3pvl - Revision history

OCA at 13:34, 1 March 2024

OCA — Fri, 01 Mar 2024 13:34:00 GMT

←Older revision		Revision as of 13:34, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3pvl' size='340' side='right'caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3pvl' size='340' side='right'caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PVL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Myo7a ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice]), USH1G, SANS ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [https://pdbe.org/3pvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [https://www.ebi.ac.uk/pdbsum/3pvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [https://pdbe.org/3pvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [https://www.ebi.ac.uk/pdbsum/3pvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[https://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[https://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>	+	[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[https://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>	+	[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The unconventional myosin VIIa (MYO7A) is one of the five proteins that form a network of complexes involved in formation of stereocilia. Defects in these proteins cause syndromic deaf-blindness in humans [Usher syndrome I (USH1)]. Many disease-causing mutations occur in myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail that binds to another USH1 protein, Sans. We report the crystal structure of MYO7A MyTH4-FERM domains in complex with the central domain (CEN) of Sans at 2.8 angstrom resolution. The MyTH4 and FERM domains form an integral structural and functional supramodule binding to two highly conserved segments (CEN1 and 2) of Sans. The MyTH4-FERM/CEN complex structure provides mechanistic explanations for known deafness-causing mutations in MYO7A MyTH4-FERM. The structure will also facilitate mechanistic and functional studies of MyTH4-FERM domains in other myosins.	+
-		+
-	~~Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.,Wu L, Pan L, Wei Z, Zhang M Science. 2011 Feb 11;331(6018):757-60. PMID:21311020<ref>PMID:21311020</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3pvl" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Pan~~, L F~~]]	+	[[Category: Pan LF]]
-	[[Category: Wei~~, Z Y~~]]	+	[[Category: Wei ZY]]
-	[[Category: Wu, L]]	+	[[Category: Wu L]]
-	[[Category: Zhang~~, M J]]~~	+	[[Category: Zhang MJ]]
-	~~[[Category: Cargo protein]]~~	+
-	~~[[Category: Motor protein-protein transport complex]]~~	+
-	~~[[Category: Novel folding]]~~	+
-	~~[[Category: Protein cargo binding]]~~	+
-	~~[[Category: Protein complex~~]]	+

OCA at 08:57, 25 May 2022

OCA — Wed, 25 May 2022 08:57:49 GMT

←Older revision		Revision as of 08:57, 25 May 2022
Line 1:		Line 1:

	==Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans==		==Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans==
-	<StructureSection load='3pvl' size='340' side='right' caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3pvl' size='340' side='right'caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PVL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Myo7a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), USH1G, SANS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Myo7a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), USH1G, SANS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [~~http~~://pdbe.org/3pvl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pvl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [https://pdbe.org/3pvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [https://www.ebi.ac.uk/pdbsum/3pvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[~~http~~://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[~~http~~://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>	+	[[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[https://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[https://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[~~http~~://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>	+	[[https://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[https://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Pan, L F]]		[[Category: Pan, L F]]

OCA at 11:18, 10 December 2016

OCA — Sat, 10 Dec 2016 11:18:37 GMT

←Older revision		Revision as of 11:18, 10 December 2016
Line 1:		Line 1:
		+
	==Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans==		==Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans==
	<StructureSection load='3pvl' size='340' side='right' caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3pvl' size='340' side='right' caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PVL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Myo7a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), USH1G, SANS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Myo7a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), USH1G, SANS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [http://www.ebi.ac.uk/pdbsum/3pvl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [http://pdbe.org/3pvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [http://www.ebi.ac.uk/pdbsum/3pvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~Q5MJ57_MOUSE Q5MJ57_MOUSE~~]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[http://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>	+	[[http://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[http://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q5MJ57_MOUSE Q5MJ57_MOUSE~~]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>	+	[[http://www.uniprot.org/uniprot/MYO7A_MOUSE MYO7A_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pvl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Pan, L F]]		[[Category: Pan, L F]]
	[[Category: Wei, Z Y]]		[[Category: Wei, Z Y]]

OCA at 11:42, 9 December 2014

OCA — Tue, 09 Dec 2014 11:42:30 GMT

←Older revision		Revision as of 11:42, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3pvl.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans==
		+	<StructureSection load='3pvl' size='340' side='right' caption='[[3pvl]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PVL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Myo7a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), USH1G, SANS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pvl RCSB], [http://www.ebi.ac.uk/pdbsum/3pvl PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/Q5MJ57_MOUSE Q5MJ57_MOUSE]] Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.<ref>PMID:7870172</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Defects in USH1G are the cause of Usher syndrome type 1G (USH1G) [MIM:[http://omim.org/entry/606943 606943]]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref> <ref>PMID:20142502</ref> <ref>PMID:16283141</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q5MJ57_MOUSE Q5MJ57_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.<ref>PMID:21493626</ref> <ref>PMID:21709241</ref> [[http://www.uniprot.org/uniprot/USH1G_HUMAN USH1G_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:21709241</ref> <ref>PMID:12588794</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The unconventional myosin VIIa (MYO7A) is one of the five proteins that form a network of complexes involved in formation of stereocilia. Defects in these proteins cause syndromic deaf-blindness in humans [Usher syndrome I (USH1)]. Many disease-causing mutations occur in myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail that binds to another USH1 protein, Sans. We report the crystal structure of MYO7A MyTH4-FERM domains in complex with the central domain (CEN) of Sans at 2.8 angstrom resolution. The MyTH4 and FERM domains form an integral structural and functional supramodule binding to two highly conserved segments (CEN1 and 2) of Sans. The MyTH4-FERM/CEN complex structure provides mechanistic explanations for known deafness-causing mutations in MYO7A MyTH4-FERM. The structure will also facilitate mechanistic and functional studies of MyTH4-FERM domains in other myosins.

-	~~{{STRUCTURE_3pvl\| PDB=3pvl \| SCENE= }}~~	+	Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.,Wu L, Pan L, Wei Z, Zhang M Science. 2011 Feb 11;331(6018):757-60. PMID:21311020<ref>PMID:21311020</ref>

-	~~===Structure~~ of ~~myosin VIIa MyTH4-FERM-SH3 in complex with~~ the ~~CEN1 of Sans===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21311020}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pvl]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].~~	+

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021311020<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Pan, L F.]]	+	[[Category: Pan, L F]]
-	[[Category: Wei, Z Y.]]	+	[[Category: Wei, Z Y]]
-	[[Category: Wu, L.]]	+	[[Category: Wu, L]]
-	[[Category: Zhang, M J.]]	+	[[Category: Zhang, M J]]
	[[Category: Cargo protein]]		[[Category: Cargo protein]]
	[[Category: Motor protein-protein transport complex]]		[[Category: Motor protein-protein transport complex]]

OCA at 05:24, 20 October 2012

OCA — Sat, 20 Oct 2012 05:24:20 GMT

←Older revision		Revision as of 05:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pvl]] is a 2 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].	+	[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].

	==See Also==		==See Also==

OCA at 09:56, 25 July 2012

OCA — Wed, 25 Jul 2012 09:56:12 GMT

←Older revision		Revision as of 09:56, 25 July 2012
Line 1:		Line 1:
-	[[Image:3pvl.~~jpg~~\|left\|200px]]	+	[[Image:3pvl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pvl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pvl\| PDB=3pvl \| SCENE= }}		{{STRUCTURE_3pvl\| PDB=3pvl \| SCENE= }}

	===Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans===		===Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21311020}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21311020 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21311020}}		{{ABSTRACT_PUBMED_21311020}}

	==About this Structure==		==About this Structure==
-	[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].	+	[[3pvl]] is a 2 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].
		+
		+	==See Also==
		+	*[[Myosin\|Myosin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21311020~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021311020</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 29:		Line 21:
	[[Category: Wu, L.]]		[[Category: Wu, L.]]
	[[Category: Zhang, M J.]]		[[Category: Zhang, M J.]]
		+	[[Category: Cargo protein]]
		+	[[Category: Motor protein-protein transport complex]]
		+	[[Category: Novel folding]]
		+	[[Category: Protein cargo binding]]
		+	[[Category: Protein complex]]

OCA at 06:59, 2 March 2011

OCA — Wed, 02 Mar 2011 06:59:12 GMT

←Older revision		Revision as of 06:59, 2 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pvl.jpg\|left\|200px]]

-	The ~~entry 3pvl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pvl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pvl\| PDB=3pvl \| SCENE= }}

-	~~Authors: Wu, L., Pan, L.F., Wei, Z.Y., Zhang, M.J.~~	+	===Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans===

-	~~Description~~: ~~Structure of myosin VIIa MyTH4~~-~~FERM~~-~~SH3 in complex~~ with ~~the CEN1 of Sans~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21311020}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21311020 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21311020}}
		+
		+	==About this Structure==
		+	[[3pvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21311020</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Pan, L F.]]
		+	[[Category: Wei, Z Y.]]
		+	[[Category: Wu, L.]]
		+	[[Category: Zhang, M J.]]

OCA at 09:35, 23 February 2011

OCA — Wed, 23 Feb 2011 09:35:48 GMT

←Older revision		Revision as of 09:35, 23 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pvl is ON HOLD until ~~sometime in the future~~	+	The entry 3pvl is ON HOLD until Paper Publication

	Authors: Wu, L., Pan, L.F., Wei, Z.Y., Zhang, M.J.		Authors: Wu, L., Pan, L.F., Wei, Z.Y., Zhang, M.J.

	Description: Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans		Description: Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans

OCA: Protected "3pvl" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2011 05:18:20 GMT

Protected "3pvl" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 16 February 2011

OCA at 05:18, 16 February 2011

OCA — Wed, 16 Feb 2011 05:18:20 GMT

←Older revision		Revision as of 05:18, 16 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pvl is ON HOLD	+	The entry 3pvl is ON HOLD until sometime in the future

	Authors: Wu, L., Pan, L.F., Wei, Z.Y., Zhang, M.J.		Authors: Wu, L., Pan, L.F., Wei, Z.Y., Zhang, M.J.

	Description: Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans		Description: Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:37:38 2010''