3q8n - Revision history

OCA at 11:37, 14 March 2024

OCA — Thu, 14 Mar 2024 11:37:22 GMT

←Older revision		Revision as of 11:37, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3q8n' size='340' side='right'caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3q8n' size='340' side='right'caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SSN:4~~-~~OXOBUTANOIC+ACID'>SSN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>gabT, MSMEG_0581 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=246196 MYCS2])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/~~4-~~aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [https://pdbe.org/3q8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [https://www.ebi.ac.uk/pdbsum/3q8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [https://pdbe.org/3q8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [https://www.ebi.ac.uk/pdbsum/3q8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8n ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0QQ04_MYCS2 A0QQ04_MYCS2]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3q8n" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-aminobutyrate--2-oxoglutarate transaminase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2]]~~	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:57, 8 June 2022

OCA — Wed, 08 Jun 2022 05:57:40 GMT

←Older revision		Revision as of 05:57, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis==		==Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis==
-	<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='3q8n' size='340' side='right'caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [~~http~~://pdbe.org/3q8n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q8n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [https://pdbe.org/3q8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [https://www.ebi.ac.uk/pdbsum/3q8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: 4-aminobutyrate--2-oxoglutarate transaminase]]		[[Category: 4-aminobutyrate--2-oxoglutarate transaminase]]
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 18:41, 1 February 2017

OCA — Wed, 01 Feb 2017 18:41:07 GMT

←Older revision		Revision as of 18:41, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis==		==Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis==
	<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [http://www.ebi.ac.uk/pdbsum/3q8n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [http://pdbe.org/3q8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [http://www.ebi.ac.uk/pdbsum/3q8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3q8n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:46, 22 April 2015

OCA — Wed, 22 Apr 2015 06:46:57 GMT

←Older revision		Revision as of 06:46, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis Mycobacterium smegmatis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1772 Mycobacterium smegmatis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-~~aminobutyrate_transaminase~~ 4-aminobutyrate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-aminobutyrate--2-oxoglutarate_transaminase 4-aminobutyrate--2-oxoglutarate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [http://www.ebi.ac.uk/pdbsum/3q8n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [http://www.ebi.ac.uk/pdbsum/3q8n PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-aminobutyrate transaminase]]	+	[[Category: 4-aminobutyrate--2-oxoglutarate transaminase]]
-	[[Category: ~~Mycobacterium smegmatis~~]]	+	[[Category: Mycs2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:18, 19 December 2014

OCA — Fri, 19 Dec 2014 10:18:37 GMT

←Older revision		Revision as of 10:18, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3q8n\| PDB=3q8n \| SCENE= }}~~	+	==Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis==
-	===Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis===	+	<StructureSection load='3q8n' size='340' side='right' caption='[[3q8n]], [[Resolution\|resolution]] 2.05Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3q8n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q8N FirstGlance]. <br>
-	[[3q8n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gabT, MSMEG_0581 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1772 Mycobacterium smegmatis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-aminobutyrate_transaminase 4-aminobutyrate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q8n RCSB], [http://www.ebi.ac.uk/pdbsum/3q8n PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: 4-aminobutyrate transaminase]]		[[Category: 4-aminobutyrate transaminase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
-	[[Category: Seattle structural genomics center for infectious disease]]
-	[[Category: Ssgcid]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Ssgcid]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:16, 8 May 2013

OCA — Wed, 08 May 2013 08:16:22 GMT

←Older revision		Revision as of 08:16, 8 May 2013
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-	[[Image:3q8n.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3q8n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3q8n\| PDB=3q8n \| SCENE= }}		{{STRUCTURE_3q8n\| PDB=3q8n \| SCENE= }}
-
	===Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis===		===Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis===
-

	==About this Structure==		==About this Structure==
Line 17:		Line 7:
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]

OCA at 06:14, 9 February 2011

OCA — Wed, 09 Feb 2011 06:14:51 GMT

←Older revision		Revision as of 06:14, 9 February 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3q8n.jpg\|left\|200px]]

-	The ~~entry 3q8n~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3q8n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3q8n\| PDB=3q8n \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis===

-	~~Description: Crystal~~ structure of 4-aminobutyrate transaminase ~~from~~ Mycobacterium smegmatis	+
		+	==About this Structure==
		+	[[3q8n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8N OCA].
		+	[[Category: 4-aminobutyrate transaminase]]
		+	[[Category: Mycobacterium smegmatis]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3q8n" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 04:52:31 GMT

Protected "3q8n" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 12 January 2011

OCA: New page: '''Unreleased structure''' The entry 3q8n is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of 4-aminobutyrate trans...

OCA — Wed, 12 Jan 2011 04:52:31 GMT

New page: '''Unreleased structure''' The entry 3q8n is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of 4-aminobutyrate trans...

New page

'''Unreleased structure'''

The entry 3q8n is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis