3q1t - Revision history

OCA at 11:30, 14 March 2024

OCA — Thu, 14 Mar 2024 11:30:18 GMT

←Older revision		Revision as of 11:30, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3q1t' size='340' side='right'caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3q1t' size='340' side='right'caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myca1 Myca1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium_104 Mycobacterium avium 104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MAV_3574 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=243243 MYCA1])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [https://pdbe.org/3q1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [https://www.ebi.ac.uk/pdbsum/3q1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [https://pdbe.org/3q1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [https://www.ebi.ac.uk/pdbsum/3q1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1t ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0A0H2ZRU2_MYCA1 A0A0H2ZRU2_MYCA1] Could possibly oxidize fatty acids using specific components.[ARBA:ARBA00002994]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/~~22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >~~/~~=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry~~. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.~~S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3q1t" style="background-color~~:~~#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]		*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Myca1]]~~	+	[[Category: Mycobacterium avium 104]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Acetyl coa]]~~	+
-	~~[[Category: Enoyl-coa]]~~	+
-	~~[[Category: Fatty acid metabolism]]~~	+
-	~~[[Category: Hydratase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	[[Category: Mycobacterium]]	+
-	~~[[Category: Non-pathogenic species]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Tuberculosis~~]]	+

OCA at 05:48, 8 June 2022

OCA — Wed, 08 Jun 2022 05:48:23 GMT

←Older revision		Revision as of 05:48, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of enoyl-coA hydratase from Mycobacterium avium==		==Crystal structure of enoyl-coA hydratase from Mycobacterium avium==
-	<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3q1t' size='340' side='right'caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [~~http~~://pdbe.org/3q1t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q1t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [https://pdbe.org/3q1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [https://www.ebi.ac.uk/pdbsum/3q1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1t ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 3q1t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3q1t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myca1]]		[[Category: Myca1]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:36, 1 February 2017

OCA — Wed, 01 Feb 2017 18:36:07 GMT

←Older revision		Revision as of 18:36, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of enoyl-coA hydratase from Mycobacterium avium==		==Crystal structure of enoyl-coA hydratase from Mycobacterium avium==
	<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [http://www.ebi.ac.uk/pdbsum/3q1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [http://pdbe.org/3q1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [http://www.ebi.ac.uk/pdbsum/3q1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q1t ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3q1t" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Enoyl-CoA hydratase\|Enoyl-~~CoA hydratase]]~~	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:33, 22 April 2015

OCA — Wed, 22 Apr 2015 06:33:44 GMT

←Older revision		Revision as of 06:33, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_avium Mycobacterium avium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1764 Mycobacterium avium~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [http://www.ebi.ac.uk/pdbsum/3q1t PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [http://www.ebi.ac.uk/pdbsum/3q1t PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]		*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium avium~~]]	+	[[Category: Myca1]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetyl coa]]		[[Category: Acetyl coa]]

OCA at 10:10, 19 December 2014

OCA — Fri, 19 Dec 2014 10:10:30 GMT

←Older revision		Revision as of 10:10, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3q1t\| PDB=3q1t \| SCENE= }}~~	+	==Crystal structure of enoyl-coA hydratase from Mycobacterium avium==
-	===Crystal structure of enoyl-coA hydratase from Mycobacterium avium===	+	<StructureSection load='3q1t' size='340' side='right' caption='[[3q1t]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1T FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_3574 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 Mycobacterium avium])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1t RCSB], [http://www.ebi.ac.uk/pdbsum/3q1t PDBsum]</span></td></tr>
		+	</table>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3q1t~~]] ~~is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA].~~	+	*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Acetyl coa]]		[[Category: Acetyl coa]]
	[[Category: Enoyl-coa]]		[[Category: Enoyl-coa]]
Line 13:		Line 20:
	[[Category: Mycobacterium]]		[[Category: Mycobacterium]]
	[[Category: Non-pathogenic species]]		[[Category: Non-pathogenic species]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]

OCA at 08:08, 8 May 2013

OCA — Wed, 08 May 2013 08:08:36 GMT

←Older revision		Revision as of 08:08, 8 May 2013
Line 1:		Line 1:
-	[[Image:3q1t.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3q1t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3q1t\| PDB=3q1t \| SCENE= }}		{{STRUCTURE_3q1t\| PDB=3q1t \| SCENE= }}
-
	===Crystal structure of enoyl-coA hydratase from Mycobacterium avium===		===Crystal structure of enoyl-coA hydratase from Mycobacterium avium===
-

	==About this Structure==		==About this Structure==
Line 16:		Line 6:
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Acetyl coa]]
		+	[[Category: Enoyl-coa]]
		+	[[Category: Fatty acid metabolism]]
		+	[[Category: Hydratase]]
		+	[[Category: Lyase]]
		+	[[Category: Mycobacterium]]
		+	[[Category: Non-pathogenic species]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tuberculosis]]

OCA at 06:29, 19 January 2011

OCA — Wed, 19 Jan 2011 06:29:51 GMT

←Older revision		Revision as of 06:29, 19 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3q1t.jpg\|left\|200px]]

-	The ~~entry 3q1t~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3q1t", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3q1t\| PDB=3q1t \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of enoyl-coA hydratase from Mycobacterium avium===

-	~~Description: Crystal~~ structure ~~of enoyl-coA hydratase~~ from Mycobacterium avium	+
		+	==About this Structure==
		+	[[3q1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1T OCA].
		+	[[Category: Mycobacterium avium]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3q1t" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 18:17:01 GMT

Protected "3q1t" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:17, 29 December 2010

OCA: New page: '''Unreleased structure''' The entry 3q1t is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of enoyl-coA hydratase f...

OCA — Wed, 29 Dec 2010 18:17:00 GMT

New page: '''Unreleased structure''' The entry 3q1t is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of enoyl-coA hydratase f...

New page

'''Unreleased structure'''

The entry 3q1t is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of enoyl-coA hydratase from Mycobacterium avium