3qm4 - Revision history

OCA at 11:50, 14 March 2024

OCA — Thu, 14 Mar 2024 11:50:45 GMT

←Older revision		Revision as of 11:50, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qm4' size='340' side='right'caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='3qm4' size='340' side='right'caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~, ~~<scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2f9q\|2f9q]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1~~ (~~[https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]~~)~~</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [https://pdbe.org/3qm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [https://pdbe.org/3qm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>	+	[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor prinomastat to 2.85 A resolution by X-ray crystallography. Prinomastat binding is well defined by electron density maps with its pyridyl nitrogen bound to the heme iron. The structure of ligand bound P450 2D6 differs significantly from the ligand free structure reported for the P450 2D6 Met374 variant (PDB# 2F9Q). Superposition of the structures reveals significant differences for beta sheet 1, helices A, F, F', G", G and H as well as the helix B-C loop. The structure of the ligand complex exhibits a closed active site cavity that conforms closely to the shape of prinomastat. The closure of the open cavity seen for the 2F9Q structure reflects a change in the direction and pitch of helix F and introduction of a turn at Gly-218, which is followed by a well defined helix F' that was not observed in the 2F9Q structure. These differences reflect considerable, structural flexibility that is likely to contribute to the catalytic versatility of P450 2D6 and the new structure provides an alternative model for in silico studies of substrate interactions with P450 2D6.	+
-		+
-	~~Crystal structure of human cytochrome P450 2D6 with prinomastat bound.,Wang A, Savas U, Hsu MH, Stout CD, Johnson EF J Biol Chem. 2012 Feb 3. PMID:22308038<ref>PMID:22308038</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qm4" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Unspecific monooxygenase]]~~	+	[[Category: Johnson EF]]
-	[[Category: Johnson~~, E F~~]]	+	[[Category: Stout CD]]
-	[[Category: Stout~~, C D~~]]	+	[[Category: Wang A]]
-	[[Category: Wang, A]]	+
-	~~[[Category: Cyp2d6]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: P450]]~~	+
-	~~[[Category: P450 2d6]]~~	+
-	~~[[Category: Prinomastat~~]]	+

OCA at 06:14, 8 June 2022

OCA — Wed, 08 Jun 2022 06:14:30 GMT

←Older revision		Revision as of 06:14, 8 June 2022
Line 1:		Line 1:

	==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==		==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==
-	<StructureSection load='3qm4' size='340' side='right' caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='3qm4' size='340' side='right'caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f9q\|2f9q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f9q\|2f9q]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [~~http~~://pdbe.org/3qm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [https://pdbe.org/3qm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>	+	[[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Johnson, E F]]		[[Category: Johnson, E F]]

OCA at 13:07, 5 August 2016

OCA — Fri, 05 Aug 2016 13:07:47 GMT

←Older revision		Revision as of 13:07, 5 August 2016
Line 1:		Line 1:
		+
	==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==		==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==
	<StructureSection load='3qm4' size='340' side='right' caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='3qm4' size='340' side='right' caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f9q\|2f9q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f9q\|2f9q]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [http://www.ebi.ac.uk/pdbsum/3qm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [http://pdbe.org/3qm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [http://www.ebi.ac.uk/pdbsum/3qm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qm4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Johnson, E F]]		[[Category: Johnson, E F]]

OCA at 19:05, 25 December 2014

OCA — Thu, 25 Dec 2014 19:05:15 GMT

←Older revision		Revision as of 19:05, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qm4.~~png~~\|~~left~~\|~~200px~~]]	+	==Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex==
		+	<StructureSection load='3qm4' size='340' side='right' caption='[[3qm4]], [[Resolution\|resolution]] 2.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QM4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f9q\|2f9q]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2D6, CYP2DL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qm4 RCSB], [http://www.ebi.ac.uk/pdbsum/3qm4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor prinomastat to 2.85 A resolution by X-ray crystallography. Prinomastat binding is well defined by electron density maps with its pyridyl nitrogen bound to the heme iron. The structure of ligand bound P450 2D6 differs significantly from the ligand free structure reported for the P450 2D6 Met374 variant (PDB# 2F9Q). Superposition of the structures reveals significant differences for beta sheet 1, helices A, F, F', G", G and H as well as the helix B-C loop. The structure of the ligand complex exhibits a closed active site cavity that conforms closely to the shape of prinomastat. The closure of the open cavity seen for the 2F9Q structure reflects a change in the direction and pitch of helix F and introduction of a turn at Gly-218, which is followed by a well defined helix F' that was not observed in the 2F9Q structure. These differences reflect considerable, structural flexibility that is likely to contribute to the catalytic versatility of P450 2D6 and the new structure provides an alternative model for in silico studies of substrate interactions with P450 2D6.

-	~~{{STRUCTURE_3qm4\| PDB=3qm4 \| SCENE= }}~~	+	Crystal structure of human cytochrome P450 2D6 with prinomastat bound.,Wang A, Savas U, Hsu MH, Stout CD, Johnson EF J Biol Chem. 2012 Feb 3. PMID:22308038<ref>PMID:22308038</ref>

-	~~===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22308038}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qm4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].~~	+

	==See Also==		==See Also==
	*[[Cytochrome P450\|Cytochrome P450]]		*[[Cytochrome P450\|Cytochrome P450]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022308038<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
-	[[Category: Johnson, E F.]]	+	[[Category: Johnson, E F]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
-	[[Category: Wang, A.]]	+	[[Category: Wang, A]]
	[[Category: Cyp2d6]]		[[Category: Cyp2d6]]
	[[Category: Heme]]		[[Category: Heme]]

OCA at 20:20, 20 October 2012

OCA — Sat, 20 Oct 2012 20:20:21 GMT

←Older revision		Revision as of 20:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qm4]] is a 2 chain structure ~~of [[Cytochrome P450]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].	+	[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].

	==See Also==		==See Also==

OCA at 06:56, 4 July 2012

OCA — Wed, 04 Jul 2012 06:56:38 GMT

←Older revision		Revision as of 06:56, 4 July 2012
Line 1:		Line 1:
	[[Image:3qm4.png\|left\|200px]]		[[Image:3qm4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qm4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qm4\| PDB=3qm4 \| SCENE= }}		{{STRUCTURE_3qm4\| PDB=3qm4 \| SCENE= }}

	===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===		===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22308038}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22308038 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22308038}}		{{ABSTRACT_PUBMED_22308038}}

	==About this Structure==		==About this Structure==
-	[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].	+	[[3qm4]] is a 2 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].
		+
		+	==See Also==
		+	*[[Cytochrome P450\|Cytochrome P450]]

	==Reference==		==Reference==

OCA at 08:48, 29 February 2012

OCA — Wed, 29 Feb 2012 08:48:36 GMT

←Older revision		Revision as of 08:48, 29 February 2012
Line 11:		Line 11:
	===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===		===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22308038}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22308038 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22308038}}

	==About this Structure==		==About this Structure==

OCA at 06:44, 22 February 2012

OCA — Wed, 22 Feb 2012 06:44:21 GMT

←Older revision		Revision as of 06:44, 22 February 2012
Line 1:		Line 1:
-	[[Image:3qm4.~~jpg~~\|left\|200px]]	+	[[Image:3qm4.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:
	==About this Structure==		==About this Structure==
	[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].		[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022308038</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]

OCA at 06:49, 15 February 2012

OCA — Wed, 15 Feb 2012 06:49:03 GMT

←Older revision		Revision as of 06:49, 15 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qm4.jpg\|left\|200px]]

-	The ~~entry 3qm4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qm4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qm4\| PDB=3qm4 \| SCENE= }}

-	~~Authors: Wang, A., Stout, C.D., Johnson, E.F.~~	+	===Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex===

-	~~Description~~: ~~Human Cytochrome P450 (CYP) 2D6~~ -Prinomastat ~~Complex~~	+
		+	==About this Structure==
		+	[[3qm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QM4 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Unspecific monooxygenase]]
		+	[[Category: Johnson, E F.]]
		+	[[Category: Stout, C D.]]
		+	[[Category: Wang, A.]]
		+	[[Category: Cyp2d6]]
		+	[[Category: Heme]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: P450]]
		+	[[Category: P450 2d6]]
		+	[[Category: Prinomastat]]

OCA at 06:05, 9 March 2011

OCA — Wed, 09 Mar 2011 06:05:36 GMT

←Older revision		Revision as of 06:05, 9 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qm4 is ON HOLD	+	The entry 3qm4 is ON HOLD until Paper Publication

	Authors: Wang, A., Stout, C.D., Johnson, E.F.		Authors: Wang, A., Stout, C.D., Johnson, E.F.

	Description: Human Cytochrome P450 (CYP) 2D6 -Prinomastat Complex		Description: Human Cytochrome P450 (CYP) 2D6 -Prinomastat Complex