3pof - Revision history

OCA at 09:58, 6 September 2023

OCA — Wed, 06 Sep 2023 09:58:08 GMT

←Older revision		Revision as of 09:58, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3pof' size='340' side='right'caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3pof' size='340' side='right'caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.501Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pob\|3pob]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [https://pdbe.org/3pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [https://www.ebi.ac.uk/pdbsum/3pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [https://pdbe.org/3pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [https://www.ebi.ac.uk/pdbsum/3pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).	+	[https://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gingras, A R~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Moody, P C.E~~]]	+	[[Category: Gingras AR]]
-	[[Category: ~~Wallis, R~~]]	+	[[Category: Moody PCE]]
-	[[Category: ~~Bloodstream]]~~	+	[[Category: Wallis R]]
-	~~[[Category: Ca2+ binding site]]~~	+
-	~~[[Category: Complement protein]]~~	+
-	~~[[Category: Cub domain]]~~	+
-	~~[[Category: Ficolin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lectin pathway of complement]]~~	+
-	~~[[Category: Mbl]]~~	+
-	~~[[Category: Mbp~~]]	+

OCA at 08:48, 25 May 2022

OCA — Wed, 25 May 2022 08:48:18 GMT

←Older revision		Revision as of 08:48, 25 May 2022
Line 1:		Line 1:

	==Crystal structure of MASP-1 CUB2 domain bound to Ca2+==		==Crystal structure of MASP-1 CUB2 domain bound to Ca2+==
-	<StructureSection load='3pof' size='340' side='right' caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3pof' size='340' side='right'caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3POF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pob\|3pob]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [~~http~~://pdbe.org/3pof PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pof PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [https://pdbe.org/3pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [https://www.ebi.ac.uk/pdbsum/3pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).	+	[[https://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3pof" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pof" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mannan-binding lectin serine protease\|Mannan-binding lectin serine protease]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Gingras, A R]]		[[Category: Gingras, A R]]
	[[Category: Moody, P C.E]]		[[Category: Moody, P C.E]]

OCA at 02:24, 5 August 2016

OCA — Fri, 05 Aug 2016 02:24:16 GMT

←Older revision		Revision as of 02:24, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of MASP-1 CUB2 domain bound to Ca2+==		==Crystal structure of MASP-1 CUB2 domain bound to Ca2+==
	<StructureSection load='3pof' size='340' side='right' caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3pof' size='340' side='right' caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [http://www.ebi.ac.uk/pdbsum/3pof PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [http://pdbe.org/3pof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [http://www.ebi.ac.uk/pdbsum/3pof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pof" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Gingras, A R]]		[[Category: Gingras, A R]]
	[[Category: Moody, P C.E]]		[[Category: Moody, P C.E]]

OCA at 22:00, 24 December 2014

OCA — Wed, 24 Dec 2014 22:00:42 GMT

←Older revision		Revision as of 22:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [http://www.ebi.ac.uk/pdbsum/3pof PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [http://www.ebi.ac.uk/pdbsum/3pof PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.,Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R Structure. 2011 Nov 9;19(11):1635-43. PMID:22078562<ref>PMID:22078562</ref>		Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.,Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R Structure. 2011 Nov 9;19(11):1635-43. PMID:22078562<ref>PMID:22078562</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Gingras, A R.]]	+	[[Category: Gingras, A R]]
-	[[Category: Moody, P C.E.]]	+	[[Category: Moody, P C.E]]
-	[[Category: Wallis, R.]]	+	[[Category: Wallis, R]]
	[[Category: Bloodstream]]		[[Category: Bloodstream]]
	[[Category: Ca2+ binding site]]		[[Category: Ca2+ binding site]]

OCA at 05:32, 4 June 2014

OCA — Wed, 04 Jun 2014 05:32:41 GMT

←Older revision		Revision as of 05:32, 4 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3pof.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of MASP-1 CUB2 domain bound to Ca2+==
		+	<StructureSection load='3pof' size='340' side='right' caption='[[3pof]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3POF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pob\|3pob]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [http://www.ebi.ac.uk/pdbsum/3pof PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency and autoimmune diseases, whereas inappropriate activation causes self-damage. In the lectin and classical pathways, complement is triggered upon recognition of a pathogen by an activating complex. Here we present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin (MBL) and the binding domain of its associated protease (MASP-1/-3). The collagen binds within a groove using a pivotal lysine side chain that interacts with Ca(2+)-coordinating residues, revealing the essential role of Ca(2+). This mode of binding is prototypic for all activating complexes of the lectin and classical pathways, and suggests a general mechanism for the global changes that drive activation. The structural insights reveal a new focus for inhibitors and we have validated this concept by targeting the binding pocket of the MASP.

-	<!--	+	Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.,Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R Structure. 2011 Nov 9;19(11):1635-43. PMID:22078562<ref>PMID:22078562</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3pof"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3pof\| PDB=3pof \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~MASP-1 CUB2 domain bound to Ca2+===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22078562}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22078562 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22078562}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pof]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022078562<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Gingras, A R.]]		[[Category: Gingras, A R.]]

OCA at 05:33, 30 November 2011

OCA — Wed, 30 Nov 2011 05:33:51 GMT

←Older revision		Revision as of 05:33, 30 November 2011
Line 1:		Line 1:
-	[[Image:3pof.~~jpg~~\|left\|200px]]	+	[[Image:3pof.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of MASP-1 CUB2 domain bound to Ca2+===		===Crystal structure of MASP-1 CUB2 domain bound to Ca2+===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22078562}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22078562 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22078562}}

	==About this Structure==		==About this Structure==
	[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA].		[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022078562</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Gingras, A R.]]		[[Category: Gingras, A R.]]

OCA at 07:41, 24 August 2011

OCA — Wed, 24 Aug 2011 07:41:38 GMT

←Older revision		Revision as of 07:41, 24 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pof.jpg\|left\|200px]]

-	The ~~entry 3pof~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pof", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pof\| PDB=3pof \| SCENE= }}

-	~~Authors: Gingras, A.R., Moody, P.C.E., Wallis, R.~~	+	===Crystal structure of MASP-1 CUB2 domain bound to Ca2+===

-	~~Description: Crystal~~ structure ~~of MASP~~-~~1 CUB2 domain bound to~~ Ca2+	+
		+	==About this Structure==
		+	[[3pof]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA].
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Gingras, A R.]]
		+	[[Category: Moody, P C.E.]]
		+	[[Category: Wallis, R.]]
		+	[[Category: Bloodstream]]
		+	[[Category: Ca2+ binding site]]
		+	[[Category: Complement protein]]
		+	[[Category: Cub domain]]
		+	[[Category: Ficolin]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lectin pathway of complement]]
		+	[[Category: Mbl]]
		+	[[Category: Mbp]]

OCA: Protected "3pof" [edit=sysop:move=sysop]

OCA — Wed, 23 Mar 2011 06:42:01 GMT

Protected "3pof" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 23 March 2011

OCA at 06:42, 23 March 2011

OCA — Wed, 23 Mar 2011 06:42:00 GMT

←Older revision		Revision as of 06:42, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pof is ON HOLD	+	The entry 3pof is ON HOLD until Paper Publication

	Authors: Gingras, A.R., Moody, P.C.E., Wallis, R.		Authors: Gingras, A.R., Moody, P.C.E., Wallis, R.

	Description: Crystal structure of MASP-1 CUB2 domain bound to Ca2+		Description: Crystal structure of MASP-1 CUB2 domain bound to Ca2+
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:14:46 2010''

OCA: New page: '''Unreleased structure''' The entry 3pof is ON HOLD Authors: Gingras, A.R., Moody, P.C.E., Wallis, R. Description: Crystal structure of MASP-1 CUB2 domain bound to Ca2+ ''Page seeded...

OCA — Wed, 01 Dec 2010 08:02:59 GMT

New page: '''Unreleased structure''' The entry 3pof is ON HOLD Authors: Gingras, A.R., Moody, P.C.E., Wallis, R. Description: Crystal structure of MASP-1 CUB2 domain bound to Ca2+ ''Page seeded...

New page

'''Unreleased structure'''

The entry 3pof is ON HOLD

Authors: Gingras, A.R., Moody, P.C.E., Wallis, R.

Description: Crystal structure of MASP-1 CUB2 domain bound to Ca2+

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:14:46 2010''