3pv4 - Revision history

OCA at 10:01, 6 September 2023

OCA — Wed, 06 Sep 2023 10:01:38 GMT

←Older revision		Revision as of 10:01, 6 September 2023
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	<StructureSection load='3pv4' size='340' side='right'caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3pv4' size='340' side='right'caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_700992 Atcc 700992~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [https://pdbe.org/3pv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [https://pdbe.org/3pv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G1K3R2_9GAMM G1K3R2_9GAMM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 700992]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hansen, G]]	+	[[Category: Legionella fallonii]]
-	[[Category: Hilgenfeld, R]]	+	[[Category: Hansen G]]
-	[[Category: Scott, H]]	+	[[Category: Hilgenfeld R]]
-	[[Category: Wrase, R]]	+	[[Category: Scott H]]
-	~~[[Category: Chaperone protease]]~~	+	[[Category: Wrase R]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Trypsin fold~~]]	+

OCA at 08:56, 25 May 2022

OCA — Wed, 25 May 2022 08:56:52 GMT

←Older revision		Revision as of 08:56, 25 May 2022
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	==Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)==		==Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)==
-	<StructureSection load='3pv4' size='340' side='right' caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3pv4' size='340' side='right'caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_700992 Atcc 700992]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_700992 Atcc 700992]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [~~http~~://pdbe.org/3pv4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pv4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [https://pdbe.org/3pv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 700992]]		[[Category: Atcc 700992]]
		+	[[Category: Large Structures]]
	[[Category: Hansen, G]]		[[Category: Hansen, G]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]

OCA at 21:17, 5 August 2016

OCA — Fri, 05 Aug 2016 21:17:06 GMT

←Older revision		Revision as of 21:17, 5 August 2016
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		+
	==Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)==		==Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)==
	<StructureSection load='3pv4' size='340' side='right' caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3pv4' size='340' side='right' caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Legionella_fallonii Legionella fallonii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700992 Atcc 700992]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [http://pdbe.org/3pv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pv4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Legionella fallonii~~]]	+	[[Category: Atcc 700992]]
	[[Category: Hansen, G]]		[[Category: Hansen, G]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]

OCA at 10:24, 19 December 2014

OCA — Fri, 19 Dec 2014 10:24:02 GMT

←Older revision		Revision as of 10:24, 19 December 2014
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-	~~{{STRUCTURE_3pv4\| PDB=3pv4 \| SCENE= }}~~	+	==Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)==
-	===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===	+	<StructureSection load='3pv4' size='340' side='right' caption='[[3pv4]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21670246}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PV4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pv4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pv4 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteases of the HtrA family are key factors dealing with folding stress in the periplasmatic compartment of prokaryotes. In Escherichia coli, the well-characterized HtrA family members DegS and DegP counteract the accumulation of unfolded outer-membrane proteins under stress conditions. Whereas DegS serves as a folding-stress sensor, DegP is a chaperone-protease facilitating refolding or degradation of defective outer-membrane proteins. Here, we report the 2.15-A-resolution crystal structure of the second major chaperone-protease of the periplasm, DegQ from Legionella fallonii. DegQ assembles into large, cage-like 12-mers that form independently of unfolded substrate proteins. We provide evidence that 12-mer formation is essential for the degradation of substrate proteins but not for the chaperone activity of DegQ. In the current model for the regulation of periplasmatic chaperone-proteases, 6-meric assemblies represent important protease-resting states. However, DegQ is unable to form such 6-mers, suggesting divergent regulatory mechanisms for DegQ and DegP. To understand how the protease activity of DegQ is controlled, we probed its functional properties employing designed protein variants. Combining crystallographic, biochemical, and mutagenic data, we present a mechanistic model that suggests how protease activity of DegQ 12-mers is intrinsically regulated and how deleterious proteolysis by free DegQ 3-mers is prevented. Our study sheds light on a previously uncharacterized component of the prokaryotic stress-response system with implications for other members of the HtrA family.

-	~~==About this Structure==~~	+	The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.,Wrase R, Scott H, Hilgenfeld R, Hansen G Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10490-5. Epub 2011 Jun 13. PMID:21670246<ref>PMID:21670246</ref>
-	~~[[3pv4]]~~ is a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3PV4 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021670246</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Legionella fallonii]]		[[Category: Legionella fallonii]]
-	[[Category: Hansen, G.]]	+	[[Category: Hansen, G]]
-	[[Category: Hilgenfeld, R.]]	+	[[Category: Hilgenfeld, R]]
-	[[Category: Scott, H.]]	+	[[Category: Scott, H]]
-	[[Category: Wrase, R.]]	+	[[Category: Wrase, R]]
	[[Category: Chaperone protease]]		[[Category: Chaperone protease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Trypsin fold]]		[[Category: Trypsin fold]]

OCA at 07:57, 16 May 2013

OCA — Thu, 16 May 2013 07:57:37 GMT

←Older revision		Revision as of 07:57, 16 May 2013
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-	[[Image:3pv4.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pv4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pv4\| PDB=3pv4 \| SCENE= }}		{{STRUCTURE_3pv4\| PDB=3pv4 \| SCENE= }}
-
	===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===		===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21670246}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21670246 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21670246}}		{{ABSTRACT_PUBMED_21670246}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:021670246</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021670246</ref><references group="xtra"/><references/>
	[[Category: Legionella fallonii]]		[[Category: Legionella fallonii]]
	[[Category: Hansen, G.]]		[[Category: Hansen, G.]]

OCA at 07:22, 13 July 2011

OCA — Wed, 13 Jul 2011 07:22:28 GMT

←Older revision		Revision as of 07:22, 13 July 2011
Line 1:		Line 1:
-	[[Image:3pv4.~~jpg~~\|left\|200px]]	+	[[Image:3pv4.png\|left\|200px]]

	<!--		<!--
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	===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===		===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21670246}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21670246 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21670246}}

	==About this Structure==		==About this Structure==
	[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA].		[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021670246</ref><references group="xtra"/>
	[[Category: Legionella fallonii]]		[[Category: Legionella fallonii]]
	[[Category: Hansen, G.]]		[[Category: Hansen, G.]]

OCA at 06:31, 15 June 2011

OCA — Wed, 15 Jun 2011 06:31:13 GMT

←Older revision		Revision as of 06:31, 15 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pv4.jpg\|left\|200px]]

-	The ~~entry 3pv4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pv4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pv4\| PDB=3pv4 \| SCENE= }}

-	~~Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.~~	+	===Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)===

-	~~Description:~~ Structure of Legionella fallonii ~~DegQ (Delta~~-~~PDZ2 variant)~~	+
		+	==About this Structure==
		+	[[3pv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_fallonii Legionella fallonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV4 OCA].
		+	[[Category: Legionella fallonii]]
		+	[[Category: Hansen, G.]]
		+	[[Category: Hilgenfeld, R.]]
		+	[[Category: Scott, H.]]
		+	[[Category: Wrase, R.]]
		+	[[Category: Chaperone protease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pdz domain]]
		+	[[Category: Trypsin fold]]

OCA: Protected "3pv4" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2011 08:00:33 GMT

Protected "3pv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 16 March 2011

OCA at 08:00, 16 March 2011

OCA — Wed, 16 Mar 2011 08:00:32 GMT

←Older revision		Revision as of 08:00, 16 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pv4 is ON HOLD	+	The entry 3pv4 is ON HOLD until Paper Publication

	Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.		Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.

	Description: Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)		Description: Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:25:53 2010''

OCA: New page: '''Unreleased structure''' The entry 3pv4 is ON HOLD Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G. Description: Structure of Legionella fallonii DegQ (Delta-PDZ2 variant) ...

OCA — Wed, 15 Dec 2010 05:13:33 GMT

New page: '''Unreleased structure''' The entry 3pv4 is ON HOLD Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G. Description: Structure of Legionella fallonii DegQ (Delta-PDZ2 variant) ...

New page

'''Unreleased structure'''

The entry 3pv4 is ON HOLD

Authors: Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.

Description: Structure of Legionella fallonii DegQ (Delta-PDZ2 variant)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:25:53 2010''