3qhf - Revision history

OCA at 11:45, 14 March 2024

OCA — Thu, 14 Mar 2024 11:45:57 GMT

←Older revision		Revision as of 11:45, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qhf' size='340' side='right'caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='3qhf' size='340' side='right'caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHF FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.655Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3qhz\|3qhz]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Immunoglobulin gamma ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), Immunoglobulin lambda ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [https://pdbe.org/3qhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [https://www.ebi.ac.uk/pdbsum/3qhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [https://pdbe.org/3qhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [https://www.ebi.ac.uk/pdbsum/3qhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhf ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the antibody-combining site and contributes to its high potency against the 1918 and 2009 pandemic H1N1 influenza viruses. The insertion arose through a series of events, including a somatic point mutation in a predicted hot-spot motif, introduction of a new hot-spot motif, a molecular duplication due to polymerase slippage, a deletion due to misalignment, and additional somatic point mutations. Atomic resolution structures of the wild-type antibody and a variant in which the insertion was removed revealed that the three-amino-acid insertion near the base of heavy-chain complementarity-determining region (CDR) H2 resulted in a bulge in that loop. This enlarged CDR H2 loop impinges on adjacent regions, causing distortion of the CDR H1 architecture and its displacement away from the antigen-combining site. Removal of the insertion restores the canonical structure of CDR H1 and CDR H2, but binding, neutralization activity, and in vivo activity were reduced markedly because of steric conflict of CDR H1 with the hemagglutinin antigen.
-
-	An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.,Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE Jr MBio. 2011 Feb 8;2(1):e00345-10. doi: 10.1128/mBio.00345-10. Print 2011. PMID:21304166<ref>PMID:21304166</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3qhf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ekiert~~, D C~~]]	+	[[Category: Ekiert DC]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Immune recognition]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Influenza a virus hemagglutinin~~]]	+

OCA at 06:09, 8 June 2022

OCA — Wed, 08 Jun 2022 06:09:04 GMT

←Older revision		Revision as of 06:09, 8 June 2022
Line 3:		Line 3:
	<StructureSection load='3qhf' size='340' side='right'caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='3qhf' size='340' side='right'caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qhz\|3qhz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qhz\|3qhz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Immunoglobulin gamma ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Immunoglobulin lambda ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Immunoglobulin gamma ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Immunoglobulin lambda ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [~~http~~://pdbe.org/3qhf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qhf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [https://pdbe.org/3qhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [https://www.ebi.ac.uk/pdbsum/3qhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:52, 25 December 2019

OCA — Wed, 25 Dec 2019 09:52:34 GMT

←Older revision		Revision as of 09:52, 25 December 2019
Line 1:		Line 1:

	==Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1==		==Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1==
-	<StructureSection load='3qhf' size='340' side='right' caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>	+	<StructureSection load='3qhf' size='340' side='right'caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHF FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ekiert, D C]]		[[Category: Ekiert, D C]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 11:18, 10 December 2016

OCA — Sat, 10 Dec 2016 11:18:45 GMT

←Older revision		Revision as of 11:18, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1==		==Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1==
	<StructureSection load='3qhf' size='340' side='right' caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='3qhf' size='340' side='right' caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qhz\|3qhz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qhz\|3qhz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Immunoglobulin gamma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Immunoglobulin lambda ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Immunoglobulin gamma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Immunoglobulin lambda ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [http://www.ebi.ac.uk/pdbsum/3qhf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [http://pdbe.org/3qhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [http://www.ebi.ac.uk/pdbsum/3qhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qhf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ekiert, D C]]		[[Category: Ekiert, D C]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 10:47, 9 December 2014

OCA — Tue, 09 Dec 2014 10:47:16 GMT

←Older revision		Revision as of 10:47, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qhf.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1==
		+	<StructureSection load='3qhf' size='340' side='right' caption='[[3qhf]], [[Resolution\|resolution]] 1.66Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHF FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qhz\|3qhz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Immunoglobulin gamma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Immunoglobulin lambda ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qhf RCSB], [http://www.ebi.ac.uk/pdbsum/3qhf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the antibody-combining site and contributes to its high potency against the 1918 and 2009 pandemic H1N1 influenza viruses. The insertion arose through a series of events, including a somatic point mutation in a predicted hot-spot motif, introduction of a new hot-spot motif, a molecular duplication due to polymerase slippage, a deletion due to misalignment, and additional somatic point mutations. Atomic resolution structures of the wild-type antibody and a variant in which the insertion was removed revealed that the three-amino-acid insertion near the base of heavy-chain complementarity-determining region (CDR) H2 resulted in a bulge in that loop. This enlarged CDR H2 loop impinges on adjacent regions, causing distortion of the CDR H1 architecture and its displacement away from the antigen-combining site. Removal of the insertion restores the canonical structure of CDR H1 and CDR H2, but binding, neutralization activity, and in vivo activity were reduced markedly because of steric conflict of CDR H1 with the hemagglutinin antigen.

-	~~{{STRUCTURE_3qhf\| PDB=3qhf \| SCENE= }}~~	+	An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.,Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE Jr MBio. 2011 Feb 8;2(1):e00345-10. doi: 10.1128/mBio.00345-10. Print 2011. PMID:21304166<ref>PMID:21304166</ref>

-	~~===Crystal Structure of Fab del2D1~~, a ~~deletion variant~~ of ~~anti-influenza antibody 2D1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21304166}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qhf]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].~~	+

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021304166<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ekiert, D C.]]	+	[[Category: Ekiert, D C]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Immune recognition]]		[[Category: Immune recognition]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Influenza a virus hemagglutinin]]		[[Category: Influenza a virus hemagglutinin]]

OCA at 09:37, 20 October 2012

OCA — Sat, 20 Oct 2012 09:37:14 GMT

←Older revision		Revision as of 09:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qhf]] is a 2 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].	+	[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].

	==See Also==		==See Also==

OCA at 23:27, 25 July 2012

OCA — Wed, 25 Jul 2012 23:27:12 GMT

←Older revision		Revision as of 23:27, 25 July 2012
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	[[Image:3qhf.png\|left\|200px]]		[[Image:3qhf.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3qhf\| PDB=3qhf \| SCENE= }}		{{STRUCTURE_3qhf\| PDB=3qhf \| SCENE= }}

	===Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1===		===Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21304166}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_21304166}}		{{ABSTRACT_PUBMED_21304166}}

	==About this Structure==		==About this Structure==
-	[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].	+	[[3qhf]] is a 2 chain structure of [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].
		+
		+	==See Also==
		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]

	==Reference==		==Reference==

OCA at 18:01, 6 July 2011

OCA — Wed, 06 Jul 2011 18:01:09 GMT

←Older revision		Revision as of 18:01, 6 July 2011
Line 1:		Line 1:
-	[[Image:3qhf.~~jpg~~\|left\|200px]]	+	[[Image:3qhf.png\|left\|200px]]

	<!--		<!--
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	===Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1===		===Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21304166}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21304166 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21304166}}

	==About this Structure==		==About this Structure==
	[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].		[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021304166</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ekiert, D C.]]		[[Category: Ekiert, D C.]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
		+	[[Category: Immune recognition]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]
		+	[[Category: Influenza a virus hemagglutinin]]

OCA at 05:43, 16 February 2011

OCA — Wed, 16 Feb 2011 05:43:37 GMT

←Older revision		Revision as of 05:43, 16 February 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qhf.jpg\|left\|200px]]

-	The ~~entry 3qhf~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qhf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qhf\| PDB=3qhf \| SCENE= }}

-	~~Authors: Ekiert~~, ~~D.C., Wilson, I.A.~~	+	===Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1===

-	~~Description: Crystal~~ Structure ~~of Fab del2D1,~~ a ~~deletion variant of anti~~-~~influenza antibody 2D1~~	+
		+	==About this Structure==
		+	[[3qhf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHF OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Ekiert, D C.]]
		+	[[Category: Wilson, I A.]]

OCA: Protected "3qhf" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2011 06:12:47 GMT

Protected "3qhf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 2 February 2011