3qcc - Revision history

OCA at 11:40, 14 March 2024

OCA — Thu, 14 Mar 2024 11:40:30 GMT

←Older revision		Revision as of 11:40, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qcc' size='340' side='right'caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3qcc' size='340' side='right'caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QCC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3qcb\|3qcb]]~~, [[~~3qcd~~\|~~3qcd~~]]~~, [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PTPG, PTPRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [https://pdbe.org/3qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [https://www.ebi.ac.uk/pdbsum/3qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [https://pdbe.org/3qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [https://www.ebi.ac.uk/pdbsum/3qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN]] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>	+	[https://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been observed in either an "open" conformation or a "closed" conformation. In the current work, X-ray structures of the catalytic domain of receptor-like protein tyrosine phosphatase gamma (RPTPgamma) revealed a ligand-induced "superopen" conformation not previously reported for PTPs. In the superopen conformation, the ligand acts as an apparent competitive inhibitor and binds in a small hydrophobic pocket adjacent to, but distinct from, the active site. In the open and closed WPD-loop conformations of RPTPgamma, the side chain of Trp1026 partially occupies this pocket. In the superopen conformation, Trp1026 is displaced allowing a 3,4-dichlorobenzyl substituent to occupy this site. The bound ligand prevents closure of the WPD-loop over the active site and disrupts the catalytic cycle of the enzyme.	+
-		+
-	Small molecule receptor protein tyrosine phosphatase gamma (RPTPgamma) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.,Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW J Med Chem. 2011 Oct 13;54(19):6548-62. Epub 2011 Sep 20. PMID:21882820<ref>PMID:21882820</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qcc" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Sheriff S]]
-	[[Category: Sheriff, S]]	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]~~	+
-	~~[[Category: Tyrosine receptor phosphatase~~]]	+

OCA at 06:02, 8 June 2022

OCA — Wed, 08 Jun 2022 06:02:03 GMT

←Older revision		Revision as of 06:02, 8 June 2022
Line 1:		Line 1:

	==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form==		==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form==
-	<StructureSection load='3qcc' size='340' side='right' caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3qcc' size='340' side='right'caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QCC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [~~http~~://pdbe.org/3qcc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qcc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [https://pdbe.org/3qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [https://www.ebi.ac.uk/pdbsum/3qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN]] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>	+	[[https://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN]] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Sheriff, S]]		[[Category: Sheriff, S]]

OCA at 15:43, 4 August 2016

OCA — Thu, 04 Aug 2016 15:43:39 GMT

←Older revision		Revision as of 15:43, 4 August 2016
Line 1:		Line 1:
		+
	==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form==		==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form==
	<StructureSection load='3qcc' size='340' side='right' caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3qcc' size='340' side='right' caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [http://www.ebi.ac.uk/pdbsum/3qcc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [http://pdbe.org/3qcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [http://www.ebi.ac.uk/pdbsum/3qcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qcc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Sheriff, S]]		[[Category: Sheriff, S]]

OCA at 10:40, 25 December 2014

OCA — Thu, 25 Dec 2014 10:40:07 GMT

←Older revision		Revision as of 10:40, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QCC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [http://www.ebi.ac.uk/pdbsum/3qcc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [http://www.ebi.ac.uk/pdbsum/3qcc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN]] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 28:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Sheriff, S.]]	+	[[Category: Sheriff, S]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]		[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]
	[[Category: Tyrosine receptor phosphatase]]		[[Category: Tyrosine receptor phosphatase]]

OCA at 06:48, 9 June 2014

OCA — Mon, 09 Jun 2014 06:48:19 GMT

←Older revision		Revision as of 06:48, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qcc.~~png~~\|~~left~~\|~~200px~~]]	+	==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form==
		+	<StructureSection load='3qcc' size='340' side='right' caption='[[3qcc]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QCC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qcb\|3qcb]], [[3qcd\|3qcd]], [[3qce\|3qce]], [[3qcf\|3qcf]], [[3qcg\|3qcg]], [[3qch\|3qch]], [[3qci\|3qci]], [[3qcj\|3qcj]], [[3qck\|3qck]], [[3qcl\|3qcl]], [[3qcm\|3qcm]], [[3qcn\|3qcn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPG, PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qcc RCSB], [http://www.ebi.ac.uk/pdbsum/3qcc PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been observed in either an "open" conformation or a "closed" conformation. In the current work, X-ray structures of the catalytic domain of receptor-like protein tyrosine phosphatase gamma (RPTPgamma) revealed a ligand-induced "superopen" conformation not previously reported for PTPs. In the superopen conformation, the ligand acts as an apparent competitive inhibitor and binds in a small hydrophobic pocket adjacent to, but distinct from, the active site. In the open and closed WPD-loop conformations of RPTPgamma, the side chain of Trp1026 partially occupies this pocket. In the superopen conformation, Trp1026 is displaced allowing a 3,4-dichlorobenzyl substituent to occupy this site. The bound ligand prevents closure of the WPD-loop over the active site and disrupts the catalytic cycle of the enzyme.

-	~~{{STRUCTURE_3qcc\| PDB=3qcc \| SCENE= }}~~	+	Small molecule receptor protein tyrosine phosphatase gamma (RPTPgamma) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.,Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW J Med Chem. 2011 Oct 13;54(19):6548-62. Epub 2011 Sep 20. PMID:21882820<ref>PMID:21882820</ref>

-	~~===Human receptor protein tyrosine phosphatase gamma~~, ~~domain 1, in complex with vanadate, orthorhombic crystal form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_21882820}}~~	+	==See Also==
-		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3qcc~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:021882820<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]

OCA at 11:30, 14 August 2012

OCA — Tue, 14 Aug 2012 11:30:32 GMT

←Older revision		Revision as of 11:30, 14 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qcc]] is a 2 chain structure ~~of [[Proten tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].	+	[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].
-		+
-	~~==See Also==~~	+
-	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]	+

	==Reference==		==Reference==

OCA at 19:20, 26 July 2012

OCA — Thu, 26 Jul 2012 19:20:59 GMT

←Older revision		Revision as of 19:20, 26 July 2012
Line 1:		Line 1:
-	[[Image:3qcc.~~jpg~~\|left\|200px]]	+	[[Image:3qcc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qcc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qcc\| PDB=3qcc \| SCENE= }}		{{STRUCTURE_3qcc\| PDB=3qcc \| SCENE= }}

	===Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form===		===Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21882820}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21882820 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21882820}}		{{ABSTRACT_PUBMED_21882820}}

	==About this Structure==		==About this Structure==
-	[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].	+	[[3qcc]] is a 2 chain structure of [[Proten tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].
		+
		+	==See Also==
		+	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]

	==Reference==		==Reference==

OCA at 07:22, 28 December 2011

OCA — Wed, 28 Dec 2011 07:22:50 GMT

←Older revision		Revision as of 07:22, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qcc.jpg\|left\|200px]]

-	The ~~entry 3qcc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qcc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qcc\| PDB=3qcc \| SCENE= }}

-	~~Authors: Sheriff~~, S.	+	===Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form===

-	~~Description~~: ~~Human receptor protein~~ tyrosine phosphatase ~~gamma~~, ~~domain 1, in~~ complex ~~with vanadate, orthorhombic crystal form~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21882820}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21882820 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21882820}}
		+
		+	==About this Structure==
		+	[[3qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021882820</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Sheriff, S.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]
		+	[[Category: Tyrosine receptor phosphatase]]

OCA at 05:48, 9 February 2011

OCA — Wed, 09 Feb 2011 05:48:49 GMT

←Older revision		Revision as of 05:48, 9 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qcc is ON HOLD	+	The entry 3qcc is ON HOLD until Paper Publication

	Authors: Sheriff, S.		Authors: Sheriff, S.

	Description: Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form		Description: Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, orthorhombic crystal form

OCA: Protected "3qcc" [edit=sysop:move=sysop]

OCA — Wed, 26 Jan 2011 12:45:59 GMT

Protected "3qcc" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 26 January 2011