3qk5 - Revision history

OCA at 11:48, 14 March 2024

OCA — Thu, 14 Mar 2024 11:48:43 GMT

←Older revision		Revision as of 11:48, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qk5' size='340' side='right'caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3qk5' size='340' side='right'caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [https://pdbe.org/3qk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [https://pdbe.org/3qk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).	+	[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors. The mechanism of action for these compounds was determined through a combination of SAR and co-crystallography with rat FAAH.	+
-		+
-	Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.,Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. Epub 2011 Feb 17. PMID:21392988<ref>PMID:21392988</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qk5" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Fatty acid amide hydrolase\|Fatty acid amide hydrolase]]		*[[Fatty acid amide hydrolase\|Fatty acid amide hydrolase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Fatty acid amide hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Min, X~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Walker, N P.C~~]]	+	[[Category: Min X]]
-	[[Category: ~~Wang, Z~~]]	+	[[Category: Walker NPC]]
-	[[Category: ~~Faah]]~~	+	[[Category: Wang Z]]
-	~~[[Category: Fatty-acid amide hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex~~]]	+

OCA at 06:12, 8 June 2022

OCA — Wed, 08 Jun 2022 06:12:14 GMT

←Older revision		Revision as of 06:12, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==		==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==
-	<StructureSection load='3qk5' size='340' side='right' caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3qk5' size='340' side='right'caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [~~http~~://pdbe.org/3qk5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [https://pdbe.org/3qk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).	+	[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 30:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Fatty acid amide hydrolase]]		[[Category: Fatty acid amide hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Min, X]]		[[Category: Min, X]]
	[[Category: Walker, N P.C]]		[[Category: Walker, N P.C]]

OCA at 21:29, 4 August 2016

OCA — Thu, 04 Aug 2016 21:29:22 GMT

←Older revision		Revision as of 21:29, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==		==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==
	<StructureSection load='3qk5' size='340' side='right' caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3qk5' size='340' side='right' caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [http://pdbe.org/3qk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qk5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Fatty acid amide hydrolase]]		[[Category: Fatty acid amide hydrolase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Min, X]]		[[Category: Min, X]]
	[[Category: Walker, N P.C]]		[[Category: Walker, N P.C]]

OCA at 13:17, 25 December 2014

OCA — Thu, 25 Dec 2014 13:17:43 GMT

←Older revision		Revision as of 13:17, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:21, 19 December 2014

OCA — Fri, 19 Dec 2014 10:21:47 GMT

←Older revision		Revision as of 10:21, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qk5\| PDB=3qk5 \| SCENE= }}~~	+	==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==
-	===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===	+	<StructureSection load='3qk5' size='340' side='right' caption='[[3qk5]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	{~~{ABSTRACT_PUBMED_21392988}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qj8\|3qj8]], [[3qj9\|3qj9]], [[3qkv\|3qkv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors. The mechanism of action for these compounds was determined through a combination of SAR and co-crystallography with rat FAAH.

-	~~==Function==~~	+	Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.,Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. Epub 2011 Feb 17. PMID:21392988<ref>PMID:21392988</ref>
-	~~[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive~~ fatty acid ~~amides like oleamide~~, ~~the endogenous cannabinoid~~, ~~anandamide and myristic amide to their corresponding acids~~, ~~thereby serving to terminate the signaling functions of these molecules~~. ~~Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qk5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021392988</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Fatty acid amide hydrolase\|Fatty acid amide hydrolase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fatty acid amide hydrolase]]		[[Category: Fatty acid amide hydrolase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Min, X.]]	+	[[Category: Min, X]]
-	[[Category: Walker, N P.C.]]	+	[[Category: Walker, N P.C]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Faah]]		[[Category: Faah]]
	[[Category: Fatty-acid amide hydrolase]]		[[Category: Fatty-acid amide hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protein-inhibitor complex]]		[[Category: Protein-inhibitor complex]]

OCA at 08:19, 8 May 2013

OCA — Wed, 08 May 2013 08:19:01 GMT

←Older revision		Revision as of 08:19, 8 May 2013
Line 1:		Line 1:
-	[[Image:3qk5.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qk5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qk5\| PDB=3qk5 \| SCENE= }}		{{STRUCTURE_3qk5\| PDB=3qk5 \| SCENE= }}
-
	===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===		===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===
		+	{{ABSTRACT_PUBMED_21392988}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21392988}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21392988 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21392988}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21392988~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021392988</ref><references group="xtra"/><references/>
	[[Category: Fatty acid amide hydrolase]]		[[Category: Fatty acid amide hydrolase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 28:		Line 16:
	[[Category: Walker, N P.C.]]		[[Category: Walker, N P.C.]]
	[[Category: Wang, Z.]]		[[Category: Wang, Z.]]
		+	[[Category: Faah]]
		+	[[Category: Fatty-acid amide hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]

OCA at 10:04, 21 April 2011

OCA — Thu, 21 Apr 2011 10:04:39 GMT

←Older revision		Revision as of 10:04, 21 April 2011
Line 1:		Line 1:
-	[[Image:3qk5.~~jpg~~\|left\|200px]]	+	[[Image:3qk5.png\|left\|200px]]

	<!--		<!--

OCA at 09:03, 6 April 2011

OCA — Wed, 06 Apr 2011 09:03:18 GMT

←Older revision		Revision as of 09:03, 6 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qk5.jpg\|left\|200px]]

-	The ~~entry 3qk5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qk5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qk5\| PDB=3qk5 \| SCENE= }}

-	~~Authors: Min, X., Walker, N.P.C., Wang, Z.~~	+	===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===

-	~~Description~~: ~~Crystal~~ structure ~~of fatty~~ acid amide hydrolase ~~with small molecule inhibitor~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21392988}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21392988 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21392988}}
		+
		+	==About this Structure==
		+	[[3qk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21392988</ref><references group="xtra"/>
		+	[[Category: Fatty acid amide hydrolase]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Min, X.]]
		+	[[Category: Walker, N P.C.]]
		+	[[Category: Wang, Z.]]

OCA at 07:44, 30 March 2011

OCA — Wed, 30 Mar 2011 07:44:36 GMT

←Older revision		Revision as of 07:44, 30 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qk5 is ON HOLD	+	The entry 3qk5 is ON HOLD until Paper Publication

	Authors: Min, X., Walker, N.P.C., Wang, Z.		Authors: Min, X., Walker, N.P.C., Wang, Z.

	Description: Crystal structure of fatty acid amide hydrolase with small molecule inhibitor		Description: Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

OCA: Protected "3qk5" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 05:50:53 GMT

Protected "3qk5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 9 February 2011