3q6k - Revision history

OCA at 05:53, 8 June 2022

OCA — Wed, 08 Jun 2022 05:53:47 GMT

←Older revision		Revision as of 05:53, 8 June 2022
Line 3:		Line 3:
	<StructureSection load='3q6k' size='340' side='right'caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='3q6k' size='340' side='right'caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lutlo Lutlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lutlo Lutlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q6p\|3q6p]], [[3q6t\|3q6t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q6p\|3q6p]], [[3q6t\|3q6t]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LJM-11, LJM11_Clu9 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7200 LUTLO])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LJM-11, LJM11_Clu9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7200 LUTLO])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [~~http~~://pdbe.org/3q6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [https://pdbe.org/3q6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [https://www.ebi.ac.uk/pdbsum/3q6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:18, 23 October 2019

OCA — Wed, 23 Oct 2019 07:18:24 GMT

←Older revision		Revision as of 07:18, 23 October 2019
Line 1:		Line 1:

	==Salivary protein from Lutzomyia longipalpis==		==Salivary protein from Lutzomyia longipalpis==
-	<StructureSection load='3q6k' size='340' side='right' caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>	+	<StructureSection load='3q6k' size='340' side='right'caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutlo Lutlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>		<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutlo Lutlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [http://pdbe.org/3q6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [http://www.ebi.ac.uk/pdbsum/3q6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [http://pdbe.org/3q6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [http://www.ebi.ac.uk/pdbsum/3q6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6k ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	LJM11, an abundant salivary protein from the sand fly Lutzomyia longipalpis, belongs to the insect "yellow" family of proteins. In this study, we immunized mice with 17 plasmids encoding L. longiplapis salivary proteins and demonstrated that LJM11 confers protective immunity against Leishmania major infection. This protection correlates with a strong induction of a delayed type hypersensitivity (DTH) response following exposure to L. longipalpis saliva. Additionally, splenocytes of exposed mice produce IFN-gamma upon stimulation with LJM11, demonstrating the systemic induction of Th1 immunity by this protein. In contrast to LJM11, LJM111, another yellow protein from L. longipalpis saliva, does not produce a DTH response in these mice, suggesting that structural or functional features specific to LJM11 are important for the induction of a robust DTH response. To examine these features, we used calorimetric analysis to probe a possible ligand binding function for the salivary yellow proteins. LJM11, LJM111, and LJM17 all acted as high affinity binders of prohemostatic and proinflammatory biogenic amines, particularly serotonin, catecholamines, and histamine. We also determined the crystal structure of LJM11, revealing a six-bladed beta-propeller fold with a single ligand binding pocket located in the central part of the propeller structure on one face of the molecule. A hypothetical model of LJM11 suggests a positive electrostatic potential on the face containing entry to the ligand binding pocket, whereas LJM111 is negative to neutral over its entire surface. This may be the reason for differences in antigenicity between the two proteins.
		+
		+	Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.,Xu X, Oliveira F, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, My Pham V, Elnaiem DE, Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JF J Biol Chem. 2011 Sep 16;286(37):32383-93. Epub 2011 Jul 27. PMID:21795673<ref>PMID:21795673</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3q6k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lutlo]]		[[Category: Lutlo]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]

OCA at 13:26, 5 August 2016

OCA — Fri, 05 Aug 2016 13:26:49 GMT

←Older revision		Revision as of 13:26, 5 August 2016
Line 1:		Line 1:
		+
	==Salivary protein from Lutzomyia longipalpis==		==Salivary protein from Lutzomyia longipalpis==
	<StructureSection load='3q6k' size='340' side='right' caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='3q6k' size='340' side='right' caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lutzomyia_longipalpis Lutzomyia longipalpis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutlo Lutlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q6p\|3q6p]], [[3q6t\|3q6t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q6p\|3q6p]], [[3q6t\|3q6t]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LJM-11, LJM11_Clu9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7200 ~~Lutzomyia longipalpis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LJM-11, LJM11_Clu9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7200 LUTLO])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [http://www.ebi.ac.uk/pdbsum/3q6k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [http://pdbe.org/3q6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [http://www.ebi.ac.uk/pdbsum/3q6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6k ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lutzomyia longipalpis~~]]	+	[[Category: Lutlo]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Chang, B W]]		[[Category: Chang, B W]]

OCA at 21:33, 3 January 2015

OCA — Sat, 03 Jan 2015 21:33:50 GMT

←Older revision		Revision as of 21:33, 3 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3q6k\| PDB=3q6k \| SCENE= }}~~	+	==Salivary protein from Lutzomyia longipalpis==
-	===Salivary protein from Lutzomyia longipalpis===	+	<StructureSection load='3q6k' size='340' side='right' caption='[[3q6k]], [[Resolution\|resolution]] 2.52Å' scene=''>
-	~~{{ABSTRACT_PUBMED_021795673}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutzomyia_longipalpis Lutzomyia longipalpis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6K FirstGlance]. <br>
-	==~~About this Structure~~==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
-	[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutzomyia_longipalpis Lutzomyia longipalpis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA].	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q6p\|3q6p]], [[3q6t\|3q6t]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LJM-11, LJM11_Clu9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7200 Lutzomyia longipalpis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q6k RCSB], [http://www.ebi.ac.uk/pdbsum/3q6k PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lutzomyia longipalpis]]		[[Category: Lutzomyia longipalpis]]
-	[[Category: Andersen, J F.]]	+	[[Category: Andersen, J F]]
-	[[Category: Chang, B W.]]	+	[[Category: Chang, B W]]
-	[[Category: Collin, N.]]	+	[[Category: Collin, N]]
-	[[Category: Ribeiro, J M.]]	+	[[Category: Ribeiro, J M]]
-	[[Category: Valenzuela, J G.]]	+	[[Category: Valenzuela, J G]]
-	[[Category: Xu, X.]]	+	[[Category: Xu, X]]
	[[Category: Beta propeller]]		[[Category: Beta propeller]]
	[[Category: Binding protein]]		[[Category: Binding protein]]

OCA at 08:28, 8 May 2013

OCA — Wed, 08 May 2013 08:28:44 GMT

←Older revision		Revision as of 08:28, 8 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3q6k\| PDB=3q6k \| SCENE= }}
		+	===Salivary protein from Lutzomyia longipalpis===
		+	{{ABSTRACT_PUBMED_021795673}}

-	~~The entry~~ 3q6k is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[3q6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lutzomyia_longipalpis Lutzomyia longipalpis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6K OCA].
-	~~Authors~~: Andersen, J.F.~~, Xu, X.,~~ Chang, B.W., Collin, N., Valenzuela, J.G., ~~Ribeiro, J.M~~.	+	[[Category: Lutzomyia longipalpis]]
-		+	[[Category: Andersen, J F.]]
-	~~Description~~: ~~Salivary~~ protein ~~from Lutzomyia longipalpis~~	+	[[Category: Chang, B W.]]
		+	[[Category: Collin, N.]]
		+	[[Category: Ribeiro, J M.]]
		+	[[Category: Valenzuela, J G.]]
		+	[[Category: Xu, X.]]
		+	[[Category: Beta propeller]]
		+	[[Category: Binding protein]]
		+	[[Category: Ligand binging protein]]
		+	[[Category: Protein binding]]
		+	[[Category: Salivary gland]]
		+	[[Category: Serotonin]]

OCA at 10:16, 21 April 2011

OCA — Thu, 21 Apr 2011 10:16:08 GMT

←Older revision		Revision as of 10:16, 21 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3q6k is ON HOLD	+	The entry 3q6k is ON HOLD until Paper Publication

	Authors: Andersen, J.F., Xu, X., Chang, B.W., Collin, N., Valenzuela, J.G., Ribeiro, J.M.		Authors: Andersen, J.F., Xu, X., Chang, B.W., Collin, N., Valenzuela, J.G., Ribeiro, J.M.

	Description: Salivary protein from Lutzomyia longipalpis		Description: Salivary protein from Lutzomyia longipalpis

OCA: Protected "3q6k" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 04:51:04 GMT

Protected "3q6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 12 January 2011

OCA: New page: '''Unreleased structure''' The entry 3q6k is ON HOLD Authors: Andersen, J.F., Xu, X., Chang, B.W., Collin, N., Valenzuela, J.G., Ribeiro, J.M. Description: Salivary protein from Lutzom...

OCA — Wed, 12 Jan 2011 04:51:03 GMT

New page: '''Unreleased structure''' The entry 3q6k is ON HOLD Authors: Andersen, J.F., Xu, X., Chang, B.W., Collin, N., Valenzuela, J.G., Ribeiro, J.M. Description: Salivary protein from Lutzom...

New page

'''Unreleased structure'''

The entry 3q6k is ON HOLD

Authors: Andersen, J.F., Xu, X., Chang, B.W., Collin, N., Valenzuela, J.G., Ribeiro, J.M.

Description: Salivary protein from Lutzomyia longipalpis