3pz4 - Revision history

OCA at 13:35, 1 March 2024

OCA — Fri, 01 Mar 2024 13:35:40 GMT

←Older revision		Revision as of 13:35, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3pz4' size='340' side='right'caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pz4' size='340' side='right'caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb, Ggtb, Rabggtb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[https://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	+	[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).

	==See Also==		==See Also==
Line 17:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Protein farnesyltransferase~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Alexandrov, K]]	+	[[Category: Alexandrov K]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Bon~~, R S~~]]	+	[[Category: Bon RS]]
-	[[Category: Goody~~, R S~~]]	+	[[Category: Goody RS]]
-	[[Category: Guo, Z]]	+	[[Category: Guo Z]]
-	[[Category: Stigter~~, E A~~]]	+	[[Category: Stigter EA]]
-	[[Category: Waldmann, H]]	+	[[Category: Waldmann H]]
-	~~[[Category: Protein prenylation]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 09:02, 25 May 2022

OCA — Wed, 25 May 2022 09:02:37 GMT

←Older revision		Revision as of 09:02, 25 May 2022
Line 1:		Line 1:

	==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==		==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==
-	<StructureSection load='3pz4' size='340' side='right' caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3pz4' size='340' side='right'caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb, Ggtb, Rabggtb ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb, Ggtb, Rabggtb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [~~http~~://pdbe.org/3pz4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[~~http~~://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	+	[[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[https://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

	==See Also==		==See Also==
-	*[[Farnesyltransferase\|Farnesyltransferase]]	+	*[[Farnesyltransferase 3D structures\|Farnesyltransferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
	[[Category: Alexandrov, K]]		[[Category: Alexandrov, K]]

OCA at 05:27, 5 August 2016

OCA — Fri, 05 Aug 2016 05:27:52 GMT

←Older revision		Revision as of 05:27, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==		==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==
	<StructureSection load='3pz4' size='340' side='right' caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pz4' size='340' side='right' caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10090 LK3 transgenic mice~~]), Fntb, Ggtb, Rabggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10090 LK3 transgenic mice~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb, Ggtb, Rabggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [http://pdbe.org/3pz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Buffalo rat]]
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
	[[Category: Alexandrov, K]]		[[Category: Alexandrov, K]]

OCA at 23:23, 24 December 2014

OCA — Wed, 24 Dec 2014 23:23:35 GMT

←Older revision		Revision as of 23:23, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}~~	+	==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==
-	===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===	+	<StructureSection load='3pz4' size='340' side='right' caption='[[3pz4]], [[Resolution\|resolution]] 2.10Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pz1\|3pz1]], [[3pz2\|3pz2]], [[3pz3\|3pz3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta, Ggta, Rabggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Fntb, Ggtb, Rabggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.		[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
-
-	==About this Structure==
-	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].

	==See Also==		==See Also==
	*[[Farnesyltransferase\|Farnesyltransferase]]		*[[Farnesyltransferase\|Farnesyltransferase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:021520375</ref><references group="xtra"/>~~<~~references~~/>	+
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
-	[[Category: Alexandrov, K.]]	+	[[Category: Alexandrov, K]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Bon, R S.]]	+	[[Category: Bon, R S]]
-	[[Category: Goody, R S.]]	+	[[Category: Goody, R S]]
-	[[Category: Guo, Z.]]	+	[[Category: Guo, Z]]
-	[[Category: Stigter, E A.]]	+	[[Category: Stigter, E A]]
-	[[Category: Waldmann, H.]]	+	[[Category: Waldmann, H]]
	[[Category: Protein prenylation]]		[[Category: Protein prenylation]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:53, 15 January 2014

OCA — Wed, 15 Jan 2014 06:53:35 GMT

←Older revision		Revision as of 06:53, 15 January 2014
Line 1:		Line 1:
-	[[Image:3pz4.png\|left\|200px]]
-
	{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}		{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}
-
	===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===		===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

	==About this Structure==		==About this Structure==
-	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].	+	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].

	==See Also==		==See Also==
Line 13:		Line 12:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021520375</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
	[[Category: Alexandrov, K.]]		[[Category: Alexandrov, K.]]

OCA at 10:09, 20 October 2012

OCA — Sat, 20 Oct 2012 10:09:56 GMT

←Older revision		Revision as of 10:09, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3pz4]] is a 2 chain structure ~~of [[Farnesyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].	+	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].

	==See Also==		==See Also==

OCA at 01:11, 26 July 2012

OCA — Thu, 26 Jul 2012 01:11:56 GMT

←Older revision		Revision as of 01:11, 26 July 2012
Line 1:		Line 1:
	[[Image:3pz4.png\|left\|200px]]		[[Image:3pz4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pz4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}		{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].	+	[[3pz4]] is a 2 chain structure of [[Farnesyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].
		+
		+	==See Also==
		+	*[[Farnesyltransferase\|Farnesyltransferase]]

	==Reference==		==Reference==
Line 26:		Line 23:
	[[Category: Stigter, E A.]]		[[Category: Stigter, E A.]]
	[[Category: Waldmann, H.]]		[[Category: Waldmann, H.]]
		+	[[Category: Protein prenylation]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 05:58, 25 May 2011

OCA — Wed, 25 May 2011 05:58:23 GMT

←Older revision		Revision as of 05:58, 25 May 2011
Line 1:		Line 1:
-	[[Image:3pz4.~~jpg~~\|left\|200px]]	+	[[Image:3pz4.png\|left\|200px]]

	<!--		<!--

OCA at 04:41, 12 May 2011

OCA — Thu, 12 May 2011 04:41:02 GMT

←Older revision		Revision as of 04:41, 12 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pz4.jpg\|left\|200px]]

-	The ~~entry 3pz4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pz4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pz4\| PDB=3pz4 \| SCENE= }}

-	~~Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.~~	+	===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===

-	~~Description: Crystal~~ structure ~~of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex~~ with ~~BMS3 and lipid substrate FPP~~	+
		+	==About this Structure==
		+	[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021520375</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Protein farnesyltransferase]]
		+	[[Category: Alexandrov, K.]]
		+	[[Category: Blankenfeldt, W.]]
		+	[[Category: Bon, R S.]]
		+	[[Category: Goody, R S.]]
		+	[[Category: Guo, Z.]]
		+	[[Category: Stigter, E A.]]
		+	[[Category: Waldmann, H.]]

OCA at 05:47, 9 February 2011

OCA — Wed, 09 Feb 2011 05:47:02 GMT

←Older revision		Revision as of 05:47, 9 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pz4 is ON HOLD	+	The entry 3pz4 is ON HOLD until Paper Publication

	Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.		Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.

	Description: Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP		Description: Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP