3q93 - Revision history

OCA at 11:37, 14 March 2024

OCA — Thu, 14 Mar 2024 11:37:40 GMT

←Older revision		Revision as of 11:37, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3q93' size='340' side='right'caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3q93' size='340' side='right'caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [https://pdbe.org/3q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [https://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [https://pdbe.org/3q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [https://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>	+	[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Arrowsmith CH]]
-	~~[[Category: Berg, S Van Der~~]]	+	[[Category: Berglund H]]
-	[[Category: Berglund, H]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Collins R]]
-	[[Category: Collins, R]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Ekblad T]]
-	[[Category: Ekblad, T]]	+	[[Category: Flodin S]]
-	[[Category: Flodin, S]]	+	[[Category: Flores A]]
-	[[Category: Flores, A]]	+	[[Category: Graslund S]]
-	[[Category: Graslund, S]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Johansson I]]
-	[[Category: Johansson, I]]	+	[[Category: Karlberg T]]
-	[[Category: Karlberg, T]]	+	[[Category: Kol S]]
-	[[Category: Kol, S]]	+	[[Category: Kotenyova T]]
-	[[Category: Kotenyova, T]]	+	[[Category: Kouznetsova E]]
-	[[Category: Kouznetsova, E]]	+	[[Category: Moche M]]
-	[[Category: Moche, M]]	+	[[Category: Nordlund P]]
-	[[Category: Nordlund, P]]	+	[[Category: Nyman T]]
-	[[Category: Nyman, T]]	+	[[Category: Persson C]]
-	[[Category: Persson, C]]	+	[[Category: Schuler H]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Schutz P]]
-	[[Category: Schuler, H]]	+	[[Category: Siponen MI]]
-	[[Category: Schutz, P]]	+	[[Category: Thorsell AG]]
-	[[Category: Siponen~~, M I~~]]	+	[[Category: Tresaugues L]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Van Der Berg S]]
-	[[Category: Tresaugues, L]]	+	[[Category: Wahlberg E]]
-	[[Category: ~~Wahlberg, E~~]]	+	[[Category: Weigelt J]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Welin M]]
-	[[Category: ~~Welin, M~~]]	+
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Magnesium binding]]~~	+
-	~~[[Category: Mutt-like]]~~	+
-	~~[[Category: Nudix]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 05:58, 8 June 2022

OCA — Wed, 08 Jun 2022 05:58:19 GMT

←Older revision		Revision as of 05:58, 8 June 2022
Line 1:		Line 1:

	==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==		==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==
-	<StructureSection load='3q93' size='340' side='right' caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3q93' size='340' side='right'caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [~~http~~://pdbe.org/3q93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [https://pdbe.org/3q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [https://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>	+	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

	==See Also==		==See Also==
-	*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]	+	*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures\|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Der]]		[[Category: Berg, S Van Der]]

OCA at 02:37, 5 August 2016

OCA — Fri, 05 Aug 2016 02:37:20 GMT

←Older revision		Revision as of 02:37, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==		==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==
	<StructureSection load='3q93' size='340' side='right' caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3q93' size='340' side='right' caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://pdbe.org/3q93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Der]]		[[Category: Berg, S Van Der]]

OCA at 22:05, 24 December 2014

OCA — Wed, 24 Dec 2014 22:05:01 GMT

←Older revision		Revision as of 22:05, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

	==See Also==		==See Also==
	*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]		*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:11, 19 December 2014

OCA — Fri, 19 Dec 2014 10:11:48 GMT

←Older revision		Revision as of 10:11, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3q93\| PDB=3q93 \| SCENE= }}~~	+	==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==
-	===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===	+	<StructureSection load='3q93' size='340' side='right' caption='[[3q93]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr>
		+	</table>

-	==~~Function~~==	+	==See Also==
-	[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-~~oxo~~-~~dGTP,~~ 8-~~oxo~~-~~dATP and 2~~-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-~~oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>~~	+	*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[3q93~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].	+
-		+
-	~~==Reference==~~	+
-	~~<references group="xtra"/>~~<~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S Van Der.]]	+	[[Category: Berg, S Van Der]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Ekblad, T.]]	+	[[Category: Ekblad, T]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kol, S.]]	+	[[Category: Kol, S]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Kouznetsova, E.]]	+	[[Category: Kouznetsova, E]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Schuler, H.]]	+	[[Category: Schuler, H]]
-	[[Category: Schutz, P.]]	+	[[Category: Schutz, P]]
-	[[Category: Siponen, M I.]]	+	[[Category: Siponen, M I]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Wahlberg, E.]]	+	[[Category: Wahlberg, E]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Magnesium binding]]		[[Category: Magnesium binding]]
Line 45:		Line 47:
	[[Category: Nudix]]		[[Category: Nudix]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 08:10, 8 May 2013

OCA — Wed, 08 May 2013 08:10:02 GMT

←Older revision		Revision as of 08:10, 8 May 2013
Line 1:		Line 1:
-	[[Image:3q93.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3q93", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3q93\| PDB=3q93 \| SCENE= }}		{{STRUCTURE_3q93\| PDB=3q93 \| SCENE= }}
-
	===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===		===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

	==About this Structure==		==About this Structure==
	[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].		[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 44:		Line 40:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Welin, M.]]		[[Category: Welin, M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Magnesium binding]]
		+	[[Category: Mutt-like]]
		+	[[Category: Nudix]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]

OCA at 07:08, 2 March 2011

OCA — Wed, 02 Mar 2011 07:08:05 GMT

←Older revision		Revision as of 07:08, 2 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3q93.jpg\|left\|200px]]

-	The ~~entry 3q93~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3q93", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3q93\| PDB=3q93 \| SCENE= }}

-	Authors: Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (~~SGC~~)	+	===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===

-	~~Description: Crystal~~ Structure ~~of Human 8~~-~~oxo-dGTPase (MTH1)~~	+
		+	==About this Structure==
		+	[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Berg, S Van Der.]]
		+	[[Category: Berglund, H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Collins, R.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Ekblad, T.]]
		+	[[Category: Flodin, S.]]
		+	[[Category: Flores, A.]]
		+	[[Category: Graslund, S.]]
		+	[[Category: Hammarstrom, M.]]
		+	[[Category: Johansson, I.]]
		+	[[Category: Karlberg, T.]]
		+	[[Category: Kol, S.]]
		+	[[Category: Kotenyova, T.]]
		+	[[Category: Kouznetsova, E.]]
		+	[[Category: Moche, M.]]
		+	[[Category: Nordlund, P.]]
		+	[[Category: Nyman, T.]]
		+	[[Category: Persson, C.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Schuler, H.]]
		+	[[Category: Schutz, P.]]
		+	[[Category: Siponen, M I.]]
		+	[[Category: Thorsell, A G.]]
		+	[[Category: Tresaugues, L.]]
		+	[[Category: Wahlberg, E.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Welin, M.]]

OCA: Protected "3q93" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2011 05:51:32 GMT

Protected "3q93" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 19 January 2011

OCA: New page: '''Unreleased structure''' The entry 3q93 is ON HOLD Authors: Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin,...

OCA — Wed, 19 Jan 2011 05:51:32 GMT

New page: '''Unreleased structure''' The entry 3q93 is ON HOLD Authors: Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin,...

New page

'''Unreleased structure'''

The entry 3q93 is ON HOLD

Authors: Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)

Description: Crystal Structure of Human 8-oxo-dGTPase (MTH1)