3qdj - Revision history

OCA at 11:41, 14 March 2024

OCA — Thu, 14 Mar 2024 11:41:39 GMT

OCA at 06:03, 8 June 2022

OCA — Wed, 08 Jun 2022 06:03:43 GMT

←Older revision		Revision as of 06:03, 8 June 2022
Line 1:		Line 1:

	==The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide==		==The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide==
-	<StructureSection load='3qdj' size='340' side='right' caption='[[3qdj]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3qdj' size='340' side='right'caption='[[3qdj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qdj]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qdj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qdg\|3qdg]], [[3qdm\|3qdm]], [[3qeq\|3qeq]], [[3qeu\|3qeu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qdg\|3qdg]], [[3qdm\|3qdm]], [[3qeq\|3qeq]], [[3qeu\|3qeu]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdj OCA], [~~http~~://pdbe.org/3qdj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qdj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qdj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdj OCA], [https://pdbe.org/3qdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdj RCSB], [https://www.ebi.ac.uk/pdbsum/3qdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
-	*[[T-cell receptor\|T-cell receptor]]	+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baker, B M]]		[[Category: Baker, B M]]
	[[Category: Borbulevych, O Y]]		[[Category: Borbulevych, O Y]]

OCA at 14:52, 5 August 2016

OCA — Fri, 05 Aug 2016 14:52:34 GMT

←Older revision		Revision as of 14:52, 5 August 2016
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		+
	==The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide==		==The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide==
	<StructureSection load='3qdj' size='340' side='right' caption='[[3qdj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3qdj' size='340' side='right' caption='[[3qdj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qdg\|3qdg]], [[3qdm\|3qdm]], [[3qeq\|3qeq]], [[3qeu\|3qeu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qdg\|3qdg]], [[3qdm\|3qdm]], [[3qeq\|3qeq]], [[3qeu\|3qeu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdj RCSB], [http://www.ebi.ac.uk/pdbsum/3qdj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdj OCA], [http://pdbe.org/3qdj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qdj RCSB], [http://www.ebi.ac.uk/pdbsum/3qdj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qdj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Baker, B M]]		[[Category: Baker, B M]]
	[[Category: Borbulevych, O Y]]		[[Category: Borbulevych, O Y]]

OCA at 10:37, 19 December 2014

OCA — Fri, 19 Dec 2014 10:37:55 GMT

←Older revision		Revision as of 10:37, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}~~	+	==The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide==
-	===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===	+	<StructureSection load='3qdj' size='340' side='right' caption='[[3qdj]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21795600}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDJ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qdg\|3qdg]], [[3qdm\|3qdm]], [[3qeq\|3qeq]], [[3qeu\|3qeu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdj RCSB], [http://www.ebi.ac.uk/pdbsum/3qdj PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T cells engineered to express TCRs specific for tumor Ags can drive cancer regression. The first TCRs used in cancer gene therapy, DMF4 and DMF5, recognize two structurally distinct peptide epitopes of the melanoma-associated MART-1/Melan-A protein, both presented by the class I MHC protein HLA-A*0201. To help understand the mechanisms of TCR cross-reactivity and provide a foundation for the further development of immunotherapy, we determined the crystallographic structures of DMF4 and DMF5 in complex with both of the MART-1/Melan-A epitopes. The two TCRs use different mechanisms to accommodate the two ligands. Although DMF4 binds the two with a different orientation, altering its position over the peptide/MHC, DMF5 binds them both identically. The simpler mode of cross-reactivity by DMF5 is associated with higher affinity toward both ligands, consistent with the superior functional avidity of DMF5. More generally, the observation of two diverging mechanisms of cross-reactivity with the same Ags and the finding that TCR-binding orientation can be determined by peptide alone extend our understanding of the mechanisms underlying TCR cross-reactivity.

-	~~==Disease==~~	+	TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms.,Borbulevych OY, Santhanagopolan SM, Hossain M, Baker BM J Immunol. 2011 Jul 27. PMID:21795600<ref>PMID:21795600</ref>
-	~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects~~ in ~~B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http:~~/~~/omim~~.~~org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin~~, ~~probably due to rapid degradation~~.~~<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states~~. ~~The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>~~PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:~~19284997~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation~~ of ~~foreign antigens to~~ the ~~immune system~~. ~~[[http://www~~.~~uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component~~ of ~~the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3qdj]] is a 5 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].~~	+

	==See Also==		==See Also==
Line 16:		Line 24:
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
	*[[T-cell receptor\|T-cell receptor]]		*[[T-cell receptor\|T-cell receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021795600</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Baker, B M.]]	+	[[Category: Baker, B M]]
-	[[Category: Borbulevych, O Y.]]	+	[[Category: Borbulevych, O Y]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Cross-reactivity]]		[[Category: Cross-reactivity]]

OCA at 00:20, 25 March 2013

OCA — Mon, 25 Mar 2013 00:20:39 GMT

←Older revision		Revision as of 00:20, 25 March 2013
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-	[[Image:3qdj.png\|left\|200px]]
-
	{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}		{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}
-
	===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===		===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===
		+	{{ABSTRACT_PUBMED_21795600}}

-	~~{{ABSTRACT_PUBMED_21795600}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 13:		Line 15:
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
		+	*[[T-cell receptor\|T-cell receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021795600</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021795600</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, B M.]]		[[Category: Baker, B M.]]

OCA at 20:41, 20 October 2012

OCA — Sat, 20 Oct 2012 20:41:38 GMT

←Older revision		Revision as of 20:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qdj]] is a 5 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].	+	[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].

	==See Also==		==See Also==

OCA at 11:18, 27 July 2012

OCA — Fri, 27 Jul 2012 11:18:50 GMT

←Older revision		Revision as of 11:18, 27 July 2012
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	[[Image:3qdj.png\|left\|200px]]		[[Image:3qdj.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}		{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}

	===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===		===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21795600}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21795600 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21795600}}		{{ABSTRACT_PUBMED_21795600}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-	*[[Major histocompatibility complex]]	+	*[[Major histocompatibility complex\|Major histocompatibility complex]]

	==Reference==		==Reference==

OCA at 06:20, 17 August 2011

OCA — Wed, 17 Aug 2011 06:20:51 GMT

←Older revision		Revision as of 06:20, 17 August 2011
Line 1:		Line 1:
-	[[Image:3qdj.~~jpg~~\|left\|200px]]	+	[[Image:3qdj.png\|left\|200px]]

	<!--		<!--
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	===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===		===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21795600}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21795600 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21795600}}

	==About this Structure==		==About this Structure==
-	[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].	+	[[3qdj]] is a 5 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin]]
		+	*[[Major histocompatibility complex]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021795600</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, B M.]]		[[Category: Baker, B M.]]

OCA at 18:59, 6 July 2011

OCA — Wed, 06 Jul 2011 18:59:41 GMT

←Older revision		Revision as of 18:59, 6 July 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qdj.jpg\|left\|200px]]

-	The ~~entry 3qdj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qdj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qdj\| PDB=3qdj \| SCENE= }}

-	~~Authors: Borbulevych, O.Y., Baker, B.M.~~	+	===The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide===

-	~~Description~~: ~~The complex between TCR DMF5 and human Class I MHC HLA~~-~~A2 with the bound MART~~-~~1(27~~-~~35) nonameric~~ peptide	+
		+	==About this Structure==
		+	[[3qdj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDJ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Baker, B M.]]
		+	[[Category: Borbulevych, O Y.]]
		+	[[Category: Cancer]]
		+	[[Category: Cross-reactivity]]
		+	[[Category: Hla-a2]]
		+	[[Category: Immune system]]
		+	[[Category: Mart-1 peptide]]
		+	[[Category: Melanoma]]
		+	[[Category: Mhc class i]]
		+	[[Category: Nonapeptide]]
		+	[[Category: Tcr dmf4]]
		+	[[Category: Tcr dmf5]]

OCA at 05:17, 1 June 2011

OCA — Wed, 01 Jun 2011 05:17:40 GMT

←Older revision		Revision as of 05:17, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qdj is ON HOLD	+	The entry 3qdj is ON HOLD until Paper Publication

	Authors: Borbulevych, O.Y., Baker, B.M.		Authors: Borbulevych, O.Y., Baker, B.M.

	Description: The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide		Description: The complex between TCR DMF5 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide