3pz2 - Revision history

OCA at 13:35, 1 March 2024

OCA — Fri, 01 Mar 2024 13:35:37 GMT

←Older revision		Revision as of 13:35, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3pz2' size='340' side='right'caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3pz2' size='340' side='right'caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [https://pdbe.org/3pz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [https://pdbe.org/3pz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[https://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.	+	[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

	==See Also==		==See Also==
Line 17:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Protein geranylgeranyltransferase type II~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Alexandrov, K]]	+	[[Category: Alexandrov K]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Bon~~, R S~~]]	+	[[Category: Bon RS]]
-	[[Category: Goody~~, R S~~]]	+	[[Category: Goody RS]]
-	[[Category: Guo, Z]]	+	[[Category: Guo Z]]
-	[[Category: Stigter~~, E A~~]]	+	[[Category: Stigter EA]]
-	[[Category: Waldmann, H]]	+	[[Category: Waldmann H]]
-	~~[[Category: Chimera protein]]~~	+
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Protein prenylation]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 09:02, 25 May 2022

OCA — Wed, 25 May 2022 09:02:23 GMT

←Older revision		Revision as of 09:02, 25 May 2022
Line 1:		Line 1:

	==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==		==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==
-	<StructureSection load='3pz2' size='340' side='right' caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3pz2' size='340' side='right'caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [~~http~~://pdbe.org/3pz2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [https://pdbe.org/3pz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[~~http~~://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.	+	[[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[https://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

	==See Also==		==See Also==
-	*[[Geranylgeranyl transferase\|Geranylgeranyl transferase]]	+	*[[Geranylgeranyl transferase 3D structures\|Geranylgeranyl transferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
	[[Category: Alexandrov, K]]		[[Category: Alexandrov, K]]

OCA at 07:51, 4 August 2016

OCA — Thu, 04 Aug 2016 07:51:01 GMT

←Older revision		Revision as of 07:51, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==		==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==
	<StructureSection load='3pz2' size='340' side='right' caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3pz2' size='340' side='right' caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10090 LK3 transgenic mice~~]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10090 LK3 transgenic mice~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [http://pdbe.org/3pz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Buffalo rat]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
	[[Category: Alexandrov, K]]		[[Category: Alexandrov, K]]

OCA at 07:13, 24 December 2014

OCA — Wed, 24 Dec 2014 07:13:37 GMT

←Older revision		Revision as of 07:13, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}~~	+	==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==
-	===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===	+	<StructureSection load='3pz2' size='340' side='right' caption='[[3pz2]], [[Resolution\|resolution]] 2.35Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz3\|3pz3]], [[3pz4\|3pz4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz2 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.		[[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3pz2~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA].	+	*[[Geranylgeranyl transferase\|Geranylgeranyl transferase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:021520375</ref><references group="xtra"/>~~<~~references~~/>	+
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
-	[[Category: Alexandrov, K.]]	+	[[Category: Alexandrov, K]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Bon, R S.]]	+	[[Category: Bon, R S]]
-	[[Category: Goody, R S.]]	+	[[Category: Goody, R S]]
-	[[Category: Guo, Z.]]	+	[[Category: Guo, Z]]
-	[[Category: Stigter, E A.]]	+	[[Category: Stigter, E A]]
-	[[Category: Waldmann, H.]]	+	[[Category: Waldmann, H]]
	[[Category: Chimera protein]]		[[Category: Chimera protein]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Protein prenylation]]		[[Category: Protein prenylation]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:16, 15 January 2014

OCA — Wed, 15 Jan 2014 07:16:57 GMT

←Older revision		Revision as of 07:16, 15 January 2014
Line 1:		Line 1:
	{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}		{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}
	===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===		===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===
-
-	==Disease==
-	[[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents.

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/~~PGTA_MOUSE PGTA_MOUSE~~]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively ~~(By similarity)~~.	+	[[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

	==About this Structure==		==About this Structure==
-	[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA].	+	[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
	[[Category: Alexandrov, K.]]		[[Category: Alexandrov, K.]]

OCA at 08:35, 8 May 2013

OCA — Wed, 08 May 2013 08:35:46 GMT

←Older revision		Revision as of 08:35, 8 May 2013
Line 1:		Line 1:
-	[[Image:3pz2.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pz2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}		{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}
		+	===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===

-	===~~Crystal structure~~ of ~~RabGGTase~~(~~DELTA LRR; DELTA IG~~) ~~in Complex with BMS3~~ and ~~lipid substrate GGPP===~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents.

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (By similarity).

	==About this Structure==		==About this Structure==
Line 16:		Line 12:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021520375</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
Line 26:		Line 22:
	[[Category: Stigter, E A.]]		[[Category: Stigter, E A.]]
	[[Category: Waldmann, H.]]		[[Category: Waldmann, H.]]
		+	[[Category: Chimera protein]]
		+	[[Category: Fusion protein]]
		+	[[Category: Protein prenylation]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 05:58, 25 May 2011

OCA — Wed, 25 May 2011 05:58:21 GMT

←Older revision		Revision as of 05:58, 25 May 2011
Line 1:		Line 1:
-	[[Image:3pz2.~~jpg~~\|left\|200px]]	+	[[Image:3pz2.png\|left\|200px]]

	<!--		<!--

OCA at 04:45, 12 May 2011

OCA — Thu, 12 May 2011 04:45:12 GMT

←Older revision		Revision as of 04:45, 12 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pz2.jpg\|left\|200px]]

-	The ~~entry 3pz2~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pz2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pz2\| PDB=3pz2 \| SCENE= }}

-	~~Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.~~	+	===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===

-	~~Description: Crystal~~ structure ~~of RabGGTase(DELTA LRR; DELTA IG) in Complex~~ with ~~BMS3 and lipid substrate GGPP~~	+
		+	==About this Structure==
		+	[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021520375</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Protein geranylgeranyltransferase type II]]
		+	[[Category: Alexandrov, K.]]
		+	[[Category: Blankenfeldt, W.]]
		+	[[Category: Bon, R S.]]
		+	[[Category: Goody, R S.]]
		+	[[Category: Guo, Z.]]
		+	[[Category: Stigter, E A.]]
		+	[[Category: Waldmann, H.]]

OCA at 05:47, 9 February 2011

OCA — Wed, 09 Feb 2011 05:47:00 GMT

←Older revision		Revision as of 05:47, 9 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pz2 is ON HOLD	+	The entry 3pz2 is ON HOLD until Paper Publication

	Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.		Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.

	Description: Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP		Description: Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

OCA: Protected "3pz2" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 18:16:09 GMT

Protected "3pz2" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:16, 29 December 2010