3pky - Revision history

OCA at 10:41, 21 February 2024

OCA — Wed, 21 Feb 2024 10:41:39 GMT

←Older revision		Revision as of 10:41, 21 February 2024
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	<StructureSection load='3pky' size='340' side='right'caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3pky' size='340' side='right'caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~, ~~<scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938~~ (~~[https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [https://pdbe.org/3pky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [https://www.ebi.ac.uk/pdbsum/3pky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pky ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [https://pdbe.org/3pky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [https://www.ebi.ac.uk/pdbsum/3pky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pky ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/LIGD_MYCTU LIGD_MYCTU] With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA strand forming a stable synaptic complex even when the 3'-protruding ends of the template DNA strands are not complementary. Has numerous activities; gap filling copies the template strand, and prefers a 5'-phosphate in the gap and rNTPS (PubMed:17174332, PubMed:17947582), DNA-directed DNA or RNA polymerase on 5'-overhangs, terminal transferase (extending ssDNA or blunt dsDNA in a non-templated fashion, preferentially with rNTPs), DNA-dependent RNA primase (synthesizes short RNAs on unprimed closed ssDNA) and 3'- to 5'-exonuclease on ssDNA (PubMed:15499016). Isolated Pol domain (and presumably the holoenzyme) is able to form complexes between 2 noncompatible protruding 3'-ends DNA ends via microhomologous DNA strands, in a end-bridging function to which it adds a templated nucleotide (PubMed:17947582). Minimal primer length is 2 nucleotides (PubMed:21255731).<ref>PMID:15499016</ref> <ref>PMID:17174332</ref> <ref>PMID:17947582</ref> <ref>PMID:21255731</ref> The preference of the polymerase domain for rNTPs over dNTPs may be advantageous in dormant cells, where the dNTP pool is limiting. In conjunction with endogenous or Mycobacterium phage Omega Ku (AC Q853W0) can reconstitute NHEJ in Saccharomyces cerevisiae.
-	~~In many prokaryotes, a specific DNA primase~~/~~polymerase (PolDom) is required for nonhomologous~~ end joining (NHEJ) repair of DNA double-strand breaks (~~DSBs~~). ~~Here~~, ~~we report~~ the ~~crystal structure of~~ a ~~catalytically active conformation of Mycobacterium tuberculosis PolDom~~, ~~consisting~~ of ~~a polymerase bound~~ to a DNA ~~end with~~ a 3' ~~overhang, two metal ions~~, and ~~an incoming nucleotide but~~, ~~significantly~~, ~~lacking a primer strand. This structure represents a polymerase:~~DNA ~~complex in a preternary intermediate state. This~~ polymerase ~~complex occurs~~ in ~~solution~~, ~~stabilizing the enzyme on~~ DNA ~~ends and promoting nucleotide extension of~~ short ~~incoming termini~~. ~~We also demonstrate that the invariant Arg~~(~~220~~), ~~contained~~ in a ~~conserved loop~~ (~~loop~~ 2)~~, plays an essential role in catalysis by regulating binding~~ of ~~a second metal ion~~ in the ~~active site~~. ~~We propose that this~~ NHEJ ~~intermediate facilitates extension reactions involving critically short or noncomplementary DNA ends, thus promoting break repair and minimizing sequence loss during DSB repair~~.	+

-	Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase.,Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ Mol Cell. 2011 Jan 21;41(2):221-31. PMID:21255731<ref>PMID:21255731</ref>	+	==See Also==
-		+	*[[DNA ligase 3D structures\|DNA ligase 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 3pky" style~~=~~"background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brissett, N C~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Doherty, A J~~]]	+	[[Category: Brissett NC]]
-	[[Category: ~~Fox, G C~~]]	+	[[Category: Doherty AJ]]
-	[[Category: ~~Pitcher, R S~~]]	+	[[Category: Fox GC]]
-	[[Category: ~~Nhej]]~~	+	[[Category: Pitcher RS]]
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Polymerase]]~~	+
-	~~[[Category: Primase]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 08:43, 25 May 2022

OCA — Wed, 25 May 2022 08:43:50 GMT

←Older revision		Revision as of 08:43, 25 May 2022
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	==Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.==		==Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.==
-	<StructureSection load='3pky' size='340' side='right' caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3pky' size='340' side='right'caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [~~http~~://pdbe.org/3pky PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pky PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pky ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [https://pdbe.org/3pky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [https://www.ebi.ac.uk/pdbsum/3pky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pky ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brissett, N C]]		[[Category: Brissett, N C]]
	[[Category: Doherty, A J]]		[[Category: Doherty, A J]]

OCA at 09:28, 5 August 2016

OCA — Fri, 05 Aug 2016 09:28:11 GMT

←Older revision		Revision as of 09:28, 5 August 2016
Line 1:		Line 1:
		+
	==Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.==		==Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.==
	<StructureSection load='3pky' size='340' side='right' caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3pky' size='340' side='right' caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [http://www.ebi.ac.uk/pdbsum/3pky PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [http://pdbe.org/3pky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [http://www.ebi.ac.uk/pdbsum/3pky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pky ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pky" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Brissett, N C]]		[[Category: Brissett, N C]]
	[[Category: Doherty, A J]]		[[Category: Doherty, A J]]

OCA at 10:21, 19 December 2014

OCA — Fri, 19 Dec 2014 10:21:12 GMT

←Older revision		Revision as of 10:21, 19 December 2014
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-	~~{{STRUCTURE_3pky\| PDB=3pky \| SCENE= }}~~	+	==Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.==
-	===Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.===	+	<StructureSection load='3pky' size='340' side='right' caption='[[3pky]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21255731}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pky]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT0965, MTCY08D9.01c, MTCY10D7.36c, Rv0938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pky RCSB], [http://www.ebi.ac.uk/pdbsum/3pky PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In many prokaryotes, a specific DNA primase/polymerase (PolDom) is required for nonhomologous end joining (NHEJ) repair of DNA double-strand breaks (DSBs). Here, we report the crystal structure of a catalytically active conformation of Mycobacterium tuberculosis PolDom, consisting of a polymerase bound to a DNA end with a 3' overhang, two metal ions, and an incoming nucleotide but, significantly, lacking a primer strand. This structure represents a polymerase:DNA complex in a preternary intermediate state. This polymerase complex occurs in solution, stabilizing the enzyme on DNA ends and promoting nucleotide extension of short incoming termini. We also demonstrate that the invariant Arg(220), contained in a conserved loop (loop 2), plays an essential role in catalysis by regulating binding of a second metal ion in the active site. We propose that this NHEJ intermediate facilitates extension reactions involving critically short or noncomplementary DNA ends, thus promoting break repair and minimizing sequence loss during DSB repair.

-	~~==About this~~ Structure==	+	Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase.,Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ Mol Cell. 2011 Jan 21;41(2):221-31. PMID:21255731<ref>PMID:21255731</ref>
-	~~[[3pky]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021255731</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Brissett, N C.]]	+	[[Category: Brissett, N C]]
-	[[Category: Doherty, A J.]]	+	[[Category: Doherty, A J]]
-	[[Category: Fox, G C.]]	+	[[Category: Fox, G C]]
-	[[Category: Pitcher, R S.]]	+	[[Category: Pitcher, R S]]
	[[Category: Nhej]]		[[Category: Nhej]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]

OCA at 08:18, 8 May 2013

OCA — Wed, 08 May 2013 08:18:12 GMT

←Older revision		Revision as of 08:18, 8 May 2013
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-	[[Image:3pky.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3pky\| PDB=3pky \| SCENE= }}		{{STRUCTURE_3pky\| PDB=3pky \| SCENE= }}
-
	===Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.===		===Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.===
-
-
-	<!--
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	{{ABSTRACT_PUBMED_21255731}}		{{ABSTRACT_PUBMED_21255731}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21255731~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021255731</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Brissett, N C.]]		[[Category: Brissett, N C.]]
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	[[Category: Fox, G C.]]		[[Category: Fox, G C.]]
	[[Category: Pitcher, R S.]]		[[Category: Pitcher, R S.]]
		+	[[Category: Nhej]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Polymerase]]
		+	[[Category: Primase]]
		+	[[Category: Protein-dna complex]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-dna complex]]

OCA at 05:41, 16 February 2011

OCA — Wed, 16 Feb 2011 05:41:09 GMT

←Older revision		Revision as of 05:41, 16 February 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3pky.jpg\|left\|200px]]

-	The ~~entry 3pky~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pky", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pky\| PDB=3pky \| SCENE= }}

-	~~Authors: Brissett~~, ~~N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J~~.	+	===Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.===

-	~~Description~~: ~~Polymerase Domain~~ from Mycobacterium tuberculosis ~~Ligase D in complex with DNA~~, ~~UTP and Manganese~~.	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21255731}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21255731 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21255731}}
		+
		+	==About this Structure==
		+	[[3pky]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21255731</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Brissett, N C.]]
		+	[[Category: Doherty, A J.]]
		+	[[Category: Fox, G C.]]
		+	[[Category: Pitcher, R S.]]

OCA: Protected "3pky" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 18:14:24 GMT

Protected "3pky" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:14, 29 December 2010

OCA at 18:14, 29 December 2010

OCA — Wed, 29 Dec 2010 18:14:24 GMT

←Older revision		Revision as of 18:14, 29 December 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pky is ON HOLD	+	The entry 3pky is ON HOLD until Paper Publication

	Authors: Brissett, N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J.		Authors: Brissett, N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J.

	Description: Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.		Description: Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:58:26 2010''

OCA: New page: '''Unreleased structure''' The entry 3pky is ON HOLD Authors: Brissett, N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J. Description: Polymerase Domain from Mycobacterium tuberculosis Lig...

OCA — Wed, 24 Nov 2010 10:46:56 GMT

New page: '''Unreleased structure''' The entry 3pky is ON HOLD Authors: Brissett, N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J. Description: Polymerase Domain from Mycobacterium tuberculosis Lig...

New page

'''Unreleased structure'''

The entry 3pky is ON HOLD

Authors: Brissett, N.C., Fox, G.C., Pitcher, R.S., Doherty, A.J.

Description: Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:58:26 2010''