3pl8 - Revision history

OCA at 09:56, 6 September 2023

OCA — Wed, 06 Sep 2023 09:56:19 GMT

←Older revision		Revision as of 09:56, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3pl8' size='340' side='right'caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3pl8' size='340' side='right'caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Coriolus_zonatus Coriolus zonatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trametes_ochracea Trametes ochracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2igo\|2igo]], [[1tt0\|1tt0]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 Coriolus zonatus])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [https://pdbe.org/3pl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pl8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [https://pdbe.org/3pl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pl8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7ZA32_TRAOC Q7ZA32_TRAOC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coriolus zonatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pyranose oxidase~~]]	+	[[Category: Trametes ochracea]]
-	[[Category: Divne, C]]	+	[[Category: Divne C]]
-	[[Category: Tan~~, T C]]~~	+	[[Category: Tan TC]]
-	~~[[Category: Fad cofactor]]~~	+
-	~~[[Category: Gmc oxidoreductase]]~~	+
-	~~[[Category: H167a mutant]]~~	+
-	~~[[Category: Homotetramer]]~~	+
-	~~[[Category: Oxidase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phbh fold]]~~	+
-	~~[[Category: Pyranose oxidation]]~~	+
-	~~[[Category: Rossmann domain]]~~	+
-	~~[[Category: Substrate complex~~]]	+

OCA at 08:44, 25 May 2022

OCA — Wed, 25 May 2022 08:44:12 GMT

←Older revision		Revision as of 08:44, 25 May 2022
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	==Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose==		==Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose==
-	<StructureSection load='3pl8' size='340' side='right' caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='3pl8' size='340' side='right'caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Coriolus_zonatus Coriolus zonatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coriolus_zonatus Coriolus zonatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2igo\|2igo]], [[1tt0\|1tt0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2igo\|2igo]], [[1tt0\|1tt0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 Coriolus zonatus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 Coriolus zonatus])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [~~http~~://pdbe.org/3pl8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pl8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pl8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [https://pdbe.org/3pl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pl8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3pl8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pl8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pyranose oxidase\|Pyranose oxidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Coriolus zonatus]]		[[Category: Coriolus zonatus]]
		+	[[Category: Large Structures]]
	[[Category: Pyranose oxidase]]		[[Category: Pyranose oxidase]]
	[[Category: Divne, C]]		[[Category: Divne, C]]

OCA at 09:02, 8 November 2017

OCA — Wed, 08 Nov 2017 09:02:15 GMT

←Older revision		Revision as of 09:02, 8 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3pl8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pl8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pyranose oxidase\|Pyranose oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:23, 10 December 2016

OCA — Sat, 10 Dec 2016 11:23:00 GMT

←Older revision		Revision as of 11:23, 10 December 2016
Line 1:		Line 1:
		+
	==Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose==		==Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose==
	<StructureSection load='3pl8' size='340' side='right' caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3pl8' size='340' side='right' caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trametes_ochracea Trametes ochracea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coriolus_zonatus Coriolus zonatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2igo\|2igo]], [[1tt0\|1tt0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2igo\|2igo]], [[1tt0\|1tt0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 ~~Trametes ochracea~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 Coriolus zonatus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pl8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [http://pdbe.org/3pl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pl8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pl8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pyranose oxidase\|Pyranose oxidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Coriolus zonatus]]
	[[Category: Pyranose oxidase]]		[[Category: Pyranose oxidase]]
-	[[Category: Trametes ochracea]]
	[[Category: Divne, C]]		[[Category: Divne, C]]
	[[Category: Tan, T C]]		[[Category: Tan, T C]]

OCA at 12:39, 9 December 2014

OCA — Tue, 09 Dec 2014 12:39:52 GMT

←Older revision		Revision as of 12:39, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3pl8.~~png~~\|~~left~~\|~~200px~~]]	+	==Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose==
		+	<StructureSection load='3pl8' size='340' side='right' caption='[[3pl8]], [[Resolution\|resolution]] 1.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_ochracea Trametes ochracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PL8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=G3F:3-DEOXY-3-FLUORO-BETA-D-GLUCOPYRANOSE'>G3F</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2igo\|2igo]], [[1tt0\|1tt0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2o ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=230624 Trametes ochracea])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyranose_oxidase Pyranose oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.10 1.1.3.10] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pl8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trametes multicolor pyranose 2-oxidase (P2O) is a flavoprotein oxidase that oxidizes d-glucose at C2 to 2-keto-d-glucose by a highly regioselective mechanism. In this work, fluorinated sugar substrates were used as mechanistic probes to investigate the basis of regioselectivity in P2O. Although frequently used to study the mechanisms of glycoside hydrolases, our work provides the first example of applying these probes to sugar oxidoreductases. Our previous structure of the P2O mutant H167A in complex with the slow substrate 2-deoxy-2-fluoro-d-glucose showed a substrate-binding mode compatible with oxidation at C3. To accommodate the sugar, a gating segment, (454)FSY(456), in the substrate recognition loop partly unfolded to create a spacious and more polar active site that is distinct from the closed state of P2O. The crystal structure presented here shows that the preferred C2 oxidation where an ordered complex of P2O H167A with 3-deoxy-3-fluoro-d-glucose at 1.35 A resolution was successfully trapped. In this semi-open C2-oxidation complex, the substrate recognition loop tightens to form an optimized substrate complex stabilized by interactions between Asp452 and glucose O4, as well as Tyr456 and the glucose O6 group, interactions that are not possible when glucose is positioned for oxidation at C3. The different conformations of the (454)FSY(456) gating segment in the semi-open and closed states induce backbone and side-chain movements of Thr169 and Asp452 that add further differential stabilization to the individual states. We expect the semi-open state (C2-oxidation state) and closed state to be good approximations of the active-site structure during the reductive half-reaction (sugar oxidation) and oxidative half-reaction (O(2) reduction).

-	~~{{STRUCTURE_3pl8\| PDB=3pl8 \| SCENE= }}~~	+	Regioselective control of beta-d-glucose oxidation by pyranose 2-oxidase is intimately coupled to conformational degeneracy.,Tan TC, Haltrich D, Divne C J Mol Biol. 2011 Jun 17;409(4):588-600. Epub 2011 Apr 15. PMID:21515286<ref>PMID:21515286</ref>

-	~~===Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21515286}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3pl8]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Trametes_ochracea Trametes ochracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA].~~	+	</StructureSection>
	[[Category: Pyranose oxidase]]		[[Category: Pyranose oxidase]]
	[[Category: Trametes ochracea]]		[[Category: Trametes ochracea]]
-	[[Category: Divne, C.]]	+	[[Category: Divne, C]]
-	[[Category: Tan, T C.]]	+	[[Category: Tan, T C]]
	[[Category: Fad cofactor]]		[[Category: Fad cofactor]]
	[[Category: Gmc oxidoreductase]]		[[Category: Gmc oxidoreductase]]

OCA at 06:44, 24 October 2012

OCA — Wed, 24 Oct 2012 06:44:44 GMT

←Older revision		Revision as of 06:44, 24 October 2012
Line 1:		Line 1:
-	[[Image:3pl8.~~jpg~~\|left\|200px]]	+	[[Image:3pl8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pl8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pl8\| PDB=3pl8 \| SCENE= }}		{{STRUCTURE_3pl8\| PDB=3pl8 \| SCENE= }}

	===Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose===		===Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose===

		+	{{ABSTRACT_PUBMED_21515286}}

	==About this Structure==		==About this Structure==
Line 18:		Line 13:
	[[Category: Divne, C.]]		[[Category: Divne, C.]]
	[[Category: Tan, T C.]]		[[Category: Tan, T C.]]
		+	[[Category: Fad cofactor]]
		+	[[Category: Gmc oxidoreductase]]
		+	[[Category: H167a mutant]]
		+	[[Category: Homotetramer]]
		+	[[Category: Oxidase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Phbh fold]]
		+	[[Category: Pyranose oxidation]]
		+	[[Category: Rossmann domain]]
		+	[[Category: Substrate complex]]

OCA: Protected "3pl8" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2011 07:27:00 GMT

Protected "3pl8" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 27 April 2011

OCA at 07:26, 27 April 2011

OCA — Wed, 27 Apr 2011 07:26:57 GMT

←Older revision		Revision as of 07:26, 27 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pl8.jpg\|left\|200px]]

-	The ~~entry 3pl8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pl8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pl8\| PDB=3pl8 \| SCENE= }}

-	~~Authors: Tan, T.C., Divne, C.~~	+	===Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose===

-	Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 1 11~~:14:~~02 2010''~~	+	==About this Structure==
		+	[[3pl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trametes_ochracea Trametes ochracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL8 OCA].
		+	[[Category: Pyranose oxidase]]
		+	[[Category: Trametes ochracea]]
		+	[[Category: Divne, C.]]
		+	[[Category: Tan, T C.]]

OCA at 08:02, 1 December 2010

OCA — Wed, 01 Dec 2010 08:02:15 GMT

←Older revision		Revision as of 08:02, 1 December 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pl8 is ON HOLD	+	The entry 3pl8 is ON HOLD until Paper Publication

	Authors: Tan, T.C., Divne, C.		Authors: Tan, T.C., Divne, C.
Line 7:		Line 7:
	Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose		Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 24 13~~:58:32 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:14:02 2010''

OCA: New page: '''Unreleased structure''' The entry 3pl8 is ON HOLD Authors: Tan, T.C., Divne, C. Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose ''Page seeded by ...

OCA — Wed, 24 Nov 2010 10:47:01 GMT

New page: '''Unreleased structure''' The entry 3pl8 is ON HOLD Authors: Tan, T.C., Divne, C. Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose ''Page seeded by ...

New page

'''Unreleased structure'''

The entry 3pl8 is ON HOLD

Authors: Tan, T.C., Divne, C.

Description: Pyranose 2-oxidase H167A complex with 3-deoxy-3-fluoro-beta-D-glucose

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:58:32 2010''