3qbz - Revision history

OCA at 11:40, 14 March 2024

OCA — Thu, 14 Mar 2024 11:40:20 GMT

←Older revision		Revision as of 11:40, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qbz' size='340' side='right'caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='3qbz' size='340' side='right'caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.692Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3oq0\|3oq0]], [[3oq4\|3oq4]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [https://pdbe.org/3qbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [https://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [https://pdbe.org/3qbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [https://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST]] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>	+	[https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Dbf4 is a conserved eukaryotic protein that functions as the regulatory subunit of the DDK (Dbf4-dependent kinase) complex. DDK plays essential roles in DNA replication initiation and checkpoint activation. During the replication checkpoint, Saccharomyces cerevisiae Dbf4 is phosphorylated in a Rad53-dependent manner and this, in turn, inhibits initiation of replication at late origins. We have determined the minimal region of Dbf4 required for the interaction with the checkpoint kinase Rad53 and solved its crystal structure. The core of this fragment of Dbf4 folds as a BRCT domain, but it includes an additional N-terminal helix unique to Dbf4. Mutation of the residues that anchor this helix to the domain core abolish the interaction between Dbf4 and Rad53, indicating that this helix is an integral element of the domain. The structure also reveals that previously characterized Dbf4 mutants with checkpoint phenotypes destabilize the domain, indicating that its structural integrity is essential for the interaction with Rad53. Collectively, these results allow us to propose a model for the association between Dbf4 and Rad53.	+
-		+
-	Saccharomyces cerevisiae DBF4 reveals a unique fold necessary for the interaction with the RAD53 kinase.,Matthews LA, Jones DR, Prasad AA, Duncker BP, Guarne A J Biol Chem. 2011 Nov 29. PMID:22130670<ref>PMID:22130670</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qbz" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Duncker, B P~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Guarne, A~~]]	+	[[Category: Duncker BP]]
-	[[Category: ~~Jones, D R]]~~	+	[[Category: Guarne A]]
-	~~[[Category: Matthews, L~~ A]]	+	[[Category: Jones DR]]
-	[[Category: ~~Prasad, A A~~]]	+	[[Category: Matthews LA]]
-	[[Category: ~~Cell cycle~~]]	+	[[Category: Prasad AA]]
-	[[Category: ~~Fha domain]]~~	+
-	~~[[Category: Rad53]]~~	+
-	~~[[Category: Replication checkpoint~~]]	+

OCA at 06:01, 8 June 2022

OCA — Wed, 08 Jun 2022 06:01:35 GMT

←Older revision		Revision as of 06:01, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==		==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==
-	<StructureSection load='3qbz' size='340' side='right' caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>	+	<StructureSection load='3qbz' size='340' side='right'caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oq0\|3oq0]], [[3oq4\|3oq4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3oq0\|3oq0]], [[3oq4\|3oq4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [~~http~~://pdbe.org/3qbz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [https://pdbe.org/3qbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [https://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST]] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>	+	[[https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST]] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Duncker, B P]]		[[Category: Duncker, B P]]
	[[Category: Guarne, A]]		[[Category: Guarne, A]]

OCA at 20:47, 5 August 2016

OCA — Fri, 05 Aug 2016 20:47:11 GMT

←Older revision		Revision as of 20:47, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==		==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==
	<StructureSection load='3qbz' size='340' side='right' caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='3qbz' size='340' side='right' caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oq0\|3oq0]], [[3oq4\|3oq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oq0\|3oq0]], [[3oq4\|3oq4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [http://www.ebi.ac.uk/pdbsum/3qbz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [http://pdbe.org/3qbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [http://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qbz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Duncker, B P]]		[[Category: Duncker, B P]]
	[[Category: Guarne, A]]		[[Category: Guarne, A]]

OCA at 21:47, 25 December 2014

OCA — Thu, 25 Dec 2014 21:47:21 GMT

←Older revision		Revision as of 21:47, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [http://www.ebi.ac.uk/pdbsum/3qbz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [http://www.ebi.ac.uk/pdbsum/3qbz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST]] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:41, 9 December 2014

OCA — Tue, 09 Dec 2014 13:41:13 GMT

←Older revision		Revision as of 13:41, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qbz.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==
		+	<StructureSection load='3qbz' size='340' side='right' caption='[[3qbz]], [[Resolution\|resolution]] 2.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3oq0\|3oq0]], [[3oq4\|3oq4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D4205, DBF4, DNA52, YD9609.07C, YDR052C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [http://www.ebi.ac.uk/pdbsum/3qbz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dbf4 is a conserved eukaryotic protein that functions as the regulatory subunit of the DDK (Dbf4-dependent kinase) complex. DDK plays essential roles in DNA replication initiation and checkpoint activation. During the replication checkpoint, Saccharomyces cerevisiae Dbf4 is phosphorylated in a Rad53-dependent manner and this, in turn, inhibits initiation of replication at late origins. We have determined the minimal region of Dbf4 required for the interaction with the checkpoint kinase Rad53 and solved its crystal structure. The core of this fragment of Dbf4 folds as a BRCT domain, but it includes an additional N-terminal helix unique to Dbf4. Mutation of the residues that anchor this helix to the domain core abolish the interaction between Dbf4 and Rad53, indicating that this helix is an integral element of the domain. The structure also reveals that previously characterized Dbf4 mutants with checkpoint phenotypes destabilize the domain, indicating that its structural integrity is essential for the interaction with Rad53. Collectively, these results allow us to propose a model for the association between Dbf4 and Rad53.

-	~~{{STRUCTURE_3qbz\| PDB=3qbz \| SCENE= }}~~	+	Saccharomyces cerevisiae DBF4 reveals a unique fold necessary for the interaction with the RAD53 kinase.,Matthews LA, Jones DR, Prasad AA, Duncker BP, Guarne A J Biol Chem. 2011 Nov 29. PMID:22130670<ref>PMID:22130670</ref>

-	~~===Crystal structure~~ of the ~~Rad53-recognition domain of Saccharomyces cerevisiae Dbf4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22130670}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3qbz]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022130670<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Duncker, B P.]]	+	[[Category: Duncker, B P]]
-	[[Category: Guarne, A.]]	+	[[Category: Guarne, A]]
-	[[Category: Jones, D R.]]	+	[[Category: Jones, D R]]
-	[[Category: Matthews, L A.]]	+	[[Category: Matthews, L A]]
-	[[Category: Prasad, A A.]]	+	[[Category: Prasad, A A]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Fha domain]]		[[Category: Fha domain]]
	[[Category: Rad53]]		[[Category: Rad53]]
	[[Category: Replication checkpoint]]		[[Category: Replication checkpoint]]

OCA at 12:47, 20 February 2013

OCA — Wed, 20 Feb 2013 12:47:36 GMT

←Older revision		Revision as of 12:47, 20 February 2013
Line 1:		Line 1:
	[[Image:3qbz.png\|left\|200px]]		[[Image:3qbz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qbz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qbz\| PDB=3qbz \| SCENE= }}		{{STRUCTURE_3qbz\| PDB=3qbz \| SCENE= }}

	===Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4===		===Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22130670}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22130670 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22130670}}		{{ABSTRACT_PUBMED_22130670}}

OCA at 06:12, 28 December 2011

OCA — Wed, 28 Dec 2011 06:12:12 GMT

←Older revision		Revision as of 06:12, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qbz.png\|left\|200px]]

-	The ~~entry 3qbz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qbz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qbz\| PDB=3qbz \| SCENE= }}

-	~~Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A.~~	+	===Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4===

-	~~Description~~: ~~Crystal structure of~~ the ~~Rad53~~-~~recognition domain of~~ Saccharomyces cerevisiae ~~Dbf4~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22130670}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22130670 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22130670}}
		+
		+	==About this Structure==
		+	[[3qbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022130670</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Duncker, B P.]]
		+	[[Category: Guarne, A.]]
		+	[[Category: Jones, D R.]]
		+	[[Category: Matthews, L A.]]
		+	[[Category: Prasad, A A.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Fha domain]]
		+	[[Category: Rad53]]
		+	[[Category: Replication checkpoint]]

OCA at 06:26, 4 May 2011

OCA — Wed, 04 May 2011 06:26:53 GMT

←Older revision		Revision as of 06:26, 4 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qbz is ON HOLD	+	The entry 3qbz is ON HOLD until Paper Publication

	Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A.		Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A.

	Description: Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4		Description: Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4

OCA: Protected "3qbz" [edit=sysop:move=sysop]

OCA — Wed, 26 Jan 2011 12:45:44 GMT

Protected "3qbz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 26 January 2011

OCA: New page: '''Unreleased structure''' The entry 3qbz is ON HOLD Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A. Description: Crystal structure of the Rad53-recogniti...

OCA — Wed, 26 Jan 2011 12:45:44 GMT

New page: '''Unreleased structure''' The entry 3qbz is ON HOLD Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A. Description: Crystal structure of the Rad53-recogniti...

New page

'''Unreleased structure'''

The entry 3qbz is ON HOLD

Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A.

Description: Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4