSection load='3phl' size='340' side='right' caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3phl' size='340' side='right'caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_ntuh-k2044 Klebsiella pneumoniae ntuh-k2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_ntuh-k2044 Klebsiella pneumoniae ntuh-k2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Klebsiella pneumoniae ntuh-k2044]]		[[Category: Klebsiella pneumoniae ntuh-k2044]]
		+	[[Category: Large Structures]]
	[[Category: UDP-glucose 6-dehydrogenase]]		[[Category: UDP-glucose 6-dehydrogenase]]
	[[Category: Chen, W H]]		[[Category: Chen, W H]]

OCA at 22:48, 4 August 2016

OCA — Thu, 04 Aug 2016 22:48:52 GMT

←Older revision		Revision as of 22:48, 4 August 2016
Line 1:		Line 1:
		+
	==The apo-form UDP-glucose 6-dehydrogenase==		==The apo-form UDP-glucose 6-dehydrogenase==
	<StructureSection load='3phl' size='340' side='right' caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3phl' size='340' side='right' caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae~~ Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_ntuh-k2044 Klebsiella pneumoniae ntuh-k2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~573~~ Klebsiella pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484021 Klebsiella pneumoniae NTUH-K2044])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [http://www.ebi.ac.uk/pdbsum/3phl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [http://pdbe.org/3phl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [http://www.ebi.ac.uk/pdbsum/3phl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3phl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3phl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Klebsiella pneumoniae]]	+	[[Category: Klebsiella pneumoniae ntuh-k2044]]
	[[Category: UDP-glucose 6-dehydrogenase]]		[[Category: UDP-glucose 6-dehydrogenase]]
	[[Category: Chen, W H]]		[[Category: Chen, W H]]

OCA at 22:41, 3 January 2015

OCA — Sat, 03 Jan 2015 22:41:19 GMT

←Older revision		Revision as of 22:41, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [http://www.ebi.ac.uk/pdbsum/3phl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [http://www.ebi.ac.uk/pdbsum/3phl PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance.,Chen YY, Ko TP, Lin CH, Chen WH, Wang AH J Struct Biol. 2011 Sep;175(3):300-10. Epub 2011 Apr 23. PMID:21536136<ref>PMID:21536136</ref>		Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance.,Chen YY, Ko TP, Lin CH, Chen WH, Wang AH J Struct Biol. 2011 Sep;175(3):300-10. Epub 2011 Apr 23. PMID:21536136<ref>PMID:21536136</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
	[[Category: UDP-glucose 6-dehydrogenase]]		[[Category: UDP-glucose 6-dehydrogenase]]
-	[[Category: Chen, W H.]]	+	[[Category: Chen, W H]]
-	[[Category: Chen, Y Y.]]	+	[[Category: Chen, Y Y]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Lin, C H.]]	+	[[Category: Lin, C H]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 05:26, 4 June 2014

OCA — Wed, 04 Jun 2014 05:26:19 GMT

←Older revision		Revision as of 05:26, 4 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3phl.~~jpg~~\|~~left~~\|~~200px~~]]	+	==The apo-form UDP-glucose 6-dehydrogenase==
		+	<StructureSection load='3phl' size='340' side='right' caption='[[3phl]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dli\|1dli]], [[3pid\|3pid]], [[3pjg\|3pjg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KP1_3701, ugd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phl RCSB], [http://www.ebi.ac.uk/pdbsum/3phl PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cationic modification of lipid A with 4-amino-4-deoxy-L-arabinopyranose (L-Ara4N) allows the pathogen Klebsiella pneumoniae to resist the antibiotic polymyxin and other cationic antimicrobial peptides. UDP-glucose dehydrogenase (Ugd) catalyzes the NAD-dependent twofold oxidation of UDP-glucose (UPG) to produce UDP-glucuronic acid (UGA), a requisite precursor in the biosynthesis of L-Ara4N and bacterial exopolysaccharides. Here we report five crystal structures of K. pneumoniae Ugd (KpUgd) in its apo form, in complex with UPG, UPG/NADH, two UGA molecules, and finally with a C-terminal His-tag. The UGA-complex structure differs from the others by a 14 degrees rotation of the N-terminal domain toward the C-terminal domain, and represents a closed enzyme conformation. It also reveals that the second UGA molecule binds to a pre-existing positively charged surface patch away from the active site. The enzyme is thus inactivated by moving the catalytically important residues C253, K256 and D257 from their original positions. Kinetic data also suggest that KpUgd has multiple binding sites for UPG, and that UGA is a competitive inhibitor. The conformational changes triggered by UGA binding to the allosteric site can be exploited in designing potent inhibitors.

-	<!--	+	Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance.,Chen YY, Ko TP, Lin CH, Chen WH, Wang AH J Struct Biol. 2011 Sep;175(3):300-10. Epub 2011 Apr 23. PMID:21536136<ref>PMID:21536136</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3phl"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3phl\| PDB=3phl \| SCENE= }}~~	+

-	~~===The apo-form UDP-glucose 6-dehydrogenase===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21536136}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21536136 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21536136}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3phl]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021536136<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
	[[Category: UDP-glucose 6-dehydrogenase]]		[[Category: UDP-glucose 6-dehydrogenase]]

OCA: Protected "3phl" [edit=sysop:move=sysop]

OCA — Wed, 28 Sep 2011 05:38:03 GMT

Protected "3phl" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 28 September 2011

OCA at 05:38, 28 September 2011

OCA — Wed, 28 Sep 2011 05:38:00 GMT

←Older revision		Revision as of 05:38, 28 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3phl.jpg\|left\|200px]]

-	The ~~entry 3phl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3phl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3phl\| PDB=3phl \| SCENE= }}

-	~~Authors: Chen, Y.~~-~~Y., Ko, T.~~-~~P., Lin, C.~~-~~H., Chen, W.-H., Wang, A.H.-J.~~	+	===The apo-form UDP-glucose 6-dehydrogenase===

-	Description: The apo-form UDP-glucose 6-dehydrogenase

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 1 11~~:13:~~40 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21536136}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21536136 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21536136}}
		+
		+	==About this Structure==
		+	[[3phl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021536136</ref><references group="xtra"/>
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: UDP-glucose 6-dehydrogenase]]
		+	[[Category: Chen, W H.]]
		+	[[Category: Chen, Y Y.]]
		+	[[Category: Ko, T P.]]
		+	[[Category: Lin, C H.]]
		+	[[Category: Wang, A H.J.]]
		+	[[Category: Dehydrogenase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA at 08:01, 1 December 2010

OCA — Wed, 01 Dec 2010 08:01:53 GMT

←Older revision		Revision as of 08:01, 1 December 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3phl is ON HOLD	+	The entry 3phl is ON HOLD until Paper Publication

	Authors: Chen, Y.-Y., Ko, T.-P., Lin, C.-H., Chen, W.-H., Wang, A.H.-J.		Authors: Chen, Y.-Y., Ko, T.-P., Lin, C.-H., Chen, W.-H., Wang, A.H.-J.
Line 7:		Line 7:
	Description: The apo-form UDP-glucose 6-dehydrogenase		Description: The apo-form UDP-glucose 6-dehydrogenase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 24 13~~:57:52 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:13:40 2010''

OCA at 10:46, 24 November 2010

OCA — Wed, 24 Nov 2010 10:46:21 GMT

←Older revision		Revision as of 10:46, 24 November 2010
Line 3:		Line 3:
	The entry 3phl is ON HOLD		The entry 3phl is ON HOLD

-	Authors: Chen, Y.-Y., Ko, T.-P., Lin, C.-H., Chen, W.-H., Wang, A. H.-J.	+	Authors: Chen, Y.-Y., Ko, T.-P., Lin, C.-H., Chen, W.-H., Wang, A.H.-J.

	Description: The apo-form UDP-glucose 6-dehydrogenase		Description: The apo-form UDP-glucose 6-dehydrogenase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Nov ~~18 00~~:34:23 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:57:52 2010''