3pyk - Revision history

OCA at 13:35, 1 March 2024

OCA — Fri, 01 Mar 2024 13:35:29 GMT

←Older revision		Revision as of 13:35, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3pyk' size='340' side='right'caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='3pyk' size='340' side='right'caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PYK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [https://pdbe.org/3pyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [https://www.ebi.ac.uk/pdbsum/3pyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [https://pdbe.org/3pyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [https://www.ebi.ac.uk/pdbsum/3pyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 A resolution X-ray crystal structure of [(eta(6)-C(6)Me(6))Ru(bispy 3)Cl](+) subset hCA II highlights the nature of the host-guest interactions.	+
-		+
-	Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.,Monnard FW, Heinisch T, Nogueira ES, Schirmer T, Ward TR Chem Commun (Camb). 2011 Aug 7;47(29):8238-40. Epub 2011 Jun 27. PMID:21706094<ref>PMID:21706094</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3pyk" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 29:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heinisch, T]]	+	[[Category: Heinisch T]]
-	[[Category: Schirmer, T]]	+	[[Category: Schirmer T]]
-	~~[[Category: 10 stranded]]~~	+
-	~~[[Category: Bicarbonate]]~~	+
-	~~[[Category: Carbonate dehydratase activity]]~~	+
-	~~[[Category: Co2]]~~	+
-	~~[[Category: Lyase activity]]~~	+
-	~~[[Category: Lyase-lyase inhibitor complex]]~~	+
-	~~[[Category: Metal ion binding]]~~	+
-	~~[[Category: Metal ion]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Sulfonamide]]~~	+
-	~~[[Category: Twisted beta-sheet]]~~	+
-	~~[[Category: Zinc ion binding~~]]	+

OCA at 09:02, 25 May 2022

OCA — Wed, 25 May 2022 09:02:07 GMT

←Older revision		Revision as of 09:02, 25 May 2022
Line 1:		Line 1:

	==Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor==		==Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor==
-	<StructureSection load='3pyk' size='340' side='right' caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='3pyk' size='340' side='right'caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PYK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [~~http~~://pdbe.org/3pyk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pyk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [https://pdbe.org/3pyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [https://www.ebi.ac.uk/pdbsum/3pyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 31:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Heinisch, T]]		[[Category: Heinisch, T]]
	[[Category: Schirmer, T]]		[[Category: Schirmer, T]]

OCA at 22:09, 4 August 2016

OCA — Thu, 04 Aug 2016 22:09:17 GMT

←Older revision		Revision as of 22:09, 4 August 2016
Line 1:		Line 1:
		+
	==Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor==		==Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor==
	<StructureSection load='3pyk' size='340' side='right' caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='3pyk' size='340' side='right' caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PYK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [http://www.ebi.ac.uk/pdbsum/3pyk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [http://pdbe.org/3pyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [http://www.ebi.ac.uk/pdbsum/3pyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pyk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Heinisch, T]]		[[Category: Heinisch, T]]
	[[Category: Schirmer, T]]		[[Category: Schirmer, T]]

OCA at 10:53, 19 December 2014

OCA — Fri, 19 Dec 2014 10:53:06 GMT

←Older revision		Revision as of 10:53, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}~~	+	==Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor==
-	===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===	+	<StructureSection load='3pyk' size='340' side='right' caption='[[3pyk]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	{~~{ABSTRACT_PUBMED_21706094}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PYK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRX:CHLORO{N-[DI(PYRIDIN-2-YL-KAPPAN)METHYL]-4-SULFAMOYLBENZAMIDE}[(1,2,3,4,5,6-ETA)-(1R,2R,3R,4S,5S,6S)-1,2,3,4,5,6-HEXAMETHYLCYCLOHEXANE-1,2,3,4,5,6-HEXAYL]RUTHENIUM(2+)'>SRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pyk RCSB], [http://www.ebi.ac.uk/pdbsum/3pyk PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 A resolution X-ray crystal structure of [(eta(6)-C(6)Me(6))Ru(bispy 3)Cl](+) subset hCA II highlights the nature of the host-guest interactions.

-	~~==Disease==~~	+	Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.,Monnard FW, Heinisch T, Nogueira ES, Schirmer T, Ward TR Chem Commun (Camb). 2011 Aug 7;47(29):8238-40. Epub 2011 Jun 27. PMID:21706094<ref>PMID:21706094</ref>
-	~~[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known~~ as ~~osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud~~-~~Vainsel syndrome or marble brain disease. Osteopetrosis is~~ a ~~rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone~~. ~~The disorder occurs in two forms: a severe autosomal recessive form occurring in utero~~, ~~infancy~~, ~~or childhood~~, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, ~~cerebral calcification~~ (~~marble brain disease~~) ~~and in some cases with mental retardation~~.~~<ref>PMID~~:~~1928091</ref><ref>~~PMID:~~1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref>~~<ref>PMID:~~15300855~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration~~ of ~~carbon dioxide~~. ~~Can hydrate cyanamide to urea~~. ~~Involved in the regulation~~ of ~~fluid secretion into the anterior chamber of the eye~~.<~~ref~~>~~PMID:10550681~~</~~ref~~>~~<ref>PMID:11831900</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021706094</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Heinisch, T.]]	+	[[Category: Heinisch, T]]
-	[[Category: Schirmer, T.]]	+	[[Category: Schirmer, T]]
	[[Category: 10 stranded]]		[[Category: 10 stranded]]
	[[Category: Bicarbonate]]		[[Category: Bicarbonate]]

OCA at 03:53, 25 March 2013

OCA — Mon, 25 Mar 2013 03:53:02 GMT

←Older revision		Revision as of 03:53, 25 March 2013
Line 1:		Line 1:
-	[[Image:3pyk.png\|left\|200px]]
-
	{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}		{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}
-
	===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===		===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===
		+	{{ABSTRACT_PUBMED_21706094}}

-	~~{{ABSTRACT_PUBMED_21706094}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref><ref>PMID:1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref><ref>PMID:15300855</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref><ref>PMID:11831900</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021706094</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021706094</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 17:17, 20 October 2012

OCA — Sat, 20 Oct 2012 17:17:04 GMT

←Older revision		Revision as of 17:17, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pyk]] is a 1 chain structure ~~of [[Carbonic anhydrase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].	+	[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].

	==See Also==		==See Also==

OCA at 00:24, 27 July 2012

OCA — Fri, 27 Jul 2012 00:24:42 GMT

←Older revision		Revision as of 00:24, 27 July 2012
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	[[Image:3pyk.png\|left\|200px]]		[[Image:3pyk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pyk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}		{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}

	===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===		===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21706094}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21706094 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21706094}}		{{ABSTRACT_PUBMED_21706094}}

	==About this Structure==		==About this Structure==
-	[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].	+	[[3pyk]] is a 1 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==

OCA at 04:58, 27 July 2011

OCA — Wed, 27 Jul 2011 04:58:42 GMT

←Older revision		Revision as of 04:58, 27 July 2011
Line 1:		Line 1:
-	[[Image:3pyk.~~jpg~~\|left\|200px]]	+	[[Image:3pyk.png\|left\|200px]]

	<!--		<!--

OCA at 07:38, 13 July 2011

OCA — Wed, 13 Jul 2011 07:38:35 GMT

←Older revision		Revision as of 07:38, 13 July 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pyk.jpg\|left\|200px]]

-	The ~~entry 3pyk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pyk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pyk\| PDB=3pyk \| SCENE= }}

-	~~Authors: Heinisch, T., Schirmer, T.~~	+	===Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor===

-	~~Description: Human Carbonic Anhydrase II~~ as ~~Host for Pianostool Complexes Bearing~~ a Sulfonamide ~~Anchor~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21706094}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21706094 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21706094}}
		+
		+	==About this Structure==
		+	[[3pyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021706094</ref><references group="xtra"/>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Heinisch, T.]]
		+	[[Category: Schirmer, T.]]
		+	[[Category: 10 stranded]]
		+	[[Category: Bicarbonate]]
		+	[[Category: Carbonate dehydratase activity]]
		+	[[Category: Co2]]
		+	[[Category: Lyase activity]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Metal ion binding]]
		+	[[Category: Metal ion]]
		+	[[Category: Protein binding]]
		+	[[Category: Sulfonamide]]
		+	[[Category: Twisted beta-sheet]]
		+	[[Category: Zinc ion binding]]

OCA at 05:35, 29 June 2011

OCA — Wed, 29 Jun 2011 05:35:43 GMT

←Older revision		Revision as of 05:35, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pyk is ON HOLD	+	The entry 3pyk is ON HOLD until Paper Publication

	Authors: Heinisch, T., Schirmer, T.		Authors: Heinisch, T., Schirmer, T.

	Description: Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor		Description: Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor