3qk8 - Revision history

OCA at 11:48, 14 March 2024

OCA — Thu, 14 Mar 2024 11:48:47 GMT

←Older revision		Revision as of 11:48, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qk8' size='340' side='right'caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3qk8' size='340' side='right'caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycmm Mycmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [https://pdbe.org/3qk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [https://pdbe.org/3qk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk8 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/B2HM22_MYCMM B2HM22_MYCMM]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3qk8" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]		*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycmm]]~~	+	[[Category: Mycobacterium marinum M]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Emerald biostructure]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Nih]]~~	+
-	~~[[Category: Sbri]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Uw~~]]	+

OCA at 06:12, 8 June 2022

OCA — Wed, 08 Jun 2022 06:12:23 GMT

←Older revision		Revision as of 06:12, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand==		==Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand==
-	<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3qk8' size='340' side='right'caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [~~http~~://pdbe.org/3qk8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qk8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [https://pdbe.org/3qk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3qk8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qk8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycmm]]		[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:51, 1 February 2017

OCA — Wed, 01 Feb 2017 18:51:05 GMT

←Older revision		Revision as of 18:51, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand==		==Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand==
	<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [http://pdbe.org/3qk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3qk8" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Enoyl-CoA hydratase\|Enoyl-~~CoA hydratase]]~~	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:18, 22 April 2015

OCA — Wed, 22 Apr 2015 07:18:50 GMT

←Older revision		Revision as of 07:18, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_marinum_m Mycobacterium marinum m~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 ~~Mycobacterium marinum M~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk8 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium marinum m~~]]	+	[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Emerald biostructure]]		[[Category: Emerald biostructure]]

OCA at 10:34, 19 December 2014

OCA — Fri, 19 Dec 2014 10:34:03 GMT

←Older revision		Revision as of 10:34, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qk8\| PDB=3qk8 \| SCENE= }}~~	+	==Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand==
-	===Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand===	+	<StructureSection load='3qk8' size='340' side='right' caption='[[3qk8]], [[Resolution\|resolution]] 1.60Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3qk8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum_m Mycobacterium marinum m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QK8 FirstGlance]. <br>
-	[[3qk8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum_m Mycobacterium marinum m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK8 OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA15, MMAR_2037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 Mycobacterium marinum M])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qk8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qk8 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium marinum m]]		[[Category: Mycobacterium marinum m]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Emerald biostructure]]		[[Category: Emerald biostructure]]
	[[Category: Lyase]]		[[Category: Lyase]]
Line 11:		Line 16:
	[[Category: Nih]]		[[Category: Nih]]
	[[Category: Sbri]]		[[Category: Sbri]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Uw]]		[[Category: Uw]]

OCA at 08:31, 8 May 2013

OCA — Wed, 08 May 2013 08:31:29 GMT

←Older revision		Revision as of 08:31, 8 May 2013
Line 1:		Line 1:
-	[[Image:3qk8.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qk8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qk8\| PDB=3qk8 \| SCENE= }}		{{STRUCTURE_3qk8\| PDB=3qk8 \| SCENE= }}
-
	===Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand===		===Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand===
-

	==About this Structure==		==About this Structure==
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	[[Category: Mycobacterium marinum m]]		[[Category: Mycobacterium marinum m]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Emerald biostructure]]
		+	[[Category: Lyase]]
		+	[[Category: Niaid]]
		+	[[Category: Nih]]
		+	[[Category: Sbri]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Uw]]

OCA: Protected "3qk8" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 06:15:57 GMT

Protected "3qk8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 9 February 2011