3q2z - Revision history

OCA at 17:09, 1 November 2023

OCA — Wed, 01 Nov 2023 17:09:50 GMT

←Older revision		Revision as of 17:09, 1 November 2023
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	<StructureSection load='3q2z' size='340' side='right'caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3q2z' size='340' side='right'caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q30\|3q30]], [[3asx\|3asx]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [https://pdbe.org/3q2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [https://www.ebi.ac.uk/pdbsum/3q2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [https://pdbe.org/3q2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [https://www.ebi.ac.uk/pdbsum/3q2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Squalene synthase]]~~	+	[[Category: Higashihashi N]]
-	[[Category: Higashihashi, N]]	+	[[Category: Ichikawa M]]
-	[[Category: Ichikawa, M]]	+	[[Category: Itoh M]]
-	[[Category: Itoh, M]]	+	[[Category: Katakura S]]
-	[[Category: Katakura, S]]	+	[[Category: Shimizu H]]
-	[[Category: Shimizu, H]]	+	[[Category: Sugita K]]
-	[[Category: Sugita, K]]	+	[[Category: Suzuki M]]
-	[[Category: Suzuki, M]]	+	[[Category: Usui H]]
-	[[Category: Usui, H]]	+	[[Category: Yamazaki K]]
-	[[Category: Yamazaki, K]]	+	[[Category: Yokomizo A]]
-	[[Category: Yokomizo, A]]	+
-	~~[[Category: Isoprene biosynthesis]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Steroid biosynthesis]]~~	+
-	~~[[Category: Sterol biosynthesis]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 05:49, 8 June 2022

OCA — Wed, 08 Jun 2022 05:49:39 GMT

←Older revision		Revision as of 05:49, 8 June 2022
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	==Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid==		==Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid==
-	<StructureSection load='3q2z' size='340' side='right' caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3q2z' size='340' side='right'caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q30\|3q30]], [[3asx\|3asx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [~~http~~://pdbe.org/3q2z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q2z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [https://pdbe.org/3q2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [https://www.ebi.ac.uk/pdbsum/3q2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 3q2z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3q2z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Higashihashi, N]]		[[Category: Higashihashi, N]]

OCA at 09:09, 8 November 2017

OCA — Wed, 08 Nov 2017 09:09:51 GMT

←Older revision		Revision as of 09:09, 8 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3q2z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3q2z" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:12, 4 August 2016

OCA — Thu, 04 Aug 2016 21:12:28 GMT

←Older revision		Revision as of 21:12, 4 August 2016
Line 1:		Line 1:
		+
	==Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid==		==Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid==
	<StructureSection load='3q2z' size='340' side='right' caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3q2z' size='340' side='right' caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [http://www.ebi.ac.uk/pdbsum/3q2z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [http://pdbe.org/3q2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [http://www.ebi.ac.uk/pdbsum/3q2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3q2z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Higashihashi, N]]		[[Category: Higashihashi, N]]

OCA at 21:08, 3 January 2015

OCA — Sat, 03 Jan 2015 21:08:18 GMT

←Older revision		Revision as of 21:08, 3 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3q2z\| PDB=3q2z \| SCENE= }}~~	+	==Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid==
-	===Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid===	+	<StructureSection load='3q2z' size='340' side='right' caption='[[3q2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	{~~{ABSTRACT_PUBMED_21353782}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3q2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q2Z FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9A:N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC+ACID'>D9A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q2z RCSB], [http://www.ebi.ac.uk/pdbsum/3q2z PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

-	~~==About this Structure==~~	+	Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.,Ichikawa M, Yokomizo A, Itoh M, Sugita K, Usui H, Shimizu H, Suzuki M, Terayama K, Kanda A Bioorg Med Chem. 2011 Mar 15;19(6):1930-49. Epub 2011 Feb 3. PMID:21353782<ref>PMID:21353782</ref>
-	~~[[3q2z]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~3Q2Z OCA~~].	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Squalene synthase\|Squalene synthase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
-	[[Category: Higashihashi, N.]]	+	[[Category: Higashihashi, N]]
-	[[Category: Ichikawa, M.]]	+	[[Category: Ichikawa, M]]
-	[[Category: Itoh, M.]]	+	[[Category: Itoh, M]]
-	[[Category: Katakura, S.]]	+	[[Category: Katakura, S]]
-	[[Category: Shimizu, H.]]	+	[[Category: Shimizu, H]]
-	[[Category: Sugita, K.]]	+	[[Category: Sugita, K]]
-	[[Category: Suzuki, M.]]	+	[[Category: Suzuki, M]]
-	[[Category: Usui, H.]]	+	[[Category: Usui, H]]
-	[[Category: Yamazaki, K.]]	+	[[Category: Yamazaki, K]]
-	[[Category: Yokomizo, A.]]	+	[[Category: Yokomizo, A]]
	[[Category: Isoprene biosynthesis]]		[[Category: Isoprene biosynthesis]]
	[[Category: Lipid synthesis]]		[[Category: Lipid synthesis]]

OCA at 08:08, 8 May 2013

OCA — Wed, 08 May 2013 08:08:02 GMT

←Older revision		Revision as of 08:08, 8 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3q2z\| PDB=3q2z \| SCENE= }}
		+	===Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid===
		+	{{ABSTRACT_PUBMED_21353782}}

-	~~The entry~~ 3q2z is ~~ON HOLD until Dec 21 2012~~	+	==About this Structure==
-		+	[[3q2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2Z OCA].
-	~~Authors~~: ~~Suzuki, M~~.~~, Shimizu, H~~.~~, Katakura, S~~.~~, Yamazaki, K~~., Higashihashi, N., Ichikawa, M.~~, Yokomizo, A.,~~ Itoh, M., Sugita, K., Usui, H.	+	[[Category: Homo sapiens]]
-		+	[[Category: Squalene synthase]]
-	~~Description~~: ~~Human Squalene synthase in complex with N-~~[~~(3R~~,~~5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl~~]-~~L-aspartic acid~~	+	[[Category: Higashihashi, N.]]
		+	[[Category: Ichikawa, M.]]
		+	[[Category: Itoh, M.]]
		+	[[Category: Katakura, S.]]
		+	[[Category: Shimizu, H.]]
		+	[[Category: Sugita, K.]]
		+	[[Category: Suzuki, M.]]
		+	[[Category: Usui, H.]]
		+	[[Category: Yamazaki, K.]]
		+	[[Category: Yokomizo, A.]]
		+	[[Category: Isoprene biosynthesis]]
		+	[[Category: Lipid synthesis]]
		+	[[Category: Multifunctional enzyme]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Steroid biosynthesis]]
		+	[[Category: Sterol biosynthesis]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 08:34, 6 April 2011

OCA — Wed, 06 Apr 2011 08:34:19 GMT

←Older revision		Revision as of 08:34, 6 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3q2z is ON HOLD	+	The entry 3q2z is ON HOLD until Dec 21 2012

	Authors: Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.		Authors: Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.

	Description: Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid		Description: Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid

OCA: Protected "3q2z" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 18:17:49 GMT

Protected "3q2z" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:17, 29 December 2010

OCA: New page: '''Unreleased structure''' The entry 3q2z is ON HOLD Authors: Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Us...

OCA — Wed, 29 Dec 2010 18:17:48 GMT

New page: '''Unreleased structure''' The entry 3q2z is ON HOLD Authors: Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Us...

New page

'''Unreleased structure'''

The entry 3q2z is ON HOLD

Authors: Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.

Description: Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid