3qdx - Revision history

OCA at 11:42, 14 March 2024

OCA — Thu, 14 Mar 2024 11:42:19 GMT

←Older revision		Revision as of 11:42, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL~~+~~GROUP~~'>~~ACE~~</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [https://pdbe.org/3qdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [https://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [https://pdbe.org/3qdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [https://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/BEL_BOLED BEL_BOLED]
-	A novel lectin has been isolated from the fruiting bodies of the common edible mushroom Boletus edulis (king bolete, penny bun, porcino, or cep) by affinity chromatography on a chitin column. We propose for the lectin the name BEL (Boletus edulis lectin). BEL inhibits selectively the proliferation of several malignant cell lines and binds the neoplastic cell specific T-antigen disaccharide, Galbeta1-3GalNAc. The lectin was structurally characterized: the molecule is a homotetramer and the 142 amino acid sequence of the chains was determined. The protein belongs to the saline-soluble family of mushroom fruiting body specific lectins. BEL was also crystallized and its three-dimensional structure was determined by X-ray diffraction to 1.15 A resolution. The structure is similar to that of Agaricus bisporus lectin. Using the appropriate co-crystals, the interactions of BEL with specific mono and disaccharides were also studied by X-ray diffraction. The six structures of carbohydrate complexes reported here provide details of the interactions of the ligands with the lectin and shed light on the selectivity of the two distinct binding sites present in each protomer.	+
-		+
-	STRUCTURE OF A LECTIN WITH ANTITUMORAL PROPERTIES IN KING BOLETE (Boletus edulis) MUSHROOMS.,Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL Glycobiology. 2011 Feb 8. PMID:21303815<ref>PMID:21303815</~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3qdx" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Boletus edulis]]		[[Category: Boletus edulis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bovi, M]]	+	[[Category: Bovi M]]
-	[[Category: Capaldi, S]]	+	[[Category: Capaldi S]]
-	[[Category: Carrizo~~, M E~~]]	+	[[Category: Carrizo ME]]
-	[[Category: Chiarelli~~, L R~~]]	+	[[Category: Chiarelli LR]]
-	[[Category: Galliano, M]]	+	[[Category: Galliano M]]
-	[[Category: Monaco~~, H L~~]]	+	[[Category: Monaco HL]]
-	[[Category: Perduca, M]]	+	[[Category: Perduca M]]
-	~~[[Category: Boletus eduli]]~~	+
-	~~[[Category: Carbohydrate]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Mushroom]]~~	+
-	~~[[Category: N-diacetyl chitobiose]]~~	+
-	~~[[Category: Sugar binding]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: T-antigen disaccharide~~]]	+

OCA at 06:04, 8 June 2022

OCA — Wed, 08 Jun 2022 06:04:14 GMT

←Older revision		Revision as of 06:04, 8 June 2022
Line 1:		Line 1:

	==Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose==		==Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose==
-	<StructureSection load='3qdx' size='340' side='right' caption='[[3qdx]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3qdx' size='340' side='right'caption='[[3qdx]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QDX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=~~CBS~~:~~DI(N-ACETYL~~-D-~~GLUCOSAMINE)~~'>~~CBS~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [~~http~~://pdbe.org/3qdx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [https://pdbe.org/3qdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [https://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Boletus edulis]]		[[Category: Boletus edulis]]
		+	[[Category: Large Structures]]
	[[Category: Bovi, M]]		[[Category: Bovi, M]]
	[[Category: Capaldi, S]]		[[Category: Capaldi, S]]

OCA at 10:23, 13 February 2019

OCA — Wed, 13 Feb 2019 10:23:22 GMT

←Older revision		Revision as of 10:23, 13 February 2019
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CBS~~:~~DI(~~N-ACETYL-D-~~GLUCOSAMINE)~~'>~~CBS~~</scene>, <scene name='pdbligand=~~A2G~~:N-ACETYL-2-~~DEOXY-2-AMINO-GALACTOSE~~'>~~A2G~~</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>

OCA at 22:42, 5 August 2016

OCA — Fri, 05 Aug 2016 22:42:59 GMT

←Older revision		Revision as of 22:42, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose==		==Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose==
	<StructureSection load='3qdx' size='340' side='right' caption='[[3qdx]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3qdx' size='340' side='right' caption='[[3qdx]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [http://www.ebi.ac.uk/pdbsum/3qdx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [http://pdbe.org/3qdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [http://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qdx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:54, 3 January 2015

OCA — Sat, 03 Jan 2015 22:54:01 GMT

←Older revision		Revision as of 22:54, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [http://www.ebi.ac.uk/pdbsum/3qdx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [http://www.ebi.ac.uk/pdbsum/3qdx PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	STRUCTURE OF A LECTIN WITH ANTITUMORAL PROPERTIES IN KING BOLETE (Boletus edulis) MUSHROOMS.,Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL Glycobiology. 2011 Feb 8. PMID:21303815<ref>PMID:21303815</ref>		STRUCTURE OF A LECTIN WITH ANTITUMORAL PROPERTIES IN KING BOLETE (Boletus edulis) MUSHROOMS.,Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL Glycobiology. 2011 Feb 8. PMID:21303815<ref>PMID:21303815</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Boletus edulis]]		[[Category: Boletus edulis]]
-	[[Category: Bovi, M.]]	+	[[Category: Bovi, M]]
-	[[Category: Capaldi, S.]]	+	[[Category: Capaldi, S]]
-	[[Category: Carrizo, M E.]]	+	[[Category: Carrizo, M E]]
-	[[Category: Chiarelli, L R.]]	+	[[Category: Chiarelli, L R]]
-	[[Category: Galliano, M.]]	+	[[Category: Galliano, M]]
-	[[Category: Monaco, H L.]]	+	[[Category: Monaco, H L]]
-	[[Category: Perduca, M.]]	+	[[Category: Perduca, M]]
	[[Category: Boletus eduli]]		[[Category: Boletus eduli]]
	[[Category: Carbohydrate]]		[[Category: Carbohydrate]]

OCA at 05:31, 4 June 2014

OCA — Wed, 04 Jun 2014 05:31:56 GMT

←Older revision		Revision as of 05:31, 4 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qdx.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose==
		+	<StructureSection load='3qdx' size='340' side='right' caption='[[3qdx]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qds\|3qds]], [[3qdt\|3qdt]], [[3qdu\|3qdu]], [[3qdw\|3qdw]], [[3qdv\|3qdv]], [[3qdy\|3qdy]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [http://www.ebi.ac.uk/pdbsum/3qdx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel lectin has been isolated from the fruiting bodies of the common edible mushroom Boletus edulis (king bolete, penny bun, porcino, or cep) by affinity chromatography on a chitin column. We propose for the lectin the name BEL (Boletus edulis lectin). BEL inhibits selectively the proliferation of several malignant cell lines and binds the neoplastic cell specific T-antigen disaccharide, Galbeta1-3GalNAc. The lectin was structurally characterized: the molecule is a homotetramer and the 142 amino acid sequence of the chains was determined. The protein belongs to the saline-soluble family of mushroom fruiting body specific lectins. BEL was also crystallized and its three-dimensional structure was determined by X-ray diffraction to 1.15 A resolution. The structure is similar to that of Agaricus bisporus lectin. Using the appropriate co-crystals, the interactions of BEL with specific mono and disaccharides were also studied by X-ray diffraction. The six structures of carbohydrate complexes reported here provide details of the interactions of the ligands with the lectin and shed light on the selectivity of the two distinct binding sites present in each protomer.

-	~~<!--~~	+	STRUCTURE OF A LECTIN WITH ANTITUMORAL PROPERTIES IN KING BOLETE (Boletus edulis) MUSHROOMS.,Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL Glycobiology. 2011 Feb 8. PMID:21303815<ref>PMID:21303815</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3qdx", creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3qdx\| PDB=3qdx \| SCENE= }}~~	+

-	~~===Structure~~ of the ~~orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21303815}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21303815 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21303815}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qdx]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021303815<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Boletus edulis]]		[[Category: Boletus edulis]]
	[[Category: Bovi, M.]]		[[Category: Bovi, M.]]

OCA at 07:34, 2 November 2011

OCA — Wed, 02 Nov 2011 07:34:57 GMT

←Older revision		Revision as of 07:34, 2 November 2011
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-	[[Image:3qdx.~~jpg~~\|left\|200px]]	+	[[Image:3qdx.png\|left\|200px]]

	<!--		<!--
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21303815~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021303815</ref><references group="xtra"/>
	[[Category: Boletus edulis]]		[[Category: Boletus edulis]]
	[[Category: Bovi, M.]]		[[Category: Bovi, M.]]
Line 31:		Line 31:
	[[Category: Monaco, H L.]]		[[Category: Monaco, H L.]]
	[[Category: Perduca, M.]]		[[Category: Perduca, M.]]
		+	[[Category: Boletus eduli]]
		+	[[Category: Carbohydrate]]
		+	[[Category: Lectin]]
		+	[[Category: Mushroom]]
		+	[[Category: N-diacetyl chitobiose]]
		+	[[Category: Sugar binding]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: T-antigen disaccharide]]

OCA at 10:01, 23 February 2011

OCA — Wed, 23 Feb 2011 10:01:14 GMT

←Older revision		Revision as of 10:01, 23 February 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qdx.jpg\|left\|200px]]

-	The ~~entry 3qdx~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qdx", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qdx\| PDB=3qdx \| SCENE= }}

-	~~Authors: Bovi~~, ~~M., Carrizo, M.E., Capaldi, S., Perduca, M., Chiarelli, L.R., Galliano, M., Monaco, H.L.~~	+	===Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose===

-	~~Description: Structure of~~ the ~~orthorhombic form of~~ the Boletus edulis ~~lectin in complex with T~~-~~antigen disaccharide and N~~,~~N-diacetyl chitobiose~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21303815}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21303815 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21303815}}
		+
		+	==About this Structure==
		+	[[3qdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21303815</ref><references group="xtra"/>
		+	[[Category: Boletus edulis]]
		+	[[Category: Bovi, M.]]
		+	[[Category: Capaldi, S.]]
		+	[[Category: Carrizo, M E.]]
		+	[[Category: Chiarelli, L R.]]
		+	[[Category: Galliano, M.]]
		+	[[Category: Monaco, H L.]]
		+	[[Category: Perduca, M.]]

OCA at 05:20, 16 February 2011

OCA — Wed, 16 Feb 2011 05:20:35 GMT

←Older revision		Revision as of 05:20, 16 February 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qdx is ON HOLD	+	The entry 3qdx is ON HOLD until Paper Publication

	Authors: Bovi, M., Carrizo, M.E., Capaldi, S., Perduca, M., Chiarelli, L.R., Galliano, M., Monaco, H.L.		Authors: Bovi, M., Carrizo, M.E., Capaldi, S., Perduca, M., Chiarelli, L.R., Galliano, M., Monaco, H.L.

-	Description: Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen and N,N-diacetyl chitobiose	+	Description: Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose

OCA: Protected "3qdx" [edit=sysop:move=sysop]

OCA — Wed, 26 Jan 2011 12:47:05 GMT

Protected "3qdx" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:47, 26 January 2011