3qjn - Revision history

OCA at 08:35, 20 March 2024

OCA — Wed, 20 Mar 2024 08:35:19 GMT

←Older revision		Revision as of 08:35, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3qjn' size='340' side='right'caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='3qjn' size='340' side='right'caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3qjm\|3qjm]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Shank1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [https://pdbe.org/3qjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [https://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [https://pdbe.org/3qjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [https://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>	+	[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The PDZ domain of the shank protein interacts with numerous cell membrane receptors and cytosolic proteins via the loosely defined binding motif X-(Ser/Thr)-X-Phi-COOH (Phi represents hydrophobic residues) at the carboxyl terminus of its target protein. This enables shank to serve as a membrane-associated scaffold for the assembly of signaling complexes. As the list of proteins that bind to the shank PDZ domain grows, it is not immediately clear what structural element(s) mediate this domain's target specificity or the plasticity required to bind its different targets. Here, we have determined the crystal structure of the shank1 PDZ in complex with the betaPIX C-terminal pentapeptide (642-646, DETNL) at 2.3A resolution and modeled shank1 PDZ binding to selected pentapeptide ligands. The resulting structures revealed a large hydrophobic pocket within the PDZ domain that can accommodate a variety of ligand residues at the P(0) position. A H-bond between His735 and Ser/Thr at the P(-2) position is invariant throughout the model structures. In addition, we identified multiple PDZ domain residues that are able to form H-bonds and salt bridges with an incoming target protein. Overall, our study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain.	+
-		+
-	The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands.,Lee JH, Park H, Park SJ, Kim HJ, Eom SH Biochem Biophys Res Commun. 2011 Apr 1;407(1):207-12. Epub 2011 Mar 3. PMID:21376703<ref>PMID:21376703</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qjn" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Eom, S H~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Kim, H J~~]]	+	[[Category: Eom SH]]
-	[[Category: ~~Lee, J H~~]]	+	[[Category: Kim HJ]]
-	[[Category: ~~Park, H~~]]	+	[[Category: Lee JH]]
-	[[Category: Park~~, S J~~]]	+	[[Category: Park H]]
-	[[Category: ~~Beta-pix]]~~	+	[[Category: Park SJ]]
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein interaction~~]]	+

OCA at 06:11, 8 June 2022

OCA — Wed, 08 Jun 2022 06:11:38 GMT

←Older revision		Revision as of 06:11, 8 June 2022
Line 1:		Line 1:

	==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==		==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==
-	<StructureSection load='3qjn' size='340' side='right' caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='3qjn' size='340' side='right'caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qjm\|3qjm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qjm\|3qjm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [~~http~~://pdbe.org/3qjn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [https://pdbe.org/3qjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [https://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>	+	[[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Eom, S H]]		[[Category: Eom, S H]]
	[[Category: Kim, H J]]		[[Category: Kim, H J]]

OCA at 15:20, 4 August 2016

OCA — Thu, 04 Aug 2016 15:20:45 GMT

←Older revision		Revision as of 15:20, 4 August 2016
Line 1:		Line 1:
		+
	==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==		==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==
	<StructureSection load='3qjn' size='340' side='right' caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='3qjn' size='340' side='right' caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QJN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qjm\|3qjm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qjm\|3qjm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://pdbe.org/3qjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qjn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Eom, S H]]		[[Category: Eom, S H]]
	[[Category: Kim, H J]]		[[Category: Kim, H J]]

OCA at 10:30, 25 December 2014

OCA — Thu, 25 Dec 2014 10:30:43 GMT

←Older revision		Revision as of 10:30, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:58, 9 December 2014

OCA — Tue, 09 Dec 2014 11:58:43 GMT

←Older revision		Revision as of 11:58, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qjn.~~png~~\|~~left~~\|~~200px~~]]	+	==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==
		+	<StructureSection load='3qjn' size='340' side='right' caption='[[3qjn]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QJN FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qjm\|3qjm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The PDZ domain of the shank protein interacts with numerous cell membrane receptors and cytosolic proteins via the loosely defined binding motif X-(Ser/Thr)-X-Phi-COOH (Phi represents hydrophobic residues) at the carboxyl terminus of its target protein. This enables shank to serve as a membrane-associated scaffold for the assembly of signaling complexes. As the list of proteins that bind to the shank PDZ domain grows, it is not immediately clear what structural element(s) mediate this domain's target specificity or the plasticity required to bind its different targets. Here, we have determined the crystal structure of the shank1 PDZ in complex with the betaPIX C-terminal pentapeptide (642-646, DETNL) at 2.3A resolution and modeled shank1 PDZ binding to selected pentapeptide ligands. The resulting structures revealed a large hydrophobic pocket within the PDZ domain that can accommodate a variety of ligand residues at the P(0) position. A H-bond between His735 and Ser/Thr at the P(-2) position is invariant throughout the model structures. In addition, we identified multiple PDZ domain residues that are able to form H-bonds and salt bridges with an incoming target protein. Overall, our study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain.

-	~~{{STRUCTURE_3qjn\| PDB=3qjn \| SCENE= }}~~	+	The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands.,Lee JH, Park H, Park SJ, Kim HJ, Eom SH Biochem Biophys Res Commun. 2011 Apr 1;407(1):207-12. Epub 2011 Mar 3. PMID:21376703<ref>PMID:21376703</ref>

-	~~===Structural flexibility~~ of ~~Shank PDZ domain is important for its binding to different ligands===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21376703}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qjn]] is a 16 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].~~	+

	==See Also==		==See Also==
	*[[Shank protein\|Shank protein]]		*[[Shank protein\|Shank protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021376703<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Eom, S H.]]	+	[[Category: Eom, S H]]
-	[[Category: Kim, H J.]]	+	[[Category: Kim, H J]]
-	[[Category: Lee, J H.]]	+	[[Category: Lee, J H]]
-	[[Category: Park, H.]]	+	[[Category: Park, H]]
-	[[Category: Park, S J.]]	+	[[Category: Park, S J]]
	[[Category: Beta-pix]]		[[Category: Beta-pix]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Protein-protein interaction]]		[[Category: Protein-protein interaction]]

OCA at 15:39, 20 October 2012

OCA — Sat, 20 Oct 2012 15:39:29 GMT

←Older revision		Revision as of 15:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qjn]] is a 16 chain structure ~~of [[Shank protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].	+	[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].

	==See Also==		==See Also==

OCA at 19:04, 26 July 2012

OCA — Thu, 26 Jul 2012 19:04:27 GMT

←Older revision		Revision as of 19:04, 26 July 2012
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	[[Image:3qjn.png\|left\|200px]]		[[Image:3qjn.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3qjn\| PDB=3qjn \| SCENE= }}		{{STRUCTURE_3qjn\| PDB=3qjn \| SCENE= }}

	===Structural flexibility of Shank PDZ domain is important for its binding to different ligands===		===Structural flexibility of Shank PDZ domain is important for its binding to different ligands===

-
-	<!--
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	{{ABSTRACT_PUBMED_21376703}}		{{ABSTRACT_PUBMED_21376703}}

OCA at 06:48, 18 April 2012

OCA — Wed, 18 Apr 2012 06:48:44 GMT

←Older revision		Revision as of 06:48, 18 April 2012
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-	[[Image:3qjn.~~jpg~~\|left\|200px]]	+	[[Image:3qjn.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].	+	[[3qjn]] is a 16 chain structure of [[Shank protein]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].
		+
		+	==See Also==
		+	*[[Shank protein\|Shank protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21376703~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021376703</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Eom, S H.]]		[[Category: Eom, S H.]]
Line 29:		Line 32:
	[[Category: Park, H.]]		[[Category: Park, H.]]
	[[Category: Park, S J.]]		[[Category: Park, S J.]]
		+	[[Category: Beta-pix]]
		+	[[Category: Pdz domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein interaction]]

OCA at 05:11, 13 April 2011

OCA — Wed, 13 Apr 2011 05:11:52 GMT

←Older revision		Revision as of 05:11, 13 April 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qjn.jpg\|left\|200px]]

-	The ~~entry 3qjn~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qjn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qjn\| PDB=3qjn \| SCENE= }}

-	~~Authors: Lee, J.H., Park, H., Park, S.J., Kim, H.J., Eom, S.H.~~	+	===Structural flexibility of Shank PDZ domain is important for its binding to different ligands===

-	~~Description~~: ~~Structural flexibility of Shank PDZ domain~~ is ~~important for its binding to different ligands~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21376703}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21376703 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21376703}}
		+
		+	==About this Structure==
		+	[[3qjn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21376703</ref><references group="xtra"/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Eom, S H.]]
		+	[[Category: Kim, H J.]]
		+	[[Category: Lee, J H.]]
		+	[[Category: Park, H.]]
		+	[[Category: Park, S J.]]

OCA: Protected "3qjn" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 05:50:33 GMT

Protected "3qjn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 9 February 2011