3qg2 - Revision history

OCA at 17:12, 1 November 2023

OCA — Wed, 01 Nov 2023 17:12:28 GMT

←Older revision		Revision as of 17:12, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3qg2' size='340' side='right'caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3qg2' size='340' side='right'caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [https://pdbe.org/3qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [https://pdbe.org/3qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]	+	[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Plafa]]
-	[[Category: Chitnumsub, P]]
-	[[Category: Kamchonwongpaisan, S]]
-	[[Category: Taweechai, S]]
-	[[Category: Vanichtanankul, J]]
-	[[Category: Yuthavong, Y]]
-	[[Category: Yuvaniyama, J]]
-	[[Category: Antifolate resistance]]
-	[[Category: Dihydrofolate reductase]]
-	[[Category: Oxidoreductase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: ~~Pyrimethamine~~]]	+	[[Category: Chitnumsub P]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Kamchonwongpaisan S]]
-	[[Category: ~~Transferase-inhibitor complex~~]]	+	[[Category: Taweechai S]]
		+	[[Category: Vanichtanankul J]]
		+	[[Category: Yuthavong Y]]
		+	[[Category: Yuvaniyama J]]

OCA at 06:07, 8 June 2022

OCA — Wed, 08 Jun 2022 06:07:36 GMT

←Older revision		Revision as of 06:07, 8 June 2022
Line 1:		Line 1:

	==Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex==		==Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex==
-	<StructureSection load='3qg2' size='340' side='right' caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3qg2' size='340' side='right'caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [~~http~~://pdbe.org/3qg2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [https://pdbe.org/3qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]	+	[[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Chitnumsub, P]]		[[Category: Chitnumsub, P]]

OCA at 12:59, 4 August 2016

OCA — Thu, 04 Aug 2016 12:59:41 GMT

←Older revision		Revision as of 12:59, 4 August 2016
Line 1:		Line 1:
		+
	==Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex==		==Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex==
	<StructureSection load='3qg2' size='340' side='right' caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3qg2' size='340' side='right' caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qg2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [http://pdbe.org/3qg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qg2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Chitnumsub, P]]		[[Category: Chitnumsub, P]]
	[[Category: Kamchonwongpaisan, S]]		[[Category: Kamchonwongpaisan, S]]
Line 35:		Line 37:
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
		+	[[Category: Plasmodium falciparum]]
	[[Category: Pyrimethamine]]		[[Category: Pyrimethamine]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-inhibitor complex]]		[[Category: Transferase-inhibitor complex]]

OCA at 14:47, 24 December 2014

OCA — Wed, 24 Dec 2014 14:47:36 GMT

←Older revision		Revision as of 14:47, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qg2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qg2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:55, 19 December 2014

OCA — Fri, 19 Dec 2014 10:55:46 GMT

←Older revision		Revision as of 10:55, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}~~	+	==Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex==
-	===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===	+	<StructureSection load='3qg2' size='340' side='right' caption='[[3qg2]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21650210}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QG2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qfx\|3qfx]], [[3qgt\|3qgt]], [[3rg9\|3rg9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qg2 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dihydrofolate reductase (DHFR) is a potential drug target for Trypanosoma brucei, a human parasite, which is the causative agent for African sleeping sickness. No drug is available against this target, since none of the classical antifolates such as pyrimethamine (PYR), cycloguanil, or trimethoprim are effective as selective inhibitors of T. brucei DHFR (TbDHFR). In order to design effective drugs that target TbDHFR, co-crystal structures with bound antifolates were studied. On comparison with malarial Plasmodium falciparum DHFR (PfDHFR), the co-crystal structures of wild-type TbDHFR reveal greater structural similarities to a mutant PfDHFR causing antifolate resistance than the wild-type enzyme. TbDHFR imposes steric hindrance for rigid inhibitors like PYR around Thr86, which is equivalent to Ser108Asn of the malarial enzymes. In addition, a missing residue on TbDHFR active-site loop together with the presence of Ile51 widens its active site even further than the structural effect of Asn51Ile, which is observed in PfDHFR structures. The structural similarities are paralleled by the similarly poor affinities of the trypanosomal enzyme for rigid inhibitors. Mutations of TbDHFR at Thr86 resulted in 10-fold enhancement or 7-fold reduction in the rigid inhibitors affinities for Thr86Ser or Thr86Asn, respectively. The co-crystal structure of TbDHFR with a flexible antifolate WR99210 suggests that its greater affinity result from its ability to avoid such Thr86 clash and occupy the widened binding space similarly to what is observed in the PfDHFR structures. Natural resistance to antifolates of TbDHFR can therefore be explained, and potential antifolate chemotherapy of trypanosomiasis should be possible taking this into account.

-	~~==Function==~~	+	Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance.,Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y ACS Chem Biol. 2011 Jun 16. PMID:21650210<ref>PMID:21650210</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme~~. ~~Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR~~:~~PIRNR000389]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qg2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021650210</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Chitnumsub, P.]]	+	[[Category: Chitnumsub, P]]
-	[[Category: Kamchonwongpaisan, S.]]	+	[[Category: Kamchonwongpaisan, S]]
-	[[Category: Taweechai, S.]]	+	[[Category: Taweechai, S]]
-	[[Category: Vanichtanankul, J.]]	+	[[Category: Vanichtanankul, J]]
-	[[Category: Yuthavong, Y.]]	+	[[Category: Yuthavong, Y]]
-	[[Category: Yuvaniyama, J.]]	+	[[Category: Yuvaniyama, J]]
	[[Category: Antifolate resistance]]		[[Category: Antifolate resistance]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Plasmodium falciparum]]
	[[Category: Pyrimethamine]]		[[Category: Pyrimethamine]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-inhibitor complex]]		[[Category: Transferase-inhibitor complex]]

OCA at 07:37, 30 June 2013

OCA — Sun, 30 Jun 2013 07:37:24 GMT

←Older revision		Revision as of 07:37, 30 June 2013
Line 1:		Line 1:
-	[[Image:3qg2.png\|left\|200px]]
-
	{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}		{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}
-
	===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===		===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===
-
	{{ABSTRACT_PUBMED_21650210}}		{{ABSTRACT_PUBMED_21650210}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

	==About this Structure==		==About this Structure==
	[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].		[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].
-
-	==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-	*[[Thymidylate synthase\|Thymidylate synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021650210</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021650210</ref><references group="xtra"/><references/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Chitnumsub, P.]]		[[Category: Chitnumsub, P.]]

OCA at 06:31, 20 October 2012

OCA — Sat, 20 Oct 2012 06:31:03 GMT

←Older revision		Revision as of 06:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qg2]] is a 2 chain structure ~~of [[Dihydrofolate reductase]] and [[Thymidylate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].	+	[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].

	==See Also==		==See Also==

OCA at 13:25, 25 July 2012

OCA — Wed, 25 Jul 2012 13:25:33 GMT

←Older revision		Revision as of 13:25, 25 July 2012
Line 1:		Line 1:
-	[[Image:3qg2.~~jpg~~\|left\|200px]]	+	[[Image:3qg2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qg2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}		{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}

	===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===		===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21650210}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21650210 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21650210}}		{{ABSTRACT_PUBMED_21650210}}

	==About this Structure==		==About this Structure==
-	[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].	+	[[3qg2]] is a 2 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	*[[Thymidylate synthase\|Thymidylate synthase]]

	==Reference==		==Reference==

OCA at 06:00, 29 June 2011

OCA — Wed, 29 Jun 2011 06:00:41 GMT

←Older revision		Revision as of 06:00, 29 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qg2.jpg\|left\|200px]]

-	The ~~entry 3qg2~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qg2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qg2\| PDB=3qg2 \| SCENE= }}

-	~~Authors: Vanichtanankul, J., Yuvaniyama, J., Taweechai~~, S~~., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.~~	+	===Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex===

-	~~Description~~: Plasmodium falciparum ~~DHFR~~-~~TS qradruple mutant (N51I+C59R+S108N+I164L, V1~~/S~~) pyrimethamine~~ complex	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21650210}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21650210 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21650210}}
		+
		+	==About this Structure==
		+	[[3qg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021650210</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Chitnumsub, P.]]
		+	[[Category: Kamchonwongpaisan, S.]]
		+	[[Category: Taweechai, S.]]
		+	[[Category: Vanichtanankul, J.]]
		+	[[Category: Yuthavong, Y.]]
		+	[[Category: Yuvaniyama, J.]]
		+	[[Category: Antifolate resistance]]
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Pyrimethamine]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-inhibitor complex]]

OCA at 06:38, 2 March 2011

OCA — Wed, 02 Mar 2011 06:38:56 GMT

←Older revision		Revision as of 06:38, 2 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qg2 is ON HOLD	+	The entry 3qg2 is ON HOLD until Paper Publication

	Authors: Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.		Authors: Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

	Description: Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex		Description: Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex