3qbq - Revision history

OCA at 17:11, 1 November 2023

OCA — Wed, 01 Nov 2023 17:11:57 GMT

←Older revision		Revision as of 17:11, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3qbq' size='340' side='right'caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3qbq' size='340' side='right'caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Rankl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~, ~~Rank (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [https://pdbe.org/3qbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [https://www.ebi.ac.uk/pdbsum/3qbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [https://pdbe.org/3qbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [https://www.ebi.ac.uk/pdbsum/3qbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.	+	[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[https://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref> <ref>PMID:20483727</ref>	+	[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Choi~~, J K~~]]	+	[[Category: Choi JK]]
-	[[Category: Hwang~~, H Y~~]]	+	[[Category: Hwang HY]]
-	[[Category: Jin~~, H M~~]]	+	[[Category: Jin HM]]
-	[[Category: Kim~~, K K~~]]	+	[[Category: Kim KK]]
-	[[Category: Kim~~, N S~~]]	+	[[Category: Kim NS]]
-	[[Category: Nguyen~~, G T.T~~]]	+	[[Category: Nguyen GTT]]
-	[[Category: Park, H]]	+	[[Category: Park H]]
-	[[Category: Ta~~, H M]]~~	+	[[Category: Ta HM]]
-	~~[[Category: Cytokine-cytokine receptor complex~~]]	+

OCA at 06:01, 8 June 2022

OCA — Wed, 08 Jun 2022 06:01:15 GMT

←Older revision		Revision as of 06:01, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of extracellular domains of mouse RANK-RANKL complex==		==Crystal structure of extracellular domains of mouse RANK-RANKL complex==
-	<StructureSection load='3qbq' size='340' side='right' caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3qbq' size='340' side='right'caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rankl ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Rank ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rankl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Rank ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [~~http~~://pdbe.org/3qbq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qbq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [https://pdbe.org/3qbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [https://www.ebi.ac.uk/pdbsum/3qbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.	+	[[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[~~http~~://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref> <ref>PMID:20483727</ref>	+	[[https://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[https://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref> <ref>PMID:20483727</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]	+	*[[Tumor necrosis factor ligand superfamily 3D structures\|Tumor necrosis factor ligand superfamily 3D structures]]
		+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Choi, J K]]		[[Category: Choi, J K]]

OCA at 22:42, 5 August 2016

OCA — Fri, 05 Aug 2016 22:42:10 GMT

←Older revision		Revision as of 22:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of extracellular domains of mouse RANK-RANKL complex==		==Crystal structure of extracellular domains of mouse RANK-RANKL complex==
	<StructureSection load='3qbq' size='340' side='right' caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3qbq' size='340' side='right' caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rankl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), Rank ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rankl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Rank ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [http://www.ebi.ac.uk/pdbsum/3qbq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [http://pdbe.org/3qbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [http://www.ebi.ac.uk/pdbsum/3qbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qbq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Choi, J K]]		[[Category: Choi, J K]]
	[[Category: Hwang, H Y]]		[[Category: Hwang, H Y]]

OCA at 10:30, 19 December 2014

OCA — Fri, 19 Dec 2014 10:30:15 GMT

←Older revision		Revision as of 10:30, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qbq\| PDB=3qbq \| SCENE= }}~~	+	==Crystal structure of extracellular domains of mouse RANK-RANKL complex==
-	===Crystal structure of extracellular domains of mouse RANK-RANKL complex===	+	<StructureSection load='3qbq' size='340' side='right' caption='[[3qbq]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21059944}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3qbq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBQ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rankl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Rank ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbq RCSB], [http://www.ebi.ac.uk/pdbsum/3qbq PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.		[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[http://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref> <ref>PMID:20483727</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The receptor activator of nuclear factor-kappaB (RANK) and its ligand RANKL, which belong to the tumor necrosis factor (TNF) receptor-ligand family, mediate osteoclastogenesis. The crystal structure of the RANKL ectodomain (eRANKL) in complex with the RANK ectodomain (eRANK) combined with biochemical assays of RANK mutants indicated that three RANK loops (Loop1, Loop2, and Loop3) bind to the interface of a trimeric eRANKL. Loop3 is particularly notable in that it is structurally distinctive from other TNF-family receptors and forms extensive contacts with RANKL. The disulfide bond (C125-C127) at the tip of Loop3 is important for determining the unique topology of Loop3, and docking E126 close to RANKL, which was supported by the inability of C127A or E126A mutants of RANK to bind to RANKL. Inhibitory activity of RANK mutants, which contain loops of osteoprotegerin (OPG), a soluble decoy receptor to RANKL, confirmed that OPG shares the similar binding mode with RANK and OPG. Loop3 plays a key role in RANKL binding. Peptide inhibitors designed to mimic Loop3 blocked the RANKL-induced differentiation of osteoclast precursors, suggesting that they could be developed as therapeutic agents for the treatment of osteoporosis and bone-related diseases. Furthermore, some of the RANK mutations associated with autosomal recessive osteopetrosis (ARO) resulted in reduced RANKL-binding activity and failure to induce osteoclastogenesis. These results, together with structural interpretation of eRANK-eRANKL interaction, provided molecular understanding for pathogenesis of ARO.

-	~~==Function==~~	+	Structure-based development of a receptor activator of nuclear factor-{kappa}B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis.,Ta HM, Nguyen GT, Jin HM, Choi J, Park H, Kim N, Hwang HY, Kim KK Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059944<ref>PMID:21059944</ref>
-	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-~~cell proliferation. May be an important regulator~~ of ~~interactions between T-cells and dendritic cells and may play~~ a ~~role in the regulation~~ of ~~the T~~-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[http://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL~~/TRANCE/OPGL; essential~~ for ~~RANKL-mediated osteoclastogenesis~~. ~~Involved in the regulation of interactions between T-cells and dendritic cells~~.~~<ref>~~PMID:~~9878548</ref>~~<ref>PMID:~~20483727~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qbq]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021059944</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Choi, J K.]]	+	[[Category: Choi, J K]]
-	[[Category: Hwang, H Y.]]	+	[[Category: Hwang, H Y]]
-	[[Category: Jin, H M.]]	+	[[Category: Jin, H M]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
-	[[Category: Kim, N S.]]	+	[[Category: Kim, N S]]
-	[[Category: Nguyen, G T.T.]]	+	[[Category: Nguyen, G T.T]]
-	[[Category: Park, H.]]	+	[[Category: Park, H]]
-	[[Category: Ta, H M.]]	+	[[Category: Ta, H M]]
	[[Category: Cytokine-cytokine receptor complex]]		[[Category: Cytokine-cytokine receptor complex]]

OCA at 06:41, 25 March 2013

OCA — Mon, 25 Mar 2013 06:41:58 GMT

←Older revision		Revision as of 06:41, 25 March 2013
Line 1:		Line 1:
-	[[Image:3qbq.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qbq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qbq\| PDB=3qbq \| SCENE= }}		{{STRUCTURE_3qbq\| PDB=3qbq \| SCENE= }}
-
	===Crystal structure of extracellular domains of mouse RANK-RANKL complex===		===Crystal structure of extracellular domains of mouse RANK-RANKL complex===
		+	{{ABSTRACT_PUBMED_21059944}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21059944}}, adds~~ the ~~Publication Abstract~~ to the ~~page~~	+	[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[http://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref><ref>PMID:20483727</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21059944 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21059944}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21059944~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021059944</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Choi, J K.]]		[[Category: Choi, J K.]]
Line 32:		Line 23:
	[[Category: Park, H.]]		[[Category: Park, H.]]
	[[Category: Ta, H M.]]		[[Category: Ta, H M.]]
		+	[[Category: Cytokine-cytokine receptor complex]]

OCA at 06:55, 2 March 2011

OCA — Wed, 02 Mar 2011 06:55:27 GMT

←Older revision		Revision as of 06:55, 2 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qbq.jpg\|left\|200px]]

-	The ~~entry 3qbq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qbq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qbq\| PDB=3qbq \| SCENE= }}

-	~~Authors: Ta, H.M., Nguyen, G.T.T., Jin, H.M., Choi, J.K., Park, H., Kim, N.S., Hwang, H.Y., Kim, K.K.~~	+	===Crystal structure of extracellular domains of mouse RANK-RANKL complex===

-	~~Description~~: ~~Crystal~~ structure ~~of extracellular domains of mouse RANK~~-~~RANKL complex~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21059944}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21059944 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21059944}}
		+
		+	==About this Structure==
		+	[[3qbq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nzy 3nzy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21059944</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Choi, J K.]]
		+	[[Category: Hwang, H Y.]]
		+	[[Category: Jin, H M.]]
		+	[[Category: Kim, K K.]]
		+	[[Category: Kim, N S.]]
		+	[[Category: Nguyen, G T.T.]]
		+	[[Category: Park, H.]]
		+	[[Category: Ta, H M.]]

OCA: Protected "3qbq" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2011 05:53:25 GMT

Protected "3qbq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:53, 19 January 2011

OCA: New page: '''Unreleased structure''' The entry 3qbq is ON HOLD Authors: Ta, H.M., Nguyen, G.T.T., Jin, H.M., Choi, J.K., Park, H., Kim, N.S., Hwang, H.Y., Kim, K.K. Description: Crystal structur...

OCA — Wed, 19 Jan 2011 05:53:25 GMT

New page: '''Unreleased structure''' The entry 3qbq is ON HOLD Authors: Ta, H.M., Nguyen, G.T.T., Jin, H.M., Choi, J.K., Park, H., Kim, N.S., Hwang, H.Y., Kim, K.K. Description: Crystal structur...

New page

'''Unreleased structure'''

The entry 3qbq is ON HOLD

Authors: Ta, H.M., Nguyen, G.T.T., Jin, H.M., Choi, J.K., Park, H., Kim, N.S., Hwang, H.Y., Kim, K.K.

Description: Crystal structure of extracellular domains of mouse RANK-RANKL complex