3q0o - Revision history

OCA at 10:45, 21 February 2024

OCA — Wed, 21 Feb 2024 10:45:02 GMT

←Older revision		Revision as of 10:45, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3q0o' size='340' side='right'caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3q0o' size='340' side='right'caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.804Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [https://pdbe.org/3q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [https://www.ebi.ac.uk/pdbsum/3q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [https://pdbe.org/3q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [https://www.ebi.ac.uk/pdbsum/3q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).	+	[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Human PUMILIO1 (PUM1) and PUMILIO2 (PUM2) are members of the PUMILIO/FBF (PUF) family that regulate specific target mRNAs posttranscriptionally. Recent studies have identified mRNA targets associated with human PUM1 and PUM2. Here, we explore the structural basis of natural target RNA recognition by human PUF proteins through crystal structures of the RNA-binding domains of PUM1 and PUM2 in complex with four cognate RNA sequences, including sequences from p38alpha and erk2 MAP kinase mRNAs. We observe three distinct modes of RNA binding around the fifth RNA base, two of which are different from the prototypical 1 repeat:1 RNA base binding mode previously identified with model RNA sequences. RNA-binding affinities of PUM1 and PUM2 are not affected dramatically by the different binding modes in vitro. However, these modes of binding create structurally variable recognition surfaces that suggest a mechanism in vivo for recruitment of downstream effector proteins defined by the PUF:RNA complex.	+
-		+
-	~~Alternate modes of cognate RNA recognition by human PUMILIO proteins.,Lu G, Hall TM Structure. 2011 Mar 9;19(3):361-7. PMID:21397187<ref>PMID:21397187</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3q0o" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hall~~, T M.T~~]]	+	[[Category: Hall TMT]]
-	[[Category: Lu, G]]	+	[[Category: Lu G]]
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Puf]]~~	+
-	~~[[Category: Pumilio-homolgy domain]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Rna binding protein-rna complex~~]]	+

OCA at 09:04, 25 May 2022

OCA — Wed, 25 May 2022 09:04:52 GMT

←Older revision		Revision as of 09:04, 25 May 2022
Line 1:		Line 1:

	==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE==		==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE==
-	<StructureSection load='3q0o' size='340' side='right' caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3q0o' size='340' side='right'caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [~~http~~://pdbe.org/3q0o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q0o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [https://pdbe.org/3q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [https://www.ebi.ac.uk/pdbsum/3q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).	+	[[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hall, T M.T]]		[[Category: Hall, T M.T]]
	[[Category: Lu, G]]		[[Category: Lu, G]]

OCA at 21:01, 4 August 2016

OCA — Thu, 04 Aug 2016 21:01:24 GMT

←Older revision		Revision as of 21:01, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE==		==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE==
	<StructureSection load='3q0o' size='340' side='right' caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3q0o' size='340' side='right' caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [http://www.ebi.ac.uk/pdbsum/3q0o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [http://pdbe.org/3q0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [http://www.ebi.ac.uk/pdbsum/3q0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3q0o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hall, T M.T]]		[[Category: Hall, T M.T]]
	[[Category: Lu, G]]		[[Category: Lu, G]]

OCA at 13:07, 25 December 2014

OCA — Thu, 25 Dec 2014 13:07:35 GMT

←Older revision		Revision as of 13:07, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [http://www.ebi.ac.uk/pdbsum/3q0o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [http://www.ebi.ac.uk/pdbsum/3q0o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:06, 19 December 2014

OCA — Fri, 19 Dec 2014 11:06:24 GMT

←Older revision		Revision as of 11:06, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}~~	+	==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE==
-	===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===	+	<StructureSection load='3q0o' size='340' side='right' caption='[[3q0o]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21397187}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0O FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q0l\|3q0l]], [[3q0m\|3q0m]], [[3q0n\|3q0n]], [[3q0p\|3q0p]], [[3q0q\|3q0q]], [[3q0r\|3q0r]], [[3q0s\|3q0s]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0o RCSB], [http://www.ebi.ac.uk/pdbsum/3q0o PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human PUMILIO1 (PUM1) and PUMILIO2 (PUM2) are members of the PUMILIO/FBF (PUF) family that regulate specific target mRNAs posttranscriptionally. Recent studies have identified mRNA targets associated with human PUM1 and PUM2. Here, we explore the structural basis of natural target RNA recognition by human PUF proteins through crystal structures of the RNA-binding domains of PUM1 and PUM2 in complex with four cognate RNA sequences, including sequences from p38alpha and erk2 MAP kinase mRNAs. We observe three distinct modes of RNA binding around the fifth RNA base, two of which are different from the prototypical 1 repeat:1 RNA base binding mode previously identified with model RNA sequences. RNA-binding affinities of PUM1 and PUM2 are not affected dramatically by the different binding modes in vitro. However, these modes of binding create structurally variable recognition surfaces that suggest a mechanism in vivo for recruitment of downstream effector proteins defined by the PUF:RNA complex.

-	~~==Function==~~	+	Alternate modes of cognate RNA recognition by human PUMILIO proteins.,Lu G, Hall TM Structure. 2011 Mar 9;19(3):361-7. PMID:21397187<ref>PMID:21397187</ref>
-	~~[[http://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific~~ RNA~~-binding protein that regulates translation and mRNA stability~~ by ~~binding the 3'-UTR of mRNA targets~~. ~~May be required to support proliferation and self-renewal of stem cells~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3q0o]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021397187</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hall, T M.T.]]	+	[[Category: Hall, T M.T]]
-	[[Category: Lu, G.]]	+	[[Category: Lu, G]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Puf]]		[[Category: Puf]]

OCA at 09:57, 19 June 2013

OCA — Wed, 19 Jun 2013 09:57:43 GMT

←Older revision		Revision as of 09:57, 19 June 2013
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	{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}		{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}
	===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===		===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===
-	{{~~ABSTRACT_PUBMED_021397187~~}}	+	{{ABSTRACT_PUBMED_21397187}}

	==Function==		==Function==
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA].		[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021397187</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hall, T M.T.]]		[[Category: Hall, T M.T.]]

OCA at 08:29, 8 May 2013

OCA — Wed, 08 May 2013 08:29:49 GMT

←Older revision		Revision as of 08:29, 8 May 2013
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-	[[Image:3q0o.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}		{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}
-
	===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===		===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===
		+	{{ABSTRACT_PUBMED_021397187}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).

	==About this Structure==		==About this Structure==
Line 17:		Line 11:
	[[Category: Hall, T M.T.]]		[[Category: Hall, T M.T.]]
	[[Category: Lu, G.]]		[[Category: Lu, G.]]
		+	[[Category: Gene regulation]]
		+	[[Category: Puf]]
		+	[[Category: Pumilio-homolgy domain]]
		+	[[Category: Rna binding]]
		+	[[Category: Rna binding protein-rna complex]]

OCA at 08:35, 16 March 2011

OCA — Wed, 16 Mar 2011 08:35:22 GMT

←Older revision		Revision as of 08:35, 16 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3q0o.jpg\|left\|200px]]

-	The ~~entry 3q0o~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3q0o", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3q0o\| PDB=3q0o \| SCENE= }}

-	~~Authors: Lu, G., Hall, T.M.T.~~	+	===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE===

-	~~Description: Crystal~~ structure ~~of the PUMILIO-homology domain from Human PUMILIO1 in complex~~ with ~~erk2 NRE~~	+
		+	==About this Structure==
		+	[[3q0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0O OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Hall, T M.T.]]
		+	[[Category: Lu, G.]]

OCA: Protected "3q0o" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 05:47:12 GMT

Protected "3q0o" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:47, 9 February 2011

OCA at 05:47, 9 February 2011

OCA — Wed, 09 Feb 2011 05:47:12 GMT

←Older revision		Revision as of 05:47, 9 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3q0o is ON HOLD	+	The entry 3q0o is ON HOLD until Paper Publication

	Authors: Lu, G., Hall, T.M.T.		Authors: Lu, G., Hall, T.M.T.

	Description: Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE		Description: Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with erk2 NRE
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:38:59 2010''